Roles for homotypic interactions and transautophosphorylation in IκB kinase (IKKβ) activation

Journal of Biological Chemistry

Volumn 278, Issue 40, 2003, Pages 38566-38570

  Tang, Eric D ^a   Inohara, Naohiro ^a   Wang, Cun Yu ^a   Nuñez, Gabriel ^a   Guan, Kun Liang ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; CELL CULTURE; OLIGOMERS;

PHOSPHORYLATION;

ENZYMES;

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUCINE ZIPPER PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL CULTURE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; IMMUNITY; INFLAMMATION; MULTIGENE FAMILY; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

CELL LINE; CELL NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETIC VECTORS; HELA CELLS; HUMANS; I-KAPPA B KINASE; LEUCINE; LIGANDS; MUTATION; NF-KAPPA B; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SERINE; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0141532167     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304374200     Document Type: Article

References (22)

1. Ghosh, S., and Karin, M. (2002) Cell 109, (suppl.) S81-S96
2. Silverman, N., and Maniatis, T. (2001) Genes Dev. 15, 2321-2342
3. Miller, B. S., and Zandi, E. (2001) J. Biol. Chem. 276, 36320-36326
4. Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krahn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S. C., and Karin, M. (2001) Science 293, 1495-1499
5. Delhase, M., Hayakawa, M., Chen, Y., and Karin, M. (1999) Science 284, 309-313
6. Zhang, S. Q., Kovalenko, A., Cantarella, G., and Wallach, D. (2000) Immunity 12, 301-311
7. Devin, A., Cook, A., Lin, Y., Rodriguez, Y., Kelliher, M., and Liu, Z. (2000) Immunity 12, 419-429
8. Yang, J., Lin, Y., Guo, Z., Cheng, J., Huang, J., Deng, L., Liao, W., Chen, Z., Liu, Z., and Su, B. (2001) Nat. Immunol. 2, 620-624
9. Leitges, M., Sanz, L., Martin, P., Duran, A., Braun, U., Garcia, J. F., Camacho, F., Diaz-Meco, M. T., Rennert, P. D., and Moscat, J. (2001) Mol. Cell 8, 771-780
10. Takaesu, G., Surabhi, R. M., Park, K. J., Ninomiya-Tsuji, J., Matsumoto, K., and Gaynor, R. B. (2003) J. Mol. Biol. 326, 105-115
11. Poyet, J. L., Srinivasula, S. M., Lin, J. H., Fernandes-Alnemri, T., Yamaoka, S., Tsichlis, P. N., and Alnemri, E. S. (2000) J. Biol. Chem. 275, 37966-37977
12. Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P. C., Chen, F. F., Ogura, Y., and Nunez, G. (2000) J. Biol. Chem. 275, 27823-27831
13. Zandi, E., Chen, Y., and Karin, M. (1998) Science 281, 1360-1363
14. Lee, F. S., Peters, R. T., Dang, L. C., and Maniatis, T. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9319-9324
15. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., and Karin, M. (1997) Cell 91, 243-252
16. Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., and Goeddel, D. V. (1997) Science 278, 866-869
17. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J., Young, D. B., Barbosa, M., Mann, M., Manning, A., and Rao, A. (1997) Science 278, 860-866
18. MacCorkle, R. A., Freeman, K. W., and Spencer, D. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3655-3660
19. Carter, R. S., Pennington, K. N., Ungurait, B. J., and Ballard, D. W. (2003) J. Biol. Chem. 278, 19642-19648
20. Prajapati, S., and Gaynor, R. B. (2002) J. Biol. Chem. 277, 24331-24339
21. Tarassishin, L., and Horwitz, M. S. (2001) Biochem. Biophys. Res. Commun. 285, 555-560
22. Tang, E. D., Wang, C. Y., Xiong, Y., and Guan, K. L. (2003) J. Biol. Chem. 10.1074/jbcM303389200