Epigallocatechin-3-gallate inhibits activation of HER-2/neu and downstream signaling pathways in human head and neck and breast carcinoma cells

Clinical Cancer Research

Volumn 9, Issue 9, 2003, Pages 3486-3491

  Masuda, Muneyuki ^a   Suzui, Masumi ^a   Lim, Jin T E ^a   Weinstein, I Bernard ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; EPIGALLOCATECHIN GALLATE; PACLITAXEL; PROTEIN BCL XL; STAT3 PROTEIN;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE ACTIVATION; GENE OVEREXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; INHIBITION KINETICS; ONCOGENE C FOS; ONCOGENE NEU; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOMA; CATECHIN; CELL DIVISION; CELL LINE, TUMOR; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOBLOTTING; LUCIFERASES; PACLITAXEL; PHOSPHORYLATION; PROGNOSIS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-FOS; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 0041333067     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Olayioye, M. A., Neve, R. M., Lane, H. A., and Hynes, N. E. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J., 19: 3159-3167, 2000.
2. Yu, D., and Hung, M. C. Overexpression of ErbB2 in cancer and ErbB2-targeting strategies. Oncogene, 19: 6115-6121, 2000.
3. Xia, W., Lau, Y. K., Zhang, H. Z., Xiao, F. Y., Johnston, D. A., Liu, A. R., Li, L., Katz, R. L., and Hung, M. C. Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin. Cancer Res., 5: 4164-4174, 1999.
4. Masuda, M., Suzui, M., and Weinstein, I. B. Effects of epigallocatechin-3-gallate (EGCG) on growth, epidermal growth factor receptor signaling pathways, gene expression and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin. Cancer Res., 7: 4220-4229, 2001.
5. Pianetti, S., Guo, S., Kavnagh, K. T., and Sonenshein, G. E. Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/Neu signaling, proliferation and transformed phenotype of breast cancer cells. Cancer Res., 62: 652-655, 2002.
6. Fernandes, A., Hamburger, A. W., and Gerwin, B. I. ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells. Int. J. Cancer, 83: 564-570, 1999.
7. Leaman, D. W., Pisharody, B., Flickinger, T. W., Commane, M. A., Schlessinger, J., Kerr, I. M., Levy, D. E., and Stark, G. R. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol. Cell Biol., 16: 369-375, 1996.
8. Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., and Darnell, J. E. J. Stat3 as an oncogene. Cell, 98: 295-303, 1999.
9. Zushi, S., Shinomura, Y., Kiyohara, T., Miyazaki, Y., Kondo, S., Sugimachi, M., Higashimoto, Y., Kanayama, S., and Matsuzawa, Y. STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells. Int. J. Cancer, 78: 326-330, 1998.
10. Ueno, N. T., Yu, D., and Hung, M. C. Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A. Oncogene, 15: 953-960, 1997.
11. Hortobagyi, G. N. Developments in chemotherapy of breast cancer. Cancer (Phila.), 88: 3073-3079, 2000.
12. Choy, H. Taxanes in combined modality therapy for solid tumors. Crit. Rev. Oncol. Hematol., 37: 237-247, 2001.
13. Masuda, M., Toh, S., Koike, K., Kuratomi, Y., Suzui, M., Deguchi, A., Komiyama, S., and Weinstein, I. B. The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil. Jpn. J. Cancer Res., 93: 329-339, 2002.
14. Harris, L. N., Yang, L., Liotcheva, V., Pauli, S., Iglehart, J. D., Colvin, O. M., and Hsieh, T. S. Induction of topoisomerase II activity after ErbB2 activation is associated with a differential response to breast cancer chemotherapy. Clin. Cancer Res., 7: 1497-1504, 2001.
15. Masuda, M., Suzui, M., Lim, J. T. E., Deguchi, A., Soh, J. W., and Weinstein, I. B. Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction. J. Exp. Ther. Oncol., 2: 350-359, 2002.
16. Bowman, T., Garcia, R., Turkson, J., and Jove, R. STATs in oncogenesis. Oncogene, 19: 2474-2488, 2000.
17. Song, J. I., and Grandis, J. R. STAT signaling in head and neck cancer. Oncogene, 19: 2489-2495, 2000.
18. Garcia, R., Bowman, T. L., Niu, G., Yu, H., Minton, S., Muro-Cacho, C. A., Cox, C. E., Falcone, R., Fairclough, R., Parsons, S., Laudano, A., Gazit, A., Levitzki, A., Kraker, A., and Jove, R. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene, 20: 2499-2513, 2001.
19. Chow, H. S., Cai, Y., Alberts, D. S., Hakim, I., Dorr, R., Shahi, F., Crowell, J. A., Yang, C. S., and Hara, Y. Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol. Biomark. Prev., 10: 53-58, 2001.
20. Yang, C. S., Chen, L., Lee, M. J., Balentine, D., Kuo, M. C., and Schantz, S. P. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol. Biomark. Prev., 7: 351-354, 1998.
21. Liang, Y. C., Lin-shiau, S. Y., Chen, C. F., and Lin, J. K. Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells. J. Cell. Biochem., 67: 55-65, 1997.
22. Sachinidis, A., Seul, C., Seewald, S., Ahn, H., Ko, Y., and Vetter, H. Green tea compounds inhibit tyrosine phosphorylation of PDGF β-receptor and transformation of A172 human glioblastoma. FEBS Lett., 471: 51-55, 2000.
23. Lamy, S., Gingras, D., and Beliveau, R. Green tea catechins inhibit endothelial growth factor receptor phosphorylation. Cancer Res., 62: 381-385, 2002.
24. Meiers, S., Kemeny, M., Weyand, U., Gastpar, R., von Angerer, E., and Marko, D. The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J. Agric. Food Chem., 49: 958-962, 2001.