A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo

Journal of Neuroscience

Volumn 25, Issue 44, 2005, Pages 10321-10335

  Shih, Andy Y ^a   Li, Ping ^a   Murphy, Timothy H ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antioxidant response element; Astrocyte; Brain; Endothelin 1; Glutathione; Ischemia; NAD(P)H:quinone oxidoreductase; Neuroprotection; NF E2 related factor; Nrf2; Oxidative stress; Stroke; Tert butylhydroquinone

Indexed keywords

ENDOTHELIN 1; GLUTATHIONE; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; IN VIVO STUDY; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN FUNCTION; RAT; REPERFUSION INJURY; SENSORIMOTOR FUNCTION; STROKE;

ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; CELLS, CULTURED; HUMANS; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 27744438478     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4014-05.2005     Document Type: Article

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