The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA

Journal of Biological Chemistry

Volumn 284, Issue 20, 2009, Pages 13881-13891

  Li, Xiaojun ^a   Ranjith Kumar, C T ^b   Brooks, Monica T ^c   Dharmaiah, S ^b   Herr, Andrew B ^c   Kao, Cheng ^b   Li, Pingwei ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ULTRACENTRIFUGATION; C-TERMINAL DOMAINS; DOUBLE-STRANDED RNA; DOUBLE-STRANDED RNA (DSRNA); GEL-FILTRATION CHROMATOGRAPHY; IMMUNE RESPONSE; IN-CELL; PROTEIN MOLECULES; STRUCTURAL BASIS;

CENTRIFUGATION; CHROMATOGRAPHIC ANALYSIS; CRYSTAL STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; GELATION; NUCLEIC ACIDS; PLANTS (BOTANY); SIGNALING; STOICHIOMETRY;

RNA;

DOUBLE STRANDED RNA; HELICASE; PROTEIN LGP2; RETINOIC ACID INDUCIBLE PROTEIN I; RETINOIC ACID INDUCIBLE PROTEIN I LIKE RECEPTOR; UNCLASSIFIED DRUG; DEAD BOX PROTEIN; DHX58 PROTEIN, HUMAN; IFIH1 PROTEIN, HUMAN; RARRES3 PROTEIN, HUMAN; RETINOIC ACID RECEPTOR; RNA HELICASE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHEMICAL MUTAGENESIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; GEL FILTRATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; STOICHIOMETRY; STRUCTURE ANALYSIS; ULTRACENTRIFUGATION; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DEAD-BOX RNA HELICASES; HUMANS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, RETINOIC ACID; RNA HELICASES; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649413594     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900818200     Document Type: Article

References (34)

1. Janeway, C. A., Jr., and Medzhitov, R. (2002) Annu. Rev. Immunol. 20, 197-216
2. Akira, S., Uematsu, S., and Takeuchi, O. (2006) Cell 124, 783-801
3. Yoneyama, M., and Fujita, T. (2007) J. Biol. Chem. 282, 15315-15318
4. Pichlmair, A., and Reis e Sousa, C. (2007) Immunity 27, 370-383
5. Thompson, A. J., and Locarnini, S. A. (2007) Immunol. Cell Biol. 85, 435-445
6. Akira, S., and Takeda, K. (2004) Nat. Rev. Immunol. 4, 499-511
7. Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., and Fujita, T. (2004) Nat. Immunol. 5, 730-737
8. Takeuchi, O., and Akira, S. (2008) Curr. Opin. Immunol. 20, 17-22
9. Akira, S., Takeda, K., and Kaisho, T. (2001) Nat. Immunol. 2, 675-680
10. Hornung, V., Ellegast, J., Kim, S., Brzozka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K. K., Schlee, M., Endres, S., and Hartmann, G. (2006) Science 314, 994-997
11. Pichlmair, A., Schulz, O., Tan, C. P., Naslund, T. I., Liljestrom, P., Weber, F., and Reis e Sousa, C. (2006) Science 314, 997-1001
12. Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., Yamaguchi, O., Otsu, K., Tsujimura, T., Koh, C. S., Reis e Sousa, C., Matsuura, Y., Fujita, T., and Akira, S. (2006) Nature 441, 101-105
13. Marques, J. T., Devosse, T., Wang, D., Zamanian-Daryoush, M., Serbinowski, P., Hartmann, R., Fujita, T., Behlke, M. A., and Williams, B. R. (2006) Nat. Biotechnol. 24, 559-565
14. Takahasi, K., Yoneyama, M., Nishihori, T., Hirai, R., Kumeta, H., Narita, R., Gale, M., Jr., Inagaki, F., and Fujita, T. (2008) Mol. Cell 29, 428-440
15. Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T. S., Fujita, T., and Akira, S. (2008) J. Exp. Med. 205, 1601-1610
16. Gitlin, L., Barchet, W., Gilfillan, S., Cella, M., Beutler, B., Flavell, R. A., Diamond, M. S., and Colonna, M. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 8459-8464
17. Yoneyama, M., and Fujita, T. (2008) Immunity 29, 178-181
18. Saito, T., Hirai, R., Loo, Y. M., Owen, D., Johnson, C. L., Sinha, S. C., Akira, S., Fujita, T., and Gale, M., Jr. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 582-587
19. Cui, S., Eisenacher, K., Kirchhofer, A., Brzozka, K., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K. K., Krug, A., and Hopfner, K. P. (2008) Mol. Cell 29, 169-179
20. Pippig, D. A., Hellmuth, J. C., Cui, S., Kirchhofer, A., Lammens, K., Lammens, A., Schmidt, A., Rothenfusser, S., and Hopfner, K. P. (2009) Nucleic Acids Res. 10.1093/nar/gkp059
21. Rothenfusser, S., Goutagny, N., DiPerna, G., Gong, M., Monks, B. G., Schoenemeyer, A., Yamamoto, M., Akira, S., and Fitzgerald, K. A. (2005) J. Immunol. 175, 5260-5268
22. Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E., Loo, Y. M., Gale, M., Jr., Akira, S., Yonehara, S., Kato, A., and Fujita, T. (2005) J. Immunol. 175, 2851-2858
23. Komuro, A., Bamming, D., and Horvath, C. M. (2008) Cytokine 43, 350-358
24. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
25. Collaborative Computational Project, number 4 (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 760-763
26. Jones, T. A., and Kjeldgaard, M. (1997) Methods Enzymol. 277, 173-208
27. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol. Crystallogr 54, 905-921
28. Lawrence, M. C., and Colman, P. M. (1993) J. Mol. Biol. 234, 946-950
29. Li, P., Huey-Tubman, K. E., Gao, T., Li, X., West, A. P., Jr., Bennett, M. J., and Bjorkman, P. J. (2007) Nat. Struct. Mol. Biol. 14, 381-387
30. Liu, L., Botos, I., Wang, Y., Leonard, J. N., Shiloach, J., Segal, D. M., and Davies, D. R. (2008) Science 320, 379-381
31. Murali, A., Li, X., Ranjith-Kumar, C. T., Bhardwaj, K., Holzenburg, A., Li, P., and Kao, C. C. (2008) J. Biol. Chem. 283, 15825-15833
32. Malathi, K., Dong, B., Gale, M., Jr., and Silverman, R. H. (2007) Nature 448, 816-819
33. Ranjith-Kumar, C. T., Murali, A., Dong, W., Srisathiyanarayanan, D., Vaughan, R., Ortiz-Alacantara, J., Bhardwaj, K., Li, X., Li, P., and Kao, C. C. (2009) J. Biol. Chem. 284, 1155-1165
34. Komuro, A., and Horvath, C. M. (2006) J. Virol. 80, 12332-12342