The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK-1

EMBO Journal

Volumn 20, Issue 1-2, 2001, Pages 47-54

  Maingret, F ^a   Patel, A J ^a   Lazdunski, M ^a   Honore E ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

2P domain K+ channels; Acidosis; CB1 receptor; Cerebellum

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; DEXANABINOL; DRONABINOL; PALMIDROL; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; RIMONABANT;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; MOLECULAR INTERACTION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACIDS; CANNABINOIDS; CERCOPITHECUS AETHIOPS; CEREBELLUM; COS CELLS; ENDOCANNABINOIDS; HALOTHANE; HUMANS; MEMBRANE POTENTIALS; MICE; MOTOR NEURONS; NERVE TISSUE PROTEINS; NEURONS; PIPERIDINES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PYRAZOLES; RATS; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0035863195     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.1.47     Document Type: Article

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