Genetic models of hypertension in experimental animals

Experimental Nephrology

Volumn 9, Issue 1, 2001, Pages 1-9

  Yagil, Yoram ^a   Yagil, Chana ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Biochips; Congenics; Consomics; Differential gene expression; Expressed sequence tags; Homology; Inbred strains; Molecular genetics; Rats; Synteny; Transgenics

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ATRIAL NATRIURETIC FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN 1; KALLIKREIN; NITRIC OXIDE SYNTHASE; RENIN;

DIABETES MELLITUS; DNA MICROARRAY; EXPRESSED SEQUENCE TAG; GENE EXPRESSION; GENE MAPPING; HYPERTENSION; INBRED STRAIN; KIDNEY PARENCHYMA; MOLECULAR GENETICS; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RAT STRAIN; SALT INTAKE; SEQUENCE HOMOLOGY; SHORT SURVEY; SPONTANEOUSLY HYPERTENSIVE RAT; STRESS; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD PRESSURE DETERMINATION; CHROMOSOME MAPPING; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENETIC TECHNIQUES; HYPERTENSION; PEDIGREE; PHENOTYPE; RATS; RATS, INBRED STRAINS;

EID: 0035227829     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (48)

1. Lessons from rat models of hypertension: From Goldblatt to genetic engineering
2. A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes
3. A radiation hybrid map of the rat genome containing 5,255 markers
4. A look for the future
5. Cortical and medullary hemodynamics in desoxycorticosterone acetate-salt hypertensive mice
6. Pressure diuresis and natriuresis in DOCA-salt mice
7. Transgenic animals: New models in hypertension research
8. Hypertension-induced end-organ damage: A new transgenic approach to an old problem
9. Exaggerated natriuresis in transgenic (mRen2)27 rats
10. A primer on the genetics of hypertension
11. Detection and positional cloning of blood pressure quantitative trait loci: Is it possible? Identifying the genes for genetic hypertension
12. Use of recombinant inbred strains for evaluation of intermediate phenotypes in spontaneous hypertension
13. The Cohen diabetic (non-insulin dependent) hypertensive rat model. Description of the model and pathologic findings
14. Characterization of new inbred strains of Dahl-Iwai salt-sensitive and salt-resistant rats
15. Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of salt sensitivity and resistance
16. Salt-induced hypertension in normotensive spontaneously hypertensive rats
17. The Milan hypertensive strain: A description of the model
18. Developmental influences on blood pressure regulation in ISIAH rats
19. Hyper-responsiveness of adrenal sympathetic nerve activity in spontaneously hypertensive rats to ganglionic blockade, mental stress and neuronglucopenia
20. Effect of stress and food restriction on blood pressure and lifespan of Dahl salt-sensitive rats
21. Renal disease susceptibility and hypertension are under independent genetic control in the Fawn-Hooded rat
22. Diabetes and hypertension: Experimental models for pharmacological studies
23. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease
24. Genetic and gender influences on sensitivity to focal cerebral ischemia in the stroke-prone spontaneously hypertensive rat
25. Susceptibility to cerebral infarction in the stroke-prone spontaneously hypertensive rat is inherited as a dominant trait
26. Telemetry for cardiovascular monitoring in a pharmacological study: New approaches to data analysis
27. Superoxide production is increased in a model of genetic hypertension: Role of endothelium
28. Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus
29. Genetic mapping of two new blood pressure quantitative trait loci by genotyping endothelin system genes
30. G proteins propel surprise
31. Role of the α, β and γ subunits of epithelial sodium channel in a model of polygenic hypertension
32. Genes encoding atrial and brain natriuretic peptides as candidates for sensitivity to brain ischemia in stroke-prone hypertensive rats
33. A gene map of the human genome
34. A genetic linkage map of the laboratory rat
35. An integrated genetic linkage map of the laboratory rat
36. Comparative gene-expression analysis
37. Genomics and hypertension: Concepts, potentials, and opportunities
38. High throughput analysis of differential gene expression
39. High density synthetic oligonucleotide arrays
40. Identifying candidate genes for blood pressure quantitative trait loci using differential gene expression and a panel of congenic strains
41. The emergence of physiological genomics
42. The Bansbury conference: Genomics to physiology and beyond: How do we get there?
43. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage in the rat chromosome 10
44. Two point mutations within the adducin gene are involved in blood pressure variation
45. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension
46. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease
47. The gene encoding atrial natriuretic peptide and the risk of human stroke
48. Genes encoding atrial and brain natriuretic peptides as candidate genes for sensitivity to brain ischemia in stroke-prone hypertensive rats