메뉴 건너뛰기




Volumn 47, Issue , 2009, Pages 203-220

Mammalian bitter taste perception

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

EID: 65449159720     PISSN: 00801844     EISSN: 18610412     Source Type: Book Series    
DOI: 10.1007/400_2008_5     Document Type: Review
Times cited : (65)

References (87)
  • 2
    • 0001075372 scopus 로고
    • Taste thresholds of further eighteen compounds and their correlation with P.T.C thresholds
    • Barnicot NA, Harris H, Kalmus H (1951) Taste thresholds of further eighteen compounds and their correlation with P.T.C thresholds. Ann Eugen 16:119-128
    • (1951) Ann Eugen , vol.16 , pp. 119-128
    • Barnicot, N.A.1    Harris, H.2    Kalmus, H.3
  • 3
    • 0033870723 scopus 로고    scopus 로고
    • Comparing sensory experiences across individuals: Recent psychophysical advances illuminate genetic variation in taste perception
    • Bartoshuk LM (2000) Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem Senses 25:447-460
    • (2000) Chem Senses , vol.25 , pp. 447-460
    • Bartoshuk, L.M.1
  • 5
    • 36248977649 scopus 로고    scopus 로고
    • Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells
    • Behrens M, Foerster S, Staehler F, Raguse JD, Meyerhof W (2007) Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J Neurosci 27:12630-12640
    • (2007) J Neurosci , vol.27 , pp. 12630-12640
    • Behrens, M.1    Foerster, S.2    Staehler, F.3    Raguse, J.D.4    Meyerhof, W.5
  • 6
    • 33746639193 scopus 로고    scopus 로고
    • Bitter taste receptors and human bitter taste perception
    • Behrens M, Meyerhof W (2006) Bitter taste receptors and human bitter taste perception. Cell Mol Life Sci 63:1501-1509
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1501-1509
    • Behrens, M.1    Meyerhof, W.2
  • 7
    • 0013816757 scopus 로고
    • Renewal of cells within taste buds
    • Beidler LM, Smallman RL (1965) Renewal of cells within taste buds. J Cell Biol 27:263-272
    • (1965) J Cell Biol , vol.27 , pp. 263-272
    • Beidler, L.M.1    Smallman, R.L.2
  • 8
    • 0021959996 scopus 로고
    • Neurophysiology of geniculate ganglion (facial nerve) taste systems: Species comparisons
    • Boudreau JC, Sivakumar L, Do LT, White TD, Oravec J, Hoang NK (1985) Neurophysiology of geniculate ganglion (facial nerve) taste systems: species comparisons. Chem Senses 10:89-127
    • (1985) Chem Senses , vol.10 , pp. 89-127
    • Boudreau, J.C.1    Sivakumar, L.2    Do, L.T.3    White, T.D.4    Oravec, J.5    Hoang, N.K.6
  • 10
    • 26444570954 scopus 로고    scopus 로고
    • Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli
    • Boughter JD Jr, Raghow S, Nelson TM, Munger SD (2005) Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli. BMC Genet 6:36
    • (2005) BMC Genet , vol.6 , pp. 36
    • Boughter Jr, J.D.1    Raghow, S.2    Nelson, T.M.3    Munger, S.D.4
  • 11
    • 27944456846 scopus 로고    scopus 로고
    • Differential covariation in taste responsiveness to bitter stimuli in rats
    • Brasser SM, Mozhui K, Smith DV (2005) Differential covariation in taste responsiveness to bitter stimuli in rats. Chem Senses 30:793-799
    • (2005) Chem Senses , vol.30 , pp. 793-799
    • Brasser, S.M.1    Mozhui, K.2    Smith, D.V.3
  • 12
    • 34547802810 scopus 로고    scopus 로고
    • Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
    • Brockhoff A, Behrens M, Massarotti A, Appendino G, Meyerhof W (2007) Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. J Agric Food Chem 55:6236-6243
    • (2007) J Agric Food Chem , vol.55 , pp. 6236-6243
    • Brockhoff, A.1    Behrens, M.2    Massarotti, A.3    Appendino, G.4    Meyerhof, W.5
  • 13
    • 0015716261 scopus 로고
    • Electrophysiological study of the gustatory effects of the sweet proteins monellin and thaumatin in monkey, guinea pig and rat
    • Brouwer JN, Hellekant G, Kasahara Y, van der Wel H, Zotterman Y (1973) Electrophysiological study of the gustatory effects of the sweet proteins monellin and thaumatin in monkey, guinea pig and rat. Acta Physiol Scand 89:550-557
    • (1973) Acta Physiol Scand , vol.89 , pp. 550-557
    • Brouwer, J.N.1    Hellekant, G.2    Kasahara, Y.3    van der Wel, H.4    Zotterman, Y.5
  • 14
    • 0036844351 scopus 로고    scopus 로고
    • The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    • Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002) The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet 32:397-401
    • (2002) Nat Genet , vol.32 , pp. 397-401
    • Bufe, B.1    Hofmann, T.2    Krautwurst, D.3    Raguse, J.D.4    Meyerhof, W.5
  • 16
    • 0035936911 scopus 로고    scopus 로고
    • Taste receptor cells that discriminate between bitter stimuli
    • Caicedo A, Roper SD (2001) Taste receptor cells that discriminate between bitter stimuli. Science 291:1557-1560
    • (2001) Science , vol.291 , pp. 1557-1560
    • Caicedo, A.1    Roper, S.D.2
  • 18
    • 0035789507 scopus 로고    scopus 로고
    • Immunocytochemical evidence for co-expression of type III IP3 receptor with signaling components of bitter taste transduction
    • Clapp TR, Stone LM, Margolskee RF, Kinnamon SC (2001) Immunocytochemical evidence for co-expression of type III IP3 receptor with signaling components of bitter taste transduction. BMC Neurosci 2:6
    • (2001) BMC Neurosci , vol.2 , pp. 6
    • Clapp, T.R.1    Stone, L.M.2    Margolskee, R.F.3    Kinnamon, S.C.4
  • 19
    • 0016285076 scopus 로고
    • Human taste responses as a function of locus of stimulation on the tongue and soft palate
    • Collings VB (1974) Human taste responses as a function of locus of stimulation on the tongue and soft palate. Percept Psychophys 16:169-174
    • (1974) Percept Psychophys , vol.16 , pp. 169-174
    • Collings, V.B.1
  • 20
    • 0030915416 scopus 로고    scopus 로고
    • Neural responses to bitter compounds in rats
    • Dahl M, Erickson RP, Simon SA (1997) Neural responses to bitter compounds in rats. Brain Res 756:22-34
    • (1997) Brain Res , vol.756 , pp. 22-34
    • Dahl, M.1    Erickson, R.P.2    Simon, S.A.3
  • 22
    • 0035404424 scopus 로고    scopus 로고
    • Covariation in individuals' sensitivities to bitter compounds: Evidence supporting multiple receptor/ transduction mechanisms
    • Delwiche JF, Buletic Z, Breslin PA (2001) Covariation in individuals' sensitivities to bitter compounds: Evidence supporting multiple receptor/ transduction mechanisms. Percept Psychophys 63:761-776
    • (2001) Percept Psychophys , vol.63 , pp. 761-776
    • Delwiche, J.F.1    Buletic, Z.2    Breslin, P.A.3
  • 23
    • 24944469668 scopus 로고    scopus 로고
    • PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands
    • Dotson CD, Roper SD, Spector AC (2005) PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands. Chem Senses 30:593-600
    • (2005) Chem Senses , vol.30 , pp. 593-600
    • Dotson, C.D.1    Roper, S.D.2    Spector, A.C.3
  • 24
    • 0018890254 scopus 로고
    • Renewal of taste bud cells in rat circumvallate papillae
    • Farbman AI (1980) Renewal of taste bud cells in rat circumvallate papillae. Cell Tissue Kinet 13:349-357
    • (1980) Cell Tissue Kinet , vol.13 , pp. 349-357
    • Farbman, A.I.1
  • 27
    • 0000146036 scopus 로고
    • The relationship between chemical constitution and taste
    • Fox AL (1932) The relationship between chemical constitution and taste. Proc Natl Acad Sci USA 18:115-120
    • (1932) Proc Natl Acad Sci USA , vol.18 , pp. 115-120
    • Fox, A.L.1
  • 28
    • 33751255052 scopus 로고    scopus 로고
    • Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli
    • Geran LC, Travers SP (2006) Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. J Neurophysiol 96:2513-2527
    • (2006) J Neurophysiol , vol.96 , pp. 2513-2527
    • Geran, L.C.1    Travers, S.P.2
  • 29
    • 0037672155 scopus 로고    scopus 로고
    • TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel
    • Hofmann T, Chubanov V, Gudermann T, Montell C (2003) TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol 13:1153-1158
    • (2003) Curr Biol , vol.13 , pp. 1153-1158
    • Hofmann, T.1    Chubanov, V.2    Gudermann, T.3    Montell, C.4
  • 30
    • 0033582645 scopus 로고    scopus 로고
    • Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity
    • Hoon MA, Adler E, Lindemeier J, Battey JF, Ryba NJ, Zuker CS (1999) Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity. Cell 96:541-551
    • (1999) Cell , vol.96 , pp. 541-551
    • Hoon, M.A.1    Adler, E.2    Lindemeier, J.3    Battey, J.F.4    Ryba, N.J.5    Zuker, C.S.6
  • 33
  • 34
    • 2542538634 scopus 로고    scopus 로고
    • A psychophysical investigation of binary bitter-compound interactions
    • Keast RS, Bournazel MM, Breslin PA (2003) A psychophysical investigation of binary bitter-compound interactions. Chem Senses 28:301-313
    • (2003) Chem Senses , vol.28 , pp. 301-313
    • Keast, R.S.1    Bournazel, M.M.2    Breslin, P.A.3
  • 35
    • 0037458815 scopus 로고    scopus 로고
    • Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    • Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D (2003) Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299:1221-1225
    • (2003) Science , vol.299 , pp. 1221-1225
    • Kim, U.K.1    Jorgenson, E.2    Coon, H.3    Leppert, M.4    Risch, N.5    Drayna, D.6
  • 36
    • 24344435450 scopus 로고    scopus 로고
    • Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci
    • Kim U, Wooding S, Ricci D, Jorde LB, Drayna D (2005) Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat 26:199-204
    • (2005) Hum Mutat , vol.26 , pp. 199-204
    • Kim, U.1    Wooding, S.2    Ricci, D.3    Jorde, L.B.4    Drayna, D.5
  • 40
    • 0344149569 scopus 로고    scopus 로고
    • Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5
    • Liu D, Liman ER (2003) Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci USA 100:15160-15165
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15160-15165
    • Liu, D.1    Liman, E.R.2
  • 42
    • 0034611738 scopus 로고    scopus 로고
    • A family of candidate taste receptors in human and mouse
    • Matsunami H, Montmayeur JP, Buck LB (2000) A family of candidate taste receptors in human and mouse. Nature 404:601-604
    • (2000) Nature , vol.404 , pp. 601-604
    • Matsunami, H.1    Montmayeur, J.P.2    Buck, L.B.3
  • 43
    • 0026718951 scopus 로고
    • Gustducin is a taste-cell-specific G protein closely related to the transducins
    • McLaughlin SK, McKinnon PJ, Margolskee RF (1992) Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357:563-569
    • (1992) Nature , vol.357 , pp. 563-569
    • McLaughlin, S.K.1    McKinnon, P.J.2    Margolskee, R.F.3
  • 46
    • 33845767337 scopus 로고    scopus 로고
    • Secretory cells of the airway express molecules of the chemoreceptive cascade
    • Merigo F, Benati D, Di Chio M, Osculati F, Sbarbati A (2007) Secretory cells of the airway express molecules of the chemoreceptive cascade. Cell Tissue Res 327:231-247
    • (2007) Cell Tissue Res , vol.327 , pp. 231-247
    • Merigo, F.1    Benati, D.2    Di Chio, M.3    Osculati, F.4    Sbarbati, A.5
  • 48
    • 0025279095 scopus 로고
    • Variations in human taste bud density and taste intensity perception
    • Miller IJ Jr, Reedy FE Jr (1990) Variations in human taste bud density and taste intensity perception. Physiol Behav 47:1213-1219
    • (1990) Physiol Behav , vol.47 , pp. 1213-1219
    • Miller Jr, I.J.1    Reedy Jr, F.E.2
  • 49
    • 0030921657 scopus 로고    scopus 로고
    • Taste buds have a cyclic nucleotide-activated channel, CNGgust
    • Misaka T, Kusakabe Y, Emori Y, Gonoi T, Arai S, Abe K (1997) Taste buds have a cyclic nucleotide-activated channel, CNGgust. J Biol Chem 272:22623-22629
    • (1997) J Biol Chem , vol.272 , pp. 22623-22629
    • Misaka, T.1    Kusakabe, Y.2    Emori, Y.3    Gonoi, T.4    Arai, S.5    Abe, K.6
  • 51
    • 0031009293 scopus 로고    scopus 로고
    • Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus
    • Ogura T, Mackay-Sim A, Kinnamon SC (1997) Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus. J Neurosci 17:3580-3587
    • (1997) J Neurosci , vol.17 , pp. 3580-3587
    • Ogura, T.1    Mackay-Sim, A.2    Kinnamon, S.C.3
  • 52
    • 1942485954 scopus 로고    scopus 로고
    • Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways
    • Ozeck M, Brust P, Xu H, Servant G (2004) Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways. Eur J Pharmacol 489:139-149
    • (2004) Eur J Pharmacol , vol.489 , pp. 139-149
    • Ozeck, M.1    Brust, P.2    Xu, H.3    Servant, G.4
  • 54
    • 0038650737 scopus 로고    scopus 로고
    • Making sense with TRP channels: Store-operated calcium entry and the ion channel Trpm5 in taste receptor cells
    • Perez CA, Margolskee RF, Kinnamon SC, Ogura T (2003) Making sense with TRP channels: Store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium 33:541-549
    • (2003) Cell Calcium , vol.33 , pp. 541-549
    • Perez, C.A.1    Margolskee, R.F.2    Kinnamon, S.C.3    Ogura, T.4
  • 56
    • 8544242989 scopus 로고    scopus 로고
    • Identification of ligands for two human bitter T2R receptors
    • Pronin AN, Tang H, Connor J, Keung W (2004) Identification of ligands for two human bitter T2R receptors. Chem Senses 29:583-593
    • (2004) Chem Senses , vol.29 , pp. 583-593
    • Pronin, A.N.1    Tang, H.2    Connor, J.3    Keung, W.4
  • 57
    • 34547858150 scopus 로고    scopus 로고
    • Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin
    • Pronin AN, Xu H, Tang H, Zhang L, Li Q, Li X (2007) Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Curr Biol 17:1403-1408
    • (2007) Curr Biol , vol.17 , pp. 1403-1408
    • Pronin, A.N.1    Xu, H.2    Tang, H.3    Zhang, L.4    Li, Q.5    Li, X.6
  • 58
    • 65449151987 scopus 로고    scopus 로고
    • Rolls E (ed.) (1995) Central taste anatomy and neurophysiology. Dekker, New York Rossler P, Kroner C, Freitag J, Noe J, Breer H (1998) Identification of a phospholipase C beta subtype in rat taste cells. Eur J Cell Biol 77:253-261
    • Rolls E (ed.) (1995) Central taste anatomy and neurophysiology. Dekker, New York Rossler P, Kroner C, Freitag J, Noe J, Breer H (1998) Identification of a phospholipase C beta subtype in rat taste cells. Eur J Cell Biol 77:253-261
  • 59
    • 0033624203 scopus 로고    scopus 로고
    • G protein betagamma complexes in circumvallate taste cells involved in bitter transduction
    • Rossler P, Boekhoff I, Tareilus E, Beck S, Breer H, Freitag J (2000) G protein betagamma complexes in circumvallate taste cells involved in bitter transduction. Chem Senses 25:413-421
    • (2000) Chem Senses , vol.25 , pp. 413-421
    • Rossler, P.1    Boekhoff, I.2    Tareilus, E.3    Beck, S.4    Breer, H.5    Freitag, J.6
  • 62
    • 17444403967 scopus 로고    scopus 로고
    • A new fate for old cells: Brush cells and related elements
    • Sbarbati A, Osculati F (2005) A new fate for old cells: Brush cells and related elements. J Anat 206:349-358
    • (2005) J Anat , vol.206 , pp. 349-358
    • Sbarbati, A.1    Osculati, F.2
  • 64
    • 0022552072 scopus 로고
    • Rats show only a weak preference for the artificial sweetener aspartame
    • Sclafani A, Abrams M (1986) Rats show only a weak preference for the artificial sweetener aspartame. Physiol Behav 37:253-256
    • (1986) Physiol Behav , vol.37 , pp. 253-256
    • Sclafani, A.1    Abrams, M.2
  • 65
    • 0033781033 scopus 로고    scopus 로고
    • Taste as a factor in the management of nutrition
    • Scott TR, Verhagen JV (2000) Taste as a factor in the management of nutrition. Nutrition 16:874-885
    • (2000) Nutrition , vol.16 , pp. 874-885
    • Scott, T.R.1    Verhagen, J.V.2
  • 66
    • 30744472932 scopus 로고    scopus 로고
    • Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes
    • Shi P, Zhang J (2006) Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol Biol Evol 23:292-300
    • (2006) Mol Biol Evol , vol.23 , pp. 292-300
    • Shi, P.1    Zhang, J.2
  • 67
    • 65449170902 scopus 로고    scopus 로고
    • Shi P, Zhang J (2008) Extraordinary diversity of chemosensory receptor gene repertoires among vertebrates. Results Probl Cell Differ doi: 400_2008_4
    • Shi P, Zhang J (2008) Extraordinary diversity of chemosensory receptor gene repertoires among vertebrates. Results Probl Cell Differ doi: 400_2008_4
  • 68
    • 0038708520 scopus 로고    scopus 로고
    • Adaptive diversification of bitter taste receptor genes in Mammalian evolution
    • Shi P, Zhang J, Yang H, Zhang YP (2003) Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol 20:805-814
    • (2003) Mol Biol Evol , vol.20 , pp. 805-814
    • Shi, P.1    Zhang, J.2    Yang, H.3    Zhang, Y.P.4
  • 70
  • 72
    • 0036522960 scopus 로고    scopus 로고
    • Rats fail to discriminate quinine from denatonium: Implications for the neural coding of bitter-tasting compounds
    • Spector AC, Kopka SL (2002) Rats fail to discriminate quinine from denatonium: Implications for the neural coding of bitter-tasting compounds. J Neurosci 22:1937-1941
    • (2002) J Neurosci , vol.22 , pp. 1937-1941
    • Spector, A.C.1    Kopka, S.L.2
  • 75
    • 0042739015 scopus 로고    scopus 로고
    • Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells
    • Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S (2003) Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells. J Neurosci 23:7376-7380
    • (2003) J Neurosci , vol.23 , pp. 7376-7380
    • Ueda, T.1    Ugawa, S.2    Yamamura, H.3    Imaizumi, Y.4    Shimada, S.5
  • 76
    • 0029957779 scopus 로고    scopus 로고
    • Transduction of bitter and sweet taste by gustducin
    • Wong GT, Gannon KS, Margolskee RF (1996) Transduction of bitter and sweet taste by gustducin. Nature 381:796-800
    • (1996) Nature , vol.381 , pp. 796-800
    • Wong, G.T.1    Gannon, K.S.2    Margolskee, R.F.3
  • 77
    • 0033565914 scopus 로고    scopus 로고
    • Directing gene expression to gustducin-positive taste receptor cells
    • Wong GT, Ruiz-Avila L, Margolskee RF (1999) Directing gene expression to gustducin-positive taste receptor cells. J Neurosci 19:5802-5809
    • (1999) J Neurosci , vol.19 , pp. 5802-5809
    • Wong, G.T.1    Ruiz-Avila, L.2    Margolskee, R.F.3
  • 80
    • 0037133261 scopus 로고    scopus 로고
    • Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
    • Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E (2002) Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci USA 99:2392-2397
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2392-2397
    • Wu, S.V.1    Rozengurt, N.2    Yang, M.3    Young, S.H.4    Sinnett-Smith, J.5    Rozengurt, E.6
  • 81
    • 25144464874 scopus 로고    scopus 로고
    • Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat
    • Wu SV, Chen MC, Rozengurt E (2005) Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol Genomics 22:139-149
    • (2005) Physiol Genomics , vol.22 , pp. 139-149
    • Wu, S.V.1    Chen, M.C.2    Rozengurt, E.3
  • 82
    • 4644308014 scopus 로고    scopus 로고
    • Different functional roles of T1R subunits in the heteromeric taste receptors
    • Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X (2004) Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci USA 101:14258-14263
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14258-14263
    • Xu, H.1    Staszewski, L.2    Tang, H.3    Adler, E.4    Zoller, M.5    Li, X.6
  • 83
    • 0034998556 scopus 로고    scopus 로고
    • Bitter taste transduced by PLC-beta(2)-dependent rise in IP(3) and alpha-gustducin-dependent fall in cyclic nucleotides
    • Yan W, Sunavala G, Rosenzweig S, Dasso M, Brand JG, Spielman AI (2001) Bitter taste transduced by PLC-beta(2)-dependent rise in IP(3) and alpha-gustducin-dependent fall in cyclic nucleotides. Am J Physiol Cell Physiol 280:C742-C751
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Yan, W.1    Sunavala, G.2    Rosenzweig, S.3    Dasso, M.4    Brand, J.G.5    Spielman, A.I.6
  • 84
    • 0027724052 scopus 로고
    • Individual-differences in sensitivity to bitter-tasting substances
    • Yokomukai Y, Cowart BJ, Beauchamp GK (1993) Individual-differences in sensitivity to bitter-tasting substances. Chem Senses 18:669-681
    • (1993) Chem Senses , vol.18 , pp. 669-681
    • Yokomukai, Y.1    Cowart, B.J.2    Beauchamp, G.K.3
  • 86
    • 0037423367 scopus 로고    scopus 로고
    • Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
    • Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003) Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways. Cell 112:293-301
    • (2003) Cell , vol.112 , pp. 293-301
    • Zhang, Y.1    Hoon, M.A.2    Chandrashekar, J.3    Mueller, K.L.4    Cook, B.5    Wu, D.6    Zuker, C.S.7    Ryba, N.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.