Ethanol inhibits the JAK-STAT signaling pathway in freshly isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: Evidence for a lack of involvement of ethanol metabolism

Clinical Biochemistry

Volumn 34, Issue 3, 2001, Pages 203-209

  Chen, Jianping ^a   Clemens, Dahn L ^b   Cederbaum, Arthur I ^c   Gao, Bin ^a,b,c,d  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

4 Methlepyrazole; Acetaldehyde; Ethanol; Hydrogen peroxide; Interferon; Interleukin 6; Janus kinase signal transducer and activator transcription factor (JAK STAT); Liver

Indexed keywords

4 METHYLPYRAZOLE; ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; COLLAGEN; CYTOCHROME P450; ENZYME INHIBITOR; HYDROGEN PEROXIDE; INTERFERON; INTERLEUKIN 6; JANUS KINASE; STAT PROTEIN;

ALCOHOL LIVER CIRRHOSIS; ALCOHOL METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DRUG ANTAGONISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ISOLATED LIVER; LIVER CELL; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION;

ACETALDEHYDE; ALCOHOL DEHYDROGENASE; ANIMALS; CELL DIVISION; CELLS, CULTURED; COLLAGEN; CYTOCHROME P-450 CYP2E1; ENZYME INHIBITORS; ETHANOL; HEPATOCYTES; HYDROGEN PEROXIDE; INTERFERON TYPE II; INTERLEUKIN-6; MALE; PROTEIN-TYROSINE KINASES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0034971511     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9120(01)00216-8     Document Type: Article

References (53)

1. The Janus protein tyrosine kinase family and its role in cytokine signaling
2. JAK/STAT signaling by cytokine receptors
3. Cytokines and neurokines: Related ligands and related receptors
4. Hematolymphopoietic and inflammatory cytokines in neural development
5. Cytokines and JAK-STAT signaling
6. Rapid activation of the Stat3 transcription complex in liver regeneration
7. Liver failure, and defective hepatocyte regeneration in interleukin-6-deficient mice
8. Growth and differentiation of rat hepatocytes: Changes in transcription factors HNF-3, HNF-4, STAT-3, and STAT-5
9. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
10. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
11. Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
12. Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells, and rat primary hepatocytes in vitro
13. Requirement of STAT5b for sexual dimorphism of body growth rates, and liver gene expression
14. Alcoholic liver disease. Treatment strategies for the potentially reversible stages
15. Ethanol and the liver
16. Interactions between alcohol and hepatitis viruses in the liver
17. Alcohol and other chemicals in the development of hepatocellular carcinoma
18. Microsomal ethanol-oxidizing system (MEOS): The first 30 years (1968-1998)-a review
19. Molecular biological aspects of alcohol-induced liver disease
20. Ethanol-induced inhibition of liver cell function: I. Effect of ethanol on hormone stimulated hepatocyte DNA synthesis and the role of ethanol metabolism
21. Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication
22. The effect of chronic ethanol feeding on ornithine decarboxylase activity and liver regeneration
23. Ethanol inhibits liver regeneration in rats without reducing transcripts of key protooncogenes
24. Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver
25. Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes
26. Interferons activate the p42/44 MAP kinase and JAK-STAT signaling pathways in hepatocytes: Differential regulation by acute ethanol via a PKC-dependent mechanism
27. Hepatitis C, and alcohol
28. The alcoholic patient with hepatitis C virus infection
29. Hepatitis C, and alcohol
30. Interferon therapy for chronic hepatitis C in habitual drinkers: Comparison with chronic hepatitis C in infrequent drinkers
31. Efficacy of interferon therapy in patients with chronic hepatitis C. Comparison between non-drinkers and drinkers
32. Effect of alcohol intake on the efficacy of interferon therapy in patients with chronic hepatitis C as evaluated by multivariate logistic regression analysis
33. Establishment of a recombinant hepatic cell line stably expressing alcohol dehydrogenase
34. Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line
35. Decreased alpha 1-adrenoceptor responsiveness and density in liver cells of thyroidectomized rats
36. Transcriptional regulation of α1b adrenergic receptors (α1bAR) by nuclear factor 1 (NF1): A decline in the concentration of NF1 correlates with the downregulation of α1bAR gene expression in regenerating liver
37. Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes
38. Acetaldehyde enhances murine alpha2(I) collagen promoter activity by Ca2+-independent protein kinase C activation in cultured rat hepatic stellate cells
39. Acetaldehyde induces c-fos, and c-jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation
40. Acetaldehyde alters proliferation, differentiation and adhesion properties of human colon adenocarcinoma cell line Caco-2
41. Ca2+-, and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain
42. Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate
43. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats
44. X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates
45. Oxidative stress triggers STAT3 tyrosine phosphorylation, and nuclear translocation in human lymphocytes
46. Activation of the JAK-STAT pathway by reactive oxygen species
47. Expression of hepatocyte growth factor mRNA in regenerating rat liver after partial hepatectomy
48. Liver regeneration
49. Ethanol elimination in regenerating rat liver: The roles of alcohol dehydrogenase and acetaldehyde
50. Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture
51. Differential expression and distribution of focal adhesion and cell adhesion molecules in rat hepatocyte differentiation
52. Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: Increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition
53. Rapid inverse changes in alpha 1B- and beta 2-adrenergic receptors and gene transcripts in acutely isolated rat liver cells