Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo

Journal of Cell Communication and Signaling

Volumn 3, Issue 1, 2009, Pages 5-18

  Brigstock, David R ^a,b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Anti fibrotic; Antisense; CCN2; Connective tissue growth factor; CTGF; Fibrogenesis; Fibrosis; Gene transcription; Hepatic fibrosis; Neutralizing; SiRNA; TGF ; Therapeutic; Transforming growth factor beta

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 CARBOXY 2 [4 [2 (5 METHYL 2 PHENYL 4 OXAZOLYL)ETHOXY]PHENYL]ETHYLAMINO]BENZOIC ACID METHYL ESTER; ALPHA1 INTERFERON; ALPHA1B INTERFERON; ANTIFIBROTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; ATORVASTATIN; CERIVASTATIN; CONNECTIVE TISSUE GROWTH FACTOR; FG 3019; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ILOPROST; IMMUNOGLOBULIN G2; MEVINOLIN; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PRAVASTATIN; PROSTAGLANDIN; PROSTAGLANDIN E2; PROTEIN KINASE INHIBITOR; RETINOIC ACID; ROSIGLITAZONE; SIMVASTATIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CLINICAL TRIAL; CONJUNCTIVA DISEASE; DISEASE MODEL; DRUG EFFICACY; DRUG MECHANISM; FIBROBLAST; FIBROGENESIS; FIBROSIS; GENE SILENCING; GENE TARGETING; HUMAN; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INTESTINAL FIBROSIS; KIDNEY DISEASE; KIDNEY FIBROSIS; LIVER FIBROSIS; LUNG FIBROSIS; LUNG INJURY; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAYNAUD PHENOMENON; SCAR FORMATION; VASCULAR FIBROSIS;

ANIMALIA;

EID: 67349196521     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-009-0043-9     Document Type: Article

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