From brain to bile: Evidence that conjugation and ω-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 37004-37010

  Björkhem, Ingemar ^a   Andersson, Ulla ^a   Ellis, Ewa ^a   Alvelius, Gunvor ^a   Ellegård, Lars ^c   Diczfalusy, Ulf ^a   Sjövall, Jan ^b   Einarsson, Curt ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CHOLESTEROL; HYDROXYLATION; METABOLISM; METABOLITES;

BILE ACIDS;

BRAIN;

24 HYDROXYCHOLESTEROL; 5 CHOLESTENE 3BETA,24,27 TRIOL; 7ALPHA HYDROXYCHOLESTEROL; BILE ACID; CHOLESTEROL DERIVATIVE; OXYSTEROL; TRITIUM; UNCLASSIFIED DRUG; 24-HYDROXYCHOLESTEROL; CHOLESTANE DERIVATIVE; CHOLESTENE 3,24,27 TRIOL; CHOLESTENE-3,24,27-TRIOL;

ARTICLE; BILE; BILE ACID SYNTHESIS; BILIARY EXCRETION; BLOOD BRAIN BARRIER; BRAIN; CHEMICAL LABELING; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; CONJUGATION; FATTY ACID OMEGA OXIDATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FISTULA; INTESTINE FLUID; ISOMER; LIPID TRANSPORT; LIVER CELL; LIVER METABOLISM; MALE; MASS SPECTROMETRY; METABOLIC REGULATION; METABOLITE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; HYDROXYLATION; ILEOCECAL VALVE; ISOLATION AND PURIFICATION; METABOLISM;

FISTULA; TRITIUM;

BILE; BILE ACIDS AND SALTS; BRAIN; CHOLESTENES; HEPATOCYTES; HUMANS; HYDROXYCHOLESTEROLS; HYDROXYLATION; ILEOCECAL VALVE; TRITIUM;

EID: 0035813114     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103828200     Document Type: Article

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