Mode of action of cannabinoids on nociceptive nerve endings

Experimental Brain Research

Volumn 196, Issue 1, 2009, Pages 79-88

  Kress, Michaela ^a   Kuner, R ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Anandamide; Cannabinoid; CB1; CB2; GPR55; Vanilloid receptor

Indexed keywords

1 (2,3 DICHLOROBENZOYL) 2 METHYL 3 (2 MORPHOLINOETHYL) 5 METHOXYINDOLE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 3 (2 IODO 5 NITROBENZOYL) 1 (1 METHYL 2 PIPERIDINYLMETHYL)INDOLE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CANNABINOID; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; ENDOCANNABINOID; GW 833972 A; ION CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANALGESIC ACTIVITY; COGNITION; DRUG MECHANISM; HUMAN; MEMORY DISORDER; MOTOR PERFORMANCE; MUSCLE SPINDLE AFFERENT NERVE; NERVE ENDING; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANALGESICS; ANIMALS; CANNABINOIDS; HUMANS; ION CHANNELS; NOCICEPTORS; PAIN; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECEPTORS, G-PROTEIN-COUPLED;

EID: 67349238803     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-009-1762-0     Document Type: Review

References (102)

1. N Agarwal P Pacher I Tegeder F Amaya CE Constantin GJ Brenner T Rubino CW Michalski G Marsicano K Monory K Mackie C Marian S Batkai D Parolaro MJ Fischer W Reeh G Kunos M Kress B Lutz CJ Woolf R Kuner 2007 Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors Nat Neurosci 10 870 879 (Pubitemid 47013432)
2. J Ahluwalia L Urban M Capogna S Bevan I Nagy 2000 Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons Neuroscience 100 685 688 (Pubitemid 30742272)
3. J Ahluwalia L Urban S Bevan M Capogna I Nagy 2002 Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neurones Neuroscience 110 747 753 (Pubitemid 34270544)
4. AN Akopian NB Ruparel AM Patwardhan KM Hargreaves 2008 Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation J Neurosci 30 1064 1075 (Pubitemid 351186337)
5. Akopian AN, Ruparel NB, Jeske NA, Patwardahan AM, Hargreaves KM (2009) Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia. Trends Pharmacol Sci (in press)
6. F Amaya G Shimosato Y Kawasaki S Hashimoto Y Tanaka RR Ji M Tanaka 2006 Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist Pain 124 175 183 (Pubitemid 44176209)
7. U Anand WR Otto D Sanchez-Herrera P Facer Y Yiangou Y Korchev R Birch C Benham C Bountra IP Chessel P Anand 2008 Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons Pain 138 667 680
8. JC Ashton ED Milligan 2008 Cannabinoids for the treatment of neuropathic pain: clinical evidence Curr Opin Invest Drugs 9 65 75
9. DM Bautista SE Jordt T Nikai PR Tsuruda AJ Read J Poblete EN Yamoah AI Basbaum D Julius 2006 TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents Cell 124 1269 1282
10. M Beltramo N Stella A Calignano SY Lin A Makriyannis D Piomelli 1997 Functional role of high-affinity anandamide transport, as revealed by selective inhibition Science 277 1097
11. M Beltramo N Bernardini R Bertorelli M Campanella E Nicolussi S Fredduzzi A Reggiani 2006 CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms Eur J Neurosci 23 1530 1538
12. MG Belvisi HJ Patel V Freund-Michel DJ Hele N Crispino MA Birrell 2008 Inhibitory activity of the novel CB2 receptor agonist GW833972A on guinea-pig and human sensory nerve function in the airways Br J Pharmacol 155 547 557
13. U Binzen W Greffrath S Hennessy M Bausen S Saaler-Reinhardt RD Treede 2006 Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons Neuroscience 142 527 539 (Pubitemid 44415325)
14. D Bridges AS Rice M Egertová MR Elphick J Winter GJ Michael 2003 Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry Neuroscience 119 812
15. MJ Caterina MA Schumacher M Tominaga TA Rosen JD Levine D Julius 1997 The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 816 824 (Pubitemid 27462969)
16. MJ Caterina TA Rosen M Tominaga AJ Brake D Julius 1999 A capsaicin-receptor homologue with a high threshold for noxious heat Nature 398 436 441 (Pubitemid 29180377)
17. HH Chuang ED Prescott H Kong S Shields S-E Jordt AI Basbaum MV Chao D Julius 2001 Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4, 5)P2-mediated inhibition Nature 411 957 962 (Pubitemid 32601493)
18. AA Coutts AJ Irving K Mackie RG Pertwee S Anavi-Goffer 2002 Localisation of cannabinoid CB1 receptor immunoreactivity in the guinea pig and rat myenteric plexus J Comp Neurol 448 410 422 (Pubitemid 34569188)
19. JB Davis J Gray MJ Gunthorpe JP Hatcher PT Davey P Overend MH Harries J Latcham C Clapham K Atkinson SA Hughes K Rance E Grau AJ Harper PL Pugh DC Rogers S Bingham A Randall SA Sheardown 2000 Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia Nature 405 183 187 (Pubitemid 30313536)
20. L De Petrocellis V Vellani A Schiano-Moriello P Marini PC Magherini P Orlando V Di Marzo 2008 Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8 J Pharmacol Exp Ther 325 1007 1015 (Pubitemid 351724325)
21. V Di Marzo 2006 Endocannabinoids: synthesis and degradation Rev Physiol Biochem Pharmacol 160 1 24
22. V Di Marzo A Fontana H Cadas S Schinelli G Cimino JC Schwartz D Piomelli 1994 Formation and inactivation of endogenous cannabinoid anandamide in central neurons Nature 372 686 691
23. V Di Marzo M Bifulco L De Petrocellis 2004 The endocannabinoid system and its therapeutic exploitation Nat Rev Drug Discov 3 771 784 (Pubitemid 39242829)
24. TP Dinh TF Freund D Piomelli 2002 A role for monoglyceride lipase in 2-arachidonoylglycerol inactivaiton Chem Phys Lipids 121 149 158 (Pubitemid 36044549)
25. SJ Elmes MD Jhaveri D Smart DA Kendall V Chapman 2004 Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naive rats and in rat models of inflammatory and neuropathic pain Eur J Neurosci 20 2320
26. RM Evans KN Wease CJ MacDonald HA Khairy RA Ross RH Scott 2008 Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites Br J Pharmacol 154 480 492 (Pubitemid 351670606)
27. P Fan 1995 Cannabinoid agonist inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons J Neurophysiol 73 910
28. D Fegley S Kathuria R Mercier C Li A Goutopoulos A Makriyannis D Piomelli 2004 Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172 Proc Natl Acad Sci USA 101 8756 8761 (Pubitemid 38745844)
29. J Fernandez-Ruiz J Romero G Velasco RM Tolon JA Ramos M Guzman 2007 Cannabinoid CB2 receptor: a new target for controlling neural cell survival Trends Pharmacol Sci 28 39 45 (Pubitemid 46038536)
30. T Fischbach W Greffrath H Nawrath R-D Treede 2007 Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive DRG neurons of the rat J Neurophysiol 98 929 938 (Pubitemid 47236043)
31. TF Freund I Katona D Piomelli 2003 Role of endogenous cannabinoids in synaptic signaling Physiol Rev 83 1017 1066 (Pubitemid 36828930)
32. AV Guerrero P Quang N Dekker RCK Jordan BL Schmidt 2008 Peripheral cannabinoids attenuate carcinoma-induced nociception in mice Neurosci Lett 433 77 81
33. J Guindon AG Hohmann 2008 Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain Br J Pharmacol 153 319 334
34. Handwerker HO, Reeh PW, Steen KH (1990) Effects of 5HT on nociceptors. In: Besson J-M (ed) Serotonin and pain. Elsevier, Amsterdam, pp 1-15 (Pubitemid 20177257)
35. CJ Hillard WS Edgemond A Jarrahian WB Campbell 1997 Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion J Neurochem 69 631 638 (Pubitemid 27327964)
36. K Hillsley C McCaul J Aerssens PJ Peeters H Gijsen D Moechars B Coulie D Grundy RH Stead 2007 Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity Neurogastroenterol Motil 19 769 777 (Pubitemid 47312400)
37. AG Hohmann M Herkenham 1999 Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study Neuroscience 90 923 931 (Pubitemid 29156757)
38. Howlett AC (2005) Cannabinoid receptor signaling. Handb Exp Pharmacol 53-79
39. MM Ibrahim H Deng AM Zvonok DA Cockayne J Kwan H Mata TW Vanderah J Lai F Porreca A Makriyannis TP Malan 2003 Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS Proc Natl Acad Sci USA 100 10529 10533 (Pubitemid 37071912)
40. MM Ibrahim F Porreca J Lai PJ Albrecht FL Rice A Khodorova G Davar A Makriyannis TW Vanderah H Mata TP Malan 2005 CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids Proc Natl Acad Sci USA 102 3093 3098 (Pubitemid 40299921)
41. MM Ibrahim ML Rude NJ Stagg HP Mata J Lai TW Vanderah F Porreca V Veerappan X Tian C George DA Parrish DP Papahatjis A Makriyannis 2006 CB2 cannabinoid receptor mediation of antinociception Pain 122 36 42
42. JC Jerman J Gray SJ Brough L Ooi D Owen JB Davis D Smart 2002 Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors Br J Anaesth 89 882 887 (Pubitemid 35460527)
43. NA Jeske AM Patwardahan N Gamper TJ Price AN Akopian KM Hargreaves 2006 Cannabinoid WN55, 212-2 regulates TRPV1 phosphorylation in sensory neurons J Biol Chem 281 32879 32890 (Pubitemid 46036843)
44. MD Jhaveri DR Sagar SJ Elmes DA Kendall V Chapman 2007 Cannabinoid CB2 receptor-mediated anti-nociception in models of acute and chronic pain Mol Neurobiol 36 26 35 (Pubitemid 351360358)
45. S-E Jordt DD McKemy D Julius 2003 Lessons from peppers and peppermint: the molecular logic of thermosensation Curr Opin Neurobiol 13 487 492 (Pubitemid 37088240)
46. S Kelly LF Donaldson 2008 Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurons in vivo Eur J Pharmacol 586 160 163
47. S Kelly MD Jhaveri DR Sagar DA Kendall V Chapman 2003 Activation of peripheral cannabinoid CB1 receptors inhibits mechanically evoked responses of spinal neurons in noninflamed rats and rats with hindpaw inflammation Eur J Neurosci 18 2239 2243 (Pubitemid 38117397)
48. AD Khanolkar D Lu MM Ibrahim RI Duclos GA Thakur TP Malan F Porreca V Veerappan X Tian C George DA Parrish DP Papahatjis A Makriyannis 2007 Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity J Med Chem 50 6493 6500 (Pubitemid 350309089)
49. 2+ influx in intermediate-size primary afferent neurons of adult rats Neuroscience 115 613 625 (Pubitemid 35284776)
50. IA Khasabova C Harding-Rose DA Simone VS Seybold 2004 Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons J Neurosci 24 1744 1753 (Pubitemid 38240972)
51. IA Khasabova SG Khasabov C Harding-Rose LG Coicou BA Seybold AE Lindberg CD Steevens DA Simone VS Seybold 2008 A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain J Neurosci 28 11141 11152
52. + currents in rat dorsal root ganglion neurons Brain Res 1062 39 47 (Pubitemid 41612127)
53. O Krishtal N Lozovaya A Fedorenko I Savelyev I Chizhamakov 2006 The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids Pflugers Arch Eur J Physiol 453 353 360 (Pubitemid 44764236)
54. G La Rana R Russo P Campolongo M Bortolato RA Mangieri V Cuomo A Iacono G Mattace Raso R Meli D Piomelli A Calignano 2008 Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide] J Pharmacol Exp Ther 317 1365 1371
55. JE Lauckner B Hille K Mackie 2005 The cannabinoid agonist WIN55, 212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins Proc Natl Acad Sci USA 102 19144 19149 (Pubitemid 43049580)
56. JE Lauckner JB Jenson H-Y Chen H-C Lu B Hille K Mackie 2008 GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M currents Proc Natl Acad Sci USA 105 2699 2704
57. A Ligresti E Morera M van der Stelt K Monory B Lutz G Ortar V Di Marzo 2004 Further evidence for the existence of a specific process for the membrane transport of anandamide Biochem J 380 265 272 (Pubitemid 38725751)
58. K Mackie N Stella 2006 Cannabinoid receptors and endocannabinoids: evidence for new players Am Assoc Pharm Sci J 8 E298 E306
59. + channel TASK-1 EMBO J 20 47 54 (Pubitemid 32099101)
60. TP Malan MM Ibrahim H Deng Q Liu H Mata TW Vanderah F Porreca A Makriyannis 2001 CB2 cannabinoid receptor-mediated peripheral antinociception Pain 93 239 245 (Pubitemid 32763181)
61. TP Malan MM Ibrahim TW Vanderah A Makriyannis F Porreca 2002 Inhibition of pain responses by activation of CB2 cannabinoid receptors Chem Phys Lipids 121 191 200 (Pubitemid 36044551)
62. G Marsicano S Goodenough K Monory K Hermann M Eder A Cannich SC Azad MG Cascio SO Gutierrez M van der Stelt ML Lopez-Rodriguez E Casanova G Schütz W Zieglgänsberger V Di Marzo C Behl B Lutz 2003 CB1 cannabinoid receptors and on-demand defense against excitotoxicity Science 302 84 88 (Pubitemid 37210691)
63. LA Matsuda SJ Lolait MJ Brownstein AC Young TI Bonner 1990 Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 561 564
64. S Mitrirattanakul N Ramakul AV Guerrero Y Matsuka T Ono H Iwase K Mackie KF Faull I Spigelman 2006 Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain Pain 126 102 114 (Pubitemid 44781351)
65. C Montell L Birnbaumer V Flockerzi RJ Bindels EA Brudford MJ Caterina CE Clapham C Harteneck S Heller D Julius I Kojima Y Mori R Penner D Prawitt AM Scharenberg G Schultz N Shimizu MX Zhu 2002 A unified nomenclature for the superfamily of TRP cation channels Mol Cell 9 229 231 (Pubitemid 34195549)
66. V Morisset L Urban 2001 Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord J Neurophysiol 86 40 48 (Pubitemid 32623210)
67. S Munro KL Thomas M Abu-Shaar 1993 Molecular characterisation of a peripheral receptor for cannabinoids Nature 365 61 65
68. AG Nackley AM Zvonok A Makriyannis AG Hohmann 2004 Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation J Neurophysiol 92 3562 3574 (Pubitemid 39506332)
69. R Nyilas B Dudok GB Uran K Mackie M Watanabe BF Cravatt TF Freund I Katona 2008 Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores glutamatergic axon terminals J Neurosci 28 1058 1063 (Pubitemid 351186335)
70. M Ocana CM Cendan EJ Cobos JM Entrena JM Baeyens 2004 Potassium channels and pain: present realities and future opportunities Eur J Pharmacol 500 203 219 (Pubitemid 39304009)
71. S Offermanns 2003 G-proteins as transducers ion transmembrane signalling Progr Biophys Mol Biol 83 101 130 (Pubitemid 36832209)
72. S Oka K Nakajima A Yamashita S Kishimoto T Sugiura 2007 Identification of GPR55 as a lysophosphatidylinositol receptor Biochem Biophys Res Comm 362 928 934 (Pubitemid 47390663)
73. ES Onaivi H Ishiguro JP Gong S Patel A Perchuk PA Meozzi 2006 Discovery of the presence and functional expression of cannabinoid CB2 receptors in the brain Ann NY Acad Sci 1074 514 536 (Pubitemid 44532857)
74. P Pacher S Barkai G Kunos 2006 The endocannabinoid system as an emerging target of pharmacotherapy Pharmacol Rev 58 389 462 (Pubitemid 44394908)
75. HJ Patel MA Birrell N Crispino DJ Hele P Venkatesan PJ Barnes 2003 Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation Br J Pharmacol 140 261 268 (Pubitemid 37249185)
76. AM Patwardahan NA Jeske TJ Price N Gamper AN Akopian KM Hargreaves 2006 The cannabinoid WIN55, 212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin Proc Natl Acad Sci USA 103 11393 11398 (Pubitemid 44156528)
77. C Potenzieri TS Brink C Pacharinsak DA Simone 2008 Cannabinoid modulation of cutaneous Aδ nociceptors during inflammation J Neurophysiol 100 2794 2806
78. TJ Price G Helesic D Parghi KM Hargreaves CM Flores 2003 The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat Neuroscience 120 155 162 (Pubitemid 36789768)
79. N Qin MP Neeper Y Liu TL Hutchinson ML Lubin CM Flores 2008 TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons J Neurosci 28 6231 6238
80. A Quartilho H Mata MM Ibrahim TW Vanderah F Porreca A Makriyannis TP Malan 2003 Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors Anesthesiology 99 955 960 (Pubitemid 37186088)
81. I Rácz A Bilkei-Gorzo A Markert F Stamer M Göthert A Zimmer 2008 Anandamide effects on 5-HT3 receptors in vivo Eur J Pharmacol 596 98 101
82. N Rimmerman HV Hughes HB Bradshaw MX Pazos K Mackie AL Prieto JM Walker 2008 Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line Br J Pharmacol 153 380 389
83. RA Ross AA Coutts SM McFarlane S Anavi-Goffer AJ Irving RG Pertwee 2001 Actions of cannabinoid receptor ligands on rat cultured sensory neurons: implications for antinociception Neuropharmacology 40 221 232 (Pubitemid 30953098)
84. RA Ross RM Evans RH Scott 2004 Cannabinoids and sensory neurons Curr Neuropharmacol 1 59 73
85. HR Ross I Napier M Connor 2008 Inhibition of recombinant human T-type calcium channels by Δ9-tetrahydrocannabinol and cannabidiol J Biol Chem 283 16124 16134
86. E Ryberg N Larsson S Sjögren S Hjorth NO Hermansson J Leonova T Elebring K Nilsson T Drmota PJ Greasley 2007 The orphan receptor GPR55 is a novel cannabinoid receptor Br J Pharmacol 152 1092 1101 (Pubitemid 350166046)
87. DR Sagar S Kelly PJ Millns CT O'Shaughnessey DA Kendall V Chapman 2005 Inhibitory effects of CB1 and CB2 receptor antagonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats Eur J Pharmacol 22 371 379 (Pubitemid 41097610)
88. C Salio J Fischer MF Franzoni M Conrath 2002 Pre- and post-synaptic localization of the CB1 cannabinoid receptor in the dorsal horn of the rat spinal cord Neuroscience 110 755 764 (Pubitemid 34270545)
89. N Schuelert JJ McDougall 2008 Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees Arthritis Rheum 58 145 153
90. D Shire C Carillon M Kaghad B Calandra M Rinaldi-Carmona G Le Fur D Caput P Ferrara 1995 An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing J Biol Chem 270 3726 3731
91. S Ständer M Schmelz D Metze T Luger R Rukwied 2005 Distribution of cannabinoid receptor 1 (CB1) an d2 (CB2) on sensory nerve fibers and adnexal structures in human skin J Dermatol Sci 38 177 188 (Pubitemid 40779571)
92. K Starowicz S Nigam V Di Marzo 2007 Biochemistry and Pharmacology of endovanilloids Pharmacol Ther 114 13 33 (Pubitemid 46498161)
93. PC Staton JP Hatcher DJ Walker AD Morrison EM Shapland JP Hughes E Chong PK Mander PJ Green A Billinton M Fulleylove HC Lancaster JC Smith LT Bailey A Wise AJ Brown JC Richardson IP Chessel 2008 The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain Pain 139 225 236
94. M Tognetto S Amadesi S Harrison C Creminon M Trevisani M Carreras M Matera P Geppetti A Bianchi 2001 Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation J Neurosci 21 1104 1109 (Pubitemid 32128755)
95. M Tominaga MJ Caterina AB Malmberg TA Rosen H Gilbert K Skinner BE Raumann AI Basbaum D Julius 1998 The cloned capsaicin receptor integrates multiple pain-producing stimuli Biophys J 21 531 543 (Pubitemid 28475505)
96. 2+ influx via TRPV1 channels EMBO J 24 3026 3037 (Pubitemid 41486339)
97. EL Veale R Buswell CE Clarke A Mathie 2007 Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide Br J Pharmacol 152 778 786 (Pubitemid 350034980)
98. JM Walker AG Hohmann 2005 Cannabinoid mechanisms of pain suppression Handb Exp Pharmacol 168 509 554
99. G Wotherspoon A Fox P McIntyre S Colley S Bevan J Winter 2005 Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons Neuroscience 135 235 245 (Pubitemid 41219752)
100. BB Yao GC Hsieh JM Frost Y Fan TR Garrison AV Daza GK Grayson CZ Zhu M Pai P Chandran AK Salyers EJ Wensink P Honore JP Sullivan MJ Dart MD Meyer 2008 In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models Br J Pharmacol 153 401
101. Y Yiangou P Facer JA Smith L Sangameswaran R Eglen R Birch C Knowles N Williams P Anand 2001 Increased acid-sensing ion channel ASIC-3 in inflamed human intestine Eur J Gastroenterol Hepatol 13 891 896 (Pubitemid 32757004)
102. PM Zygmunt DA Andersson ED Hogestatt 2002 Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism J Neurosci 22 4720 4727 (Pubitemid 37465687)