Toward modeling hemorrhagic and encephalitic complications of Alzheimer amyloid-β vaccination in nonhuman primates

Current Opinion in Immunology

Volumn 16, Issue 5, 2004, Pages 607-615

  Gandy, Sam ^a   Walker, Lary ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLIN; AMYLOID BETA PROTEIN; ANTIBODY; MONOCLONAL ANTIBODY; PERTUSSIS TOXIN; QS 21;

ALZHEIMER DISEASE; BRAIN HEMORRHAGE; CAUSE OF DEATH; CLINICAL FEATURE; CLINICAL TRIAL; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG SCREENING; ENCEPHALITIS; EXPERIMENTAL MODEL; HISTOPATHOLOGY; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNIZATION; IMMUNOPATHOLOGY; IMMUNOTHERAPY; MACROPHAGE; MENINGOENCEPHALITIS; NEUROBIOLOGY; NONHUMAN; PASSIVE IMMUNIZATION; PREDICTION; PRIMATE; REVIEW; RISK ASSESSMENT; SENILE PLAQUE; SPECIES COMPARISON; TRANSGENIC MOUSE; VACCINATION; VASCULAR AMYLOIDOSIS;

ALZHEIMER DISEASE; ALZHEIMER VACCINES; AMYLOID BETA-PROTEIN; ANIMALS; CEREBRAL AMYLOID ANGIOPATHY; CLINICAL TRIALS; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HUMANS; INTRACRANIAL HEMORRHAGES; PRIMATES;

EID: 4444281147     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.08.002     Document Type: Review

References (59)

1. D. Schenk, R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, and K. Khan Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse Nature 400 1999 173 177
2. D. Morgan, D.M. Diamond, P.E. Gottschall, K.E. Ugen, C. Dickey, J. Hardy, K. Duff, P. Jantzen, G. DiCarlo, and D. Wilcock A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease Nature 408 2000 982 985
3. C. Janus, J. Pearson, J. McLaurin, P.M. Mathews, Y. Jiang, S.D. Schmidt, M.A. Chishti, P. Horne, D. Heslin, and J. French A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease Nature 408 2000 979 982
4. R.B. DeMattos, K.R. Bales, D.J. Cummins, J.C. Dodart, S.M. Paul, and D.M. Holtzman Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease Proc Natl Acad Sci USA 98 2001 850 855
5. R.B. DeMattos, K.R. Bales, D.J. Cummins, S.M. Paul, and D.M. Holtzman Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease Science 295 2002 2264 2267
6. E.M. Sigurdsson, H. Scholtzova, P.D. Mehta, B. Frangione, and T. Wisniewski Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice Am J Pathol 159 2001 439 447
7. J.C. Dodart, K.R. Bales, K.S. Gannon, S.J. Greene, R.B. DeMattos, C. Mathis, C.A. DeLong, S. Wu, X. Wu, D.M. Holtzman, and S.M. Paul Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model Nat Neurosci 5 2002 452 457
8. L.A. Kotilinek, B. Bacskai, M. Westerman, T. Kawarabayashi, L. Younkin, B.T. Hyman, S. Younkin, and K.H. Ashe Reversible memory loss in a mouse transgenic model of Alzheimer's disease J Neurosci 22 2002 6331 6335
9. M. Pfeifer, S. Boncristiano, L. Bondolfi, A. Stalder, T. Deller, M. Staufenbiel, P.M. Mathews, and M. Jucker Cerebral hemorrhage after passive anti-Abeta immunotherapy Science 298 2002 1379
10. F.L. Heppner, S. Gandy, and J. McLaurin Current concepts and future prospects for Alzheimer disease vaccines Alz Dis Assoc Disord 18 2004 38 43
11. D. Frenkel, I. Dewachter, F. Van Leuven, and B. Solomon Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization Vaccine 21 2003 1060 1065
12. C.A. Lemere, E.T. Spooner, J. LaFrancois, B. Malester, C. Mori, J.F. Leverone, Y. Matsuoka, J.W. Taylor, R.B. DeMattos, and D.M. Holtzman Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice Neurobiol Dis 14 2003 10 18
13. Y. Matsuoka, M. Saito, J. LaFrancois, M. Saito, K. Gaynor, V. Olm, L. Wang, E. Casey, Y. Lu, and C. Shiratori Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid J Neurosci 23 2003 29 33
14. -/- knock-out mice J Neurosci 23 2003 8532 8538
15. F. Bard, R. Barbour, C. Cannon, R. Carretto, M. Fox, D. Games, T. Guido, K. Hoenow, K. Hu, and K. Johnson-Wood Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology Proc Natl Acad Sci USA 100 2003 2023 2028
16. C. Hock, U. Konietzko, J.R. Streffer, J. Tracy, A. Signorell, B. Muller-Tillmanns, U. Lemke, K. Henke, E. Moritz, and E. Garcia Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease Neuron 38 2003 547 554 The authors present the first suggestion that Aβ vaccination slows cognitive decline in human Alzheimer's disease.
17. J. McLaurin, R. Cecal, M.E. Kierstead, X. Tian, A.L. Phinney, M. Manea, J.E. French, M.H. Lambermon, A.A. Darabie, and M.E. Brown Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis Nat Med 8 2002 1263 1269
18. J.A. Nicoll, D. Wilkinson, C. Holmes, P. Steart, H. Markham, and R.O. Weller Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report Nat Med 9 2003 448 452 This is the first comprehensive pathological analysis of the brain of an Aβ-immunized AD patient.
19. I. Ferrer, M. Boada Rovira, M.L. Sanchez Guerra, M.J. Rey, and F. Costa-Jussa Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease Brain Pathol 14 2004 11 20
20. B. Winblad, and K.I. Blum Hints of a therapeutic vaccine for Alzheimer's? Neuron 38 2003 517 518
21. D. Schenk Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning Nat Rev Neurosci 3 2002 824 828
22. J.M. Orgogozo, S. Gilman, J.F. Dartigues, B. Laurent, M. Puel, L.C. Kirby, P. Jouanny, B. Dubois, L. Eisner, and S. Flitman Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization Neurology 61 2003 46 54
23. R. Furlan, E. Brambilla, F. Sanvito, L. Roccatagliata, S. Olivieri, A. Bergami, S. Pluchino, A. Uccelli, G. Comi, and G. Martino Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice Brain 126 2003 285 291 The authors provide the first evidence that Aβ can induce autoimmune encephalitis in a mouse model.
24. A. Ghochikyan, V. Vasilevko, I. Petrushina, N. Movsesyan, D. Babikyan, W. Tian, N. Sadzikava, T.M. Ross, E. Head, D.H. Cribbs, and M.G. Agadjanyan Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene Eur J Immunol 33 2003 3232 3241
25. T. Town, J. Tan, N. Sansone, D. Obregon, T. Klein, and M. Mullan Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42 Neurosci Lett 307 2001 101 104
26. D.H. Cribbs, A. Ghochikyan, V. Vasilevko, M. Tran, I. Petrushina, N. Sadzikava, D. Babikyan, P. Kesslak, T. Kieber-Emmons, C.W. Cotman, and M.G. Agadjanyan Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid Int Immunol 15 2003 505 514
27. D. Frenkel, O. Katz, and B. Solomon Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration Proc Natl Acad Sci USA 97 2000 11455 11459
28. D. Frenkel, B. Solomon, and I. Benhar Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody J Neuroimmunol 106 2000 23 31
29. E.A. Burns Effects of aging on immune function J Nutr Health Aging 8 2004 9 18
30. L.S. Perlmutter, and H.C. Chui Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review Brain Res 24 1990 677 686
31. H.V. Vinters Cerebral amyloid angiopathy Barnett HJM J.P. Mohr B.M. Stein F.M. Yatsu Stroke: Pathophysiology, diagnosis and management 1992 Churchill Livingstone New York 821 858
32. L.C. Walker, and R.A. Durham Cerebrovascular amyloidosis: Experimental analysis in vitro and in vivo Histol Histopathol 14 1999 827 837
33. H.V. Vinters, and J-P.G. Vonsattel Neuropathologic features and grading of Alzheimer-related and sporadic CAA M.M. Verbeek de Waal RMW H.V. Vinters Cerebral Amyloid Angiopathy in Alzheimer's Disease and Related Disorders 2000 Kluwer Dordrecht, Germany 137 155
34. T. Revesz, J. Ghiso, T. Lashley, G. Plant, A. Rostagno, B. Frangione, and J.L. Holton Cerebral amyloid angiopathies: A pathologic, biochemical and genetic view J Neuropathol Exp Neurol 62 2003 885 898
35. C.S. Kase Cerebral amyloid angiopathy C.S. Kase L.R. Caplan Intracerebral Hemorrhage 1994 Butterworth-Heinemann Boston 179 200
36. K.A. Jellinger Alzheimer disease and cerebrovascular pathology: an update J Neural Transm 109 2002 813 836
37. C.L. Joachim, J.H. Morris, and D.J. Selkoe Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases Ann Neurol 24 1988 50 56
38. J.M. Olichney, L.A. Hansen, C.R. Hofstetter, M. Grundman, R. Katzman, and L.J. Thal Cerebral infarction in Alzheimer's disease is associated with severe amyloid angiopathy and hypertension Arch Neurol 52 1995 702 708
39. J.A. Eng, M.P. Frosch, K. Choi, G.W. Rebeck, and S.M. Greenberg Clinical manifestations of cerebral amyloid angiopathy-related inflammation Ann Neurol 55 2004 250 256
40. C.P. Genain, and S.L. Hauser Creation of a model for multiple sclerosis in Callithrix jacchus marmosets J Mol Med 75 1997 187 197
41. A. Uccelli Characterization of the TCRB chain repertoire in the New World monkey Callithrix jacchus J Immunol 158 1997 1201 1207
42. Brok HPM: Myelin/oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis in common marmosets: the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule. J Immunol 2004, in press.
43. B.A. 't Hart Histological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis Am J Pathol 153 1998 649 663
44. B.A. 't Hart, M. van Meurs, Brok HPM, L. Massacesi, J. Bauer, L. Boon, R.E. Bontrop, and J.D. Laman A new primate model for multiple sclerosis in the marmoset Immunol Today 21 2000 290 297
45. L.C. Walker, and L.C. Cork The neurobiology of aging in nonhuman primates R.D. Terry R. Katzman K.L. Bick S.S. Sisodia Alzheimer Disease 1999 Lippincott Williams and Wilkins Philadelphia 233 243
46. H. Fukumoto, D.L. Rosene, M.B. Moss, S. Raju, B.T. Hyman, and M.C. Irizarry Beta-secretase activity increases with aging in human, monkey, and mouse brain Am J Pathol 164 2004 719 725
47. L.C. Walker, C.A. Kitt, E. Schwam, B. Buckwald, F. Garcia, J. Sepinwall, and D.L. Price Senile plaques in aged squirrel monkeys Neurobiol Aging 8 1987 291 296
48. L.C. Walker, C. Masters, K. Beyreuther, and D.L. Price Amyloid in the brains of aged squirrel monkeys Acta Neuropathol 80 1990 381 387
49. E. Levy, A. Amorim, B. Frangione, and L.C. Walker Beta-Amyloid precursor protein gene in squirrel monkeys with cerebral amyloid angiopathy Neurobiol Aging 16 1995 805 808
50. L.H. Wei, L.C. Walker, and E. Levy Cystatin C. Icelandic-like mutation in an animal model of cerebrovascular beta-amyloidosis Stroke 27 1996 2080 2085
51. L. Morelli, L. Wei, A. Amorim, J. McDermid, C.R. Abee, B. Frangione, L.C. Walker, and E. Levy Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype FEBS Lett 379 1996 132 134
52. J.R. Ghilardi, M. Catton, E.R. Stimson, S. Rogers, L.C. Walker, J.E. Maggio, and P.W. Mantyh Intra-arterial infusion of [125I] A beta 1-40 labels amyloid deposits in the aged primate brain in vivo Neuroreport 7 1996 2607 2611
53. N. Sawamura, A. Tamaoka, S. Shoji, E.H. Koo, L.C. Walker, and H. Mori Characterization of amyloid beta protein species in cerebral amyloid angiopathy of a squirrel monkey by immunocytochemistry and enzyme-linked immunosorbent assay Brain Res 764 1997 225 229
54. J.B. Mackic, M.H. Weiss, W. Miao, E. Kirkman, J. Ghiso, M. Calero, J. Bading, B. Frangione, and B.V. Zlokovic Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy J Neurochem 70 1998 210 215
55. J.R. Bading, S. Yamada, J.B. Mackic, L. Kirkman, C. Miller, M. Calero, J. Ghiso, B. Frangione, and B.V. Zlokovic Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy J Drug Target 10 2002 359 368
56. L.C. Walker, D.L. Price, M.L. Voytko, and D.B. Schenk Labeling of cerebral amyloid in vivo with a monoclonal antibody J Neuropathol Exp Neurol 53 1994 377 383
57. S. Gandy, R.B. DeMattos, C.A. Lemere, F.L. Heppner, J. Leverone, A. Aguzzi, W.B. Ershler, J. Dai, P. Fraser, and P. St George Hyslop Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta) Mech Ageing Dev 125 2004 149 151 The authors describe the first nonhuman primate model of Aβ vaccination. They demonstrate elevated circulating levels of both Aβ and anti-Aβ antibodies, and exclude the possibility that Aβ vaccination frequently induces subclinical encephalitis.
58. A.W. Chan, K.Y. Chong, C. Martinovich, C. Simerly, and G. Schatten Transgenic monkeys produced by retroviral gene transfer into mature oocytes Science 291 2001 309 312
59. C.E. Finch, and R.M. Sapolsky The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms Neurobiol Aging 20 1999 407 428