Alcohol-induced regulation of nuclear regulatory factor-κβ in human monocytes

Alcoholism: Clinical and Experimental Research

Volumn 21, Issue 6, 1997, Pages 988-994

  Mandrekar, Pranoti ^a   Catalano, Donna ^a   Szabo, Gyongyi ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Ethanol; Inflammatory cytokines; Intracellular signaling; Nuclear regulatory factors; TNF

Indexed keywords

ALCOHOL; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL ADHESION; DNA BINDING; FEMALE; GENE ACTIVATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0030885957     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1997.tb04242.x     Document Type: Article

References (21)

1. Szabo G, Mandrekar P, Catalano D: Inhibition of superantigeninduced T cell proliferation and monocyte IL-1β, TNFα, and IL-6 production by acute ethanol treatment. J Leukoc Biol 58:342-351, 1995
2. Szabo G, Verma B, Catalano D: Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: The role of impaired monocyte antigen presentation capacity and mediator production. J Leukoc Biol 54:534-544, 1993
3. Szabo G, Mandrekar P, Newman L, Catalano D: Regulation of human monocyte functions by acute ethanol treatment: Decreased TNFα, IL-1β and elevated IL-10, and TGFβ production. Alcohol Clin Exp Res 20:900-907, 1996
4. Nelson S, Bagby GJ, Bainton G, Warren WR: The effects of acute and chronic alcoholism on tumor necrosis factor and inflammatory response. J Infect Dis 1989:422-429, 1989
5. Bermudez LE, Young L: Ethanol augments intracellular survival of Mycobactrium avium complex and impairs macrophage responses to cytokines. J Infect Dis 163:1286-1292, 1991
6. McClain CJ, Cohen DA: Increased tumor necrosis factor production by monocytes in alcoholic patients, Hepatology 9:349-351, 1989
7. Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI: Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 13:267-276, 1991
8. Collart MA, Bauerle P, Vassali P: Regulation of tumor necrosis factor alpha transcription in macrophages. Involvement of four NF-κB motifs and constitutive and inducible form of NF-κB. Mol Cell Biol 10:1478-1506, 1990
9. Ahakhov AN, Collart MA, Vassali P, Nedospasou SA, Jongenel CV: κB-type enhancers are involved in LPS-mediated transcriptional activation of the TNFα gene in primary macrophages. J Exp Med 171:35-47, 1990
10. Bauerle PA, Henkel T: Function and activation of NF-κB in the immune system. Ann Rev Immunol 12:141-179, 1994
11. Beg AA, Baldwin AS: The IκB proteins: Multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev 7:2064-2070, 1993
12. Kopp E, Gosh S: NFκB and Rel proteins in innate immunity. Adv Immunol 58:1-27, 1994
13. Gosh S, Baltimore D: Activation in vitro of NFκB by phosphorylation of its inhibitor IκB. Natire 344:678-682, 1990
14. Ziegler-Heithrock MW, Wedel A, Schraut W, et al: Tolerance to lipopolysaccaride involves mobilization of nuclear factor κB with predominance of p50 monodimers. J Biol Chem 269:17001-17004, 1994
15. Muller JM, Zeigler-Heitbrock WL, Baeuerle PA: Nueler factor κB, a mediator of lipopolysaccharide effects. Immunobiology 187:233-256, 1995
16. Dignam JD, Lebovitz RM, Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-89, 1983
17. Verma BK, Fogarasi M, Szabo G: Down-regulation of TNFα activity by acute ethanol treatment in human peripheral blood monocytes. J Clin immunol 13:8-22, 1993
18. Feinberg AP, Fogelstein B: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Ann Biochem 132:6-13, 1983
19. Frankenberger M, Pfarte A, Sternsdorf T, et al: Constitutive nuclear NF-κB in cells of the monocytic lineage. Biochem J 304:87-94, 1994
20. Tsukatnoto IL Rippe R, Nieniela O, Lin M: Roles of exidative stree in activation of Kupffer and Ito cells in liver fibrinogenesis. J Gastroenterol Hepatol 10:S50-53, 1995
21. Fox SE, Cantrell HC, Leingang AK: Inhibition of the Kupffer cell inflammatory response by acute ethanol: NF-κB activation and subsequent cytokine production. Biochem Biophys Res Comm 225:123-40, 1996