Maze learning and motor activity deficits in adult mice induced by iron exposure during a critical postnatal period

Developmental Brain Research

Volumn 119, Issue 1, 2000, Pages 65-74

  Fredriksson, Anders ^a   Schröder, Nadja ^b   Eriksson, Per ^a   Izquierdo, Ivan ^b   Archer, Trevor ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Basal ganglia; Habituation; Iron administration; Motor behaviour; NMRI mouse; Postnatal; Radial maze learning

Indexed keywords

FERROUS SUCCINATE; IRON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; CONTROLLED STUDY; HABITUATION; IRON OVERLOAD; LEARNING DISORDER; LOCOMOTION; MALE; MAZE TEST; MOTOR ACTIVITY; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PERINATAL PERIOD; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; WEIGHT GAIN;

ANIMALS; ANIMALS, NEWBORN; BASAL GANGLIA; BEHAVIOR, ANIMAL; BRAIN; FEMALE; FERROUS COMPOUNDS; FRONTAL LOBE; HABITUATION, PSYCHOPHYSIOLOGIC; HYPERKINESIS; HYPOKINESIA; IRON; IRON OVERLOAD; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED STRAINS; MOTOR ACTIVITY; REACTION TIME;

EID: 0342905028     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(99)00160-1     Document Type: Article

References (58)

1. Ahlbom J., Fredriksson A., Eriksson P. Exposure to an organophosphate (DFP) during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behaviour in adult mice. Brain Res. 677:1995;13-19.
2. Archer T., Fredriksson A., Jonsson G., Lewander T., Mohammed A.K., Ross S.B., Soderberg U. Central noradrenaline depletion antagonizes aspects of D-amphetamine-induced hyperactivity in the rat. Psychopharmacology. 88:1986;141-146.
3. Bolles R.G., Woods P.J. The ontogeny of behaviour in the albino rat. Anim. Behav. 12:1964;427-441.
4. Bradley C.K., Hillman L., Sherman A.R., Leedy D., Cordano A. Evaluation of two iron-fortified, milk-based formulas during infancy. Pediatrics. 91:1993;908-914.
5. Campbell B.A., Lytle L.D., Fibiger H.C. Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. Science. 166:1969;635-637.
6. Celada A., Busset R., Gutierrez J., Herreros V. No correlation between iron concentration in breast milk and maternal iron stores. Helv. Pediatr. Acta. 37:1982;11-16.
7. Connor J.R., Pavlick G., Karli D., Menzies S.L., Palmer C. A histochemical study of iron-positive cells in the developing rat brain. J. Comp. Neurol. 355:1995;111-123.
8. Crowe A., Morgan E.H. Iron and copper interact during their uptake and deposition in the brain and other organs of developing rats exposed to dietary excess of the two metals. J. Nutr. 126:1996;183-194.
9. Danielsson B.R., Fredriksson A., Dahlgren L., Gardlund A.T., Olsson L., Dencker L., Archer T. Behavioural effects of prenatal metallic mercury inhalation exposure in rats. Neurotoxicol. Teratol. 15:1993;391-396.
10. A.N. Davison, J. Dobbing, Applied Neurochemistry, Blackwell, Oxford, 1968, pp. 178-221, 253-316.
11. Dewey K.G., Finley D.A., Lonnerdal B. Breast milk volume and composition during late lactation (7-20 months). J. Pediatr. Gastroenterol. Nutr. 3:1984;713-720.
12. Dewey K.G., Lonnerdal B. Milk and nutrient intake of breast-fed infants from 1 to 6 months: relation to growth and fatness. J. Pediatr. Gastroenterol. Nutr. 2:1983;497-506.
13. Dexter D.T., Carayon A., Javoy-Agid F., Agid Y., Wells F.R., Daniel S.E., Lees A.J., Jenner P., Marsden C.D. Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain. 114:1991;1953-1975.
14. Dexter D.T., Wells F.R., Agid F., Agid Y., Lees A.J., Jenner P., Marsden C.D. Increased nigral iron content in postmortem Parkinsonian brain. Lancet. 2:1987;1219-1220. letter.
15. Drayer B.P., Olanow W., Burger P., Johnson G.A., Herfkens R., Riederer S. Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. Radiology. 159:1986;493-498.
16. Dwork A.J., Lawler G., Zybert P.A., Durkin M., Osman M., Willson N., Barkai A.I. An autoradiographic study of the uptake and distribution of iron by the brain of the young rat. Brain Res. 518:1990;31-39.
17. Eriksson P. Developmental neurotoxicity of environmental agents in the neonate. Neurotoxicology. 18:1997;719-726.
18. Eriksson P., Ahlbom J., Fredriksson A. Exposure to DDT during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behaviour in adult mice. Brain Res. 582:1992;277-281.
19. Evans P.H. Free radicals in brain metabolism and pathology. Br. Med. Bull. 49:1993;577-587.
20. Fellman V., Rapola J., Pihko H., Varilo T., Raivio K.O. Iron-overload disease in infants involving fetal growth retardation, lactic acidosis, liver hemosiderosis, and aminoaciduria. Lancet. 351:1998;490-493.
21. Fredriksson A., Archer T. Alpha-phenyl-tert-butyl-nitrone (PBN) reverses age-related maze-learning performance and motor-activity deficits in C57 BL/6 mice. Behav. Pharmacol. 7:1996;245-253.
22. Fredriksson A., Dahlgren L., Danielsson B., Eriksson P., Dencker L., Archer T. Behavioural effects of neonatal metallic mercury exposure in rats. Toxicology. 74:1992;151-160.
23. Fredriksson A., Dencker L., Archer T., Danielsson B.R. Prenatal co-exposure to metallic mercury vapour and methylmercury produce interactive behavioural changes in adult rats. Neurotoxicol. Teratol. 18:1996;129-134.
24. Fredriksson A., Schröder N., Eriksson P., Izquierdo I., Archer T. Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice. Toxicol. Appl. Pharmacol. 159:1999;25-30.
25. M.A. Geyer, N.R. Swerdlow, Multiple transmitters modulate prepulse inhibition of startle: relevance to schizophrenia, Editorial Sintesis, Madrid, 1999, pp. 343-354.
26. 3H ]Dopa in various regions of the brain J. Neurochem. 13:1966;655-669.
27. Jacobs A. Iron overload - clinical and pathologic aspects. Hematology. 14:1977;89-113.
28. B. Janetzky, H. Reichmann, M.B.H. Youdim, P. Riederer, Iron and Oxidative Damage in Neurodegenerative Diseases, Willey-Liss, 1997, pp. 407-421.
29. Kienzl E., Puchinger L., Jellinger K., Linert W., Stachelberger H., Jameson R.F. The role of transition metals in the pathogenesis of Parkinson's disease. J. Neurol. Sci. 134:1995;69-78. Suppl.
30. R. Kirk, Experimental Design: Procedures for the Behavioural Sciences, Brooks/Cole, Belmont, CA, 1995.
31. Lonnerdal B. Effects of maternal dietary intake on human milk composition. J. Nutr. 116:1986;499-513.
32. Lonnerdal B. Effects of milk and milk components on calcium, magnesium, and trace element absorption during infancy. Physiol. Rev. 77:1997;643-669.
33. 125I ]transferrin injected into the ventricular system of the rat Brain Res. 790:1998;115-128.
34. Oestreicher E., Sengstock G.J., Riederer P., Olanow C.W., Dunn A.J., Arendash G.W. Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study. Brain Res. 660:1994;8-18.
35. Olanow C.W. Magnetic-resonance-imaging in Parkinsonism. Neurol. Clin. 10:1992;405-420.
36. Olton D.S., Walker J.A., Gage F.H. Hippocampal connections and spatial discrimination. Brain Res. 139:1978;295-308.
37. Olton D.S., Werz M.A. Hippocampal function and behaviour: spatial discrimination and response inhibition. Physiol. Behav. 20:1978;597-605.
38. Park C.H., Bacon B.R., Brittenham G.M., Tavill A.S. Pathology of dietary carbonyl iron overload in rats. Lab. Invest. 57:1987;555-563.
39. Rakic P., Goldman-Rakic P.S. The development and modifiability of the cerebral cortex. Overview. Neurosci. Res. Program Bull. 20:1982;433-438.
40. Riederer P., Sofic E., Rausch W.D., Schmidt B., Reynolds G.P., Jellinger K., Youdim M.B. Transition metals, ferritin, glutathione, and ascorbic acid in Parkinsonian brains. J. Neurochem. 52:1989;515-520.
41. M.R. Rosenzweig, A.L. Leiman, S.M. Breedlove, Biological Psychology: An Introduction to Behavioural, Cognitive, and Clinical Neuroscience, 2nd edn., Sinauer Assoc., Sunderland, MA, 1999, 561 pp.
42. Rustin P., von Kleist-Retzow J.C., Rotig A., Munnich A. Iron overload and mitochondrial diseases. Lancet. 351:1998;1286-1287. letter; comment.
43. Schmidt W.J., Kretschmer B.D. Behavioural pharmacology of glutamate receptors in the basal ganglia. Neurosci. Biobehav. Rev. 21:1997;381-392.
44. Schulz-Lell G., Buss R., Oldigs H.D., Dorner K., Schaub J. Iron balances in infant nutrition. Acta Pediatr. Scand. 76:1987;585-591.
45. Sengstock G.J., Olanow C.W., Dunn A.J., Barone S. Jr., Arendash G.W. Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behaviour following iron infusion into the rat substantia nigra. Exp. Neurol. 130:1994;82-94.
46. Sengstock G.J., Olanow C.W., Menzies R.A., Dunn A.J., Arendash G.W. Infusion of iron into the rat substantia nigra: nigral pathology and dose-dependent loss of striatal dopaminergic markers. J. Neurosci. Res. 35:1993;67-82.
47. Sobotka T.J., Whittaker P., Sobotka J.M., Brodie R.E., Quander D.Y., Robl M., Bryant M., Barton C.N. Neurobehavioural dysfunctions associated with dietary iron overload. Physiol. Behav. 59:1996;213-219.
48. R. Strong, M. Mattamal, A., Andorn, Free radicals, the aging brain, and age-related neurodegenerative disorders, Free Radicals in Aging, CRC Press, Boca Raton, FL, 1993, pp. 223-246.
49. Swaiman K.F. Hallervorden-Spatz syndrome and brain iron metabolism. Arch. Neurol. 48:1991;1285-1293.
50. Taylor E.M., Crowe A., Morgan E.H. Transferrin and iron uptake by the brain: effects of altered iron status. J. Neurochem. 57:1991;1584-1592.
51. Taylor E.M., Morgan E.H. Developmental changes in transferrin and iron uptake by the brain in the rat. Dev. Brain Res. 55:1990;35-42.
52. Temlett J.A., Landsberg J.P., Watt F., Grime G.W. Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiParkinsonian African green monkey: evidence from proton microprobe elemental microanalysis. J. Neurochem. 62:1994;134-416.
53. Ungerstedt U., Ljungberg T., Steg G. Behavioural, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine neurons. Adv. Neurol. 5:1974;421-426.
54. Walshe J.M., Cox D.W. Effect of treatment of Wilson's disease on natural history of haemochromatosis. Lancet. 352:1998;112-113.
55. Whittaker P., Chanderbhan R., Calvert R., Dunkel V. Cellular and molecular responses in the Sprague-Dawley rat to chronic iron overload. J. Trace Elem. Exp. Med. 7:1994;19-31.
56. Whittaker P., Wamer W., Calvert R. Effect of chronic iron load on iron status, lipid peroxidation, cell proliferation, and DNA damage. J. Trace Elem. Exp. Med. 5:1992;227-236.
57. Youdim M.B., Ben-Shachar D., Riederer P. Iron in brain function and dysfunction with emphasis on Parkinson's disease. Eur. Neurol. 31:1991;34-40.
58. Zavaleta N., Nombera J., Rojas R., Hambraeus L., Gislason J., Lönnerdal B. Iron and lactoferrin in milk of anemic mothers given iron supplements. Nutr. Res. 15:1995;681-690.