Broad Substrate Specificity of Human Cytochrome P450 46A1 Which Initiates Cholesterol Degradation in the Brain

Biochemistry

Volumn 42, Issue 48, 2003, Pages 14284-14292

  Mast, Natalia ^a   Norcross, Ryan ^b   Andersson, Ulla ^c   Shou, Magang ^b   Nakayama, Kazuo ^a   Bjorkhem, Ingemar ^c   Pikuleva, Irina A ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELL CULTURE; CHEMICAL BONDS; CYTOLOGY; DRUG PRODUCTS; HYDROXYLATION; METABOLISM;

CYTOCHROMES;

BIOCHEMISTRY;

24 HYDROXYCHOLESTEROL; 24,25 DIHYDROXYCHOLESTEROL; 24,27 DIHYDROXYCHOLESTEROL; 24-HYDROXYCHOLESTEROL; 7ALPHA HYDROXYCHOLESTEROL; CHOLESTANOL; CHOLESTEROL; CHOLESTEROL 24 HYDROXYLASE; CHOLESTEROL 24-HYDROXYLASE; CHOLESTEROL DERIVATIVE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 46A1; DEXTROMETHORPHAN; DICLOFENAC; DRUG; HYDROXYL GROUP; NEUROSTEROID; OXYSTEROL; PHENACETIN; PROGESTERONE; RECOMBINANT ENZYME; RECOMBINANT PROTEIN; STEROID; STEROID MONOOXYGENASE; TESTOSTERONE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; BINDING SITE; BIOSYNTHESIS; BIOTRANSFORMATION; BLOOD BRAIN BARRIER; BRAIN; BRAIN METABOLISM; CATALYSIS; CATALYST; CELL LINE; CHEMICAL BOND; CHEMICAL REACTION; CHEMISTRY; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CULTURE MEDIUM; DEETHYLATION; DEMETHYLATION; DRUG HYDROXYLATION; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROXYLATION; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; STEROID HYDROXYLATION;

BINDING SITES; BIOTRANSFORMATION; BRAIN; CATALYSIS; CELL LINE; CHOLESTEROL; HUMANS; HYDROXYCHOLESTEROLS; HYDROXYLATION; PHARMACEUTICAL PREPARATIONS; RECOMBINANT PROTEINS; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0345492012     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035512f     Document Type: Article

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