Inhibitory activity of the novel CB 2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways

British Journal of Pharmacology

Volumn 155, Issue 4, 2008, Pages 547-557

  Belvisi, M G ^a   Patel, H J ^a   Freund Michel, V ^a   Hele, D J ^a   Crispino, N ^a   Birrell, M A ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Airway plasma protein extravasation; Asthma chronic obstructive pulmonary disease; Cannabinoids; Human, sensory nerves; Neurogenic inflammation

Indexed keywords

5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CAPSAICIN; CITRIC ACID; DEXANABINOL; GW 833972A; PROSTAGLANDIN E2; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; COUGHING; DEPOLARIZATION; DRUG STRUCTURE; GUINEA PIG; HUMAN; HUMAN TISSUE; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CONDUCTION; VAGUS NERVE;

ADULT; ANIMALS; CAPSAICIN; CITRIC ACID; COUGH; FEMALE; GUINEA PIGS; HUMANS; MALE; MIDDLE AGED; NEURONS, AFFERENT; PLASMA; PYRIDINES; PYRIMIDINES; RECEPTOR, CANNABINOID, CB2; SALINE SOLUTION, HYPERTONIC;

EID: 53849098350     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.298     Document Type: Article

References (42)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to receptors and channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153: S1-S209.
2. Barnes PJ (2001). Neurogenic inflammation in the airways. Respir Physiol 125: 145-154.
3. Barnes PJ, Baraniuk JN, Belvisi MG (1991). Neuropeptides in the respiratory tract. Am Rev Respir Dis 144: 1187-1198.
4. Belvisi MG (2002). Overview of the innervation of the lung. Curr Opin Pharmacol 2: 211-215.
5. Belvisi MG (2003). Sensory nerves and airway inflammation: role of Ad and C-fibres. Pulm Pharmacol Ther 16: 1-7.
6. Belvisi MG, Rogers DF, Barnes PJ (1989). Neurogenic plasma protein extravasation: inhibition by morphine in guinea-pig airways in vivo. J Appl Physiol 66: 268-272.
7. Birrell MA, Crispino N, Hele DJ, Patel HJ, Yacoub MH, Barnes PJ et al. (2002). Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD. Br J Pharmacol 136: 620-628.
8. Buckley NE, McCoy KL, Mezey E, Bonner T, Zimmer A, Felder C et al. (2000). Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor. Eur J Pharmacol 396: 141-149.
9. Calignano A, Katona I, Desarnaud F, Giuffrida A, La Rana G, Mackie K et al. (2000). Bidirectional control of airway responsiveness by endogenous cannabinoids. Nature 408: 96-101.
10. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ (2004). Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 557: 543-558.
11. 2 cannabinoid receptors are implicated in inflammatory pain. Pain 96: 253-260.
12. Coleridge HM, Coleridge JCG (1994). Pulmonary reflexes: neural mechanisms of pulmonary defence. Annu Rev Physiol 5: 69-91.
13. Coleridge JCG, Coleridge HM (1984). Afferent Vagal C-Fibre innervation of the lungs and its functional significance. Rev Physiol Biochem Pharmacol 99: 1-110.
14. Dowell SJ, Brown AJ (2002). Yeast assays for G-protein-coupled receptors. Recept Channels 8: 343-352.
15. 2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Pain 118: 327-335.
16. 2 receptors. Mol Pharmacol 48: 443-450.
17. Fox AJ, Barnes PJ, Venkatesan P, Belvisi MG (1997). Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea-pig. J Clin Invest 99: 513-519.
18. Fox AJ, Lalloo UG, Belvisi MG, Bernareggi M, Chung KF, Barnes PJ (1996). Bradykinin-evoked sensitisation of airway sensory nerves: A mechanism for ACE-inhibitor cough. Nat Med 2: 814-817.
19. Fox AJ, Urban L, Barnes PJ, Dray A (1995). Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig. Neuroscience 67: 741-752.
20. Galiegue S, Mary S, Marchland J, Dussossoy D, Carriere D, Carayon P et al. (1995). Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232: 54-61.
21. Griffin G, Fernando SR, Ross RA, McKay NG, Ashford MLJ, Shire D et al. (1997). Evidence for the presence of CB2 like cannabinoid receptors on peripheral nerve terminals. Eur J Pharmacol 339: 53-61.
22. Hanus L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, Horowitz M et al. (1999). HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. Proc Natl Acad Sci USA 96: 14228-14333.
23. Harris J, Drew LJ, Chapman V (2000). Spinal anandamide inhibits nociceptive transmission via cannabinoid receptor activation in vivo. NeuroReport 11: 2817-2819.
24. Karlsson J-A (1993). A role for capsaicin-sensitive, tachykinin containing nerves in chronic coughing and sneezing, but not in asthma: a hypothesis. Thorax 48: 396-400.
25. Karlsson J-A, Sant'Ambrogio G, Widdicome J (1988). Afferent neural pathways in cough and reflex bronchoconstriction. J Appl Physiol 65: 1007-1023.
26. Kehl LJ, Hamamoto DT, Wacnik PW, Croft DL, Norsted BD, Wilcox GL et al. (2003). A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain. Pain 103: 175-186.
27. Lalloo UG, Fox AJ, Belvisi MG, Chung KF, Barnes PJ (1995). Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea-pigs. J Appl Physiol 79: 1082-1087.
28. Lee LY, Morton RF (1995). Pulmonary chemoreflex sensitivity is enhanced by prostaglandin E2 in anesthetized rats. J Appl Physiol 79: 1679-1686.
29. Lei YH, Barnes PJ, Rodgers DF (1992). Inhibition of neurogenic plasma protein exudation in guinea-pig airways by CP-96,345, a new non-peptide NK1 receptor antagonist. Br J Pharmacol 105: 261-262.
30. 2 cannabinoid receptors. Chem Phys Lipids 121: 191-200.
31. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
32. Munro S, Thomas KL, Abu-Shaar M (1993). Molecular characterisation of a peripheral receptor for cannabinoids. Nature 365: 61-65.
33. 2) receptor activation. Br J Pharmacol 140: 261-268.
34. Porter AC, Felder CC (2001). The endocannabinoid nervous system: unique opportunities for therapeutic intervention. Pharmacol Ther 90: 45-60.
35. Richardson JD, Aanonsen L, Hargreaves KM (1998a). Antihyperalgesic effects of spinal cannabinoids. Eur J Pharmacol 345: 145-153.
36. Richardson JD, Kilo S, Hargreaves KM (1998b). Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75: 111-119.
37. Rinaldi-Carmona M, Barth F, Heaulme M, Shire D, Calandra B, Congy C et al. (1994). SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350: 240-244.
38. 2 cannabinoid receptor. J Pharmacol Exp Ther 284: 644-650.
39. 2. J Appl Physiol 58: 1823-1831.
40. Sant'Ambrogio G, Remmers JE, De Groot WJ, Callas G, Mortola JP (1978). Localisation of rapidly adapting receptors in the trachea and main stem bronchus of the dog. Respir Physiol 33: 359-365.
41. Smith JA, Amagasu SM, Eglen RM, Hunter JC, Bley KR (1998). Characterisation of prostanoid receptor-evoked responses in rat sensory neurones. Br J Pharmacol 124: 513-523.
42. Widdicombe JG (1954). Receptors in the trachea and bronchi of the cat. J Physiol 123: 71-104.