Variations in dietary iron alter brain iron metabolism in developing rats

Journal of Nutrition

Volumn 130, Issue 2, 2000, Pages 254-263

  Piñero, Domingo J ^a   Li, Nan Qian ^b   Connor, James R ^a   Beard, John L ^b  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Brain; Development; Iron deficiency; Iron excess; Rats

Indexed keywords

FERRITIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN METABOLISM; DIET SUPPLEMENTATION; DIETARY INTAKE; FEMALE; IRON DEFICIENCY; IRON METABOLISM; MALE; NONHUMAN; POSTNATAL DEVELOPMENT; PROTEIN DETERMINATION; RAT;

ANIMALIA;

EID: 0342948905     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.2.254     Document Type: Article

References (37)

1. Allen, N. H. (1997) Pregnancy and iron deficiency: unresolved issues. Nutr. Rev. 55: 91-101.
2. Ashkenazi, R., Ben-Shachar, D. & Youdim, M.B.H. (1982) Nutritional iron and dopamine binding sites in the rat brain. Pharmacol. Biochem. Behav. 17: (suppl.1) 43-47.
3. Baynes, R. D. & Bothwell, T. H. (1990) Iron deficiency. Annu. Rev. Nutr. 10: 133-148.
4. Beard, J. L., Chen, Q., Connor, J. & Jones, B. C. (1994) Altered monoamine metabolism in caudate-putamen of iron-deficient rats. Pharmacol. Biochem. Behav. 48: 621-624.
5. Beard, J. L., Connor, J. R. & Jones, B. C. (1993a) Brain iron: location and function. Prog. Food Nutr. Sci. 17: 183-221.
6. Beard, J. L., Connor, J. R. & Jones, B. C. (1993b) Iron in the brain. Nutr. Rev. 51: 157-170.
7. Chen, Q., Beard, J. L. & Jones, B. C. (1995a) Abnormal brain monoamine metabolism in iron deficiency anemia. J. Nutr. Biochem. 6: 486-493.
8. Chen, Q., Connor, J. R. & Beard J. L. (1995b) Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats. J. Nutr. 125: 1529-1535.
9. Connor, J. R. (1994) Iron acquisition and expression of iron regulatory proteins in the developing brain: manipulation by ethanol exposure, iron deprivation and cellular dysfunction. Dev. Neurosci. 16: 233-247.
10. Connor, J. R., Menzies, S. L., St. Martin, S. M. & Mufson, E. J. (1992a) A histochemical study of iron, transferrin and ferritin in Alzheimer's diseased brains. J. Neurosci. Res. 31: 75-83.
11. Connor, J. R., Snyder, B. S., Arosio, P., Loeffler, D. A. & LeWitt, P. (1995) A quantitative analysis of isoferritins in select regions of aged, Parkinsonian, and Alzeimer's diseased brains. J. Neurochem. 65: 717-724.
12. Connor, J. R., Snyder, B. S., Beard, J. L., Fine, R. E. & Mufson, E. J. (1992b) Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease. J. Neurosci. Res. 31: 327-335.
13. Cook, J.D. (1980a) Iron, pp.105-109. Churchill Livingstone, New York, NY.
14. Cook, J.D. (1980b) Iron, pp.32-36. Churchill Livingstone, New York, NY.
15. Crowe, A. & Morgan, E. H. (1992) Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res. 592: 8-16.
16. Dallman, P. R., Siimes, M. A. & Manies, E. C. (1975) Brain iron: persistent deficiency following short term iron deprivation in the young rat. Br. J. Haematol. 31: 209-215.
17. Dallman, P. R. & Spirito, R. A. (1977) Brain iron in the rat: extremely slow turnover in normal rats may explain the long lasting effects of early iron deficiency. J. Nutr. 107: 1075-1081.
18. Davison, A. N. & Dobbing, J. (1966) Myelination as a vulnerable period in brain development. Br. Med. Bull. 22: 40-44.
19. de Andraca, I., Castillo, M. & Walter, T. (1997) Psychomotor development and behavior in iron-deficient anemic infants. Nutr. Rev. 55: 125-132.
20. Dobbing, J. & Sands, J. (1979) Comparative aspects of the brain growth spurt. Early Hum. Dev. 3(1): 79-83.
21. Dwork, A. J., Lawler, G., Zybert, P. A., Durkin, M., Osman, M., Willson, N. & Barkai, A. I. (1990) An autoradiographic study of the uptake and distribution of iron by the brain of the young rat. Brain Res. 518: 31-39.
22. Erikson, K. M., Beard, J. L. & Connor, J. R. (1998) Distribution of brain iron, ferritin, and transferrin in the 28-day-old piglet. Nutr. Biochem. 9: 276-284.
23. Erikson, K. M., Piñero, D. J., Connor, J. R. & Beard, J. L. (1997) Regional brain, iron, ferritin, and transferrin concentrations during iron deficiency and iron repletion in developing rats. J. Nutr. 127: 2030-2038.
24. Felt, B. & Lozoff, B. (1996) Brain iron and behavior in rats are not normalized by treatment of iron deficiency anemia during early development. J. Nutr. 126: 693-701.
25. Focht, S., Snyder, B. S., Beard, J. L., van Gelder, W., Williams, L. R. & Connor, J. R. (1997) Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains. Neuroscience 79: 255-261.
26. Good, P. F., Olanow, C. W. & Perl, D. P. (1992) Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminun in Parkinson's disease: a LAMMA study. Brain Res. 593: 343-346.
27. Hill, J. M. (1988) The distribution of iron in the brain. In: Brain Iron: Neurochemistry and Beahvioural Aspects (Youdim, M.B.H., ed.), pp. 1-4. Taylor and Francis, London, UK.
28. Hill, J. M., Ruff, M. R., Weber, R. J. & Pert, C. B. (1985) Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution. Proc. Natl. Acad. Sci. U.S.A. 82: 4453-4557.
29. Kalaria, R. N., Sromek, S. M., Grahovac, I. & Harik, S. I. (1992) Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease. Brain Res. 585: 87-93.
30. Loeffler, D. A., Connor, J. R., Juneau, P. L., Snyder, B. S., Kanaley, L., DeMaggio, A. J., Nguyen, H., Brickman, C. M. & LeWitt, P. A. (1995) Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J. Neurochem. 65: 710-724.
31. Morris, C. M., Keith, A. B., Edwardson, J. A. & Pullen, R.G.L. (1992) Uptake and distribution of iron and transferrin in the adult rat brain. J. Neurochem. 59: 300-306.
32. Morse, A. C., Beard, J. L & Jones, B. C. (1999) A genetic developmental model of iron deficiency: biological aspects. Proc. Soc. Exp. Biol. Med. 220: 147-152.
33. Nelson, C., Erikson, K. M., Piñero, D. J. & Beard, J. L. (1997) In vivo dopamine is altered in iron-deficient anemic rats. J. Nutr. 127: 2282-2288.
34. Rao, J. & Jagadeesan, V. (1995) Development of a rat model for iron deficiency and texicological studies: a comparison among Fischer 344, Wistar, and Sprague-Dawley strains. Lab. Anim. Sci. 45: 393-397.
35. Reeves, P. G., Nielsen, F. H. & Fahey, G. C., Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123: 1939-1951.
36. Roskams, A. J. & Connor, J. R. (1994) Iron, transferrin, and ferritin in the rat brain during development and aging. J. Neurochem. 63: 709-716.
37. Youdim, M.B.H., Ben-Shachar, D. & Yehuda, S. (1989) Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am. J. Clin. Nutr. 50: 607-617.