CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin

Molecular Biology of the Cell

Volumn 15, Issue 12, 2004, Pages 5635-5646

  Chen, Yunliang ^a   Abraham, David J ^a   Shi Wen, Xu ^a   Pearson, Jeremy D ^b   Black, Carol M ^a   Lyons, Karen M ^c   Leask, Andrew ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALPHA ACTIN; ALPHA5 INTEGRIN; CONNECTIVE TISSUE GROWTH FACTOR; ENDOGLIN; FIBRONECTIN; FIBRONECTIN RECEPTOR; FOCAL ADHESION KINASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEOHEPARAN SULFATE; SYNDECAN 4; VERY LATE ACTIVATION ANTIGEN 4;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL ADHESION; CONTROLLED STUDY; FIBROSIS; FILOPODIUM; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; TISSUE REPAIR; WESTERN BLOTTING; WOUND HEALING;

ANIMALS; BUTADIENES; CELL ADHESION; CELL SHAPE; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; FIBRONECTINS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; HEPARIN; HUMANS; IMMEDIATE-EARLY PROTEINS; INTEGRINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; NITRILES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEOGLYCANS; PSEUDOPODIA; SKIN; SYNDECANS;

ANIMALIA;

EID: 9444299108     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E04-06-0490     Document Type: Article

References (50)

1. Abraham, D.J., Shiwen, X., Black, C.M., Sa, S., Xu, Y., and Leask, A. (2000). Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J. Biol. Chem. 275, 15220-15225.
2. Abreu, J.G., Ketpura, N.I., Reversade, B., and De Robertis, E.M. (2002). Connective-tissue growth factor (CCN2) modulates cell signalling by BMP and TGF-beta. Nat. Cell Biol. 4, 599-604.
3. Babic, A.M., Chen, C.C., and Lau, L.F. (1999). Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol. Cell. Biol. 19, 2958-2966.
4. Badylak, S.F. (2002). The extracellular matrix as a scaffold for tissue reconstruction. Semin. Cell Dev. Biol. 13, 377-383.
5. Ball, D.K., Rachfal, A.W., Kemper, S.A., and Brigstock, D.R. (2003). The heparin-binding 10 kDa fragment of connective tissue growth factor (CCN2) containing module 4 alone stimulates cell adhesion. J. Endocrinol. 176, R1-R7.
6. Bork, P. (1993). The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett. 327, 125-130.
7. Brigstock, D.R., Steffen, C.L., Kim, G.Y., Vegunta, R.K., Diehl, J.R., and Harding, P.A. (1997). Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J. Biol. Chem. 272, 20275-20282.
8. Chang, H.Y., Chi, J.T., Dudoit, S., Bondre, C., van de Rijn, M., Botstein, D., and Brown, P.O. (2002). Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc. Natl. Acad. Sci. USA 99, 12877-12882.
9. Chuong, C.M., et al. (2002). What is the 'true' function of skin? Exp. Dermatol. 11, 159-187.
10. Chen, C.C., Chen, N., and Lau, L.F. (2001a). The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J. Biol. Chem. 276, 10443-10452.
11. Chen, Y., Blom, I.E., Sa, S., Goldschmeding, R., Abraham, D.J., and Leask, A. (2002). CCN2 expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int. 62, 1149-1159.
12. Chen, Y., Segarini, P., Raoufi, F., Bradham, D., and Leask, A. (2001b). Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome. Exp. Cell Res. 271, 109-117.
13. Clark, R.A. (1985). Cutaneous tissue repair: basic biologic considerations. I. J. Am. Acad. Dermatol. 13, 701-725.
14. Einhauer, A., and Jungbauer, A. (2001). The FLAG peptide, a versatile fusion tag for the purification of recombinant proteins. J. Biochem. Biophys. Methods 49, 455-465.
15. Favata, M.F., et al. (1998). Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273, 18623-18632.
16. Fuchs, E., and Byrne, C. (1994). The epidermis: rising to the surface. Curr. Opin. Genet. Dev. 4, 725-736.
17. Gabbiani, G. (2003). The myofibroblast in wound healing and fibrocontractive diseases. J. Pathol. 200, 500-503.
18. Gao, R., Ball, D.K., Perbal, B., and Brigstock, D.R. (2004). Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells. J. Hepatol. 40, 431-438.
19. Gao, R., and Brigstock, D.R. (2003). Connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol. Res. 27, 214-220.
20. Gao, R., and Brigstock, D.R. (2004). Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan. J. Biol. Chem. 279, 8848-8855.
21. Grotendorst, G.R. (1997). Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev. 8, 171-179.
22. Grzeszkiewicz, T.M., Lindner, V., Chen, N., Lam, S.C., and Lau, L.F. (2002). The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans. Endocrinology 143, 1441-1450.
23. Holmes, A., Abraham, D.J., Chen, Y., Denton, C., Shiwen, X., Black, C.M., and Leask, A. (2003). Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1. J. Biol. Chem. 278, 13008-13015.
24. Holmes, A., Abraham, D.J., Sa, S., Shiwen, X., Black, C.M., and Leask, A. (2001). CCN2 and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J. Biol. Chem. 276, 10594-10601.
25. Igarashi, A., Okochi, H., Bradham, D.M., and Grotendorst, G.R. (1993). Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol. Biol. Cell 4, 637-645.
26. Igarashi, A., Nashiro, K., Kikuchi, K., Sato, S., Ihn, H., Grotendorst, G.R., and Takehara, K. (1995). Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J. Investig. Dermatol. 105, 280-284.
27. Ivkovic, S., Yoon, B.S., Popoff, S.N., Safadi, F.F., Libuda, D.E., Stephenson, R.C., Daluiski, A., and Lyons, K.M. (2003). Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130, 2779-2791.
28. Kielty, C.M., and Shuttleworth, C.A. (1997). Microfibrillar elements of the dermal matrix. Microsc. Res. Tech. 38, 413-427.
29. Latinkic, B.V., Mercurio, S., Bennett, B., Hirst, E.M., Xu, Q., Lau, L.F., Mohun, T.J., and Smith, J.C. (2003). Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling. Development 130, 2429-2441.
30. Lau, L.F., and Lam, S.C. (1999). The CCN family of angiogenic regulators: the integrin connection. Exp. Cell Res. 248, 44-57.
31. Leask, A, et al. (2002). Dysregulation of TGFbeta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis Rheum. 46, 1857-1865.
32. Leask, A., Holmes, A., Black, C.M., and Abraham, D.J. (2003). Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J. Biol. Chem. 278, 13008-13015.
33. Leask, A., and Abraham, D.J. (2003). The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem. Cell Biol. 81, 355-363.
34. Leask, A., Denton, C.P., and Abraham, D.J. (2004). Insights into the molecular mechanism of sustained fibrosis: the role of connective tissue growth factor in scleroderma. J. Investig. Dermatol. 122, 1-6.
35. Leask, A., and Abraham, D.J. (2004). The control of TGFβ signaling in wound healing and fibrosis. FASEB J. 18, 816-827.
36. Leu, S.J., Liu, Y., Chen, N., Chen, C.C., Lam, S.C., and Lau, L.F. (2003). Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61). J. Biol. Chem. 278, 33801-33808.
37. Masur, S.K., Dewal, H.S., Dinh, T.T., Erenburg, I., and Petridou, S. (1996). Myofibroblasts differentiate from fibroblasts when plated at low density Proc. Natl. Acad. Sci. USA 93, 4219-4223.
38. Mori, T., Kawara, S., Shinozaki, M., Hayashi, N., Kakinuma, T., Igarashi, A., Takigawa, M., Nakanishi, T., and Takehara, K. (1999). Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model. J. Cell. Physiol. 181, 153-159.
39. Moussad, E.E., and Brigstock, D.R. (2000). Connective tissue growth factor: what's in a name? Mol. Genet. Metab. 71, 276-292.
40. Nishida, T., Kubota, S., Fukunaga, T., Kondo, S., Yosimichi, G., Nakanishi, T., Takano-Yamamoto, T., and Takigawa, M. (2003). CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes J. Cell. Physiol. 196, 265-275.
41. Perbal, B. (2001). NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol. Pathol. 54, 57-79.
42. Saoncella, S., Echtermeyer, F., Denhez, F., Nowlen, J.K., Mosher, D.F., Robinson, S.D., Hynes, R.O., and Goetinck, P.F. (1999). Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers Proc. Natl. Acad. Sci. USA 96, 2805-2810.
43. Schober, J.M., Lau, L.F., Ugarova, T.P., and Lam, S.C. (2002). Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 99, 4457-4465.
44. Segarini, P.R., Nesbitt, J.E., Li, D., Hays, L.G., Yates JR 3rd, and Carmichael, D.F. (2001). The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor. J. Biol. Chem. 276, 40659-40667.
45. Shi-wen, X., et al. (2000). Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. Exp. Cell Res. 259, 213-224.
46. Shi-Wen, X., et al. (2004). Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol. Biol. Cell 15, 2707-2719.
47. Stratton, R., Rajkumar, V., Ponticos, M., Nichols, B., Shiwen, X., Black, C.M., Abraham, D.J., and Leask, A. (2002). Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway. FASEB J. 16, 1949-1951.
48. Werner, S., and Grose, R. (2003). Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 83, 835-870.
49. Wilcox-Adelman, S.A., Denhez, F., and Goetinck, P.F. (2002). Syndecan-4 modulates focal adhesion kinase phosphorylation. J. Biol. Chem. 277, 32970-32977.
50. Zamir, E., and Geiger, B. (2001). Components of cell-matrix adhesions. J. Cell Sci. 114, 3577-3579.