Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 2, 2007, Pages

  Li, Hongwei ^a   Gao, Yongxin ^a   Grobe, Justin L ^a   Raizada, Mohan K ^a   Katovich, Michael J ^a   Sumners, Colin ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Adenovirus; Angiotensin II; Angiotensin receptor blocker; Gene transfer; Hypertension

Indexed keywords

ADENOVIRUS VECTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ENHANCED GREEN FLUORESCENT PROTEIN; LOSARTAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; GENE TRANSFER; HYPERTENSION; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT;

ADENOVIRIDAE; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GENETIC VECTORS; HYPERTENSION; IMIDAZOLES; LOSARTAN; MALE; MYOCARDIUM; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 2; TIME FACTORS; TRANSDUCTION, GENETIC; UP-REGULATION;

EID: 33846977415     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00938.2006     Document Type: Article

References (56)

1. 1 receptor antagonist. J Biol Chem 276: 39721-39726, 2001.
2. Adachi Y, Saito Y, Kishimoto I, Harada M, Kuwahara K, Takahashi N, Kawakami R, Nakanishi M, Nakagawa Y, Tanimoto K, Saitoh Y, Yasuno S, Usami S, Iwai M, Horiuchi M, Nakao K. Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice. Circulation 107: 2406-2408, 2003.
3. Akishita M, Yamada H, Dzau VJ, Horiuchi M. Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun 261: 345-349, 1999.
4. Alfakih K, Maqbool A, Sivananthan M, Walters K, Bainbridge G, Ridgway J, Balmforth AJ, Hall AS. Left ventricle mass index and the common, functional, X-linked angiotensin II type-2 receptor gene polymorphism (-1332 G/A) in patients with systemic hypertension. Hypertension 43: 1189-1194, 2004.
5. 2 blockade on cardiac hypertrophy as induced by high dietary salt in the proatrial natriuretic peptide (ANP) gene-disrupted mouse. Can J Physiol Pharmacol 84: 625-634, 2006.
6. 2 receptor antagonist in hypertensive rats. Hypertension 34: 1112-1116, 1999.
7. Bauer S, Maier SK, Neyses L, Maass AH. Optimization of gene transfer into neonatal rat cardiomyocytes and unmasking of cytomegalovirus promoter silencing. DNA Cell Biol 24: 381-387, 2005.
8. 2 receptors. Circ Res 94: 1623-1629, 2004.
9. Bonnet F, Cooper ME, Carey RM, Casley D, Cao Z. Vascular expression of angiotensin type 2 receptor in the adult rat: influence of angiotensin II infusion. J Hypertens 19: 1075-1081, 2001.
10. Brooks AR, Harkins RN, Wang P, Qian HS, Liu P, Rubanyi GM. Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle. J Gene Med 6: 395-404, 2004.
11. Burnier M, Maillard M. Angiotensin II receptor antagonists: where do we stand? IDrugs 3: 304-309, 2000.
12. 2 receptor comes of age. Hypertension 45: 840-844, 2005.
13. Carey RM, Howell NL, Jin XH, Siragy HM. Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats. Hypertension 38: 1272-1277, 2001.
14. 2) angiotensin receptor. Acta Physiol Scand 168: 65-71, 2000.
15. 1 receptors in the rat. Am J Physiol Endocrinol Metab 274: E115-E123, 1998.
16. 2 receptors. J Cardiovasc Pharmacol 39: 107-116, 2002.
17. Cosentino F, Savoia C, De Paolis P, Francia P, Russo A, Maffei A, Venturelli V, Schiavoni M, Lembo G, Volpe M. Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists. Am J Hypertens 18: 493-499, 2005.
18. D'Amore A, Black MJ, Thomas WG. The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy. Hypertension 6: 1347-1354, 2005.
19. De Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 52: 415-472, 2000.
20. 1 receptor antagonism in conscious normotensive but not hypertensive rats. Am J Physiol Heart Circ Physiol 288: H2289-H2297, 2005.
21. Falcon BL, Stewart JM, Bourassa E, Katovich MJ, Walter G, Speth RC, Sumners C, Raizada MK. Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension. Physiol Genomics 19: 255-261, 2004.
22. Fournier A, Messerli FH, Achard JM, Fernandez L. Cerebroprotection mediated by angiotensin II: a hypothesis supported by recent randomized clinical trials. J Am Coll Cardiol 43: 1343-1337, 2004.
23. 2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens 16: 2039 -2043, 1998.
24. Gilles R, Vingerhoedt N, Howes J, Griffin M, Howes LG. Increase in systemic blood pressure during intra-arterial PD123319 infusion: evidence for functional expression of angiotensin type 2 receptors in normal volunteers. Blood Press 13: 110-114, 2004.
25. Gonzalez M, Lobos L, Castillo F, Galleguillos L, Lopez NC, Michea L. High-salt diet inhibits expression of angiotensin type 2 receptor in resistance arteries. Hypertension 45: 853-859, 2005.
26. 2 receptor knockout mice. Acta Physiol Scand 181: 487-494, 2004.
27. Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 377: 744-747, 1995.
28. 2 receptors in the pressure-overloaded aorta after banding. Hypertension 43: 1258-1263, 2004.
29. Horiuchi M, Akishita M, Dzau VJ. Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension 33: 613-621, 1999.
30. 2 receptor activation in rats. J Hypertens 23: 2209-2217, 2005.
31. Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BL, Inagami T. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 377: 748-750.
32. 2 receptor-dependent vasodilation is mediated by activation of vascular kinin generation under flow conditions. Br J Pharmacol 136: 484-491, 2002.
33. 2 receptor blockade reduces cardiac interstitial cell DNA synthesis and cardiac function after rat myocardial infarction. J Mol Cell Cardiol 30: 425-434, 1998.
34. Li HW, Gao YX, Raizada MK, Sumners C. Intronic enhancement of angiotensin II type 2 receptor transgene expression in vitro and in vivo. Biochem Biophys Res Commun 336: 29-35, 2005.
35. 2 angiotensin receptor antagonists in angiotensin II-infused rats. Hypertension 31: 487-492, 1998.
36. 2 receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries. Hypertension 34: 659-665, 1999.
37. Matsusaka T, Katori H, Homma T, Ichikawa I. Mechanism of cardiac fibrosis by angiotensin. New insight revealed by genetic engineering. Trends Cardiovasc Med 9: 180-184, 1999.
38. Metcalfe BL, Huentelman MJ, Parilak LD, Taylor DG, Katovich MJ, Knot HJ, Sumners C, Raizada MK. Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer. Hypertension 43: 1233-1238, 2004.
39. 2 receptor in postinfarction left ventricular remodeling. Hypertension 41: 814-818, 2003.
40. 1R-AS gene therapy. Hypertension 39: 969 -975, 2002.
41. 2 receptor-mediated vasodilation in the heart: effect of myocardial infarction. Am J Physiol Heart Circ Physiol 281: H2590-H2596, 2001.
42. Schuijt MP, de Vries R, Saxena PR, Danser AHJ. No vasoactive role of the angiotensin II type 2 receptor in normotensive Wistar rats. J Hypertens 17: 1879-1884, 1999.
43. 2 receptor in hypertension. Am J Hypertens 13: 62S-67S, 2000.
44. Siragy HM, de Gasparo M, Carey RM. Angiotensin type 2 receptor mediates valsartan-induced hypotension in conscious rats. Hypertension 35: 1074-1077, 2000.
45. 2) angiotensin receptor. Proc Natl Acad Sci USA 96: 6506-6510, 1999.
46. Suzuki H, Yamamoto T, Ikegaya N, Hishida A. Dietary salt intake modulates progression of antithymocyte serum nephritis through alteration of glomerular angiotensin II receptor expression. Am J Physiol Renal Physiol 286: F267-F277, 2004.
47. 2 knockout mice. Biochem Biophys Res Commun 258: 194-198, 1999.
48. Timmermans PB, Chiu AT, Herblin WF, Wong PC, Smith RD. Angiotensin II receptor subtypes. Am J Hypertens 5: 406-410, 1992.
49. Tsutsumi Y, Matsubara H, Masaki H, Kurihara H, Murasawa S, Takai S, Miyazaki M, Nozawa Y, Ozono R, Nakagawa K, Miwa T, Kawada N, Mori Y, Shibasaki Y, Tanaka Y, Fujiyama S, Koyama Y, Fujiyama A, Takahashi H, Iwasaka T. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest 104: 925-935, 1999.
50. 2 receptor expression after renal ablation. Am J Physiol Renal Physiol 288: F207-F213, 2005.
51. Volpe M. Treatment of systolic hypertension: spotlight on recent studies with angiotensin II antagonists. J Hum Hypertens 19: 93-102, 2005.
52. Wang H, Gallinat S, Li HW, Sumners C, Raizada MK, Katovich MJ. Elevated blood pressure in normotensive rats produced by "knockdown" of the angiotensin type 2 receptor. Exp Physiol 89: 313-322, 2004.
53. Weber MA. Interrupting the renin-angiotensin system: the role of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of hypertension. Am J Hypertens 12: 189S-194S, 1999.
54. 1 receptor blockade. Hypertension 40: 516-520, 2002.
55. 1 antagonists in mice. Hypertension 40: 244-250, 2002.
56. Zhang X, Azhar G, Nagano K, Wei JY. Differential vulnerability to oxidative stress in rat cardiac myocytes versus fibroblasts. J Am Coll Cardiol 38: 2055-2062, 2001.