메뉴 건너뛰기




Volumn 10, Issue 9, 2008, Pages 1039-1047

RNA interfering connective tissue growth factor prevents rat hepatic stellate cell activation and extracellular matrix production

Author keywords

Connective tissue growth factor; Extracellular matrix; Hepatic stellate cell; Liver fibrosis; Small interfering RNA

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; HYALURONIC ACID; MESSENGER RNA; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; SMALL INTERFERING RNA;

EID: 52649169800     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1223     Document Type: Article
Times cited : (30)

References (33)
  • 1
    • 2642585736 scopus 로고    scopus 로고
    • How can transforming growth factor beta be targeted usefully to combat liver fibrosis?
    • Shek FW, Benyon RC. How can transforming growth factor beta be targeted usefully to combat liver fibrosis? Eur J Gastroenterol Hepatol 2004; 16: 123-126.
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 123-126
    • Shek, F.W.1    Benyon, R.C.2
  • 3
    • 0036456869 scopus 로고    scopus 로고
    • Hepatic fibrosis: From bench to bedside
    • Schuppan D, Porov Y. Hepatic fibrosis: from bench to bedside. J Gastroenterol Hepatol 2002; 17(Suppl 3): S300-S305.
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.SUPPL. 3
    • Schuppan, D.1    Porov, Y.2
  • 4
    • 84867516266 scopus 로고    scopus 로고
    • Molecular basis of hepatic fibrosis
    • Hui AY, Friedman SL. Molecular basis of hepatic fibrosis. Expert Rev Mol Med 2003; 14: 1-23.
    • (2003) Expert Rev Mol Med , vol.14 , pp. 1-23
    • Hui, A.Y.1    Friedman, S.L.2
  • 5
    • 0036775477 scopus 로고    scopus 로고
    • Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy?
    • Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 2002; 21: 473-482.
    • (2002) Matrix Biol , vol.21 , pp. 473-482
    • Blom, I.E.1    Goldschmeding, R.2    Leask, A.3
  • 6
    • 0442291674 scopus 로고    scopus 로고
    • The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology
    • Leask A, Abraham DJ. The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 2003; 81: 355-363.
    • (2003) Biochem Cell Biol , vol.81 , pp. 355-363
    • Leask, A.1    Abraham, D.J.2
  • 7
    • 0342264463 scopus 로고    scopus 로고
    • Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells
    • Williams EJ, Gaca MD, Brigstock DR, Arthur MJ, Benyon RC. Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J Hepatol 2000; 32: 754-761.
    • (2000) J Hepatol , vol.32 , pp. 754-761
    • Williams, E.J.1    Gaca, M.D.2    Brigstock, D.R.3    Arthur, M.J.4    Benyon, R.C.5
  • 8
    • 0032862910 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor in experimental rat and human liver fibrosis
    • Paradis V, Dargere D, Vidaud M, et al. Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 1999; 30: 968-976.
    • (1999) Hepatology , vol.30 , pp. 968-976
    • Paradis, V.1    Dargere, D.2    Vidaud, M.3
  • 9
    • 0242690484 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated stellate cells
    • Gao R, Brigstock D. Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated stellate cells. Hepatol Res 2003; 27: 214-220.
    • (2003) Hepatol Res , vol.27 , pp. 214-220
    • Gao, R.1    Brigstock, D.2
  • 10
    • 0036281460 scopus 로고    scopus 로고
    • Effect and regulation of connective tissue growth factor on hepatic stellate cells
    • Paradis V, Dargere D, Bonvoust F, Vidaud M, Segarini P, Bedossa P. Effect and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 2002; 82: 767-774.
    • (2002) Lab Invest , vol.82 , pp. 767-774
    • Paradis, V.1    Dargere, D.2    Bonvoust, F.3    Vidaud, M.4    Segarini, P.5    Bedossa, P.6
  • 11
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411: 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 12
    • 33746249009 scopus 로고    scopus 로고
    • Intrahepatic gene silencing by RNA interference
    • Shackel NA, Rockey DC. Intrahepatic gene silencing by RNA interference. Gastroenterology 2004; 126: 356-358.
    • (2004) Gastroenterology , vol.126 , pp. 356-358
    • Shackel, N.A.1    Rockey, D.C.2
  • 13
    • 0036727416 scopus 로고    scopus 로고
    • Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
    • Lewis DL, Hagstrom JE, Loomis AG, Wolff JA, Herwijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 2002; 32: 107-108.
    • (2002) Nat Genet , vol.32 , pp. 107-108
    • Lewis, D.L.1    Hagstrom, J.E.2    Loomis, A.G.3    Wolff, J.A.4    Herwijer, H.5
  • 14
    • 0037348329 scopus 로고    scopus 로고
    • RNA interference targeting Fas protects mice from fulminant hepatitis
    • Song E, Lee SK, Wang J, et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003; 9: 347-351.
    • (2003) Nat Med , vol.9 , pp. 347-351
    • Song, E.1    Lee, S.K.2    Wang, J.3
  • 15
    • 0038610713 scopus 로고    scopus 로고
    • Caspase 8 small interfering RNA prevents acute liver failure in mice
    • Zender L, Hutker S, Liedtke C, et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Natl Acad Sci USA 2003; 100: 7797-7802.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7797-7802
    • Zender, L.1    Hutker, S.2    Liedtke, C.3
  • 16
    • 33746265975 scopus 로고    scopus 로고
    • Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats
    • Li G, Xie Q, Shi Y, et al. Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats. J Gene Med 2006; 8: 889-900.
    • (2006) J Gene Med , vol.8 , pp. 889-900
    • Li, G.1    Xie, Q.2    Shi, Y.3
  • 17
    • 12744279509 scopus 로고    scopus 로고
    • Antisense downregulation of SARS-CoV gene expression in Vero E6 cells
    • Yi S, Haifeng L, Jie J, Dehua Y, Bing H, Youxin J. Antisense downregulation of SARS-CoV gene expression in Vero E6 cells. J Gene Med 2005; 7: 97-107.
    • (2005) J Gene Med , vol.7 , pp. 97-107
    • Yi, S.1    Haifeng, L.2    Jie, J.3    Dehua, Y.4    Bing, H.5    Youxin, J.6
  • 18
    • 0042092032 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis
    • Rachfal AW, Brigstock DR. Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis. Hepatol Res 2003; 26: 1-9.
    • (2003) Hepatol Res , vol.26 , pp. 1-9
    • Rachfal, A.W.1    Brigstock, D.R.2
  • 19
    • 0034802171 scopus 로고    scopus 로고
    • High glucose and hyperinsulinemia stimulate connective tissue e growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
    • Paradis V, Perlemuter G, Bonvoust F, et al. High glucose and hyperinsulinemia stimulate connective tissue e growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology 2001; 34: 738-744.
    • (2001) Hepatology , vol.34 , pp. 738-744
    • Paradis, V.1    Perlemuter, G.2    Bonvoust, F.3
  • 20
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998; 16: 137-161.
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 21
    • 0033195998 scopus 로고    scopus 로고
    • Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    • Ashcroft GS, Yang X, Glick AB, et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1999; 1: 260-266.
    • (1999) Nat Cell Biol , vol.1 , pp. 260-266
    • Ashcroft, G.S.1    Yang, X.2    Glick, A.B.3
  • 22
    • 1942532990 scopus 로고    scopus 로고
    • Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta1-stimulated porcine skin fibroblasts
    • Wang JF, Olson ME, Ma L, Brigstock DR, Hart DA. Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta1-stimulated porcine skin fibroblasts. Wound Repair Regen 2004; 12: 205-216.
    • (2004) Wound Repair Regen , vol.12 , pp. 205-216
    • Wang, J.F.1    Olson, M.E.2    Ma, L.3    Brigstock, D.R.4    Hart, D.A.5
  • 23
    • 0036838772 scopus 로고    scopus 로고
    • Pathogenesis of fibrosis: Role of TGF-beta and CTGF
    • Ihn H. Pathogenesis of fibrosis: role of TGF-beta and CTGF. Curr Opin Rheumatol 2002; 14: 681-685.
    • (2002) Curr Opin Rheumatol , vol.14 , pp. 681-685
    • Ihn, H.1
  • 24
    • 2942622398 scopus 로고    scopus 로고
    • Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking
    • Issa R, Zhou X, Constandinou CM, et al. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology 2004; 126: 1795-1808.
    • (2004) Gastroenterology , vol.126 , pp. 1795-1808
    • Issa, R.1    Zhou, X.2    Constandinou, C.M.3
  • 25
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis
    • Iredale JP, Benyon RC, Pickering J, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. J Clin Invest 1998; 102: 538-549.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3
  • 26
    • 0038082099 scopus 로고    scopus 로고
    • Hepatic stellate cells: Unique characteristics in cell biology and phenotype
    • Sato M, Suzuki S, Senoo H. Hepatic stellate cells: unique characteristics in cell biology and phenotype. Cell Struct Funct 2003; 28: 105-112.
    • (2003) Cell Struct Funct , vol.28 , pp. 105-112
    • Sato, M.1    Suzuki, S.2    Senoo, H.3
  • 28
    • 0033813903 scopus 로고    scopus 로고
    • Connective tissue growth factor: What's in a name?
    • Moussad EE, Brigstock DR. Connective tissue growth factor: what's in a name? Mol Genet Metab 2000; 71: 276-292.
    • (2000) Mol Genet Metab , vol.71 , pp. 276-292
    • Moussad, E.E.1    Brigstock, D.R.2
  • 29
    • 0033915471 scopus 로고    scopus 로고
    • Connective tissue growth factor in human liver cirrhosis
    • Abou-Shady M, Friess H, Zimmermann A, et al. Connective tissue growth factor in human liver cirrhosis. Liver 2000; 20: 296-304.
    • (2000) Liver , vol.20 , pp. 296-304
    • Abou-Shady, M.1    Friess, H.2    Zimmermann, A.3
  • 30
    • 0034802171 scopus 로고    scopus 로고
    • High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
    • Paradis V, Perlemuter G, Bonvoust F, et al. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology 2001; 34: 738-744.
    • (2001) Hepatology , vol.34 , pp. 738-744
    • Paradis, V.1    Perlemuter, G.2    Bonvoust, F.3
  • 31
    • 34848865661 scopus 로고    scopus 로고
    • Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
    • Gressner OA, Lahme B, Demirci I, Gressner AM, Weiskirchen R. Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol 2007; 47: 669-710.
    • (2007) J Hepatol , vol.47 , pp. 669-710
    • Gressner, O.A.1    Lahme, B.2    Demirci, I.3    Gressner, A.M.4    Weiskirchen, R.5
  • 32
    • 36348932917 scopus 로고    scopus 로고
    • Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
    • Weng HL, Ciuclan L, Liu Y, et al. Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology 2007; 46: 1257-1270.
    • (2007) Hepatology , vol.46 , pp. 1257-1270
    • Weng, H.L.1    Ciuclan, L.2    Liu, Y.3
  • 33
    • 33746249009 scopus 로고    scopus 로고
    • Intrahepatic gene silencing by RNA interference
    • Shackel NA, Rockey DC. Intrahepatic gene silencing by RNA interference. Gastroenterology 2004; 126: 356-358.
    • (2004) Gastroenterology , vol.126 , pp. 356-358
    • Shackel, N.A.1    Rockey, D.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.