Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 10, 2001, Pages 5821-5826

  Haridas, Valsala ^a   Higuchi, Masahiro ^b   Jayatilake, Gamini S ^c   Bailey, David ^c   Mujoo, Kalpana ^a   Blake, Mary E ^d   Arntzen, Charles J ^d,e   Gutterman, Jordan U ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Hauser Laboratories   (United States)

^d United States Department of Agriculture Agricultural Research Service and Boyce Thompson Institute for Plant Research   (United States)

^e ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Caspases; Cytochrome c; Membrane potential; Mitochondria; ROS

Indexed keywords

ANNEXIN; AVICIN; AVICIN G; CASPASE 3; CASPASE INHIBITOR; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; SAPONIN; TRITERPENOID; UNCLASSIFIED DRUG;

ACACIA VICTORIAE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL FRACTIONATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRION; PLANT; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

APOPTOSIS; CARBOHYDRATE SEQUENCE; CASPASES; CYTOCHROME C GROUP; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; MEMBRANE POTENTIALS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; REACTIVE OXYGEN SPECIES; ROSALES; SAPONINS; TRITERPENES;

ACACIA VICTORIAE; FABACEAE;

EID: 0035826692     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.101619098     Document Type: Article

References (46)

1. Jacobson, M. D., Weil, M. & Raff, M. C. (1997) Cell 88, 347-354.
2. Thompson, C. B. (1995) Science 267, 1456-1462.
3. Ashkenazi, A. & Dixit, V. M. (1998) Science 281, 1305-1308.
4. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., et al. (1998) Cell 94, 339-352.
5. Green, D. R. & Reed, J. C. (1998) Science 281, 1309-1312.
6. Nicholson, D. W. & Thornberry, N. A. (1997) Trends Biochem. Sci. 22, 299-306.
7. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S, & Dixit, V. M. (1995) Cell 81, 801-809.
8. Pezzuto, J. M. (1997) Biochem. Pharmacol. 53, 121-133.
9. Vyas, D. M. & Kadow, J. F. (1995) Prog. Med. Chem. 32, 289-337.
10. Pommier, Y., Kohlhagen, G., Kohn, K. W., Leteurtre, F., Wani, M. C. & Wall, M. E. (1995) Proc. Natl. Acad. Sci. USA 92, 8861-8865.
11. Allen, O. N. & Allen, E. K. (1981) The Leguminosae: A Sourcebook of Characteristics, Uses and Modulation (Univ. of Wisconsin Press, Madison, WI).
12. Ali, M., Heaton, A. & Leach, D. (1997) J. Nat. Prod. 60, 1150-1151.
13. Hansen, M. B., Nielsen, S. E. & Berg, K. (1989) J. Immunol. Methods 119, 203-210.
14. Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., La Face, D. M. & Green, D. R. (1995) J. Exp. Med. 182, 1545-1556.
15. Enari, M., Hug, H. & Nagata, S. (1995) Nature (London) 375, 78-81.
16. Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B. & Kroemer, G. (1995) J. Exp. Med. 182, 367-377.
17. Oridate, N., Suzuki, S., Higuchi, M., Mitchell, M. F., Hong, W. K. & Lotan, R. (1997) J. Natl. Cancer Inst. 89, 1191-1198.
18. Raff, M. C. (1992) Nature (London) 356, 397-400.
19. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W. & Vogelstein, B. (1997) Nature (London) 389, 300-305.
20. Basu, S., Bayoumy, S., Zhang, Y., Lozano, J. & Kolesnick, R. (1998) J. Biol. Chem. 273, 30419-30426.
21. Friesen, C., Herr, I., Krammer, P. H. & Debatin, K.-M. (1996) Nat. Med. 2, 574-577.
22. Schutte, B., Nuydens, R., Geerts, H. & Ramaekers, F. (1998) J. Neurosci. Methods 86, 63-69.
23. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P. & Wang, X. (1997) Science 275, 1129-1132.
24. Kluck, R. M., Bossy-Wetzel, E., Green, D. R. & Newmeyer, D. D. (1997) Science 275, 1132-1136.
25. Zou, H., Henzel, W. J., Liu, X., Lutschg, A. & Wang, X. (1997) Cell 90, 405-413.
26. Kuwana, T., Smith, J. J., Muzio, M., Dixit, V. M., Newmeyer, D. & Kornbluth, S. (1988) J. Biol. Chem. 273, 16589-16594.
27. Petit, P. X., Susin, S-A., Zamzami, N., Mignotte, B. & Kroemer, G. (1996) FEBS Lett. 396, 7-13.
28. Manon, S., Chaudhari, B. & Guerin, M. (1997) FEBS Lett. 415, 29-32.
29. Vander Heiden, M. G., Chandel, N., Schumacker, P. T. & Thompson, C. B. (1999) Mol. Cell 3, 159-167.
30. Marzo, I., Brenner, C., Zamzami, N., Susin, S. A., Beutner, G., Brdiczka, D., Xie, Z.-H., Reed, J. C. & Kroemer, G. (1998) J. Exp. Med. 187, 1261-1271.
31. Korsmeyer, S. J. (1995) Trends Genet. 11, 101-105.
32. Skulachev, V. P. (1998) FEBS Lett. 423, 275-280.
33. Na, S., Chuang, T.-H., Cunningham, A., Turi, T. G., Hanke, J. H., Bokoch, G. M. & Danley, D. E. (1996) J. Biol. Chem. 271, 11209-11213.
34. Costantini, P., Jacotot, E., Decaudin, D. & Kroemer, G. (2000) J. Natl. Cancer Inst. 92, 1042-1053.
35. Pisha, E., Chai, H., Lee, I. S., Chagwedera, T. E., Farnsworth, N. R., Cordell, G. A., Beecher, C. W., Fong, H. H., Kinghorn, A. D., Brown, D. M., et al. (1995) Nat. Med. 1, 1046-1051.
36. Fulda, S., Friesen, C., Los, M., Scaffidi, C., Benendict, M., Nunez, G., Krammer, P. H., Peter, M. E. & Debatin, K.-M. (1997) Cancer Res. 57, 4956-4964.
37. Beutler, J. A., Kashman, Y., Pannell, L. K., Cardellina, J. H., Alexander, R. A., Balaschak, M. S., Prather, T. R., Shoemaker, R. H. & Boyd, M. R. (1997) Bioorg. Med. Chem. 5, 1509-1517.
38. Harrington, E. A., Fanidi, A. & Evan, G. I. (1994) Curr. Opin. Genet. Dev. 4, 120-129.
39. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Frisch, S. & Reed, J. C. (1998) Science 282, 1318-1321.
40. Soengas, M. S., Alarcon, R. M., Yoshida, H., Giaccia, A. J., Hakem, R., Mak, T. W. & Lowe, S. W. (1999) Science 284, 156-159.
41. Gross, A., McDonnell, J. M. & Korsmeyer, S. J. (1999) Genes Dev. 13, 1899-1911.
42. Ourisson, G. & Nakatani, Y. (1994) Chem. Biol. 1, 11-23.
43. Gray, M. W., Burger, G. & Lang, B. F. (1999) Science 283, 1476-1481.
44. Clardy, J. (1995) Proc. Natl. Acad. Sci. USA 92, 56-61.
45. Schrieber, S. L. (1998) Bioorg. Med. Chem. 6, 1127-1152.
46. Mujoo, K., Haridas, V., Hoffman, J. J., Wächter, G. A., Hutter, L. K., Yilling, L., Blake, M. E., Jayatilake, G. S., Bailey, D., Mills, G. B., et al. (2001) Cancer Res., in press.