Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: Evidence that simvastatin affects cholesterol metabolism in the human brain

Archives of Neurology

Volumn 59, Issue 2, 2002, Pages 213-216

  Locatelli, Sandra ^a   Lütjohann, Dieter ^a   Schmidt, Hartmut H J ^b   Otto, Carsten ^c   Beisiegel, Ulrike ^d   Von Bergmann, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

24 HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; LATHOSTEROL; LIPOPROTEIN; SIMVASTATIN; UNCLASSIFIED DRUG;

ADULT; ALZHEIMER DISEASE; ARTICLE; BRAIN; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CLINICAL TRIAL; DRUG MEGADOSE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HYPERCHOLESTEROLEMIA; INCIDENCE; LIPOPROTEIN BLOOD LEVEL; MALE; MASS SPECTROMETRY; MULTICENTER STUDY; PRIORITY JOURNAL;

EID: 0036128358     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.59.2.213     Document Type: Article

References (29)

1. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease
2. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: A case-control study
3. Coronary artery disease, hypertension, ApoE, and cholesterol: A link to Alzheimer's disease?
4. Amyloid and lipids in the pathology of Alzheimer disease
5. Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population-based study
6. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
7. Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol
8. Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells
9. The role of cholesterol in the biosynthesis of beta-amyloid
10. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
11. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
12. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
13. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
14. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
15. Statins and the risk of dementia
16. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients
17. Plasma 24S-hydroxycholesterol: A peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease
18. Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
19. Cholesterol homeostasis in human brain: Turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
20. Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: A stable isotope study
21. Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects
22. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative centrifuge
23. Comparison of intestinal absorption of cholesterol with different plant sterols in man
24. 2techniques in vivo and in vitro
25. Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: Cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice
26. Lipid-altering efficacy and safety of simvastatin 80 mg/day: Long-term experience in a large group of patients with hypercholesterolemia
27. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver
28. Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans
29. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo