Progress in the development of nonpeptidomimetic BACE 1 inhibitors for Alzheimer's disease

Current Medicinal Chemistry

Volumn 16, Issue 14, 2009, Pages 1806-1820

  Huang, Wen Hai ^a   Sheng, Rong ^a   Hu, Yong Zhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Alzheimer's disease (AD); BACE 1 inhibitor; Nonpeptidomimetic inhibitors

Indexed keywords

2 AMINO ISOINDOLE DERIVATIVE; 2 AMINO PYRIDINONE DERIVATIVE; 2 AMINO QUINAZOLINE DERIVATIVE; 2 AMINO QUINOLINE DERIVATIVE; 2 AMINOTHIAZOLE DERIVATIVE; 6 AMINO IMIDAZOPYRIMIDINE DERIVATIVE; ACYLGUANIDINE DERIVATIVE; BETA SECRETASE; BETA SECRETASE INHIBITOR; HETEROARYL PHENYLPROPAN 2 AMINE DERIVATIVE; ISOPHTHALAMIDE DERIVATIVE; NONPEPTIDOMIMETIC BETA SECRETASE INHIBITOR; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; PROTEINASE INHIBITOR; SECRETASE;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; IC 50; PATENT; REVIEW; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; HUMANS; MODELS, MOLECULAR; PROTEASE INHIBITORS;

EID: 67651047153     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709788186174     Document Type: Review

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