Is RGS-2 a new drug development target in cardiovascular disease?

Expert Opinion on Therapeutic Targets

Volumn 8, Issue 4, 2004, Pages 355-358

  Doggrell, Sheila A ^a  

^a Doggrell Biomedical Communications   (New Zealand)

Author keywords

cGMP dependent protein kinase Type I (PKGI) ; Hypertension; Nitric oxide (NO) relaxation pathway; Regulator of G protein signalling (RGS) 2

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ACETYLCHOLINE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CANDESARTAN; CARDIOVASCULAR AGENT; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; ENDOTHELIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANYLATE CYCLASE INHIBITOR; INOSITOL 1,4,5 TRISPHOSPHATE; LEUCINE ZIPPER PROTEIN; NITRIC OXIDE; NITROPRUSSIDE SODIUM; NORADRENALIN; PHENYLEPHRINE; PROTEIN KINASE; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 1; RECOMBINANT PROTEIN; RECOMBINANT RGS PROTEIN 2; RGS PROTEIN; RGS2 PROTEIN; SEROTONIN; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR EFFECT; DRUG TARGETING; HYPERTENSION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN BINDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION; VIRUS IMMUNITY;

ANIMALS; CARDIOVASCULAR DISEASES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; HYPERTENSION; MICE; MICE, TRANSGENIC; RGS PROTEINS;

EID: 4344575064     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.8.4.355     Document Type: Article

References (6)

1. TANG M, WANG G, LU P et al.: Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat. Med (2003) 12:1506-1512.
2. HEXIMER SP, KNUTSEN RH, SUN X et al.: Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J. Clin. Invest. (2003) 111:445-452.
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4. SURKS HK, MOCHIZUKI N, KASAI Y et al.: Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase Iα. Science (1999) 19:1583-1587.
5. OLIVEIRA-DOS-SANTOS AJ, MATSUMOTO G, SNOW BE et al.: Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc. Natl. Acad. Sci. USA (2000) 97:12272-12277.
6. BERNSTEIN LS, RAMINENI S, HAGUE C et al.: RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11α signaling. J. Biol. Chem. (2004) 279:21248-21256.