Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARγ pathway as a therapeutic target in Friedreich's ataxia

Human Molecular Genetics

Volumn 18, Issue 13, 2009, Pages 2452-2461

  Coppola, Giovanni ^a   Marmolino, Daniele ^b   Lu, Daning ^a   Wang, Qing ^a   Cnop, Miriam ^b,c   Rai, Myriam ^b   Acquaviva, Fabio ^d   Cocozza, Sergio ^d   Pandolfo, Massimo ^b   Geschwind, Daniel H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c ERASME HOSPITAL   (Belgium)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FRATAXIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DOWN REGULATION; FRIEDREICH ATAXIA; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE TARGETING; GENOME ANALYSIS; HEART MUSCLE; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SKELETAL MUSCLE; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; CELLS, CULTURED; FRIEDREICH ATAXIA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOMICS; HUMANS; INSULIN RESISTANCE; IRON-BINDING PROTEINS; LIVER; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUSCLE, SKELETAL; MYOCARDIUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SPECIFICITY; PPAR GAMMA; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 67249133451     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp183     Document Type: Article

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