Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection

Angewandte Chemie - International Edition

Volumn 42, Issue 12, 2003, Pages 1356-1360

  Tsantrizos, Youla S ^a   Bolger, Gordon ^a   Bonneau, Pierre ^a   Cameron, Dale R ^a   Goudreau, Nathalie ^a   Kukolj, George ^a   LaPlante, Steven R ^a   Llinàs Brunet, Montse ^a   Nar, Herbert ^b   Lamarre, Daniel ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Hepatitis C; Inhibitors; NMR spectroscopy; Structure elucidation; Structure activity relationships

Indexed keywords

CELLS; CONFORMATIONS; RNA; SUBSTRATES; VIRUSES;

PROTEASE;

ENZYME INHIBITION;

ANTIVIRUS AGENT; MACROCYCLIC COMPOUND; PROTEINASE INHIBITOR; VIRUS RNA;

ARTICLE; DRUG ABSORPTION; DRUG SCREENING; GENETIC CODE; GEOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; OPEN READING FRAME; PREDICTION; VIRAL GENETICS; VIRUS GENOME; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BINDING SITES; CARCINOMA, HEPATOCELLULAR; HEPACIVIRUS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0037471233     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200390347     Document Type: Article

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