Human genetics, animal models and computer simulations for studying hypertension

Trends in Genetics

Volumn 20, Issue 3, 2004, Pages 136-145

  Takahashi, Nobuyuki ^a   Smithies, Oliver ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN I; BRADYKININ B2 RECEPTOR; CHYMASE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; KALLIKREIN; KININ; KININOGEN; RENIN;

ANALYTIC METHOD; ANIMAL MODEL; COMPUTER SIMULATION; ESSENTIAL HYPERTENSION; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT LOCUS MAPPING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

ANIMALIA;

EID: 1242338846     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2004.01.004     Document Type: Review

References (68)

1. Pickering G. Laragh J. Hypertension manual: mechanisms, methods and managment. 1973;3-30 Yorke Medical Books.
2. Ward R. Laragh J., Brenner B. Hypertension- pathophysiology, Diagnosis and Management. 1990;81-100 Raven Press.
3. Lifton R.P., et al. Molecular mechanisms of human hypertension. Cell. 104:2001;545-556.
4. Jeunemaitre X., et al. Molecular basis of human hypertension: role of angiotensinogen. Cell. 71:1992;169-180.
5. Nakayama T., et al. Functional deletion mutation of the 5′-flanking region of type A human natriuretic peptide receptor gene and its association with essential hypertension and left ventricular hypertrophy in the Japanese. Circ. Res. 86:2000;841-845.
6. Doris P.A. Hypertension genetics, single nucleotide polymorphisms, and the common disease: common variant hypothesis. Hypertension. 39:2002;323-331.
7. Rapp J.P. Genetic analysis of inherited hypertension in the rat. Physiol. Rev. 80:2000;135-172.
8. Printz M.P., et al. Genetic models in applied physiology. HXB/BXH rat recombinant inbred strain platform: a newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics. J. Appl. Physiol. 94:2003;2510-2522.
9. Kreutz R., Hubner N. Congenic rat strains are important tools for the genetic dissection of essential hypertension. Semin. Nephrol. 22:2002;135-147.
10. Kwitek-Black A.E., Jacob H.J. The use of designer rats in the genetic dissection of hypertension. Curr. Hypertens. Rep. 3:2001;12-18.
11. Nabika T., et al. Congenic rats for hypertension: how useful are they for the hunting of hypertension genes? Clin. Exp. Pharmacol. Physiol. 27:2000;251-256.
12. Dominiczak A.F., et al. Genes and hypertension: from gene mapping in experimental models to vascular gene transfer strategies. Hypertension. 35:2000;164-172.
13. Kim H.S., et al. Genetic control of blood pressure and the angiotensinogen locus. Proc. Natl. Acad. Sci. U. S. A. 92:1995;2735-2739.
14. Krege J.H., et al. Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension. 29:1997;150-157.
15. Smithies O., et al. Importance of quantitative genetic variations in the etiology of hypertension. Kidney Int. 58:2000;2265-2280.
16. Takahashi N., Smithies O. Gene targeting approaches to analyzing hypertension. J. Am. Soc. Nephrol. 10:1999;1598-1605.
17. Krege J.H., et al. A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension. 25:1995;1111-1115.
18. Inoue I., et al. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J. Clin. Invest. 99:1997;1786-1797.
19. Mill J.G., Kaiser M. Analysis of phenotypic consequences of renin gene polymorphism in Lyon rats. Arq. Bras. Cardiol. 78:2002;425-438.
20. Yanai K., et al. Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J. Biol. Chem. 275:2000;5-8.
21. Rigat B., et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86:1990;1343-1346.
22. Resende L.A., et al. Alternate angiotensin II-forming pathways and their importance in physiological or physiopathological conditions. Arq. Neuropsiquiatr. 60:2002;563-565.
23. Boehm M., Nabel E.G. Angiotensin-converting enzyme 2-a new cardiac regulator. New Engl. J. Med. 347:2002;1795-1797.
24. Eriksson U., et al. Just the beginning: novel functions for angiotensin-converting enzymes. Curr. Biol. 12:2002;R745-R752.
25. Turner A.J., Hooper N.M. The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol. Sci. 23:2002;177-183.
26. Crackower M.A., et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417:2002;822-828.
27. Oudit G.Y., et al. The role of ACE2 in cardiovascular physiology. Trends Cardiovasc. Med. 13:2003;93-101.
28. Inagami T. Molecular biology and signaling of angiotensin receptors: an overview. J. Am. Soc. Nephrol. 10:(Suppl. 11):1999;S2-S7.
29. Oliverio M.I., et al. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc. Natl. Acad. Sci. U. S. A. 95:1998;15496-15501.
30. Oliverio M.I., et al. Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. Am. J. Physiol. 272:1997;F515-F520.
31. Takahashi N., et al. Computer simulations of blood pressure regulation. Endocrinology. 144:2003;2184-2190.
32. Murphey L.J., et al. Angiotensin-converting enzyme insertion/deletion polymorphism modulates the human in vivo metabolism of bradykinin. Circulation. 102:2000;829-832.
33. Campbell D.J., et al. Effects of converting enzyme inhibitors on angiotensin and bradykinin peptides. Hypertension. 23:1994;439-449.
34. Marre M., et al. Relationships between angiotensin I converting enzyme gene polymorphism, plasma levels, and diabetic retinal and renal complications. Diabetes. 43:1994;384-388.
35. Doria A., et al. Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I-converting enzyme gene. Diabetes. 43:1994;690-695.
36. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet. 355:2000;253-259.
37. Huang W., et al. Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse. Proc. Natl. Acad. Sci. U. S. A. 98:2001;13330-13334.
38. Greger R. Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Physiol. Rev. 65:1985;760-797.
39. Schnermann J., et al. Activation of tubulo-glomerular feedback by chloride transport. Pflugers Arch. 362:1976;229-240.
40. Takahashi N., et al. Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc. Natl. Acad. Sci. U. S. A. 97:2000;5434-5439.
41. Takahashi N., et al. Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene. J. Am. Soc. Nephrol. 13:2002;604-610.
42. Hummler E., et al. Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat. Genet. 12:1996;325-328.
43. Schultheis P.J., et al. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+exchanger. Nat. Genet. 19:1998;282-285.
44. Chou C.L., et al. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J. Clin. Invest. 103:1999;491-496.
45. Yang B., et al. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J. Biol. Chem. 276:2001;2775-2779.
46. Matsumura Y., et al. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Nat. Genet. 21:1999;95-98.
47. Knouff C., et al. Doubling expression of the low density lipoprotein receptor by truncation of the 3′-untranslated region sequence ameliorates type iii hyperlipoproteinemia in mice expressing the human apoe2 isoform. J. Biol. Chem. 276:2001;3856-3862.
48. Esther C.R. Jr, et al. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab. Invest. 74:1996;953-965.
49. Krege J.H., et al. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 375:1995;146-148.
50. Tanimoto K., et al. Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269:1994;31334-31337.
51. Kim H.S., et al. Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J. Biol. Chem. 274:1999;14210-14217.
52. Okubo S., et al. Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. Kidney Int. 53:1998;617-625.
53. Sugaya T., et al. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J. Biol. Chem. 270:1995;18719-18722.
54. Ito M., et al. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc. Natl. Acad. Sci. U. S. A. 92:1995;3521-3525.
55. Le T.H., et al. Physiogical impact of increases expression of the AT1 angiotensin receptor. Hypertension. 42:2003;507-514.
56. Chen X., et al. Targeting deletion of angiotensin type 1B receptor gene in the mouse. Am. J. Physiol. 272:1997;F299-F304.
57. Ichiki T., et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 377:1995;748-750.
58. Hein L., et al. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature. 377:1995;744-747.
59. Gross V., et al. Long-term blood pressure telemetry in AT2 receptor-disrupted mice. J. Hypertens. 18:2000;955-961.
60. Gross V., et al. Heart rate variability and baroreflex function in AT2 receptor- disrupted mice. Hypertension. 40:2002;207-213.
61. Madeddu P., et al. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation. 96:1997;3570-3578.
62. Emanueli C., et al. Enhanced blood pressure sensitivity to deoxycorticosterone in mice with disruption of bradykinin B2 receptor gene. Hypertension. 31:1998;1278-1283.
63. Emanueli C., et al. Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice. Circulation. 100:1999;2359-2365.
64. Cervenka L., et al. Early onset salt-sensitive hypertension in bradykinin B(2) receptor null mice. Hypertension. 34:1999;176-180.
65. Wang D.Z., et al. Hypotension in transgenic mice overexpressing human bradykinin B2 receptor. Hypertension. 29:1997;488-493.
66. Wang J., et al. Human tissue kallikrein induces hypotension in transgenic mice. Hypertension. 23:1994;236-243.
67. Clark A.F., et al. Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology. J. Biol. Chem. 272:1997;18185-18190.
68. Sharp M.G., et al. Targeted inactivation of the Ren-2 gene in mice. Hypertension. 28:1996;1126-1131.