Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 4 56-4, 2004, Pages

  Bradley, Jenni ^a   Leibold, Elizabeth A ^b   Harris, Z Leah ^c   Wobken, Jane D ^a   Clarke, Stephen ^d   Zumbrennen, Kimberly B ^b   Eisenstein, Richard S ^d   Georgieff, Michael K ^a,e  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Ferritin; Ferroportin; Pregnancy; Syncytiotrophoblast; Transferrin receptor

Indexed keywords

FERRITIN; FERROPORTIN 1; IRON REGULATORY FACTOR; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; RNA; TRANSFERRIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; FERRITIN BLOOD LEVEL; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IRON TRANSPORT; PLACENTAL TRANSFER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN RNA BINDING; SYNCYTIOTROPHOBLAST; THIRD TRIMESTER PREGNANCY; TRANSCRIPTION REGULATION; UMBILICAL CORD BLOOD; WESTERN BLOTTING;

ADULT; ANTIGENS, CD; BLOTTING, WESTERN; CARRIER PROTEINS; FEMALE; FERRITINS; FETAL BLOOD; FETUS; GESTATIONAL AGE; HUMANS; IMMUNOHISTOCHEMISTRY; IRON; IRON-REGULATORY PROTEINS; NUTRITIONAL STATUS; PLACENTA; PREGNANCY; PREGNANCY TRIMESTER, THIRD; PROTEIN BINDING; RECEPTORS, TRANSFERRIN;

EID: 4644301618     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00525.2003     Document Type: Article

References (44)

1. Abboud S and Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275: 19906-19912, 2000.
2. Anderson GJ, Frazer DM, McKie AT, and Vulpe CD. The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption. Blood Cell Mol Dis 29: 367-375, 2002.
3. Andrews NC. Disorders of iron metabolism. N Engl J Med 341: 1986-1995, 1999.
4. Babson SG and Benda GI. Growth graphs for the clinical assessment of infants of varying gestational age. J Pediatr 89: 814-820, 1976.
5. Berant M, Khourie M, and Menzies IS. Effect of iron deficiency on small intestinal permeability in infants and young children. J Pediatr Gastroenterol Nutr 14: 17-20, 1992.
6. Bergamaschi G, Bergamaschi P, Carlevati S, and Cazzola M. Transferrin receptor expression in the human placenta. Haematologica 754: 220-223, 1990.
7. Bracci R, Perrone S, and Buonocore G. Oxidant injury in neonatal erythrocytes during the perinatal period. Acta Paediatr 438: S130-S134, 2002.
8. Buonocoare G, Perrone S, Longini M, Paffetti P, Marzocchi B, Vezzosi P, and Bracci R. Oxidative stress in preterm babies at birth and on the seventh day of life. Pediatr Res 52: 46-49, 2003.
9. Chockalingam U, Murphy E, Ophoven JC, and Georgieff MK. The influence of gestational age, size for dates, and prenatal steroids on cord transferrin levels in newborn infants. J Pediatr Gastroenterol Nutr 6: 276-280, 1987.
10. Chockalingam U, Murphy E, Ophoven JC, Weisdorf SA, and Georgieff MK. Cord transferrin and ferritin levels in newborn infants at risk for prenatal uteroplacental insufficiency and chronic hypoxia. J Pediatr 111: 283-286, 1987.
11. Cox TM and Halsall DJ. Hemochromatosis-neonatal and young subjects. Blood Cell Mol Dis 29: 411-417, 2002.
12. Dix DJ, Lin PN, McKenzie AR, Waiden WE, and Theil EC. The influence of the base-paired flanking region on structure and function of the ferritin mRNA iron regulatory element. J Mol Biol 231: 230-240, 1993.
13. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, and Zon LI. Positional cloning of zebrafish ferroportin-1 identifies a conserved vertebrate iron transporter. Nature 403: 776-781, 2000.
14. Eisenstein RS. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr 20: 627-662, 2000.
15. Galy B, Ferring D, Muckenthaler M, Minana B, Bell O, and Hentze MW. Mouse models for IRP deficiency Cre/lox-assisted targeting of iron regulatory protein 1 and 2 genes. Abstr Int Bio Iron Soc World Congr Iron Metab Bethesda, MD, 2003, p. 227.
16. Gambling L, Danzeisen R, Fosset C, Andersen HS, Dunford S, Srai SK, and McArdle HJ. Iron and copper interactions in development and the effect on pregnancy outcome. J Nutr 133: 1554S-1556S, 2003.
17. Gambling L, Danzzeisen R, Gair S, Lea RG, Charania Z, Lolanky N, Joory KD, Srai SK, and McArdle HJ. Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochem J 356: 883-889, 2001.
18. Georgieff MK, Berry SA, Wobken JD, and Leibold EA. Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency. Placenta 20: 87-93, 1999.
19. Georgieff MK, Landen MB, Mills MM, Hedlund BE, Faassen AE, Schmidt RL, Ophoven JJ, and Widness JA. Abnormal iron distribution in infants of diabetic mothers: spectrum and maternal antecedents. J Pediatr 117: 455-461, 1990.
20. Georgieff MK, Mills MM, Gordon K, and Wobken JD. Reduced neonatal liver iron concentrations after utero-placental insufficiency. J Pediatr 127: 308-311, 1995.
21. Georgieff MK, Wobken JK, Welle J, Burdo JR, and Connor JR. Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta. Placenta 21: 799-804, 2000.
22. Grantham-McGregor S and Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 131: 649S-668S, 2001.
23. Guo B, Yu Y, and Leibold EA. Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J Biol Chem 269: 24252-24260, 1994.
24. Ke YH, Sierzputowska-Gracz H, Gdaniec Z, and Theil EC. Internal loop/bulge and hairpin loop of the iron-responsive element of ferritin mRNA contribute to maximal iron regulatory protein 2 binding and translational regulation in the iso-iron-responsive element/iso-iron regulatory protein family. Biochemistry 39: 6235-6242, 2000.
25. Ke YH, Wu J Leibold EA, Walden WE, and Theil EC. Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding. J Biol Chem 273: 23637-23640, 1998.
26. Kuhn L, Schulman HM, and Ponka P. Iron-transferrin requirements and transferrin receptor expression in proliferating cells. In: Iron Transport and Storage, edited by Ponka P, Schulman HM, and Woodworth RC. Boca Raton, FL: CRC, 1990, p. 149-192.
27. LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E, Drake SK, Miller G, Abu-Asab M, Tsokos M, Switzer R, Grinberg A, Love P, Tresser N, and Rouault TA. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet 27: 209-214, 2001.
28. Leibold EA and Munro HN. Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′-untranslated region of ferritin heavy- and light-subunit mRNAs. Proc Natl Acad Sci USA 85: 2171-2175, 1988.
29. Levy JE, Jin O, Fujiwara Y, Kuo F, and Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 21: 396-399, 1999.
30. Lieu PT, Heiskala M, Peterson PA, and Yang Y. The role of iron in health and disease. Mol Aspects Med 22: 1-87, 2001.
31. Liu X, Hill P, and Haile DJ. Role of ferroportin iron-responsive element in iron- and nitric oxide-dependent gene regulation. Blood Cell Mol Dis 29: 315-326, 2002.
32. Ma Y, Specian RD, Yeh KY, Yeh M, Rodriguez-Paris J, and Glass J. The transcytosis of divalent metal transporter 1 and apo-transferrin during iron uptake in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol 283: G965-G974, 2002.
33. MacPhail AP, Charlton RW, Bothwell TH, and Torrance JD. The relationship between maternal and infant iron status. Scand J Haematol 25: 141-150, 1980.
34. Molteni RA, Stys SJ, and Battaglia FC. Relationship of fetal and placental weight in human beings: fetal/placental weight ratios at various gestational ages and birth weight distributions. J Reprod Med 21: 327-333, 1978.
35. O'Brien KO, Zavaleta N, Abrams SA, and Caulfield LE. Maternal iron status influences iron transfer to the fetus during the third trimester of pregnancy. Am J Clin Nutr 77: 924-930, 2003.
36. Oski FA. The hematologic aspects of the maternal-fetal relationship. In: Hematologic Problems in the Newborn (3rd ed.), edited by Oski FA and Naiman JL. Philadelphia, PA: Saunders, 1982, p. 32-33.
37. Petry CD, Eaton MA, Wobken JD, Mills MM, Johnson DE, and Georgieff MK. Iron deficiency of liver, heart, and brain in newborn infants of diabetic mothers. J Pediatr 121: 109-114, 1992.
38. Petry CD, Wobken JD, McKay H, Eaton MA, Seybold VS, Johnson DE, and Georgieff MK. Placental transferrin receptor in diabetic pregnancies with increased fetal iron demand. Am J Physiol Endocrinol Metab 267: E507-E514, 1994.
39. Rasmussen KM, Is there a causal relationship between iron deficiency or iron-deficiency anemia and weight at birth, length of gestation and perinatal morality? J Nutr 131: 590S-603S, 2001.
40. Rios E, Lipschitz DA, Cook JD, and Smith NJ. Relationship of maternal and infant iron stores as assessed by determination of plasma ferritin. Pediatrics 55: 694-699, 1975.
41. Srai SK, Bomford A, and McArdle HJ. Iron transport across cell membranes: molecular understanding of duodenal and placental iron uptake. Best Pract Res Clin Haematol 15: 243-259, 2002.
42. Theil EC and Eisenstein RS. Combinatorial mRNA regulation: iron regulatory proteins and iso-iron responsive elements (iso-IREs). J Biol Chem 275: 40659-40662, 2000.
43. Verrijt CEH, Kroos MJ, Huijskes-Heins MI, Cleton-Soeteman MI, van Run PR, van Eijk HG, and van Dijk JP. Accumulation and release of iron in polarly and non-polarly cultured trophoblast cells isolated from human term placentas. Eur J Obstet Gynecol Reprod Biol 86: 73-81, 1999.
44. Wessling-Resnick M. Iron transport. Annu Rev Nutr 20: 129-151, 2000.