Iron homeostasis in the neonate

Pediatrics

Volumn 123, Issue 4, 2009, Pages 1208-1216

  Collard, Keith J ^a  

^a UNIVERSITY OF PLYMOUTH   (United Kingdom)

Author keywords

Growth and development; Infant; Iron homeostasis; Newborn; Premature

Indexed keywords

IRON; ANTIMICROBIAL CATIONIC PEPTIDE; CATION TRANSPORT PROTEIN; HEPCIDIN; LACTOFERRIN; METAL TRANSPORTING PROTEIN 1; SERUM ALBUMIN; SOLUTE CARRIER FAMILY 11 (PROTON COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

BACTERIAL INFECTION; HOMEOSTASIS; INTESTINE ABSORPTION; IRON TRANSPORT; PERINATAL DEVELOPMENT; POSTNATAL DEVELOPMENT; PREMATURITY; PRIORITY JOURNAL; REVIEW; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; BREAST FEEDING; CHILD DEVELOPMENT; HUMAN; METABOLISM; NEWBORN; NEWBORN ANEMIA; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANEMIA, NEONATAL; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD-BRAIN BARRIER; BRAIN; BREAST FEEDING; CATION TRANSPORT PROTEINS; CHILD DEVELOPMENT; HOMEOSTASIS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INTESTINAL ABSORPTION; IRON; LACTOFERRIN; OXIDATIVE STRESS; SERUM ALBUMIN;

EID: 65349115915     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2008-1047     Document Type: Review

References (91)

1. Dunn LL, Rahamanto YS, Richardson DR. Iron uptake and metabolism in the new millennium. Trends Cell Biol. 2007;17(2):93-100 (Pubitemid 46199183)
2. Fredriksson A, Schroder N, Eriksson P, Izquierdo I, Archer T. Maze learning and motor activity deficits in adult mice induced by iron exposure during a critical postnatal period. Brain Res Dev Brain Res. 2000;119(1):65-74 (Pubitemid 30058383)
3. Piñero DJ, Li NQ, Connor JR, Beard JL. Variations in dietary iron alter brain iron metabolism in developing rats. J Nutr. 2000;130(2):254-263
4. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long lasting neural and behavioural effect of iron deficiency in infancy. Nutr Rev. 2006;64(5 pt 2):S34-S41
5. Shafir T, Angulo-Barroso R, Jing Y, Angelilli ML, Jacobson SW, Lozoff B. Iron deficiency and infant motor development. Early Hum Dev. 2008;84(7):479-485
6. Buonocore G, Perrone S, Bracci R. Free radicals and brain damage in the newborn. Biol Neonate. 2001;79(3-4):180-186 (Pubitemid 32247083)
7. Marzocchi B, Perrone S, Paffetti P, et al. Non protein-bound iron and plasma protein oxidative stress at birth. Pediatr Res. 2005;58(6):1295-1299 (Pubitemid 43755716)
8. Kaur D, Peng J, Chita SJ, et al. Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age. Neurobiol Aging. 2007;28:907-913 (Pubitemid 46589736)
9. Rao R, Georgieff MK. Iron in foetal and neonatal nutrition. Semin Fetal Neonatal Med. 2007;12(1):54-63
10. Patruta SI, Hörl WH. Iron and infection. Kidney Int Suppl. 1999;69:S125-S130 (Pubitemid 29113593)
11. Dani C, Reali MF, Bertani G, Masrtelli E, Pezzati M, Rubaltelli FF. The role of blood transfusions and iron uptake in retinopathy of prematurity. Early Hum Dev. 2001;62(1):57-63 (Pubitemid 32178136)
12. Wardle SP, Drury J, Garr R, Weindling AM. Effect of blood transfusions on lipid peroxidation in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2002;86(1):F46-48 (Pubitemid 34074758)
13. Collard KJ. Is there a causal relationship between the receipt of blood transfusions and the development of chronic lung disease of prematurity? Med Hypotheses. 2006;66(2):355-364
14. Lönnerdal B. Trace element nutrition of infants: molecular approaches. J Trace Elem Med Biol. 2005;19(1):3-6 (Pubitemid 41253911)
15. Gunshin H, MacKenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388(6641):482- 488 (Pubitemid 27328927)
16. Chung J, Wessling-Resnick M. Molecular mechanisms and regulation of iron transport. Crit Rev Clin Lab Sci. 2003;40(2):151-182 (Pubitemid 36529013)
17. Cherukuri S, Potla R, Sarkar J, Nurko S, Harris ZL, Fox PL. Unexpected role of ceruloplasmin in intestinal iron absorption. Cell Metab. 2005;2(5):309-319
18. Leong WI, Bowlus CL, Tallkvist J, Lonnerdal B. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Am J Physiol Gastrointest Liver Physiol. 2003;285(6):G1153-G1161 (Pubitemid 37449002)
19. Bradley J, Liebold EA, Harris ZL, et al. Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta. Am J Physiol Regul Integr Comp Physiol. 2004;287(4):R894-R891 (Pubitemid 39280477)
20. Leong W-I, Bowlus CL, Talkvist J, Lonnerdal B. Iron supplementation during infancy-effects on expression of iron transporters, iron absorption, and iron utilisation in rat pups. Am J Clin Nutr. 2003;78(6):1203-1211 (Pubitemid 39663463)
21. Domellöf M, Lönnerdal B, Abrams SA, Hernell O. Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods. Am J Clin Nutr. 2002;76(1):198-204 (Pubitemid 34686567)
22. Friel JK, Martin SM, Langdon M, Hertzberg GR, Buettner GR. Milk from mothers of both premature and full-term infants provides better antioxidant protection than does infant formula. Pediatr Res. 2002;51(5):612-618 (Pubitemid 34453579)
23. Friel JK, Aziz K, Andrews WL, Serfass RE. Iron absorption and oxidant stress during erythropoietin therapy in very low birth weight premature infants: a cohort study. BMC Pediatr. 2005;5:29 (Pubitemid 41418278)
24. Braekker K, Bechenstein AG, Halvorsen BL, Blomhoff R, Haaland K, Staff AL. Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants. J Pediatr. 2007;151(1):23-28 (Pubitemid 46950891)
25. Raghuveer TS, Buettner GR. Iron supplements and oxidative stress in very low birth weight babies. J Pediatr. 2008;152(6):890-891; author reply 891
26. Raghuveer TS, McGuire EM, Martin SM, et al. Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products. Pediatr Res. 2002;52(6):964-972 (Pubitemid 35379480)
27. Aycicek A, Erel OE, Kocyigit A, Selek S, Demorkil MR. Breast milk provides better antioxidant power than does formula. Nutrition. 2006;22(6):616-619 (Pubitemid 44269299)
28. Lopez V, Suzuki YA, Lonnerdal B. Ontogenic changes in lactoferrin receptor and DMT-1 in mouse small intestine: implications for iron absorption during early life. Biochem Cell Biol. 2006;84(3):337-344 (Pubitemid 44341308)
29. Mikogami T, Marianne T, Spik G. Effect of intracellular iron depletion by picolinic acid on the expression of the lactoferrin receptor in the human colon carcinoma cell subclone HT29-18-C1. Biochem J. 1995;308(pt 2):391-397
30. Kume S, Tanabe S. Effect of supplemental lactoferrin with ferrous iron on iron status in newborn calves. J Dairy Sci. 1996;79(3):459-464 (Pubitemid 126429070)
31. Ward PP, Mendoza-Meneses M, Cunningham GA, Conneely OM. Iron status in mice carrying a targeted disruption of lactoferrin. Mol Cell Biol. 2003;23(1):178-185 (Pubitemid 36008511)
32. Hanson LH, Sawicki V, Lewis A, Nuijens JH, Neville MC, Zhang P. Does human lactoferrin in the milk of transgenic mice deliver iron to suckling neonates? Adv Exp Med Biol. 2001;501:233-239 (Pubitemid 34102201)
33. Ng PC, Lam CWK, Lee CH, To KF, Chan IHS, Wong E. Hepatic iron storage in very low birthweight infants after multiple blood transfusions. Arch Dis Child Fetal Neonatal Ed. 2001;84(2):F101-F105 (Pubitemid 32250851)
34. Scott PH, Berger HM, Kennard C, Scott P, Wharton BA. Effect of gestational age and intrauterine nutrition on plasma transferrin and iron in the newborn. Arch Dis Child. 1975;50(10):796-798
35. Lackmann GM, Hesse L, Tollner U. Reduced iron-associated antioxidants in premature newborns suffering intracerebral hemorrhage. Free Rad Biol Med. 1996;20(3):407-409 (Pubitemid 26079117)
36. Galinier A, Periquet B, Lambert W, et al. Reference range for micronutrients and nutritional marker proteins in cord blood of neonates appropriated for gestational ages. Early Hum Dev. 2005;81(7):583-593 (Pubitemid 40961567)
37. Moison RM, Haasnoot AA, Van Zoeren-Grobben D, Berger HM. Plasma proteins in acute and chronic lung disease of the newborn. Free Radic Biol Med. 1998;25(3):321-328 (Pubitemid 28326207)
38. Fryer AA, Jones P, Strange R, Hume R, Bell JE. Plasma protein levels in normal human fetuses: 13 to 41 weeks gestation. Br J Obstet Gynaecol. 1993;100(9):850-855 (Pubitemid 23280570)
39. Rosenfeld W, Concepcion L, Evans H, Jhaveri R, Sahdev S, Zabaleta I. Serial trypsin inhibitory capacity and ceruloplasmin levels in prematures at risk for bronchopulmonary dysplasia. Am Rev Respir Dis. 1986;134(6):1229-1232 (Pubitemid 17216902)
40. Fukuzawa K, Saitoh Y, Akai K, et al. Antioxidant effect of bovine serum albumin on membrane lipid peroxidation induced by iron chelation and superoxide. Biochim Biophys Acta. 2005;1668(1):145-155 (Pubitemid 40164742)
41. Loban A, Kime R, Powers H. Iron-binding antioxidant potential of plasma albumin. Clin Sci (Lond). 1997;93(5):445-451 (Pubitemid 27489940)
42. Collard KJ, Godeck S, Holley JE, Quinn MW. Pulmonary antioxidant levels and oxidative damage in ventilated premature babies. Arch Dis Child Fetal Neonatal Ed. 2004;89(5):F412-F416 (Pubitemid 39178817)
43. Wardle SP, Drury J, Garr K, Weindling AM. Effect of blood transfusions on lipid peroxidation in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2002;86(1):F46-F48 (Pubitemid 34074758)
44. Kotecha S. Lung growth: implications for the newborn infant. Arch Dis Child Fetal Neonatal Ed. 2000;82(1):F69-F74 (Pubitemid 30316489)
45. Bracci R, Perrone S, Buonocore G. Oxidant injury in neonatal erythrocytes during the perinatal period. Acta Paediatr Suppl. 2002;91(438):130-134 (Pubitemid 35347074)
46. Comporti M, Signorini C, Buonocore G, Ciccola L. Iron release oxidative stress and erythrocyte ageing. Free Rad Biol Med. 2002;32(7):568-576 (Pubitemid 34241489)
47. Collard KJ, Godeck S, Holley JE. Blood transfusion and pulmonary lipid peroxidation in ventilated premature babies. Pediatr Pulmonol. 2005;39(3):257-261 (Pubitemid 40460695)
48. Buonocore G, Perrone S, Longini M, et al. Non protein bound iron as early predictive marker of neonatal brain damage. Brain. 2003;126(pt 5):1224-1230 (Pubitemid 36522963)
49. Kling PJ, Reichard RD, Roberts RA. The effects of transfusions on oxidative stress and plasma erythropoietin levels in premature infants. Ann Haematol. 2000;79:B13
50. Hirano K, Morinobu T, Kim H, et al. Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2001;84(3):F188-F193 (Pubitemid 32411258)
51. Dani C, Martelli E, Bertini G, et al. Effect of blood transfusions on oxidative stress in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2004;89(5):F408-F411 (Pubitemid 39178816)
52. Vyas JR, Currie A, Dunster C, Kelly FJ, Kotecha S. Ascorbic acid concentration in airways lining fluid from infants who develop chronic lung disease of prematurity. Eur J Pediatr. 2001;160(3):177-184 (Pubitemid 32206347)
53. Pollak A, Hayde M, Hayn M, et al. Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants. Pediatrics. 2001;107(1):78-85 (Pubitemid 32055419)
54. Fujiu T, Maruyama K, Koizumi T. Oral iron supplementation in preterm infants treated with erythropoietin. Pediatr Int. 2004;46(6):635-639 (Pubitemid 40096003)
55. Ultee CA, van der Deure J, Swart J, Lasham C, van Baar AL. Delayed cord clamping in preterm infants delivered at 34-36 weeks gestation: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2008;93(1):F20-23
56. Hutton EK, Hassan ES. Late vs early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials. JAMA. 2007;297(11):1241-1252 (Pubitemid 46465732)
57. Weeks A. Umbilical cord clamping after birth. BMJ. 2007;335(7615):312-313 (Pubitemid 47310852)
58. Watson RE, Desesso JM, Hurtt ME, Cappon GD. Postnatal growth and morphological development of the brain: a species comparison. Birth Defects Res B Dev Reprod Toxicol. 2006;77(5):471-484 (Pubitemid 44657371)
59. Rice D, Barone S Jr. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect. 2000;108(suppl 3):511-533 (Pubitemid 30466179)
60. Siddappa AJ, Rao RB, Wobken JD, Liebold EA, Connor JR, Georgieff MK. Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J Neurosci Res. 2002;68(6):761-775 (Pubitemid 34594993)
61. Siddappa AJ, Rao RB, Wobken JD, et al. Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal brain. Pediatr Res. 2003;53(5):800-807 (Pubitemid 36504724)
62. Haorah J, Ramirez SH, Schall K, Smith D, Pandya R, Persidsky Y. Oxidative stress activates protein kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J Neurochem. 2007;101(2):566-576 (Pubitemid 46525283)
63. Ke Y, Chang YZ, Duan XL, et al. Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in the brain. Neurobiol Aging. 2005;26(5):739-748 (Pubitemid 40233011)
64. Erikson KM, Pinero DJ, Connor JR, Beard JL. Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr. 1997;127(10):2030-2038 (Pubitemid 27424443)
65. Beard JL, Unger EL, Bianco LE, Paul T, Rundle SE, Jones BC. Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats. J Nutr. 2007;137(5):1176-1182 (Pubitemid 46701908)
66. Beard J, Erikson KM, Jones BC. Neonatal iron deficiency results in irreversible changes in dopamine function in rats. J Nutr. 2003;133(4):1174-1179 (Pubitemid 36407145)
67. Steinmacher J, Pohlandt F, Bode H, Sander S, Kron M, Frary AR. Randomised trial of early versus late enteral iron supplementation in infants with a birth weight of less than 1301 grams: neurocognitive development at 5.3 years corrected age. Pediatrics. 2007;120(3):538-546 (Pubitemid 47358297)
68. Connor JR. Iron regulation in the brain at the cell and molecular level. In: Hersko C, ed. Progress in Iron Research. New York, NY: Plenum Press; 1994:229-238 (Pubitemid 24348507)
69. Wu LL, Zhang L, Shao J, Quin YF, Yang RW, Zhao ZY. Effect of perinatal iron deficiency on myelination and associated behaviors in rat pups. Behav Brain Res. 2008;188(2):263-270
70. Jorgenson LA, Wobken JD, Georgieff MK. Postnatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurones. Dev Neurosci. 2003;25(6):412-420 (Pubitemid 38250494)
71. Rao R, Tisac I, Townsend EL, Ennis K, Gruetter R, Georgieff MK. Perinatal iron deficiency predisposes the developing rat hippocampus to greater injury from mild to moderate hypoxia-ischaemia. J Cereb Blood Flow Metab. 2007;27(4):729-740 (Pubitemid 46474609)
72. Hugman A. Hepcidin: an important new regulator of iron homeostasis. Clin Lab Haematol. 2006;28(2):75-83
73. Ganz T, Nemeth E. Iron imports IV: hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006;290(2):G199-G203
74. De Domenico I, Ward DM, Kaplan J. Hepcidin regulation: ironing out the details. J Clin Invest. 2007;117(7):1755-1758 (Pubitemid 47036308)
75. Niederkofler V, Salie R, Arbor S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005;115(8):2180-2186 (Pubitemid 41134159)
76. Balogh A, Szabó M, Kelen D, et al. Prohepcidin levels during human postnatal adaptation. Pediatr Hematol Oncol. 2007;24(5):361-368 (Pubitemid 47035896)
77. Roe MA, Spinks C, Heath AL, et al. Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women. Br J Nutr. 2007;97(3):544-549
78. Tiker F, Celik B, Tarcan A, Kilicoag H, Ozxbek N, Gurakan B. Serum prohepcidin levels and relationships with iron parameters in healthy preterm and term infants. Pediatr Hematol Oncol. 2006;23(4):293-297
79. Nemeth E, Ganz T. Hepcidin and iron-loading anemias. Haematologica. 2006;91(6):727-732 (Pubitemid 44014536)
80. Kattamis A, Papassotiriou I, Palaiologou D, et al. The effects of erythropoietic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica. 2006;91(6):809-812 (Pubitemid 44014549)
81. Kling PJ, Winzerling JJ. Iron status and the treatment of the anemia of prematurity. Clin Perinatol. 2002;29(2):283-294
82. Georgieff MK. Abnormal iron distribution in infants of diabetic mothers: spectrum and antecedents. J Pediatr. 1990;117(3):455-461 (Pubitemid 20315676)
83. Vokurka M, Krijt J, Sulc K, Nelas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res. 2006;55(6):667-674 (Pubitemid 46021227)
84. Kong WN, Chang YZ, Wang SM, Zhat XL, Shang JX, Li LX. Effect of erythropoietin on hepcidin, DMT-1, with IRE, and hephaestin gene expression in duodenum of rats. J Gastroenterol. 2008;43(2):136-143
85. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006;108(12):3730-3735
86. Riveras S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005;106(6):2196-2199 (Pubitemid 41291740)
87. Nicolas G, Chauvet L, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110(7):1037-1044
88. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003;102(3):783-788 (Pubitemid 36917762)
89. Vanden Hoek TL, Becker LB, Shao Z, Li C, Schumacker PT. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem. 1998;273(29):18092-18098 (Pubitemid 28334725)
90. Choi SO, Cho YS, Kim HL, Park JW. ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPα and STAT-3. Biochem Biophys Res Comm. 2007;356(1):312-317 (Pubitemid 46413166)
91. Speer CP. Inflammation and bronchopulmonary dysplasia. Semin Neonatol. 2003;8(1):29-38 (Pubitemid 36356491)