CYP2E1 Overexpression Alters Hepatocyte Death from Menadione and Fatty Acids by Activation of ERK1/2 Signaling

Hepatology

Volumn 39, Issue 2, 2004, Pages 444-455

  Schattenberg, Jörn M ^a   Wang, Yongjun ^a   Rigoli, Raina M ^a   Koop, Dennis R ^b   Czaja, Mark J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBRINOLYTIC AGENT; ANTIOXIDANT; ARACHIDONIC ACID; CYTOCHROME P450 2E1; EPIDERMAL GROWTH FACTOR RECEPTOR; FATTY ACID; GAMMA LINOLENIC ACID; MENADIONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; RAF PROTEIN; SUPEROXIDE; TRANSCRIPTION FACTOR AP 1; UNSATURATED FATTY ACID;

ANIMAL; ANIMAL CELL; ARTICLE; CELL DEATH; CELL LINE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; GENETICS; LIVER CELL; LIVER INJURY; METABOLISM; NONHUMAN; OXIDATIVE STRESS; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SENSITIZATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIFIBRINOLYTIC AGENTS; ANTIOXIDANTS; ARACHIDONIC ACID; CELL DEATH; CELL LINE; CYTOCHROME P-450 CYP2E1; FATTY ACIDS, UNSATURATED; HEPATOCYTES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; VITAMIN K 3;

EID: 1242291933     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20067     Document Type: Article

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