Avicin D: A protein reactive plant isoprenoid dephosphorylates Stat3 by regulating both kinase and phosphatase activities

PLoS ONE

Volumn 4, Issue 5, 2009, Pages

  Haridas, Valsala ^a   Nishimura, Goshi ^a,c   Xu, Zhi Xiang ^a   Connolly, Fiona ^a   Hanausek, Margaret ^b   Walaszek, Zbigniew ^b   Zoltaszek, Robert ^b   Gutterman, Jordan U ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; AVICIN D; CYCLIN D1; JANUS KINASE; MYC PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN BCL 2; STAT3 PROTEIN; SURVIVIN; UNCLASSIFIED DRUG; VASCULOTROPIN; 7,12 DIMETHYLBENZ[A]ANTHRACENE; CARCINOGEN; PHOSPHOPROTEIN PHOSPHATASE; SAPONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SKIN CANCER; ANIMAL; CELL LINE; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; METABOLISM; MULTIPLE MYELOMA; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; WESTERN BLOTTING;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CARCINOGENS; CELL LINE; CELL LINE, TUMOR; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOHISTOCHEMISTRY; JANUS KINASES; MICE; MICROSCOPY, FLUORESCENCE; MULTIPLE MYELOMA; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; SAPONINS; STAT3 TRANSCRIPTION FACTOR;

EID: 65949117606     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005578     Document Type: Article

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