-
1
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo, J.M.; Gilman, S.; Dartigues, J.F.; Laurent, B.; Puel, M.; Kirby, L.C.; Jouanny, P.; Dubois, B.; Eisner, L.; Flitman, S.; Michel, B.F.; Boada, M.; Frank, A.; Hock, C. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology, 2003, 61, 46-54.
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
Laurent, B.4
Puel, M.5
Kirby, L.C.6
Jouanny, P.7
Dubois, B.8
Eisner, L.9
Flitman, S.10
Michel, B.F.11
Boada, M.12
Frank, A.13
Hock, C.14
-
2
-
-
0029671451
-
Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains
-
Kuo, Y.M.; Emmerling, M.R.; Vigo-Pelfrey, C.; Kasunic, T.C.; Kirkpatrick, J.B.; Murdoch, G.H.; Ball, M.J.; Roher, A.E. Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J. Biol. Chem., 1996, 271, 4077-81.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 4077-4081
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Vigo-Pelfrey, C.3
Kasunic, T.C.4
Kirkpatrick, J.B.5
Murdoch, G.H.6
Ball, M.J.7
Roher, A.E.8
-
3
-
-
9444245809
-
Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease
-
Roher, A.E.; Chaney, M.O.; Kuo, Y.M.; Webster, S.D.; Stine, W.B.; Haverkamp, L.J.; Woods, A.S.; Cotter, R.J.; Tuohy, J.M.; Krafft, G.A.; Bonnell, B.S.; Emmerling, M.R. Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease. J. Biol. Chem., 1996, 271, 20631-35.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 20631-20635
-
-
Roher, A.E.1
Chaney, M.O.2
Kuo, Y.M.3
Webster, S.D.4
Stine, W.B.5
Haverkamp, L.J.6
Woods, A.S.7
Cotter, R.J.8
Tuohy, J.M.9
Krafft, G.A.10
Bonnell, B.S.11
Emmerling, M.R.12
-
4
-
-
0033974885
-
A unifying hypothesis of Alzheimer's disease. III. Risk factors
-
Heininger, K. A unifying hypothesis of Alzheimer's disease. III. Risk factors. Hum. Psychopharmacol., 2000, 15, 1-70.
-
(2000)
Hum. Psychopharmacol
, vol.15
, pp. 1-70
-
-
Heininger, K.1
-
5
-
-
0030971789
-
Disaggregation of Alzheimer beta-amyloid by site-directed mAb
-
Solomon, B.; Koppel, R.; Frankel, D.; Hanan-Aharon, E. Disaggregation of Alzheimer beta-amyloid by site-directed mAb. Proc. Natl. Acad. Sci. USA, 1997, 94, 4109-12.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 4109-4112
-
-
Solomon, B.1
Koppel, R.2
Frankel, D.3
Hanan-Aharon, E.4
-
6
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk, D.; Barbour, R.; Dunn, W.; Gordon, G.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Liao, Z.; Lieberburg, I.; Motter, R.; Mutter, L.; Soriano, F.; Shopp, G.; Vasquez, N.; Vandevert, C.; Walker, S.; Wogulis, M.; Yednock, T.; Games, D.; Seubert, P. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature, 1999, 400, 173-7.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
7
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus, C.; Pearson, J.; McLaurin, J.; Mathews, P.M.; Jiang, Y.; Schmidt, S.D.; Chishti, M.A.; Horne, P.; Heslin, D.; French, J.; Mount, H.T.; Nixon, R.A.; Mercken, M.; Bergeron, C.; Fraser, P.E.; St George-Hyslop, P.; Westaway, D. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature, 2000, 408, 979-82.
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
Mathews, P.M.4
Jiang, Y.5
Schmidt, S.D.6
Chishti, M.A.7
Horne, P.8
Heslin, D.9
French, J.10
Mount, H.T.11
Nixon, R.A.12
Mercken, M.13
Bergeron, C.14
Fraser, P.E.15
St George-Hyslop, P.16
Westaway, D.17
-
8
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan, D.; Diamond, D.M.; Gottschall, P.E.; Ugen, K.E.; Dickey, C.; Hardy, J.; Duff, K.; Jantzen, P.; DiCarlo, G.; Wilcock, D.; Connor, K.; Hatcher, J.; Hope, C.; Gordon, M.; Arendash, G.W. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature, 2000, 408, 982-5.
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
Ugen, K.E.4
Dickey, C.5
Hardy, J.6
Duff, K.7
Jantzen, P.8
DiCarlo, G.9
Wilcock, D.10
Connor, K.11
Hatcher, J.12
Hope, C.13
Gordon, M.14
Arendash, G.W.15
-
9
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
DeMattos, R.B.; Bales, K.R.; Cummins, D.J.; Dodart, J.C.; Paul, S.M.; Holtzman, D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 2001, 98, 8850-5.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Dodart, J.C.4
Paul, S.M.5
Holtzman, D.M.6
-
10
-
-
5144234938
-
Immunotherapy for Alzheimer's disease
-
Gelinas, D.S.; DaSilva, K.; Fenili, D.; St George-Hyslop, P.; McLaurin, J. Immunotherapy for Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 2004, 101(Suppl 2), 14657-62.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.SUPPL. 2
, pp. 14657-14662
-
-
Gelinas, D.S.1
DaSilva, K.2
Fenili, D.3
St George-Hyslop, P.4
McLaurin, J.5
-
11
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard, F.; Cannon, C.; Barbour, R.; Burke, R.L.; Games, D.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; Khan, K.; Kholodenko, D.; Lee, M.; Lieberburg, I.; Motter, R.; Nguyen, M.; Soriano, F.; Vasquez, N.; Weiss, K.; Welch, B.; Seubert, P.; Schenk, D.; Yednock, T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med., 2000, 6, 916-9.
-
(2000)
Nat. Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
12
-
-
0347445722
-
A genomic analysis of rat proteases and protease inhibitors
-
Puente, X.S.; Lopez-Otin, C. A genomic analysis of rat proteases and protease inhibitors. Genome Res., 2004, 14, 609-22.
-
(2004)
Genome Res
, vol.14
, pp. 609-622
-
-
Puente, X.S.1
Lopez-Otin, C.2
-
13
-
-
0037803570
-
Human and mouse proteases: A comparative genomic approach
-
Puente, X.S.; Sanchez, L.M.; Overall, C.M.; Lopez-Otin, C. Human and mouse proteases: a comparative genomic approach. Nat. Rev. Genet., 2003, 4, 544-58.
-
(2003)
Nat. Rev. Genet
, vol.4
, pp. 544-558
-
-
Puente, X.S.1
Sanchez, L.M.2
Overall, C.M.3
Lopez-Otin, C.4
-
14
-
-
4444281147
-
Toward modeling hemorrhagic and encephalitic complications of Alzheimer amyloid-beta vaccination in nonhuman primates
-
Gandy, S.; Walker, L. Toward modeling hemorrhagic and encephalitic complications of Alzheimer amyloid-beta vaccination in nonhuman primates. Curr. Opin. Immunol., 2004, 16, 607-15.
-
(2004)
Curr. Opin. Immunol
, vol.16
, pp. 607-615
-
-
Gandy, S.1
Walker, L.2
-
15
-
-
3042692322
-
Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet
-
Lemere, C.A.; Beierschmitt, A.; Iglesias, M.; Spooner, E.T.; Bloom, J.K.; Leverone, J.F.; Zheng, J.B.; Seabrook, T.J.; Louard, D.; Li, D.; Selkoe, D.J.; Palmour, R.M.; Ervin, F.R. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am. J. Pathol., 2004, 165, 283-97.
-
(2004)
Am. J. Pathol
, vol.165
, pp. 283-297
-
-
Lemere, C.A.1
Beierschmitt, A.2
Iglesias, M.3
Spooner, E.T.4
Bloom, J.K.5
Leverone, J.F.6
Zheng, J.B.7
Seabrook, T.J.8
Louard, D.9
Li, D.10
Selkoe, D.J.11
Palmour, R.M.12
Ervin, F.R.13
-
16
-
-
0035918312
-
Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains
-
Kuo, Y.M.; Kokjohn, T.A.; Beach, T.G.; Sue, L.I.; Brune, D.; Lopez, J.C.; Kalback, W.M.; Abramowski, D.; Sturchler-Pierrat, C.; Staufenbiel, M.; Roher, A.E. Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains. J. Biol. Chem., 2001, 276, 12991-8.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 12991-12998
-
-
Kuo, Y.M.1
Kokjohn, T.A.2
Beach, T.G.3
Sue, L.I.4
Brune, D.5
Lopez, J.C.6
Kalback, W.M.7
Abramowski, D.8
Sturchler-Pierrat, C.9
Staufenbiel, M.10
Roher, A.E.11
-
17
-
-
0035718905
-
The evolution of A beta peptide burden in the APP23 transgenic mice: Implications for A beta deposition in Alzheimer disease
-
Kuo, Y.M.; Beach, T.G.; Sue, L.I.; Scott, S.; Layne, K.J.; Kokjohn, T.A.; Kalback, W.M.; Luehrs, D.C.; Vishnivetskaya, T.A.; Abramowski, D.; Sturchler-Pierrat, C.; Staufenbiel, M.; Weller, R.O.; Roher, A.E. The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease. Mol. Med., 2001, 7, 609-18.
-
(2001)
Mol. Med
, vol.7
, pp. 609-618
-
-
Kuo, Y.M.1
Beach, T.G.2
Sue, L.I.3
Scott, S.4
Layne, K.J.5
Kokjohn, T.A.6
Kalback, W.M.7
Luehrs, D.C.8
Vishnivetskaya, T.A.9
Abramowski, D.10
Sturchler-Pierrat, C.11
Staufenbiel, M.12
Weller, R.O.13
Roher, A.E.14
-
18
-
-
0036813085
-
Of mice and men: The relevance of transgenic mice Abeta immunizations to Alzheimer's disease
-
Roher, A.E.; Kokjohn, T.A. Of mice and men: the relevance of transgenic mice Abeta immunizations to Alzheimer's disease. J. Alzheimer's Dis., 2002, 4, 431-4.
-
(2002)
J. Alzheimer's Dis
, vol.4
, pp. 431-434
-
-
Roher, A.E.1
Kokjohn, T.A.2
-
19
-
-
0037154117
-
APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques
-
Kalback, W.; Watson, M.D.; Kokjohn, T.A.; Kuo, Y.M.; Weiss, N.; Luehrs, D.C.; Lopez, J.; Brune, D.; Sisodia, S.S.; Staufenbiel, M.; Emmerling, M.; Roher, A.E. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry, 2002, 41, 922-8.
-
(2002)
Biochemistry
, vol.41
, pp. 922-928
-
-
Kalback, W.1
Watson, M.D.2
Kokjohn, T.A.3
Kuo, Y.M.4
Weiss, N.5
Luehrs, D.C.6
Lopez, J.7
Brune, D.8
Sisodia, S.S.9
Staufenbiel, M.10
Emmerling, M.11
Roher, A.E.12
-
20
-
-
27144553121
-
Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides
-
Esh, C.; Patton, L.; Kalback, W.; Kokjohn, T.A.; Lopez, J.; Brune, D.; Newell, A.J.; Beach, T.; Schenk, D.; Games, D.; Paul, S.; Bales, K.; Ghetti, B.; Castano, E.M.; Roher, A.E. Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides, Biochemistry, 2005, 44, 13807-19.
-
(2005)
Biochemistry
, vol.44
, pp. 13807-13819
-
-
Esh, C.1
Patton, L.2
Kalback, W.3
Kokjohn, T.A.4
Lopez, J.5
Brune, D.6
Newell, A.J.7
Beach, T.8
Schenk, D.9
Games, D.10
Paul, S.11
Bales, K.12
Ghetti, B.13
Castano, E.M.14
Roher, A.E.15
-
21
-
-
35148869239
-
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation
-
Van Vickle, G.D.; Esh, C.L.; Kalback, W.M.; Patton, R.L.; Luehrs, D.C.; Kokjohn, T.A.; Fifield, F.G.; Fraser, P.E.; Westaway, D.; McLaurin, J.; Lopez, J.; Brune, D.; Newel, A.J.; Poston, M.; Beach, T.G.; Roher, A.E. TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation. Biochemistry, 2007, 46, 10317-27.
-
(2007)
Biochemistry
, vol.46
, pp. 10317-10327
-
-
Van Vickle, G.D.1
Esh, C.L.2
Kalback, W.M.3
Patton, R.L.4
Luehrs, D.C.5
Kokjohn, T.A.6
Fifield, F.G.7
Fraser, P.E.8
Westaway, D.9
McLaurin, J.10
Lopez, J.11
Brune, D.12
Newel, A.J.13
Poston, M.14
Beach, T.G.15
Roher, A.E.16
-
22
-
-
48749106996
-
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy
-
Van Vickle, G.D.; Esh, C.L.; Daugs, I.D.; Kokjohn, T.A.; Kalback, W.M.; Patton, R.L.; Luehrs, D.C.; Walker, D.G.; Lue, L.F.; Beach, T.G.; Davis, J.; Van Nostrand, W.E.; Castano, E.M.; Roher, A.E. Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy. Am. J. Pathol., 2008, 173, 483-93.
-
(2008)
Am. J. Pathol
, vol.173
, pp. 483-493
-
-
Van Vickle, G.D.1
Esh, C.L.2
Daugs, I.D.3
Kokjohn, T.A.4
Kalback, W.M.5
Patton, R.L.6
Luehrs, D.C.7
Walker, D.G.8
Lue, L.F.9
Beach, T.G.10
Davis, J.11
Van Nostrand, W.E.12
Castano, E.M.13
Roher, A.E.14
-
23
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games, D.; Adams, D.; Alessandrini, R.; Barbour, R.; Berthelette, P.; Blackwell, C.; Carr, T.; Clemens, J.; Donaldson, T.; Gillespie, F.; Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature, 1995, 373, 523-7.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
Blackwell, C.6
Carr, T.7
Clemens, J.8
Donaldson, T.9
Gillespie, F.10
-
24
-
-
10744230663
-
The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates
-
Roher, A.E.; Kokjohn, T.A.; Esh, C.; Weiss, N.; Childress, J.; Kalback, W.; Luehrs, D.C.; Lopez, J.; Brune, D.; Kuo, Y.M.; Farlow, M.; Murrell, J.; Vidal, R.; Ghetti, B. The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates. J. Biol. Chem., 2004, 279, 5829-36.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 5829-5836
-
-
Roher, A.E.1
Kokjohn, T.A.2
Esh, C.3
Weiss, N.4
Childress, J.5
Kalback, W.6
Luehrs, D.C.7
Lopez, J.8
Brune, D.9
Kuo, Y.M.10
Farlow, M.11
Murrell, J.12
Vidal, R.13
Ghetti, B.14
-
25
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Nicoll, J.A.; Wilkinson, D.; Holmes, C.; Steart, P.; Markham, H.; Weller, R.O. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med., 2003, 9, 448-52.
-
(2003)
Nat. Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
Weller, R.O.6
-
26
-
-
1042265187
-
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
-
Ferrer, I.; Boada, R.M.; Sanchez G.M.L.; Rey, M.J.; Costa-Jussa, F. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease, Brain Pathol., 2004, 14, 11-20.
-
(2004)
Brain Pathol
, vol.14
, pp. 11-20
-
-
Ferrer, I.1
Boada, R.M.2
Sanchez, G.M.L.3
Rey, M.J.4
Costa-Jussa, F.5
-
27
-
-
19944429065
-
Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
-
Masliah, E.; Hansen, L.; Adame, A.; Crews, L.; Bard, F.; Lee, C.; Seubert, P.; Games, D.; Kirby, L.; Schenk, D. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology, 2005, 64, 129-31.
-
(2005)
Neurology
, vol.64
, pp. 129-131
-
-
Masliah, E.1
Hansen, L.2
Adame, A.3
Crews, L.4
Bard, F.5
Lee, C.6
Seubert, P.7
Games, D.8
Kirby, L.9
Schenk, D.10
-
28
-
-
33748767945
-
Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: A biochemical analysis
-
Patton, R.L.; Kalback, W.M.; Esh, C.L.; Kokjohn, T.A.; Van Vickle, G.D.; Luehrs, D.C.; Kuo, Y.M.; Lopez, J.; Brune, D.; Ferrer, I.; Masliah, E.; Newel, A.J.; Beach, T.G.; Castano, E.M.; Roher, A.E. Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis. Am. J. Pathol., 2006, 169, 1048-63.
-
(2006)
Am. J. Pathol
, vol.169
, pp. 1048-1063
-
-
Patton, R.L.1
Kalback, W.M.2
Esh, C.L.3
Kokjohn, T.A.4
Van Vickle, G.D.5
Luehrs, D.C.6
Kuo, Y.M.7
Lopez, J.8
Brune, D.9
Ferrer, I.10
Masliah, E.11
Newel, A.J.12
Beach, T.G.13
Castano, E.M.14
Roher, A.E.15
-
29
-
-
33750586141
-
Abeta species removal after abeta42 immunization
-
Nicoll, J.A.; Barton, E.; Boche, D.; Neal, J.W.; Ferrer, I.; Thompson, P.; Vlachouli, C.; Wilkinson, D.; Bayer, A.; Games, D.; Seubert, P.; Schenk, D.; Holmes, C. Abeta species removal after abeta42 immunization. J. Neuropathol. Exp. Neurol., 2006, 65, 1040-8.
-
(2006)
J. Neuropathol. Exp. Neurol
, vol.65
, pp. 1040-1048
-
-
Nicoll, J.A.1
Barton, E.2
Boche, D.3
Neal, J.W.4
Ferrer, I.5
Thompson, P.6
Vlachouli, C.7
Wilkinson, D.8
Bayer, A.9
Games, D.10
Seubert, P.11
Schenk, D.12
Holmes, C.13
-
30
-
-
47149112621
-
Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
-
Holmes, C.; Boche, D.; Wilkinson, D.; Yadegarfar, G.; Hopkins, V.; Bayer, A.; Jones, R.W.; Bullock, R.; Love, S.; Neal, J.W.; Zotova, E.; Nicoll, J.A. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet, 2008, 372, 216-23.
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
Jones, R.W.7
Bullock, R.8
Love, S.9
Neal, J.W.10
Zotova, E.11
Nicoll, J.A.12
-
31
-
-
0027491355
-
Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue
-
Roher, A.E.; Palmer, K.C.; Yurewicz, E.C.; Ball, M.J.; Greenberg, B.D. Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue. J. Neurochem., 1993, 61, 1916-26.
-
(1993)
J. Neurochem
, vol.61
, pp. 1916-1926
-
-
Roher, A.E.1
Palmer, K.C.2
Yurewicz, E.C.3
Ball, M.J.4
Greenberg, B.D.5
-
32
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart, J.C.; Bales, K.R.; Gannon, K.S.; Greene, S.J.; DeMattos, R.B.; Mathis, C.; DeLong, C.A.; Wu, S.; Wu, X.; Holtzman, D.M.; Paul, S.M. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat. Neurosci., 2002, 5, 452-7.
-
(2002)
Nat. Neurosci
, vol.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
Greene, S.J.4
DeMattos, R.B.5
Mathis, C.6
DeLong, C.A.7
Wu, S.8
Wu, X.9
Holtzman, D.M.10
Paul, S.M.11
-
33
-
-
0036853548
-
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
-
Hock, C.; Konietzko, U.; Papassotiropoulos, A.; Wollmer, A.; Streffer, J.; von Rotz, R.C.; Davey, G.; Moritz, E.; Nitsch, R.M. Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat. Med., 2002, 8, 1270-5.
-
(2002)
Nat. Med
, vol.8
, pp. 1270-1275
-
-
Hock, C.1
Konietzko, U.2
Papassotiropoulos, A.3
Wollmer, A.4
Streffer, J.5
von Rotz, R.C.6
Davey, G.7
Moritz, E.8
Nitsch, R.M.9
-
34
-
-
24644458809
-
Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies
-
Lee, M.; Bard, F.; Johnson-Wood, K.; Lee, C.; Hu, K.; Griffith, S.G.; Black, R.S.; Schenk, D.; Seubert, P. Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies. Ann. Neurol., 2005, 58, 430-5.
-
(2005)
Ann. Neurol
, vol.58
, pp. 430-435
-
-
Lee, M.1
Bard, F.2
Johnson-Wood, K.3
Lee, C.4
Hu, K.5
Griffith, S.G.6
Black, R.S.7
Schenk, D.8
Seubert, P.9
-
35
-
-
0036852750
-
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis
-
McLaurin, J.; Cecal, R.; Kierstead, M.E.; Tian, X.; Phinney, A.L.; Manea, M.; French, J.E.; Lambermon, M.H.; Darabie, A.A.; Brown, M.E.; Janus, C.; Chishti, M.A.; Horne, P.; Westaway, D.; Fraser, P.E.; Mount, H.T.; Przybylski, M.; St George-Hyslop, P. Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat. Med., 2002, 8, 1263-9.
-
(2002)
Nat. Med
, vol.8
, pp. 1263-1269
-
-
McLaurin, J.1
Cecal, R.2
Kierstead, M.E.3
Tian, X.4
Phinney, A.L.5
Manea, M.6
French, J.E.7
Lambermon, M.H.8
Darabie, A.A.9
Brown, M.E.10
Janus, C.11
Chishti, M.A.12
Horne, P.13
Westaway, D.14
Fraser, P.E.15
Mount, H.T.16
Przybylski, M.17
St George-Hyslop, P.18
-
36
-
-
18544386562
-
Increased Abeta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease
-
Roher, A.E.; Weiss, N.; Kokjohn, T.A.; Kuo, Y.M.; Kalback, W.; Anthony, J.; Watson, D.; Luehrs, D.C.; Sue, L.; Walker, D.; Emmerling, M.; Goux, W.; Beach, T. Increased Abeta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease. Biochemistry, 2002, 41, 11080-90.
-
(2002)
Biochemistry
, vol.41
, pp. 11080-11090
-
-
Roher, A.E.1
Weiss, N.2
Kokjohn, T.A.3
Kuo, Y.M.4
Kalback, W.5
Anthony, J.6
Watson, D.7
Luehrs, D.C.8
Sue, L.9
Walker, D.10
Emmerling, M.11
Goux, W.12
Beach, T.13
-
37
-
-
10744225278
-
Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease
-
Roher, A.E.; Kuo, Y.M.; Esh, C.; Knebel, C.; Weiss, N.; Kalback, W.; Luehrs, D.C.; Childress, J.L.; Beach, T.G.; Weller, R.O.; Kokjohn, T.A. Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease. Mol. Med., 2003, 9, 112-22.
-
(2003)
Mol. Med
, vol.9
, pp. 112-122
-
-
Roher, A.E.1
Kuo, Y.M.2
Esh, C.3
Knebel, C.4
Weiss, N.5
Kalback, W.6
Luehrs, D.C.7
Childress, J.L.8
Beach, T.G.9
Weller, R.O.10
Kokjohn, T.A.11
-
38
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
Oddo, S.; Billings, L.; Kesslak, J.P.; Cribbs, D.H.; LaFerla, F.M. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron, 2004, 43, 321-32.
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
LaFerla, F.M.5
-
39
-
-
0037391853
-
Alzheimer disease's double-edged vaccine
-
Greenberg, S.M.; Bacskai, B.J.; Hyman, B.T. Alzheimer disease's double-edged vaccine. Nat. Med., 2003, 9, 389-90.
-
(2003)
Nat. Med
, vol.9
, pp. 389-390
-
-
Greenberg, S.M.1
Bacskai, B.J.2
Hyman, B.T.3
-
40
-
-
0037317234
-
Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice
-
Furlan, R.; Brambilla, E.; Sanvito, F.; Roccatagliata, L.; Olivieri, S.; Bergami, A.; Pluchino, S.; Uccelli, A.; Comi, G.; Martino, G. Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice. Brain, 2003, 126, 285-91.
-
(2003)
Brain
, vol.126
, pp. 285-291
-
-
Furlan, R.1
Brambilla, E.2
Sanvito, F.3
Roccatagliata, L.4
Olivieri, S.5
Bergami, A.6
Pluchino, S.7
Uccelli, A.8
Comi, G.9
Martino, G.10
-
41
-
-
18144380723
-
Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis
-
Lee, E.B.; Leng, L.Z.; Lee, V.M.; Trojanowski, J.Q. Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. FEBS Lett., 2005, 579, 2564-8.
-
(2005)
FEBS Lett
, vol.579
, pp. 2564-2568
-
-
Lee, E.B.1
Leng, L.Z.2
Lee, V.M.3
Trojanowski, J.Q.4
-
42
-
-
43649096717
-
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: Effects on cognitive function and brain Abeta
-
Head, E.; Pop, V.; Vasilevko, V.; Hill, M.; Saing, T.; Sarsoza, F.; Nistor, M.; Christie, L.A.; Milton, S.; Glabe, C.; Barrett, E.; Cribbs, D. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. J. Neurosci., 2008, 28, 3555-66.
-
(2008)
J. Neurosci
, vol.28
, pp. 3555-3566
-
-
Head, E.1
Pop, V.2
Vasilevko, V.3
Hill, M.4
Saing, T.5
Sarsoza, F.6
Nistor, M.7
Christie, L.A.8
Milton, S.9
Glabe, C.10
Barrett, E.11
Cribbs, D.12
-
43
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock, C.; Konietzko, U.; Streffer, J.R.; Tracy, J.; Signorell, A.; Muller-Tillmanns, B.; Lemke, U.; Henke, K.; Moritz, E.; Garcia, E.; Wollmer, M.A.; Umbricht, D.; de Quervain, D.J.; Hofmann, M.; Maddalena, A.; Papassotiropoulos, A.; Nitsch, R.M. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron, 2003, 38, 547-54.
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
Tracy, J.4
Signorell, A.5
Muller-Tillmanns, B.6
Lemke, U.7
Henke, K.8
Moritz, E.9
Garcia, E.10
Wollmer, M.A.11
Umbricht, D.12
de Quervain, D.J.13
Hofmann, M.14
Maddalena, A.15
Papassotiropoulos, A.16
Nitsch, R.M.17
-
44
-
-
20944448555
-
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman, S.; Koller, M.; Black, R.S.; Jenkins, L.; Griffith, S.G.; Fox, N.C.; Eisner, L.; Kirby, L.; Rovira, M.B.; Forette, F.; Orgogozo, J.M. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology, 2005, 64, 1553-62.
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
Jenkins, L.4
Griffith, S.G.5
Fox, N.C.6
Eisner, L.7
Kirby, L.8
Rovira, M.B.9
Forette, F.10
Orgogozo, J.M.11
-
45
-
-
18144415471
-
Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
-
Fox, N.C.; Black, R.S.; Gilman, S.; Rossor, M.N.; Griffith, S.G.; Jenkins, L.; Koller, M. Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology, 2005, 64, 1563-72.
-
(2005)
Neurology
, vol.64
, pp. 1563-1572
-
-
Fox, N.C.1
Black, R.S.2
Gilman, S.3
Rossor, M.N.4
Griffith, S.G.5
Jenkins, L.6
Koller, M.7
-
46
-
-
40449135167
-
Beta-amyloid burden is not associated with rates of brain atrophy
-
Josephs, K.A.; Whitwell, J.L.; Ahmed, Z.; Shiung, M.M.; Weigand, S.D.; Knopman, D.S.; Boeve, B.F.; Parisi, J.E.; Petersen, R.C.; Dickson, D.W.; Jack, C.R., Jr. Beta-amyloid burden is not associated with rates of brain atrophy. Ann. Neurol., 2008, 63, 204-12.
-
(2008)
Ann. Neurol
, vol.63
, pp. 204-212
-
-
Josephs, K.A.1
Whitwell, J.L.2
Ahmed, Z.3
Shiung, M.M.4
Weigand, S.D.5
Knopman, D.S.6
Boeve, B.F.7
Parisi, J.E.8
Petersen, R.C.9
Dickson, D.W.10
Jack Jr., C.R.11
-
47
-
-
0034746897
-
Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition
-
Das, P.; Murphy, M.P.; Younkin, L.H.; Younkin, S.G.; Golde, T.E. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol. Aging, 2001, 22, 721-7.
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 721-727
-
-
Das, P.1
Murphy, M.P.2
Younkin, L.H.3
Younkin, S.G.4
Golde, T.E.5
-
48
-
-
34249984684
-
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
-
Klunk, W.E.; Price, J.C.; Mathis, C.A.; Tsopelas, N.D.; Lopresti, B.J.; Ziolko, S.K.; Bi, W.; Hoge, J.A.; Cohen, A.D.; Ikonomovic, M.D.; Saxton, J.A.; Snitz, B.E.; Pollen, D.A.; Moonis, M.; Lippa, C.F.; Swearer, J.M.; Johnson, K.A.; Rentz, D.M.; Fischman, A.J.; Aizenstein, H.J.; DeKosky, S.T. Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J. Neurosci., 2007, 27, 6174-84.
-
(2007)
J. Neurosci
, vol.27
, pp. 6174-6184
-
-
Klunk, W.E.1
Price, J.C.2
Mathis, C.A.3
Tsopelas, N.D.4
Lopresti, B.J.5
Ziolko, S.K.6
Bi, W.7
Hoge, J.A.8
Cohen, A.D.9
Ikonomovic, M.D.10
Saxton, J.A.11
Snitz, B.E.12
Pollen, D.A.13
Moonis, M.14
Lippa, C.F.15
Swearer, J.M.16
Johnson, K.A.17
Rentz, D.M.18
Fischman, A.J.19
Aizenstein, H.J.20
DeKosky, S.T.21
more..
-
49
-
-
38949123792
-
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease
-
Meyer-Luehmann, M.; Spires-Jones, T.L.; Prada, C.; Garcia-Alloza, M.; de Calignon, A.; Rozkalne, A.; Koenigsknecht-Talboo, J.; Holtzman, D.M.; Bacskai, B.J.; Hyman, B.T. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature, 2008, 451, 720-4.
-
(2008)
Nature
, vol.451
, pp. 720-724
-
-
Meyer-Luehmann, M.1
Spires-Jones, T.L.2
Prada, C.3
Garcia-Alloza, M.4
de Calignon, A.5
Rozkalne, A.6
Koenigsknecht-Talboo, J.7
Holtzman, D.M.8
Bacskai, B.J.9
Hyman, B.T.10
-
50
-
-
0027332081
-
Beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer disease
-
Roher, A.E.; Lowenson, J.D.; Clarke, S.; Woods, A.S.; Cotter, R.J.; Gowing, E.; Ball, M.J. Beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc. Natl. Acad. Sci. USA, 1993, 90, 10836-40.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10836-10840
-
-
Roher, A.E.1
Lowenson, J.D.2
Clarke, S.3
Woods, A.S.4
Cotter, R.J.5
Gowing, E.6
Ball, M.J.7
-
51
-
-
0037112201
-
Cerebral hemorrhage after passive anti-Abeta immunotherapy
-
Pfeifer, M.; Boncristiano, S.; Bondolfi, L.; Stalder, A.; Deller, T.; Staufenbiel, M.; Mathews, P.M.; Jucker, M. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science, 2002, 298, 1379.
-
(2002)
Science
, vol.298
, pp. 1379
-
-
Pfeifer, M.1
Boncristiano, S.2
Bondolfi, L.3
Stalder, A.4
Deller, T.5
Staufenbiel, M.6
Mathews, P.M.7
Jucker, M.8
-
52
-
-
33845904135
-
Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid
-
Wilcock, D.M.; Jantzen, P.T.; Li, Q.; Morgan, D.; Gordon, M.N. Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. Neuroscience, 2007, 144, 950-60.
-
(2007)
Neuroscience
, vol.144
, pp. 950-960
-
-
Wilcock, D.M.1
Jantzen, P.T.2
Li, Q.3
Morgan, D.4
Gordon, M.N.5
-
53
-
-
0036703483
-
Reversible memory loss in a mouse transgenic model of Alzheimer's disease
-
Kotilinek, L.A.; Bacskai, B.; Westerman, M.; Kawarabayashi, T.; Younkin, L.; Hyman, B.T.; Younkin, S.; Ashe, K.H. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J. Neurosci., 2002, 22, 6331-5.
-
(2002)
J. Neurosci
, vol.22
, pp. 6331-6335
-
-
Kotilinek, L.A.1
Bacskai, B.2
Westerman, M.3
Kawarabayashi, T.4
Younkin, L.5
Hyman, B.T.6
Younkin, S.7
Ashe, K.H.8
-
54
-
-
0034440140
-
A unifying hypothesis of Alzheimer's disease. IV: Causation and sequence of events
-
Spec No, 213-328
-
Heininger, K. A unifying hypothesis of Alzheimer's disease. IV: causation and sequence of events, Rev. Neurosci., 2000, 11(Spec No), 213-328.
-
(2000)
Rev. Neurosci
, vol.11
-
-
Heininger, K.1
-
55
-
-
43649102007
-
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
-
Relkin, N.R.; Szabo, P.; Adamiak, B.; Burgut, T.; Monthe, C.; Lent, R.W.; Younkin, S.; Younkin, L.; Schiff, R.; Weksler, M.E. 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol. Aging, 2008.
-
(2008)
Neurobiol. Aging
-
-
Relkin, N.R.1
Szabo, P.2
Adamiak, B.3
Burgut, T.4
Monthe, C.5
Lent, R.W.6
Younkin, S.7
Younkin, L.8
Schiff, R.9
Weksler, M.E.10
-
56
-
-
23844551164
-
Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques
-
Miravalle, L.; Calero, M.; Takao, M.; Roher, A.E.; Ghetti, B.; Vidal, R. Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques. Biochemistry, 2005, 44, 10810-21.
-
(2005)
Biochemistry
, vol.44
, pp. 10810-10821
-
-
Miravalle, L.1
Calero, M.2
Takao, M.3
Roher, A.E.4
Ghetti, B.5
Vidal, R.6
|