Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: Role of CYP2E1 and TNF-α and activation of JNK and P38 MAP kinase

Free Radical Biology and Medicine

Volumn 47, Issue 5, 2009, Pages 518-528

  Wang, Xiaodong ^a   Lu, Yongke ^a   Xie, Bin ^b   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Alcoholic fatty liver; Cytochrome P450 2e1; Free radicals; MAP kinase; Oxidative stress; TNF

Indexed keywords

ALCOHOL; AMINOTRANSFERASE; CASPASE 3; CASPASE 8; CYTOCHROME P450 2E1; FAS ANTIGEN; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN ANTIBODY; SODIUM CHLORIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EOSINOPHILIA; FATTY LIVER; INFLAMMATORY CELL; LIVER HEMORRHAGE; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TOXICOKINETICS; WILD TYPE;

ANIMALS; ANTIBODIES; ANTIGENS, CD95; CYTOCHROME P-450 CYP2E1; DRUG SYNERGISM; DRUG-INDUCED LIVER INJURY; ENZYME ACTIVATION; ENZYME INHIBITORS; ETHANOL; FEEDING METHODS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER DISEASES; MICE; MICE, KNOCKOUT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 67650725415     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.05.021     Document Type: Article

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