Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro

Japanese Journal of Ophthalmology

Volumn 52, Issue 1, 2008, Pages 8-15

  Yamanaka, Osamu ^a   Saika, Shizuya ^a   Ikeda, Kazuo ^b   Miyazaki, Ken Ichi ^a   Kitano, Ai ^a   Ohnishi, Yoshitaka ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

Connective tissue growth factor; Extracellular matrix; Filtration surgery; Transforming growth factor ; Wound healing

Indexed keywords

COLLAGEN TYPE 1; COMPLEMENTARY DNA; CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONJUNCTIVA; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST CULTURE; FILTERING OPERATION; HUMAN; HUMAN CELL; IMMUNOLOCALIZATION; IN VITRO STUDY; INHIBITION KINETICS; MODEL; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SYNTHESIS; SCAR FORMATION; WOUND; WOUND HEALING;

CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; COLLAGEN TYPE I; CONJUNCTIVA; DNA, ANTISENSE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBRONECTINS; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1;

EID: 41549093608     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10384-007-0497-3     Document Type: Article

References (35)

1. Cordeiro MF, Mead A, Ali RR, et al. Novel antisense oligonucleotides targeting TGF-beta inhibit in vivo scarring and improve surgical outcome. Gene Ther 2003;10:59-71.
2. Elder MJ, Dart JKG, Lightman S. Conjunctival fibrosis in ocular cicatricial pemphigoid-the role of cytokines. Exp Eye Res 1997;65:165-176.
3. Jampel HD, Roche N, Stark WJ, Roberts AB. Transforming growth factor-β in human aqueous humor. Curr Eye Res 1990;9:963-969.
4. Khaw PT, Chang L, Wong TT, Mead A, Daniels JT, Cordeiro MF. Modulation of wound healing after glaucoma surgery. Curr Opin Ophthalmol 2001;12:143-148.
5. Massague J. How cells read TGF-β signals. Nat Rev Mol Cell Biol 2000;1:169-178.
6. Massague J, Chen YG. Controlling TGF-β signaling. Gene Dev 2000;14:627-644.
7. Siriwardena D, Khaw PT, King AJ, et al. Human antitransforming growth factor b2 monoclonal antibody-a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study. Ophthalmology 2002;109:427-431.
8. Grotendorst GR. Review. Connective tissue growth factor: a mediator of TGF-β action on fibroblasts. Cytokine Growth Factor Rev 1997;8:171-179.
9. Ihn H. Review. Pathogenesis of fibrosis: role of TGF-β and CTGF. Curr Opin Rheumatol 2002;14:681-685.
10. van Setten G, Aspiotis M, Blalock TD, et al. Connective tissue growth factor in ptergium: simultaneous presence with vascular endothelial growth factor-possible contributing factor to conjunctival scarring. Graefes Arch Clin Exp Ophthalmol 2003;241:135-139.
11. van Setten GB, Blalock TD, Grotendorst G, Schultz GS. Detection of connective tissue growth factor in human aqueous humor. Opthalmic Res 2002;34:306-308.
12. Saika S, Okada Y, Miyamoto T, et al. Smad translocation and growth suppression in lens epithelial cells by endogenous TGFβ2 during wound repair. Exp Eye Res 2001;72:679-686.
13. Saika S, Saika S, Liu CY, et al. TGFβ2 in corneal morphogenesis during mouse embryonic development. Dev Biol 2001;240:419-432.
14. Saika S, Yamanaka O, Baba Y, et al. Accumulation of latent transforming growth factor-beta binding protein-1 and TGF beta 1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts. Graefes Arch Clin Exp Ophthalmol 2001;239:234-241.
15. Yamanaka O, Saika S, Okada Y, Ooshima A, Ohnishi Y. Effects of interferon-gamma on human subconjunctival fibroblasts in the presence of TGF beta 1: reversal of TGF beta-stimulated collagen production. Graefes Arch Clin Exp Ophthalmol 2003;241:116-124.
16. Cordeiro MF, Bhattacharya SS, Schultz GS, Khaw PT. TGF-β1,-β2, and-β3 in vitro: biphasic effects on Tenon's fibroblast contraction, proliferation, and migration. Invest Ophthalmol Vis Sci 2000;41:756-763.
17. Abreu JG, Ketpura NI, Reversade B, de Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Nat Cell Biol 2002;4:599-604.
18. Moussad EE, Rageh MA, Wilson AK, Geisert RD, Brigstock DR. Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor beta type 1 (TGF-beta 1) at the utero-placental interface during early pregnancy in the pig. Mol Pathol 2002;55:186-192.
19. Folger PA, Zekaria D, Grotendorst G, Masur SK. Transforming growth factor-beta-stimulated connective tissue growth factor expression during corneal myofibroblast differentiation. Invest Ophthalmol Vis Sci 2001;42:2534-2541.
20. Jester JV, Huang J, Petroll WM, Cavanagh HD. TGFβ induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGFβ, PDGF and integrin signaling. Exp Eye Res 2002;75:645-657.
21. Taylor LM, Khachigian LM. Induction of platelet-derived growth factor B-chain expression by transforming growth factor-β involves transactivation by Smads. J Biol Chem 2000;275:16709-16716.
22. Belyea DA, Dan JA, Stamper RL, Lieberman MF, Spencer. Late onset of sequential multifocal bleb leaks after glaucoma filtration surgery with 5-fluorouracil and mitomycin C. Am J Ophthalmol 1997;124:40-45.
23. Greenfield DS, Liebmann JM, Jee J, Ritch R. Late-onset bleb leaks after glaucoma filtering surgery. Arch Ophthalmol 1998;116:443-447.
24. Higginbotham EJ, Stevens RK, Musch DC, et al. Bleb-related endophthalmitis after trabeculectomy with mitomycin C. Ophthalmology 1996;103:650-656.
25. Duncan MR, Frazier KS, Abramson S, et al. Connective growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP FASEB J 1999;13:1774-1786.
26. Chen MM, Lam A, Abraham JA, Schreiner GF, Joly AH. CTGF expression is induced by TGF-β in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. J Mol Cell Cardiol 2000;32:1805-1819.
27. Gore-Hyer E, Shegogue D, Markiewicz M, et al. TGF-β and CTGF have overlapping and distinct fibrogenic effects on human renal cells. Am J Physiol 2002;283:F707-716.
28. Rachfal AW, Brigstock DR. Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis. Hepatol Res 2003;26:1-9.
29. Razzaque MS, Foster CS, Ahmed AR. Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci 2003;44:1998-2003.
30. Lakos G, Takagawa S, Chen SJ et al. Targeted disruption of TGF-β/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol 2004;165:203-217.
31. Saika S, Ooshima A, Yamanaka O, Okada Y, Tanaka S, Ohnishi Y. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Opthalmol 1996;234:S214-222.
32. Saika S, Yamanaka O, Hashizume N, et al. Cis-hydroxyproline inhibits on adhesion, migration and proliferation of cultured rabbit keratocytes. Ophthalmic Res 1993;25:363-370.
33. Daniels JT, Schultz GS, Blalock TD, Garrett Q, Grotendorst GR. Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts. Am J Pathol 2003;163:2043-2052.
34. Arnott JA, Nuglozeh E, Rico MC, et al. Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta 1-induced extracellular matrix production in osteoblasts. J Cell Physiol 2007;210:843-852.
35. Chujo S, Shirasaki F, Kawara S, et al. Connective tissue growth factor causes persistent proalpha 2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model. J Cell Physiol 2005;203:447-456.