Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: Protective role in UVA-induced apoptosis

Journal of Investigative Dermatology

Volumn 124, Issue 4, 2005, Pages 825-832

  Hirota, Ayako ^a   Kawachi, Yasuhiro ^a   Itoh, Ken ^a   Nakamura, Yasuhiro ^a   Xu, Xuezhu ^a   Banno, Tomohiro ^a   Takahashi, Takenori ^a   Yamamoto, Masayuki ^a   Otsuka, Fujio ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Apoptosis; Keap1; Nrf2; UVA

Indexed keywords

ANTIOXIDANT; CYTOPLASM PROTEIN; HEMATOPORPHYRIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PHOTOSENSITIZING AGENT; REGULATOR PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CUTANEOUS PARAMETERS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CANCER; SKIN PROTECTION; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION;

EID: 16844375366     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23670.x     Document Type: Article

References (47)

1. Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, Cook JL: Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274:26071-26078, 1999
2. Ananthaswamy HN, Pierceall WE: Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem Photobiol 52:1119-1136, 1990
3. Cadet J, Berger M, Douki T, Morin B, Raoul S, Ravanat JL, Spinelli S: Effects of UV and visible radiation on DNA-final base damage. Biol Chem 378:1275-1286, 1997
4. Chui DH, Tang W, Orkin SH: cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor. Biochem Biophys Res Commun 209:40-46, 1995
5. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees JJ: Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379:335-339, 1996
6. Godar DE: Light and death: Photons and apoptosis. J Investig Dermatol Symp Proc 4:17-23, 1999a
7. Godar DE: UVA1 radiation triggers two different final apoptotic pathways. J Invest Dermatol 112:3-12, 1999b
8. Grether-Beck S, Buettner R, Krutmann J: Ultraviolet A radiation-induced expression of human genes: Molecular and photobiological mechanisms. Biol Chem 378:1231-1236, 1997
9. Grether-Beck S, Olaizola-Horn S, Schmitt H, et al: Activation of transcription factor AP-2 mediates UVA radiation-and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene. Proc Natl Acad Sci USA 93:14586-14591, 1996
10. Griffith OW, Mulcahy RT: The enzymes of glutathione synthesis: Gamma-glutamylcysteine synthetase. Adv Enzymol Relat Areas Mol Biol 73:209-267, 1999
11. Hayes JD, Chanas SA, Henderson CJ, et al: The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans 28:33-41, 2000
12. Herrmann G, Wlaschek M, Lange TS, Prenzel K, Goerz G, Scharffetter-Kochanek K: UVA irradiation stimulates the synthesis of various matrix-metalloproteinases (MMPs) in cultured human fibroblasts. Exp Dermatol 2:92-97, 1993
13. Ichihashi M, Ueda M, Budiyanto A, et al: UV-induced skin damage. Toxicology 189:21-39, 2003
14. Ishii T, Itoh K, Sato H, Bannai S: Oxidative stress-inducible proteins in macrophages. Free Radic Res 31:351-355, 1999
15. Ishii T, Itoh K, Takahashi S, et al: Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275:16023-16029, 2000
16. Itoh K, Chiba T, Takahashi S, et al: An Nrf2/small Mat heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-322, 1997
17. Itoh K, Ishii T, Wakabayashi N, Yamamoto M: Regulatory mechanisms of cellular response to oxidative stress. Free Radic Res 31:319-324, 1999a
18. Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13:76-86, 1999b
19. Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T, Yamamoto M: Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8:379-391, 2003
20. Keyse SM, Tyrrell RM: Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc Natl Acad Sci USA 86:99-103, 1989
21. Kotlo KU, Yehiely F, Efimova E, et al: Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells. Oncogene 22:797-806, 2003
22. Kulms D, Schwarz T: Independent contribution of three different pathways to ultraviolet-B-induced apoptosis. Biochem Pharmacol 64:837-841, 2002
23. Lee JM, Shih AY, Murphy TH, Johnson JA: NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J Biol Chem 278:37948-37956, 2003
24. Ley RD: Photoreactivation of UV-induced pyrimidine dimers and erythema in the marsupial Monodelphis domestica. Proc Natl Acad Sci USA 82:2409-2411, 1985
25. McMahon M, Itoh K, Yamamoto M, Hayes JD: Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278:21592-21600, 2003
26. Morito N, Yoh K, Itoh K, Hirayama A, Koyama A, Yamamoto M, Takahashi S: Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels. Oncogene 22:9275-9281, 2003
27. Packer L, Valacchi G: Antioxidants and the response of skin to oxidative stress: Vitamin E as a key indicator. Skin Pharmacol Appl Skin Physiol 15:282-290, 2002
28. Peng Q, Moan J, Nesland JM: Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy. Ultrastruct Pathol 20:109-129, 1996
29. Poh-Fitzpatrick MB: Molecular and cellular mechanisms of porphyrin photosensitization. Photodermatol 3:148-157, 1986
30. Rosenstein BS, Mitchell DL: Action spectra for the induction of pyrimidine (6-4)pyrimidone photoproducts and cyclobutane pyrimidine dimers in normal human skin fibroblasts. Photochem Photobiol 45:775-780, 1987
31. Sasaki H, Sato H, Kuriyama-Matsumura K, et al: Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. J Biol Chem 277:44765-44771, 2002
32. Scharffetter K, Wlaschek M, Hogg A, et al: UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo. Arch Dermatol Res 283:506-511, 1991
33. Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, Schauen M, Blaudschun R, Wenk J: UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem 378:1247-1257, 1997
34. Schreiber E, Matthias P, Muller MM, Schaffner W: Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells. Nucleic Acids Res 17:6419, 1989
35. Seo KI, Cho KH, Park KC, Youn JI, Eun HC, Kim KT, Park SC: Change of glutathione S-transferases in the skin by ultraviolet B irradiation. J Dermatol Sci 13:153-160, 1996
36. Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S: Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62:5196-5203, 2002
37. Tyrrell RM, Keyse SM: New trends in photobiology. The interaction of UVA radiation with cultured cells. J Photochem Photobiol B 4:349-361, 1990
38. Tyrrell RM, Pidoux M: Correlation between endogenous glutathione content and sensitivity of cultured human skin cells to radiation at defined wave-lengths in the solar ultraviolet range. Photochem Photobiol 47:405-412, 1988
39. van den Dobbelsteen DJ, Nobel CS, Schlegel J, Cotgreave IA, Orrenius S, Slater AF: Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J Biol Chem 271:15420-15427, 1996
40. Vayalil PK, Elmets CA, Katiyar SK: Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MARK proteins in SKH-1 hairless mouse skin. Carcinogenesis 24:927-936, 2003
41. Venugopal R, Jaiswal AK: Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H: Quinone oxidoreductasel gene. Proc Natl Acad Sci USA 93:14960-14965, 1996
42. Wakabayashi N, Itoh K, Wakabayashi J, et al: Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35:238-245, 2003
43. Warner WG, Wei RR: In vitro photooxidation of nucleic acids by ultraviolet A radiation. Photochem Photobiol 65:560-563, 1997
44. Wang Y, Rosenstein B, Goldwyn S, Zhang X, Lebwohl M, Wei H: Differential regulation of P53 and Bcl-2 expression by ultraviolet A and B. J Invest Dermatol 111:380-384, 1998
45. Wild AC, Moinova HR, Mulcahy RT: Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. J Biol Chem 274:33627-33636, 1999
46. Zhang DD, Hannink M: Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23:8137-8151, 2003
47. Zhang H, Rosdahl I: Ultraviolet A and B differently induce intracellular protein expression in human skin melanocytes-A speculation of separate pathways in initiation of melanoma. Carcinogenesis 24:1929-1934, 2003