메뉴 건너뛰기




Volumn 26, Issue 1, 2009, Pages 41-51

20 Years of hypertension research using genetically modified animals: No clinically promising approaches in sight

Author keywords

Diagnostic and therapeutic application; Genetically modified animals GMO; Primary hypertension; Target molecules

Indexed keywords

ANIMAL MODEL; BLOOD PRESSURE; DNA MODIFICATION; DRUG RESEARCH; GENETIC ANALYSIS; HYPERTENSION; MEDICAL RESEARCH; NONHUMAN; REVIEW; SPECIES DIFFERENTIATION; TRANSGENIC ANIMAL; ANIMAL; ANIMAL TESTING ALTERNATIVE; ARTICLE; HUMAN; MOUSE; PATHOPHYSIOLOGY; RAT; RESEARCH ETHICS;

EID: 66149108461     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (173)
  • 1
    • 23844543479 scopus 로고    scopus 로고
    • Antisense oligonucleotides: The state of the art
    • Aboul-Fadl, T. (2005). Antisense oligonucleotides: the state of the art. Curr. Med. Chem. 12, 2193-2214.
    • (2005) Curr. Med. Chem. , vol.12 , pp. 2193-2214
    • Aboul-Fadl, T.1
  • 2
    • 34247615614 scopus 로고    scopus 로고
    • Heme oxygenase-1 gene therapy: Recent advances and therapeutic applications
    • Abraham, N. G., Asija, A., Drummond, G., Peterson, S. (2007). Heme oxygenase-1 gene therapy: Recent advances and therapeutic applications. Curr. Gene Ther. 7, 89-108.
    • (2007) Curr. Gene Ther. , vol.7 , pp. 89-108
    • Abraham, N.G.1    Asija, A.2    Drummond, G.3    Peterson, S.4
  • 3
    • 0034055982 scopus 로고    scopus 로고
    • Renal response to tissue injury: Lessons from heme oxygenase-1 Gene ablation and expression
    • Agarwal, A. and Nick, H. S. (2000). Renal response to tissue injury: lessons from heme oxygenase-1 Gene ablation and expression. J. Am. Soc. Nephrol. 11, 965-973.
    • (2000) J. Am. Soc. Nephrol. , vol.11 , pp. 965-973
    • Agarwal, A.1    Nick, H.S.2
  • 5
    • 0034168602 scopus 로고    scopus 로고
    • What can knockout mice contribute to an understanding of hypertension?
    • Audoloy, L. P., Le, T. H. and Coffman, T. M. (2000). What can knockout mice contribute to an understanding of hypertension? Curr. Hypertens. Rep. 2, 192-197.
    • (2000) Curr. Hypertens. Rep. , vol.2 , pp. 192-197
    • Audoloy, L.P.1    Le, T.H.2    Coffman, T.M.3
  • 6
    • 0033665330 scopus 로고    scopus 로고
    • Transgenic animals in cardiovascular disease research
    • Bader, M., Bohnemeier, H., Zollmann, F. S. et al. (2000).Transgenic animals in cardiovascular disease research. Exp. Physiology 85, 713-731.
    • (2000) Exp. Physiology , vol.85 , pp. 713-731
    • Bader, M.1    Bohnemeier, H.2    Zollmann, F.S.3
  • 8
    • 23044443651 scopus 로고    scopus 로고
    • Induction and analysis of cardiac hypertrophy in transgenic animal models
    • Barbosa, M. E., Alenina, N. and Bader, M. (2005). Induction and analysis of cardiac hypertrophy in transgenic animal models. Methods Mol. Med. 112, 339-352.
    • (2005) Methods Mol. Med. , vol.112 , pp. 339-352
    • Barbosa, M.E.1    Alenina, N.2    Bader, M.3
  • 9
    • 33744922911 scopus 로고    scopus 로고
    • Profile of past and current clinical trials involving endothelin receptor antagonists: The novel "-sentan" class of drug
    • Battistini, B., Berthiaume, N., Kelland, N. F. et al. (2006). Profile of past and current clinical trials involving endothelin receptor antagonists: the novel "-sentan" class of drug. Exp Biol. Med. 231, 653-695.
    • (2006) Exp Biol. Med. , vol.231 , pp. 653-695
    • Battistini, B.1    Berthiaume, N.2    Kelland, N.F.3
  • 10
    • 1942485274 scopus 로고    scopus 로고
    • Adrenomedullin - What do we know 10 years since its discovery?
    • Beltowski, J., Jamroz, A. (2004). Adrenomedullin - what do we know 10 years since its discovery? Pol. J. Pharmacol. 56, 5-27. (Pubitemid 38515282)
    • (2004) Polish Journal of Pharmacology , vol.56 , Issue.1 , pp. 5-27
    • Beltowski, J.1    Jamroz, A.2
  • 11
    • 20544456187 scopus 로고    scopus 로고
    • Establishing the role of angiotensin-converting enzyme in renal function and blood pressure control through the analysis of genetically modified mice
    • Bernstein, K. E., Xiao, H. D., Adams, J. W. et al. (2005). Establishing the role of angiotensin-converting enzyme in renal function and blood pressure control through the analysis of genetically modified mice. J. Am. Soc. Nephrol. 16, 583-591.
    • (2005) J. Am. Soc. Nephrol. , vol.16 , pp. 583-591
    • Bernstein, K.E.1    Xiao, H.D.2    Adams, J.W.3
  • 12
    • 20444439901 scopus 로고    scopus 로고
    • Six truisms concerning ACE and the renin-angiotensin system edaced from the genetic analysis of mice
    • Bernstein, K. E., Xiao, H. D., Frenzel, K. et al. (2005). Six truisms concerning ACE and the renin-angiotensin system edaced from the genetic analysis of mice. Circ Res. 96, 1135-1144.
    • (2005) Circ Res. , vol.96 , pp. 1135-1144
    • Bernstein, K.E.1    Xiao, H.D.2    Frenzel, K.3
  • 13
    • 34247505653 scopus 로고    scopus 로고
    • A single-pill combination of amlodipine besylate and atorvastatin calcium (update)
    • DOI 10.1358/dot.2007.43.3.1079878
    • Blank, R., Hobbs, F. D., Zamorano, J. and Girerd, X. (2007). A single-pill combination of amlodipine besylate and atorvastatin calcium (update). Drugs Today 43, 157-177. (Pubitemid 46661539)
    • (2007) Drugs of Today , vol.43 , Issue.3 , pp. 157-177
    • Blank, R.1    Hobbs, F.D.R.2    Zamorano, J.3    Girerd, X.4
  • 15
    • 2442704167 scopus 로고    scopus 로고
    • Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists
    • Bolli, M. H., Marfurt, J., Grisostomi, C. et al. (2004). Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists. J. Med. Chem. 47, 2776-2795.
    • (2004) J. Med. Chem. , vol.47 , pp. 2776-2795
    • Bolli, M.H.1    Marfurt, J.2    Grisostomi, C.3
  • 16
    • 0034137151 scopus 로고    scopus 로고
    • The role of beta(2)-adrenergic receptor variation in human hypertension
    • Bray, M. S. and Boerwinkle, E. (2000). The role of beta(2)-adrenergic receptor variation in human hypertension. Curr. Hypertens. Rep. 2, 39-43.
    • (2000) Curr. Hypertens. Rep. , vol.2 , pp. 39-43
    • Bray, M.S.1    Boerwinkle, E.2
  • 18
    • 0033988783 scopus 로고    scopus 로고
    • Prostaglandin receptors: Their role in regulating renal function
    • Breyer, M. D. and Breyer, R. M. (2000). Prostaglandin receptors: their role in regulating renal function. Curr. Opin. Nephrol. Hypertens. 9, 23-29.
    • (2000) Curr. Opin. Nephrol. Hypertens. , vol.9 , pp. 23-29
    • Breyer, M.D.1    Breyer, R.M.2
  • 19
    • 0034018418 scopus 로고    scopus 로고
    • Structure-function analyses of eicosanoid receptors. Physiologic and therapeutic implications
    • Breyer, R. M., Kennedy, C. R., Zhang, Y. and Breyer, M. D. (2000). Structure-function analyses of eicosanoid receptors. Physiologic and therapeutic implications. Ann. N. Y. Acad. Sci. 905, 221-231.
    • (2000) Ann. N. Y. Acad. Sci. , vol.905 , pp. 221-231
    • Breyer, R.M.1    Kennedy, C.R.2    Zhang, Y.3    Breyer, M.D.4
  • 20
    • 10944248801 scopus 로고    scopus 로고
    • Mouse functional genomics requires standardization of mouse handling and housing conditions
    • DOI 10.1007/s00335-004-2393-1
    • Champy, M. F., Selloum, M., Piard, L. et al. (2004). Mouse functional genomics requires standardization of mouse handling and housing conditions. Mamm. Genome 15, 768-783. (Pubitemid 40012690)
    • (2004) Mammalian Genome , vol.15 , Issue.10 , pp. 768-783
    • Champy, M.-F.1    Selloum, M.2    Piard, L.3    Zeitler, V.4    Caradec, C.5    Chambon, P.6    Auwerx, J.7
  • 21
    • 33745642704 scopus 로고    scopus 로고
    • The tissue kallikrein-kinin system protects against cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction
    • Chao, J., Bledsoe, G., Yin, H. and Chao, L. (2006). The tissue kallikrein-kinin system protects against cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction. J. Biol. Chem. 387, 665-675.
    • (2006) J. Biol. Chem. , vol.387 , pp. 665-675
    • Chao, J.1    Bledsoe, G.2    Yin, H.3    Chao, L.4
  • 22
    • 18844368834 scopus 로고    scopus 로고
    • Kallikrein-kinin in stroke, cardiovascular and renal disease
    • Chao, J. and Chao, L. (2005). Kallikrein-kinin in stroke, cardiovascular and renal disease. Exp. Physiol. 90, 291-298.
    • (2005) Exp. Physiol. , vol.90 , pp. 291-298
    • Chao, J.1    Chao, L.2
  • 24
    • 0038545240 scopus 로고    scopus 로고
    • Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function
    • Chen, Y. H., Yet, S. F. and Perrella, M. A. (2003). Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function. Exp. Biol. Med. 228, 447-453.
    • (2003) Exp. Biol. Med. , vol.228 , pp. 447-453
    • Chen, Y.H.1    Yet, S.F.2    Perrella, M.A.3
  • 25
    • 0942300602 scopus 로고    scopus 로고
    • Liquid-phase combinatorial synthesis of 1,4-benzodiazepine-2,5-diones as the candidates of endothelin receptor antagonism
    • Cheng, M. F. and Fang, J. M. (2004). Liquid-phase combinatorial synthesis of 1,4-benzodiazepine-2,5-diones as the candidates of endothelin receptor antagonism. J. Comb. Chem. 6, 99-104.
    • (2004) J. Comb. Chem. , vol.6 , pp. 99-104
    • Cheng, M.F.1    Fang, J.M.2
  • 27
    • 31344444441 scopus 로고    scopus 로고
    • ADMA: Its role in vascular disease
    • Cooke, J. P. (2005). ADMA: its role in vascular disease. Vasc. Med. 10 (Suppl. 7), S11-17.
    • (2005) Vasc. Med. , vol.10 , Issue.SUPPL. 7
    • Cooke, J.P.1
  • 28
    • 4043133117 scopus 로고    scopus 로고
    • Exploring type I angiotensin (AT1) receptor functions through gene targeting
    • Crowley, S. D., Tharaux, P. L., Audoly, L. P. and Coffman, T. M. (2004). Exploring type I angiotensin (AT1) receptor functions through gene targeting. Acta Physio.l Scand. 181, 561-570.
    • (2004) Acta Physio.l Scand. , vol.181 , pp. 561-570
    • Crowley, S.D.1    Tharaux, P.L.2    Audoly, L.P.3    Coffman, T.M.4
  • 30
    • 0033917514 scopus 로고    scopus 로고
    • Understanding hypertension through genetic manipulation in mice
    • Cvetkovic, B. and Sigmund, C. D. (2000). Understanding hypertension through genetic manipulation in mice. Kidney Int. 57, 863-874.
    • (2000) Kidney Int. , vol.57 , pp. 863-874
    • Cvetkovic, B.1    Sigmund, C.D.2
  • 32
    • 0034786788 scopus 로고    scopus 로고
    • Genetic manipulation of beta-adrenergic signalling in heart failure
    • Davidson, M. J. and Koch, W. J. (2001). Genetic manipulation of beta-adrenergic signalling in heart failure. Acta Physiol. Scand. 173, 145-150.
    • (2001) Acta Physiol. Scand. , vol.173 , pp. 145-150
    • Davidson, M.J.1    Koch, W.J.2
  • 33
    • 34548667662 scopus 로고    scopus 로고
    • Programming hypertension - Animal models: Causes and mechanisms
    • Denton, K. M., Kett, M. M. and Dodic M. (2006). Programming hypertension - Animal models: causes and mechanisms. Adv. in Exp. Med. Biol. 573, 103-120.
    • (2006) Adv. in Exp. Med. Biol. , vol.573 , pp. 103-120
    • Denton, K.M.1    Kett, M.M.2    Dodic, M.3
  • 34
    • 23844457669 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide and hypertension
    • Deng, P. Y. and Li, Y. J. (2005). Calcitonin gene-related peptide and hypertension. Peptides 26, 1676-1685.
    • (2005) Peptides , vol.26 , pp. 1676-1685
    • Deng, P.Y.1    Li, Y.J.2
  • 36
    • 23644436020 scopus 로고    scopus 로고
    • Heme oxygenase-1 expression in disease states
    • Deshane, J., Wright, M. and Agarwal, A. (2005). Heme oxygenase-1 expression in disease states. Acta Biochim. Pol. 52, 273-284.
    • (2005) Acta Biochim. Pol. , vol.52 , pp. 273-284
    • Deshane, J.1    Wright, M.2    Agarwal, A.3
  • 37
    • 4344575064 scopus 로고    scopus 로고
    • Is RGS-2 a new drug development target in cardiovascular disease?
    • Doggrell, S. A. (2004). Is RGS-2 a new drug development target in cardiovascular disease? Expert Opin. Ther. Targets. 8, 355-358.
    • (2004) Expert Opin. Ther. Targets. , vol.8 , pp. 355-358
    • Doggrell, S.A.1
  • 38
    • 33947374287 scopus 로고    scopus 로고
    • Endothelial progenitor cells: A promising therapeutic alternative for cardiovascular disease
    • Dong, C. and Goldschmidt-Clermont, P. J. (2007). Endothelial progenitor cells: a promising therapeutic alternative for cardiovascular disease. J. Interv. Cardiol. 20, 93-99.
    • (2007) J. Interv. Cardiol. , vol.20 , pp. 93-99
    • Dong, C.1    Goldschmidt-Clermont, P.J.2
  • 39
    • 1642414294 scopus 로고    scopus 로고
    • Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine
    • DOI 10.1097/00004872-200403000-00027
    • Escames, G., Khaldy, H., Leon, J. et al. (2004).Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine. J. Hypertens. 22, 629-635. (Pubitemid 38368498)
    • (2004) Journal of Hypertension , vol.22 , Issue.3 , pp. 629-635
    • Escames, G.1    Khaldy, H.2    Leon, J.3    Gonzalez, L.4    Acuna-Castroviejo, D.5
  • 40
    • 0036918738 scopus 로고    scopus 로고
    • Clinical trials of gene therapy for atherosclerotic cardiovascular disease
    • Freedman, S. B. (2002). Clinical trials of gene therapy for atherosclerotic cardiovascular disease. Curr. Opin. Lipidol. 13, 653-661.
    • (2002) Curr. Opin. Lipidol. , vol.13 , pp. 653-661
    • Freedman, S.B.1
  • 41
    • 0034535624 scopus 로고    scopus 로고
    • Genomic expression systems on hierarchy and network leading to hypertension: Long on history, short on facts
    • Fukamizu, A. (2000). Genomic expression systems on hierarchy and network leading to hypertension: long on history, short on facts. Hypertension Res. 23, 545-552.
    • (2000) Hypertension Res. , vol.23 , pp. 545-552
    • Fukamizu, A.1
  • 44
    • 0034623866 scopus 로고    scopus 로고
    • Current perspectives on the use of gene therapy for hypertension
    • Gelband, C. H., Katovich, M. J. and Raizada, M. K. (2000). Current perspectives on the use of gene therapy for hypertension. Circ. Res. 87, 1118-1122.
    • (2000) Circ. Res. , vol.87 , pp. 1118-1122
    • Gelband, C.H.1    Katovich, M.J.2    Raizada, M.K.3
  • 45
    • 0034999544 scopus 로고    scopus 로고
    • Vascular adrenoceptors: An update
    • Guimaraes, S. and Moura, D. (2001). Vascular adrenoceptors: an update. Pharmacol. Rev. 53, 319-356.
    • (2001) Pharmacol. Rev. , vol.53 , pp. 319-356
    • Guimaraes, S.1    Moura, D.2
  • 46
    • 1942470625 scopus 로고    scopus 로고
    • Contribution of connexins to the function of the vascular wall
    • Haefliger, J. A., Nicod, P. and Meda, P. (2004). Contribution of connexins to the function of the vascular wall. Cardiovasc. Res. 62, 345-56.
    • (2004) Cardiovasc. Res. , vol.62 , pp. 345-356
    • Haefliger, J.A.1    Nicod, P.2    Meda, P.3
  • 47
    • 27744434609 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis: Mechanisms and clinical implications
    • Halabi, C. M. and Sigmund, C. D. (2005). Peroxisome proliferator- activated receptor-gamma and its agonists in hypertension and atherosclerosis: mechanisms and clinical implications. Am. J. Cardiovasc. Drugs 5, 389-398.
    • (2005) Am. J. Cardiovasc. Drugs , vol.5 , pp. 389-398
    • Halabi, C.M.1    Sigmund, C.D.2
  • 48
    • 33745058056 scopus 로고    scopus 로고
    • Role of G-protein-coupled receptor kinase 2 in the heart. Do regulatory mechanisms open novel therapeutic perspectives?
    • Hansen, J. L., Theilade, J., Aplin, M. and Sheikh, S. P. (2006). Role of G-protein-coupled receptor kinase 2 in the heart. Do regulatory mechanisms open novel therapeutic perspectives? Trends Cardiovasc. Med. 16, 169-177.
    • (2006) Trends Cardiovasc. Med. , vol.16 , pp. 169-177
    • Hansen, J.L.1    Theilade, J.2    Aplin, M.3    Sheikh, S.P.4
  • 49
    • 4043135886 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and the renal renin-angiotensin system
    • Harris, R. C., Zhang, M. Z. and Cheng, H. F. (2004). Cyclooxygenase-2 and the renal renin-angiotensin system. Acta Physiol. Scand. 181, 543-547.
    • (2004) Acta Physiol. Scand. , vol.181 , pp. 543-547
    • Harris, R.C.1    Zhang, M.Z.2    Cheng, H.F.3
  • 50
    • 3142651901 scopus 로고    scopus 로고
    • Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization
    • Hata, J. A., Williams, M. L. and Koch, W. J. (2004). Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization. J. Mol. Cell Cardiol. 37, 11-21.
    • (2004) J. Mol. Cell Cardiol. , vol.37 , pp. 11-21
    • Hata, J.A.1    Williams, M.L.2    Koch, W.J.3
  • 51
    • 17144399923 scopus 로고    scopus 로고
    • Genetic studies in rat models: Insights into cardiovascular disease
    • Herrera, V. L. and Ruiz-Opazo, N. (2005). Genetic studies in rat models: insights into cardiovascular disease. Curr. Opin. Lipidol. 16, 119-191.
    • (2005) Curr. Opin. Lipidol. , vol.16 , pp. 119-191
    • Herrera, V.L.1    Ruiz-Opazo, N.2
  • 52
    • 33751098277 scopus 로고    scopus 로고
    • Gene therapy for vascular disease
    • Heistad, D. D. (2006). Gene therapy for vascular disease. Vascal. Pharmacol. 45, 331-333.
    • (2006) Vascal. Pharmacol. , vol.45 , pp. 331-333
    • Heistad, D.D.1
  • 54
    • 0037216307 scopus 로고    scopus 로고
    • Effect of overproduction of nitric oxide in the brain stem on the cardiovascular response in conscious rats
    • Hirooka, Y., Kishi, T., Sakai, K. et al. (2003). Effect of overproduction of nitric oxide in the brain stem on the cardiovascular response in conscious rats. J. Cardiovasc. Pharmacol. 41, S119-126.
    • (2003) J. Cardiovasc. Pharmacol. , vol.41
    • Hirooka, Y.1    Kishi, T.2    Sakai, K.3
  • 55
    • 33645551286 scopus 로고    scopus 로고
    • Signaling through PI3Kgamma: A common platform for leukocyte, platelet and cardiovascular stress sensing
    • Hirsch, E., Lembo, G., Montrucchio, G. et al. (2006). Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing. Thromb. Haemost. 95, 29-35.
    • (2006) Thromb. Haemost. , vol.95 , pp. 29-35
    • Hirsch, E.1    Lembo, G.2    Montrucchio, G.3
  • 56
    • 33745797993 scopus 로고    scopus 로고
    • Eicosanoids and renal vascular function in diseases
    • Imig, J. D. (2006). Eicosanoids and renal vascular function in diseases. Clin. Sci. (Lond) 111, 21-34.
    • (2006) Clin. Sci. (Lond) , vol.111 , pp. 21-34
    • Imig, J.D.1
  • 57
    • 33749234216 scopus 로고    scopus 로고
    • Drugs, their targets and the nature and number of drug targets
    • Imming, P., Sinning, C. and Meyer, A. (2007). Drugs, their targets and the nature and number of drug targets. Nat. Rev. Drug Discov. 5, 821-34.
    • (2007) Nat. Rev. Drug Discov. , vol.5 , pp. 821-834
    • Imming, P.1    Sinning, C.2    Meyer, A.3
  • 59
    • 33645405103 scopus 로고    scopus 로고
    • 2+ exchanger: Implications for the pathogenesis and therapy of salt-dependent hypertension
    • 2+ exchanger: implications for the pathogenesis and therapy of salt-dependent hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R 536-545.
    • (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.290
    • Iwamoto, T.1
  • 60
    • 0034087475 scopus 로고    scopus 로고
    • In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors
    • Kable, J. W., Murrin, L. C. and Bylund, D. B. (2000). In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors. J. Pharmacol. Exp. Ther. 293, 1-7.
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 1-7
    • Kable, J.W.1    Murrin, L.C.2    Bylund, D.B.3
  • 61
    • 0345118244 scopus 로고    scopus 로고
    • Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat
    • DOI 10.1016/j.lfs.2003.09.036
    • Kamanaka, Y., Kawabata, A., Matsuya, H. et al. (2003). Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat. Life Sci. 74, 793-802. (Pubitemid 37494905)
    • (2003) Life Sciences , vol.74 , Issue.6 , pp. 793-802
    • Kamanaka, Y.1    Kawabata, A.2    Matsuya, H.3    Taga, C.4    Sekiguchi, F.5    Kawao, N.6
  • 62
    • 27844532499 scopus 로고    scopus 로고
    • Alpha(2)-adrenergic receptor signalling in hypertension
    • Kanagy, N. L. (2005). Alpha(2)-adrenergic receptor signalling in hypertension. Clin. Sci. (Lond) 109, 431-437.
    • (2005) Clin. Sci. (Lond) , vol.109 , pp. 431-437
    • Kanagy, N.L.1
  • 63
    • 21844453395 scopus 로고    scopus 로고
    • Transgenic and gene-knockout rodents as research tools for cardiovascular disorders
    • Kapoor, K. and Dikshit, M. (2005). Transgenic and gene-knockout rodents as research tools for cardiovascular disordersScand. J. Lab. Animal Sc. 32, 49-67.
    • (2005) Scand. J. Lab. Animal Sc. , vol.32 , pp. 49-67
    • Kapoor, K.1    Dikshit, M.2
  • 64
    • 0037281663 scopus 로고    scopus 로고
    • The renal kallikrein-kinin system: Its role as a safety valve for excess sodium intake, and its attenuation as a possible etiologic factor in salt-sensitive hypertension
    • Katori, M. and Majima, M. (2003). The renal kallikrein-kinin system: its role as a safety valve for excess sodium intake, and its attenuation as a possible etiologic factor in salt-sensitive hypertension. Crit. Rev. Clin. Lab. Sci. 40, 43-115.
    • (2003) Crit. Rev. Clin. Lab. Sci. , vol.40 , pp. 43-115
    • Katori, M.1    Majima, M.2
  • 65
    • 2342439733 scopus 로고    scopus 로고
    • The adrenergic pathway and heart failure
    • Keys, J. R. and Koc,h W. J. (2004). The adrenergic pathway and heart failure. Recent Prog. Horm. Res. 59, 13-30.
    • (2004) Recent Prog. Horm. Res. , vol.59 , pp. 13-30
    • Keys, J.R.1    Koch, W.J.2
  • 66
    • 0035724762 scopus 로고    scopus 로고
    • Gene therapy for cardiovascular disease: A case for cautious optimism
    • Khurana, R., Martin, J. F., Zachary, I. (2001). Gene therapy for cardiovascular disease: a case for cautious optimism. Hypertension 38, 1210-1216. (Pubitemid 34252833)
    • (2001) Hypertension , vol.38 , Issue.5 , pp. 1210-1216
    • Khurana, R.1    Martin, J.F.2    Zachary, I.3
  • 67
    • 25444522479 scopus 로고    scopus 로고
    • Role of angiogenesis in cardiovascular disease: A critical appraisal
    • Khurana, R., Simons, M., Martin, J. F. and Zachary, I. C. (2005). Role of angiogenesis in cardiovascular disease: a critical appraisal. Circulation 112, 1813-1824.
    • (2005) Circulation , vol.112 , pp. 1813-1824
    • Khurana, R.1    Simons, M.2    Martin, J.F.3    Zachary, I.C.4
  • 68
    • 33749028167 scopus 로고    scopus 로고
    • Acupuncture reduces experimental renovascular hypertension through mechanisms involving nitric oxide synthases
    • Kim, D.D., Pica, A.M., Duran, R. G. and Duran, W. N. (2006). Acupuncture reduces experimental renovascular hypertension through mechanisms involving nitric oxide synthases. Microcirculation.13, 577-585.
    • (2006) Microcirculation , vol.13 , pp. 577-585
    • Kim, D.D.1    Pica, A.M.2    Duran, R.G.3    Duran, W.N.4
  • 69
    • 22144435531 scopus 로고    scopus 로고
    • Chromogranin A: A surprising link between granule biogenesis and hypertension
    • Kim, T., Loh, Y. P. (2005). Chromogranin A: a surprising link between granule biogenesis and hypertension. J. Clin. Invest. 115, 1711-1713.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1711-1713
    • Kim, T.1    Loh, Y.P.2
  • 70
    • 33645577621 scopus 로고    scopus 로고
    • Products of heme oxygenase and their potential therapeutic applications
    • Kirkby, K. A. and Adin, C. A. (2006). Products of heme oxygenase and their potential therapeutic applications. Am. J. Physiol. Renal. Physiol. 290, F 563-571.
    • (2006) Am. J. Physiol. Renal. Physiol. , vol.290
    • Kirkby, K.A.1    Adin, C.A.2
  • 71
    • 0036947237 scopus 로고    scopus 로고
    • Gene transfer of beta-adrenergic signaling components for heart failure
    • Koch, W. J. (2002). Gene transfer of beta-adrenergic signaling components for heart failure. J. Card. Fail. 8, S 526-531.
    • (2002) J. Card. Fail. , vol.8
    • Koch, W.J.1
  • 72
    • 33645739923 scopus 로고    scopus 로고
    • The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure
    • Kohan, D. E. (2006). The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure. Curr. Opin. Nephrol. Hypertens. 15, 34-40.
    • (2006) Curr. Opin. Nephrol. Hypertens. , vol.15 , pp. 34-40
    • Kohan, D.E.1
  • 73
    • 0346508857 scopus 로고    scopus 로고
    • Symposium on the etiology of hypertension - Summarizing studies in 20th century. 2. Genetic engineering in hypertension research
    • Kurihara, H. (2001). Symposium on the etiology of hypertension - summarizing studies in 20th century. 2. Genetic engineering in hypertension research. Intern. Med. 40, 147-151.
    • (2001) Intern. Med. , vol.40 , pp. 147-151
    • Kurihara, H.1
  • 74
    • 0036792751 scopus 로고    scopus 로고
    • Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II
    • Landmesser, U., Cai, H., Dikalov, S. et al. (2002). Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension 40, 511-515.
    • (2002) Hypertension , vol.40 , pp. 511-515
    • Landmesser, U.1    Cai, H.2    Dikalov, S.3
  • 75
    • 0034169792 scopus 로고    scopus 로고
    • Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways
    • Lake-Bruse, K. D. and Sigmund, C. D. (2000). Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways. Curr. Hypertens. Rep. 2, 211-216.
    • (2000) Curr. Hypertens. Rep. , vol.2 , pp. 211-216
    • Lake-Bruse, K.D.1    Sigmund, C.D.2
  • 76
    • 4043174157 scopus 로고    scopus 로고
    • Transgenic mice for studies of the renin-angiotensin system in hypertension
    • Lavoie, J. L., Bianco, R. A., Sakai, K. et al. (2004). Transgenic mice for studies of the renin-angiotensin system in hypertension. Acta Physiol. Scand. 181, 511-511.
    • (2004) Acta Physiol. Scand. , vol.181 , pp. 511-511
    • Lavoie, J.L.1    Bianco, R.A.2    Sakai, K.3
  • 77
    • 0037327310 scopus 로고    scopus 로고
    • RGS2: A "turn-off" in hypertension
    • Le, T. H. and Coffman, T. M. (2003). RGS2: a "turn-off" in hypertension. J. Clin. Invest. 111, 441-443.
    • (2003) J. Clin. Invest. , vol.111 , pp. 441-443
    • Le, T.H.1    Coffman, T.M.2
  • 78
    • 33746005647 scopus 로고    scopus 로고
    • A central role of eNOS in the protective effect of wine against metabolic syndrome
    • Leighton, F., Miranda-Rottmann, S. and Urquiaga, I. (2006). A central role of eNOS in the protective effect of wine against metabolic syndrome. Cell. Biochem. Funct. 24, 291-298.
    • (2006) Cell. Biochem. Funct. , vol.24 , pp. 291-298
    • Leighton, F.1    Miranda-Rottmann, S.2    Urquiaga, I.3
  • 80
    • 33846977415 scopus 로고    scopus 로고
    • Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor
    • Li, H., Gao, Y., Grobe, J. L. et al. (2007). Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor. Am. J. Physiol. Heart Circ. Physiol. 292, H727-735.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Li, H.1    Gao, Y.2    Grobe, J.L.3
  • 81
    • 27144547588 scopus 로고    scopus 로고
    • Tierversuche in der biomedizinischen Forschung
    • Lindl, T., Völkel, M. and Kolar, R. (2005). Tierversuche in der biomedizinischen Forschung. ALTEX 22, 143-151.
    • (2005) ALTEX , vol.22 , pp. 143-151
    • Lindl, T.1    Völkel, M.2    Kolar, R.3
  • 82
    • 29144508395 scopus 로고    scopus 로고
    • Finding new drug targets in the 21st century
    • Lindsay, M. A. (2005). Finding new drug targets in the 21st century. Drug Discovery Today 10, 1683-1687.
    • (2005) Drug Discovery Today , vol.10 , pp. 1683-1687
    • Lindsay, M.A.1
  • 83
    • 33744459527 scopus 로고    scopus 로고
    • DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages
    • Liu, K. L., Chen, H. W., Wang, R. Y. et al. (2006). DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages. J. Agric. Food Client. 54, 3472-3478.
    • (2006) J. Agric. Food Client , vol.54 , pp. 3472-3478
    • Liu, K.L.1    Chen, H.W.2    Wang, R.Y.3
  • 84
    • 0347479294 scopus 로고    scopus 로고
    • Inhibition of Cyclic Strain-Induced Endothelin-1 Gene Expression by Resveratrol
    • DOI 10.1161/01.HYP.0000103162.76220.51
    • Liu, J. C., Chen, J. J., Chan, P. et al. (2003). Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol. Hypertension 42, 1198-1205. (Pubitemid 37549077)
    • (2003) Hypertension , vol.42 , Issue.6 , pp. 1198-1205
    • Liu, J.-C.1    Chen, J.-J.2    Chan, P.3    Cheng, C.-F.4    Cheng, T.-H.5
  • 85
    • 27544491447 scopus 로고    scopus 로고
    • Angiogenic and antiangiogenic gene therapy
    • Malecki, M., Kolsut, P. and Proczka, R. (2005). Angiogenic and antiangiogenic gene therapy. Gene Titer. 12, S159-169.
    • (2005) Gene Titer. , vol.12
    • Malecki, M.1    Kolsut, P.2    Proczka, R.3
  • 86
    • 11244264499 scopus 로고    scopus 로고
    • The plasma and tissue kininogen-kallikrein-kinin system: Role in the cardiovascular system
    • Marcondes, S. and Antunes, E. (2005). The plasma and tissue kininogen-kallikrein-kinin system: role in the cardiovascular system. Curr. Med. Chem. Cardiovasc. Hematol. Agents. 3, 33-44.
    • (2005) Curr. Med. Chem. Cardiovasc. Hematol. Agents , vol.3 , pp. 33-44
    • Marcondes, S.1    Antunes, E.2
  • 87
    • 33746332073 scopus 로고    scopus 로고
    • Pathophysiology and therapeutic possibilities of calcitonin gene-related peptide in hypertension
    • Marquez-Rodas, I., Longo, F., Rothlin, R. P. and Balfagon, G. (2006). Pathophysiology and therapeutic possibilities of calcitonin gene-related peptide in hypertension. J. Physiol. Biochem. 62, 45-56.
    • (2006) J. Physiol. Biochem. , vol.62 , pp. 45-56
    • Marquez-Rodas, I.1    Longo, F.2    Rothlin, R.P.3    Balfagon, G.4
  • 89
    • 33845261612 scopus 로고    scopus 로고
    • Vascular protection of dual therapy (atorvastatin-amlodipine) in hypertensive patients
    • Martin-Ventura, J. L., Tunon, J., Duran, M. C. et al. (2006). Vascular protection of dual therapy (atorvastatin-amlodipine) in hypertensive patients. J. Am. Soc. Nephrol. 17, S189-193.
    • (2006) J. Am. Soc. Nephrol. , vol.17
    • Martin-Ventura, J.L.1    Tunon, J.2    Duran, M.C.3
  • 91
    • 5344271164 scopus 로고    scopus 로고
    • Endothelium-targeted gene and cell-based therapies for cardiovascular disease
    • Melo, L. G., Gnecchi, M., Pachori, A. S. et al. (2004). Endothelium-targeted gene and cell-based therapies for cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 24, 1761-1774.
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 1761-1774
    • Melo, L.G.1    Gnecchi, M.2    Pachori, A.S.3
  • 93
    • 0034729574 scopus 로고    scopus 로고
    • ANP in regulation of arterial pressure and fluid-electrolyte balance: Lessons from genetic mouse models
    • Melo, L. G., Steinhelper, M. E., Pang, S. C. et al. (2000). ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models. Physiol. Genomics 29, 45-58.
    • (2000) Physiol. Genomics , vol.29 , pp. 45-58
    • Melo, L.G.1    Steinhelper, M.E.2    Pang, S.C.3
  • 94
    • 19344363250 scopus 로고    scopus 로고
    • Pathophysiological roles of G-protein-coupled receptor kinases
    • Metaye, T., Gibelin, H., Perdrisot, R. and Kraimps, J. L. (2005). Pathophysiological roles of G-protein-coupled receptor kinases. Cell Signal. 17, 917-28.
    • (2005) Cell Signal. , vol.17 , pp. 917-928
    • Metaye, T.1    Gibelin, H.2    Perdrisot, R.3    Kraimps, J.L.4
  • 95
  • 96
    • 33745946837 scopus 로고    scopus 로고
    • Bone morphogenic protein-4 induces hypertension in mice: Role of noggin, vascular NADPH oxidases, and impaired vasorelaxation
    • DOI 10.1161/CIRCULATIONAHA.106.611822, PII 0000301720060620000009
    • Miriyala, S., Gongora Nieto, M. C., Mingone, C. et al. (2006). Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation. 113, 2818-25. (Pubitemid 44305294)
    • (2006) Circulation , vol.113 , Issue.24 , pp. 2818-2825
    • Miriyala, S.1    Nieto, M.C.G.2    Mingone, C.3    Smith, D.4    Dikalov, S.5    Harrison, D.G.6    Jo, H.7
  • 97
    • 33750200993 scopus 로고    scopus 로고
    • Tetrahydrobiopterin and cardiovascular disease
    • Moens, A. L. and Kass, D. A. (2006). Tetrahydrobiopterin and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 26, 2439-2444.
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 2439-2444
    • Moens, A.L.1    Kass, D.A.2
  • 98
    • 33745599582 scopus 로고    scopus 로고
    • A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility
    • Moore, J. H., Gilbert, J. C., Tsai, C. T. et al. (2006). A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. J. Theor. Biol. 241, 252-261.
    • (2006) J. Theor. Biol. , vol.241 , pp. 252-261
    • Moore, J.H.1    Gilbert, J.C.2    Tsai, C.T.3
  • 99
    • 33645029277 scopus 로고    scopus 로고
    • Cardiovascular and metabolic effects of natriuretic peptides
    • Moro, C. and Berlan, M.(2006). Cardiovascular and metabolic effects of natriuretic peptides. Fundam. Clin. Pharmacol. 1, 41-49.
    • (2006) Fundam. Clin. Pharmacol. , vol.1 , pp. 41-49
    • Moro, C.1    Berlan, M.2
  • 100
    • 0038721322 scopus 로고    scopus 로고
    • Angiotensin II and endothelin induce inflammation and thereby promote hypertension-induced end-organ damage
    • Muller, D. N., Fiebeler, A., Park, J. K. et al. (2003). Angiotensin II and endothelin induce inflammation and thereby promote hypertension-induced end-organ damage. Clin. Nephrol. 60, S 2-12.
    • (2003) Clin. Nephrol. , vol.60
    • Muller, D.N.1    Fiebeler, A.2    Park, J.K.3
  • 101
  • 102
    • 1542289726 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin H-induced renal injury
    • Muller, D. N., Theuer, J., Shagdarsuren, E. et al. (2004). A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin H-induced renal injury. Am. J. Pathol. 164, 521-532.
    • (2004) Am. J. Pathol. , vol.164 , pp. 521-532
    • Muller, D.N.1    Theuer, J.2    Shagdarsuren, E.3
  • 103
    • 33645849217 scopus 로고    scopus 로고
    • Hypertension, kidney, and transgenics: A fresh perspective
    • Mullins, L. J., Bailey, M. A. and Mullins, J. J. (2006). Hypertension, kidney, and transgenics: a fresh perspective. Physiol. Rev. 86, 709-746.
    • (2006) Physiol. Rev. , vol.86 , pp. 709-746
    • Mullins, L.J.1    Bailey, M.A.2    Mullins, J.J.3
  • 104
    • 33645849217 scopus 로고    scopus 로고
    • Hypertension, kidney, and transgenics: A fresh perspective
    • Mullins, L. J., Bailey, M. A. and Mullins, J. J. (2006). Hypertension, kidney, and transgenics: a fresh perspective. Physiol. Rev. 86, 709-746.
    • (2006) Physiol. Rev. , vol.86 , pp. 709-746
    • Mullins, L.J.1    Bailey, M.A.2    Mullins, J.J.3
  • 105
    • 33645754429 scopus 로고    scopus 로고
    • Natriuretic peptides as therapeutic targets
    • Mukaddam-Daher, S. (2006). Natriuretic peptides as therapeutic targets. Expert Opin. Titer. Targets. 10, 239-252.
    • (2006) Expert Opin. Titer. Targets , vol.10 , pp. 239-252
    • Mukaddam-Daher, S.1
  • 106
    • 0037278633 scopus 로고    scopus 로고
    • Current successes and limitations of using genetic modification for blood pressure research
    • Mullins, L. J. and Mullins, J. (2003). Current successes and limitations of using genetic modification for blood pressure research. Pflugers Arch. 445, 491-494. (Pubitemid 36222997)
    • (2003) Pflugers Archiv European Journal of Physiology , vol.445 , Issue.4 , pp. 491-494
    • Mullins, L.J.1    Mullins, J.2
  • 107
    • 33645569141 scopus 로고    scopus 로고
    • Significant and prolonged antisense effect of a multifunctional envelopetype nano device encapsulating antisense oligodeoxynucleotide
    • Nakamura, Y., Kogure, K., Yamada, Y. et al. (2006). Significant and prolonged antisense effect of a multifunctional envelopetype nano device encapsulating antisense oligodeoxynucleotide. J. Pharm. Pharmacol. 58, 431-437.
    • (2006) J. Pharm. Pharmacol. , vol.58 , pp. 431-437
    • Nakamura, Y.1    Kogure, K.2    Yamada, Y.3
  • 108
    • 23044505095 scopus 로고    scopus 로고
    • Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells
    • Nascimento-Silva, V., Arruda, M. A., Barja-Fidalgo, C. et al. (2005). Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells. Am. J. Physiol. Cell Physiol. 289, C 557-563.
    • (2005) Am. J. Physiol. Cell Physiol. , vol.289
    • Nascimento-Silva, V.1    Arruda, M.A.2    Barja-Fidalgo, C.3
  • 110
    • 0036091244 scopus 로고    scopus 로고
    • Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: Therapeutic implications
    • Niu, T., Chen X. and Xu X. (2002). Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications. Drugs 62, 977-993. (Pubitemid 34533759)
    • (2002) Drugs , vol.62 , Issue.7 , pp. 977-993
    • Niu, T.1    Chen, X.2    Xu, X.3
  • 111
    • 33645723450 scopus 로고    scopus 로고
    • Molecular aspects of ischemic heart disease: Ischemia/reperfusion-induced genetic changes and potential applications of gene and RNA interference therapy
    • Nordlie, M. A., Wold, L. E., Simkhovich, B. Z. et al. (2006). Molecular aspects of ischemic heart disease: ischemia/reperfusion-induced genetic changes and potential applications of gene and RNA interference therapy. J. Cardiovasc. Pharmacol. Ther. 11, 17-30.
    • (2006) J. Cardiovasc. Pharmacol. Ther. , vol.11 , pp. 17-30
    • Nordlie, M.A.1    Wold, L.E.2    Simkhovich, B.Z.3
  • 112
    • 0034105969 scopus 로고    scopus 로고
    • Renal dopaminergic mechanisms and hypertension: A chronology of advances
    • O'Connell, D. P. and Aherne, A. M. (2000). Renal dopaminergic mechanisms and hypertension: a chronology of advances. Clin. Exp. Hypertens. 22, 217-249.
    • (2000) Clin. Exp. Hypertens. , vol.22 , pp. 217-249
    • O'Connell, D.P.1    Aherne, A.M.2
  • 113
    • 33645529873 scopus 로고    scopus 로고
    • Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload
    • O'Connell, T. D., Swigart, P. M., Rodrigo, M. C. et al. (2006). Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J. Clin. Invest. 116, 1005-1015.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1005-1015
    • O'Connell, T.D.1    Swigart, P.M.2    Rodrigo, M.C.3
  • 114
    • 33750350429 scopus 로고    scopus 로고
    • Effect of cationic flaxseed protein hydrolysate fractions on the in vitro structure and activity of calmodulin-dependent endothelial nitric oxide synthase
    • Omoni, A. O. and Aluko, R. E. (2006). Effect of cationic flaxseed protein hydrolysate fractions on the in vitro structure and activity of calmodulin-dependent endothelial nitric oxide synthase. Mol. Nutr. Food Res. 50, 958-966.
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 958-966
    • Omoni, A.O.1    Aluko, R.E.2
  • 115
    • 33748436682 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension
    • Opay, A. L., Mouton, C. R., Mullins, J. J. and Mitchell, K. D. (2006). Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension. Am. J. Physiol. Renal Physiol. 291, F 612-618.
    • (2006) Am. J. Physiol. Renal Physiol. , vol.291
    • Opay, A.L.1    Mouton, C.R.2    Mullins, J.J.3    Mitchell, K.D.4
  • 116
    • 3242698804 scopus 로고    scopus 로고
    • The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
    • Oudit, G. Y., Sun, H., Kerfant, B. G. et al. (2004). The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J. Mol. Cell Cardiol. 37, 449-471.
    • (2004) J. Mol. Cell Cardiol. , vol.37 , pp. 449-471
    • Oudit, G.Y.1    Sun, H.2    Kerfant, B.G.3
  • 117
    • 33746359630 scopus 로고    scopus 로고
    • New biotechnological methods to reduce oxidative stress in the cardiovascular system: Focusing on the Bach1/heme oxygenase-1 pathway
    • Ozono, R. (2004). New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. Curr. Pharm. Biotechnol. 7, 87-93.
    • (2004) Curr. Pharm. Biotechnol. , vol.7 , pp. 87-93
    • Ozono, R.1
  • 118
    • 4344563121 scopus 로고    scopus 로고
    • Importance of NPY Y1 receptor-mediated pathways: Assessment using NPY Y1 receptor knockouts
    • Pedrazzini, T. (2004). Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts. Neuropeptides 38, 267-275.
    • (2004) Neuropeptides , vol.38 , pp. 267-275
    • Pedrazzini, T.1
  • 119
    • 9644272492 scopus 로고    scopus 로고
    • Photocontrol of nitric oxide production in cell culture using a caged isoform selective inhibitor
    • Perdicakis, B., Montgomery, H. J., Abbott, G. L. et al. (2005). Photocontrol of nitric oxide production in cell culture using a caged isoform selective inhibitor. Bioorg. Med. Client. 13, 47-57.
    • (2005) Bioorg. Med. Client. , vol.13 , pp. 47-57
    • Perdicakis, B.1    Montgomery, H.J.2    Abbott, G.L.3
  • 120
    • 0141919542 scopus 로고    scopus 로고
    • Role of heme oxygenase-1 in cardiovascular function
    • Perrella, M. A. and Yet, S. F. (2003). Role of heme oxygenase-1 in cardiovascular function. Curr. Pharm. Des. 9, 2479-2487.
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 2479-2487
    • Perrella, M.A.1    Yet, S.F.2
  • 121
    • 0141457810 scopus 로고    scopus 로고
    • The beta-adrenergic receptor kinase in heart failure
    • Petrofski, J. A. and Koch, W. J. (2003). The beta-adrenergic receptor kinase in heart failure. J. Mol. Cell. Cardiol. 35, 1167-1174.
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , pp. 1167-1174
    • Petrofski, J.A.1    Koch, W.J.2
  • 122
    • 0033858886 scopus 로고    scopus 로고
    • The potential role of antisense oligodeoxynucleotide therapy for cardiovascular disease
    • Phillips, M. I., Galli, S. M. and Mehta, J. L. (2000). The potential role of antisense oligodeoxynucleotide therapy for cardiovascular disease. Drugs 60, 239-248.
    • (2000) Drugs , vol.60 , pp. 239-248
    • Phillips, M.I.1    Galli, S.M.2    Mehta, J.L.3
  • 123
    • 0034199888 scopus 로고    scopus 로고
    • Somatic gene therapy for hypertension
    • Phillips, M. I. (2000). Somatic gene therapy for hypertension. Braz. J. Med. Biol. Res. 33, 715-721.
    • (2000) Braz. J. Med. Biol. Res. , vol.33 , pp. 715-721
    • Phillips, M.I.1
  • 124
    • 0035459161 scopus 로고    scopus 로고
    • Gene therapy for hypertension: The preclinical data
    • Phillips, M. I. (2001). Gene therapy for hypertension: the preclinical data. Hypertension 38, 543-548.
    • (2001) Hypertension , vol.38 , pp. 543-548
    • Phillips, M.I.1
  • 126
    • 28444499677 scopus 로고    scopus 로고
    • S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction
    • Pleger, S. T., Remppis, A., Heidt, B. et al. (2005). S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Mol. Ther. 12, 1120-1129.
    • (2005) Mol. Ther. , vol.12 , pp. 1120-1129
    • Pleger, S.T.1    Remppis, A.2    Heidt, B.3
  • 127
    • 34347342795 scopus 로고    scopus 로고
    • Gene-based therapy for hypertension: Do preclinical data suggest a promising future?
    • Puddu, G. M. (2006). Gene-based therapy for hypertension: do preclinical data suggest a promising future? Cardiology 108, 40-47.
    • (2006) Cardiology , vol.108 , pp. 40-47
    • Puddu, G.M.1
  • 128
    • 3042557823 scopus 로고    scopus 로고
    • Gene therapy approaches for cardiovascular diseases
    • Quarck, R. and Holvoet, P. (2004). Gene therapy approaches for cardiovascular diseases. Curr. Gene Ther. 4, 207-223.
    • (2004) Curr. Gene Ther. , vol.4 , pp. 207-223
    • Quarck, R.1    Holvoet, P.2
  • 129
    • 33744492066 scopus 로고    scopus 로고
    • Beta-adrenergic receptors and nitric oxide generation in the cardiovascular system
    • Queen, L. R. and Ferro, A. (2006). Beta-adrenergic receptors and nitric oxide generation in the cardiovascular system. Cell Mol. Life Sci. 63, 1070-1083.
    • (2006) Cell Mol. Life Sci. , vol.63 , pp. 1070-1083
    • Queen, L.R.1    Ferro, A.2
  • 130
    • 31744442315 scopus 로고    scopus 로고
    • Potential of gene therapy strategy for the treatment of hypertension
    • DOI 10.1161/01.HYP.0000196685.91424.01
    • Raizada, M. K. and Der Sarkissian, S. (2006). Potential of gene therapy strategy for the treatment of hypertension. Hypertension 47, 6-9. (Pubitemid 43177805)
    • (2006) Hypertension , vol.47 , Issue.1 , pp. 6-9
    • Raizada, M.K.1    Der Sarkissian, S.2
  • 135
    • 25444495547 scopus 로고    scopus 로고
    • Regulable atrial natriuretic peptide gene therapy for hypertension
    • Schillinger, K. J., Tsai, S. Y., Taffet, G. E. et al. (2006). Regulable atrial natriuretic peptide gene therapy for hypertension. Proc. Natl. Acad. Sci. USA. 102, 13789-13794.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 13789-13794
    • Schillinger, K.J.1    Tsai, S.Y.2    Taffet, G.E.3
  • 136
    • 33745058715 scopus 로고    scopus 로고
    • Development of inhibitors of the aspartyl protease renin for the treatment of hypertension
    • Scott, B. B., McGeehan, G. M. and Harrison, R. K. (2006). Development of inhibitors of the aspartyl protease renin for the treatment of hypertension. Curr. Protein Pept. Sci. 7, 241-254.
    • (2006) Curr. Protein Pept. Sci. , vol.7 , pp. 241-254
    • Scott, B.B.1    McGeehan, G.M.2    Harrison, R.K.3
  • 138
    • 1642388491 scopus 로고    scopus 로고
    • Telomeres and cardiovascular disease: Does size matter?
    • Serrano, A. L. and Andres, V. (2004). Telomeres and cardiovascular disease: does size matter? Circ. Res. 94, 575-84.
    • (2004) Circ. Res. , vol.94 , pp. 575-584
    • Serrano, A.L.1    Andres, V.2
  • 139
    • 33745443574 scopus 로고    scopus 로고
    • Blood pressure reduction is not the only determinant of outcome
    • Sever, P. S., Poulter, N. R., Elliott, W. J. et al. (2006). Blood pressure reduction is not the only determinant of outcome. Circulation 113, 2754-2774.
    • (2006) Circulation , vol.113 , pp. 2754-2774
    • Sever, P.S.1    Poulter, N.R.2    Elliott, W.J.3
  • 140
    • 0242266595 scopus 로고    scopus 로고
    • Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells
    • Shen, L. J., Lin, W. C., Beloussow, K. et al. (2003). Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells. Biochem. Pharmacol. 66, 1945-1952.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 1945-1952
    • Shen, L.J.1    Lin, W.C.2    Beloussow, K.3
  • 141
    • 18944372106 scopus 로고    scopus 로고
    • Adrenomedullin as a potent antioxidative and antiatherosclerotic substance
    • DOI 10.1358/dnp.2005.18.3.892764
    • Shimosawa, T. and Fujita, T. (2005). Adrenomedullin as a potent antioxidative and antiatherosclerotic substance. Drug News Perspect. 18, 185-189. (Pubitemid 40704840)
    • (2005) Drug News and Perspectives , vol.18 , Issue.3 , pp. 185-189
    • Shimosawa, T.1    Fujita, T.2
  • 142
    • 0037299218 scopus 로고    scopus 로고
    • Organ-protective effects of adrenomedullin
    • Shimosawa, T., Matsui, H., Xing, G. et al. (2003). Organ-protective effects of adrenomedullin. Hypertens. Res. 26, S109-112.
    • (2003) Hypertens. Res. , vol.26
    • Shimosawa, T.1    Matsui, H.2    Xing, G.3
  • 143
    • 1842787751 scopus 로고    scopus 로고
    • Role of the selective aldosterone receptor blockers in arterial hypertension
    • Sierra, C. and Ruilope, L. M. (2004). Role of the selective aldosterone receptor blockers in arterial hypertension. J. Renin Angiotensin Aldosterone Syst. 5, 23-25.
    • (2004) J. Renin Angiotensin Aldosterone Syst. , vol.5 , pp. 23-25
    • Sierra, C.1    Ruilope, L.M.2
  • 145
    • 27744445785 scopus 로고    scopus 로고
    • Bioplex technology: Novel synthetic gene delivery pharmaceutical based on peptides anchored to nucleic acids
    • Simonson, O. E., Svahn, M. G., Tornquist, E. et al. (2005). Bioplex technology: novel synthetic gene delivery pharmaceutical based on peptides anchored to nucleic acids. Curr. Pharm. Des. 11, 3671-3680.
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 3671-3680
    • Simonson, O.E.1    Svahn, M.G.2    Tornquist, E.3
  • 146
    • 17744376024 scopus 로고    scopus 로고
    • Many little things: One geneticist's view of complex diseases
    • Smithies, O. (2005). Many little things: one geneticist's view of complex diseases. Nat. Rev. Genet. 6, 419-425.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 419-425
    • Smithies, O.1
  • 147
    • 34748838312 scopus 로고
    • Antihypertensive effects of an aldosterone antagonist
    • Sturtevant, F. M. (1958). Antihypertensive effects of an aldosterone antagonist. Science 127, 1393-1394.
    • (1958) Science , vol.127 , pp. 1393-1394
    • Sturtevant, F.M.1
  • 148
    • 0035256894 scopus 로고    scopus 로고
    • Mouse models of blood pressure regulation and hypertension
    • Sugiyama, F., Yagami, K. and Paigen, B. (2001). Mouse models of blood pressure regulation and hypertension. Curr. Hypertens. Rep. 3, 41-48.
    • (2001) Curr. Hypertens. Rep. , vol.3 , pp. 41-48
    • Sugiyama, F.1    Yagami, K.2    Paigen, B.3
  • 149
    • 33746379034 scopus 로고    scopus 로고
    • Current understanding of the mechanism and role of ROS in angiotensin II signal transduction
    • Suzuki, H., Frank, G. D., Utsunomiya, H. et al. (2006). Current understanding of the mechanism and role of ROS in angiotensin II signal transduction. Curr. Pharm. Biotechnol. 2, 81-86.
    • (2006) Curr. Pharm. Biotechnol. , vol.2 , pp. 81-86
    • Suzuki, H.1    Frank, G.D.2    Utsunomiya, H.3
  • 150
    • 1242338846 scopus 로고    scopus 로고
    • Human genetics, animal models and computer simulations for studying hypertension
    • DOI 10.1016/j.tig.2004.01.004
    • Takahashi, N. and Smithies, O. (2004). Human genetics, animal models and computer simulations for studying hypertension. Trends Genet. 20, 136-145. (Pubitemid 38230028)
    • (2004) Trends in Genetics , vol.20 , Issue.3 , pp. 136-145
    • Takahashi, N.1    Smithies, O.2
  • 151
    • 20944445197 scopus 로고    scopus 로고
    • Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load
    • Takimoto, E., Champion, H. C., Li, M. et al. (2005). Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. J. Clin. Invest. 115, 1221-1231.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1221-1231
    • Takimoto, E.1    Champion, H.C.2    Li, M.3
  • 154
    • 33745511931 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications
    • Touyz, R. M. and Schiffrin, E. L. (2006). Peroxisome proliferator- activated receptors in vascular biology-molecular mechanisms and clinical implications. Vascul. Pharmacol. 45, 19-28.
    • (2006) Vascul. Pharmacol. , vol.45 , pp. 19-28
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 155
    • 4444329422 scopus 로고    scopus 로고
    • Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: What is the clinical significance?
    • Touyz, R. M. (2004). Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension 44, 248-252.
    • (2004) Hypertension , vol.44 , pp. 248-252
    • Touyz, R.M.1
  • 156
    • 0033822382 scopus 로고    scopus 로고
    • Roles of prostanoids revealed from studies using mice lacking specific prostanoid receptors
    • Ushikubi, F., Sugimoto, Y., Ichikawa, A. and Narumiya, S. (2000). Roles of prostanoids revealed from studies using mice lacking specific prostanoid receptors. Jpn. J. Pharmacol. 83, 279-285.
    • (2000) Jpn. J. Pharmacol. , vol.83 , pp. 279-285
    • Ushikubi, F.1    Sugimoto, Y.2    Ichikawa, A.3    Narumiya, S.4
  • 157
    • 0842328645 scopus 로고    scopus 로고
    • Functional genomics as an emerging strategy for the investigation of central mechanisms in experimental hypertension
    • Veerasingham, S. J., Sellers, K. W. and Raizada, M. K. (2004). Functional genomics as an emerging strategy for the investigation of central mechanisms in experimental hypertension. Prog. Biophys. Mol. Biol. 84, 107-123.
    • (2004) Prog. Biophys. Mol. Biol. , vol.84 , pp. 107-123
    • Veerasingham, S.J.1    Sellers, K.W.2    Raizada, M.K.3
  • 158
    • 33747180821 scopus 로고    scopus 로고
    • Tachykinins and the cardiovascular system
    • Walsh, D. A. and McWilliams, D. F. (2006). Tachykinins and the cardiovascular system. Curr. Drug Targets. 7, 1031-1042.
    • (2006) Curr. Drug Targets , vol.7 , pp. 1031-1042
    • Walsh, D.A.1    McWilliams, D.F.2
  • 159
    • 24044465198 scopus 로고    scopus 로고
    • Hematopoietic development from human embryonic stem cell lines
    • Wang, L., Menendez, P., Cerdan, C. and Bhatia, M. (2005). Hematopoietic development from human embryonic stem cell lines. Exp. Hematol. 33, 987-996.
    • (2005) Exp. Hematol. , vol.33 , pp. 987-996
    • Wang, L.1    Menendez, P.2    Cerdan, C.3    Bhatia, M.4
  • 160
    • 0036763241 scopus 로고    scopus 로고
    • Role of sensory nervous system vasoactive peptides in hypertension
    • Watson, R. E., Supowit, S. C., Zhao, H. et al. (2002). Role of sensory nervous system vasoactive peptides in hypertension. Braz. J. Med, Biol. Res. 35, 1033-1045.
    • (2002) Braz. J. Med, Biol. Res. , vol.35 , pp. 1033-1045
    • Watson, R.E.1    Supowit, S.C.2    Zhao, H.3
  • 161
    • 25844513144 scopus 로고    scopus 로고
    • Oxidative stress and nitric oxide deficiency in the kidney: A critical link to hypertension?
    • Wilcox, C. S. (2005). Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension? Am. J. Physiol. Regul. Integr. Comp. Physiol. 289, R913-935.
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.289
    • Wilcox, C.S.1
  • 162
    • 33644840376 scopus 로고    scopus 로고
    • Special feature: Cardiovascular-kidney interactions in health and disease
    • Wilcox, C. S. (2006). Special feature: Cardiovascular-kidney interactions in health and disease. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R34-R36.
    • (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.290
    • Wilcox, C.S.1
  • 164
    • 29844442868 scopus 로고    scopus 로고
    • Carbon monoxide: Endogenous production, physiological functions, and pharmacological applications
    • Wu, L. and Wang, R. (2005). Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol. Rev. 57, 585-630.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 585-630
    • Wu, L.1    Wang, R.2
  • 165
    • 0035227829 scopus 로고    scopus 로고
    • Genetic models of hypertension in experimental animals
    • Yagil, Y. and Yagil, C. (2001). Genetic models of hypertension in experimental animals. Exp. Nephrol. 9, 1-9.
    • (2001) Exp. Nephrol. , vol.9 , pp. 1-9
    • Yagil, Y.1    Yagil, C.2
  • 169
    • 0037267313 scopus 로고    scopus 로고
    • Knockouts model the 100 best-selling drugs - Will they model the next 100?
    • Zambrowicz, B. P. and Sands, A. T. (2003). Knockouts model the 100 best-selling drugs - will they model the next 100? Nat. Rev. Drug. Discov. 2, 38-51.
    • (2003) Nat. Rev. Drug. Discov. , vol.2 , pp. 38-51
    • Zambrowicz, B.P.1    Sands, A.T.2
  • 170
    • 33750056383 scopus 로고    scopus 로고
    • A new approach for treatment of hypertension: Modifying D1 dopamine receptor function
    • Zeng, C., Felder, R. A., Jose, P. A. (2006). A new approach for treatment of hypertension: modifying D1 dopamine receptor function. Cardiovasc. Hematol. Agents Med. Client. 4, 369-377.
    • (2006) Cardiovasc. Hematol. Agents Med. Client , vol.4 , pp. 369-377
    • Zeng, C.1    Felder, R.A.2    Jose, P.A.3
  • 171
    • 11144251640 scopus 로고    scopus 로고
    • Functional genomics of the dopaminergic system in hypertension
    • Zeng, C., Sanada, H., Watanabe, H. et al. (2004). Functional genomics of the dopaminergic system in hypertension. Physiol. Genomics 19, 233-246.
    • (2004) Physiol. Genomics , vol.19 , pp. 233-246
    • Zeng, C.1    Sanada, H.2    Watanabe, H.3
  • 172
    • 34247160943 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure
    • DOI 10.1161/01.RES.0000264081.78659.45
    • Zhang, P., Xu, X., Hu, X. et al. (2007). Inducible nitric oxide synthase deficiency protects the heart from systolic overloadinduced ventricular hypertrophy and congestive heart failure. Circ.Res. 100, 1089-1098. (Pubitemid 46598934)
    • (2007) Circulation Research , vol.100 , Issue.7 , pp. 1089-1098
    • Zhang, P.1    Xu, X.2    Hu, X.3    Van Deel, E.D.4    Zhu, G.5    Chen, Y.6
  • 173
    • 33749371071 scopus 로고    scopus 로고
    • The role of urotensin II in cardiovascular and renal physiology and diseases
    • Zhu, Y. C., Zhu, Y. Z. and Moore, P. K. (2006). The role of urotensin II in cardiovascular and renal physiology and diseases. Br. J. Pharmacol. 148, 884-901.
    • (2006) Br. J. Pharmacol. , vol.148 , pp. 884-901
    • Zhu, Y.C.1    Zhu, Y.Z.2    Moore, P.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.