DMT1 and FPN1 expression during infancy: Developmental regulation of iron absorption

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 285, Issue 6 48-6, 2003, Pages

  Leong, Weng In ^a   Bowlus, Christopher L ^b   Tallkvist, Jonas ^c   Lönnerdal, Bo ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Ferritin; Ferroportin1; Iron deficiency; Iron transporters; Rat pups

Indexed keywords

FERRITIN; FERROPORTIN 1; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PROTEIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENT; FEMALE; INFANCY; IRON ABSORPTION; IRON DEFICIENCY; IRON THERAPY; IRON TRANSPORT; MOLECULAR MECHANICS; MUCOSA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

EID: 0344494842     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00107.2003     Document Type: Article

References (24)

1. Abboud S and Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275: 19906-19912, 2000.
2. Bothwell TH. The control of iron absorption. Br J Haematol 14: 453-456, 1968.
3. Bothwell TH and Charlton RW. Absorption of iron. Annu Rev Med 21: 145-156, 1970.
4. Canonne-Hergaux F, Fleming MD, Levy JE, Gauthier S, Ralph T, Picard V, Andrews NC, and Gros P. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood 96: 3964-3970, 2000.
5. Canonne-Hergaux F, Gruenheid S, Ponka P, and Gros P. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93: 4406-4417, 1999.
6. Clegg MS, Keen CL, Lönnerdal B, and Hurley LS. Influence of ashing techniques on the analysis of trace elements in animal tissue. Biol Trace Elem Res 3: 107-115, 1981.
7. De Andraca I, Castillo M, and Walter T. Psychomotor development and behavior in iron-deficient anemic infants. Nutr Rev 55: 125-132, 1997.
8. Domellöf M, Cohen RJ, Dewey KG, Hernell O, Rivera LL, and Lönnerdal B. Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age. J Pediatr 138: 679-687, 2001.
9. Domellöf M, Lönnerdal B, Abrams SA, and Hernell O. Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods. Am J Clin Nutr 76: 198-204, 2002.
10. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, and Zon LI. Positional cloning of zebrafish ferroportinl identifies a conserved vertebrate iron exporter. Nature 403: 776-781, 2000.
11. Fleming MD, Trenor C, Su MA, Foernzler D, Beier DR, Dietrich WF, and Andrews NC. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16: 383-386, 1997.
12. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, and Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488, 1997.
13. Hubert N and Hentze MW. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function. Proc Natl Acad Sci USA 99: 12345-12350, 2002.
14. Hurtado EK, Claussen AH, and Scott KG. Early childhood anemia and mild or moderate mental retardation. Am J Clin Nutr 69: 115-119, 1999.
15. Keen CL, Lönnerdal B, Clegg MS, and Hurley LS. Developmental changes in composition of rat milk: trace elements, minerals, protein, carbohydrate and fat. J Nutr 111: 226-236, 1981.
16. Leong W, Bowlus CL, Tallkvist J, and Lönnerdal B. Intestinal DMT1 gene expression, iron absorption and tissue iron of infant rats given iron supplements (Abstract). FASEB J 15: A60, 2001.
17. Lowry OH, Rosenbrough NT, Farr AL, and Randall R. Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275, 1951.
18. McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly M, Richardson C, Barlow D, Bomford A, Peters TJ, Raja KB, Shirali S, Hediger MA, Farzaneth F, and Simpson RJ. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291: 1755-1759, 2001.
19. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, and Simpson RJ. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5: 299-309, 2000.
20. Oates PS, Trinder D, and Morgan EH. Gastrointestinal function, divalent metal transporter-1 expression and intestinal iron absorption. Pflügers Arch 440: 496-502, 2000.
21. Pollitt E. Iron deficiency and educational deficiency. Nutr Rev 55: 133-141, 1997.
22. Pollitt E. Early iron deficiency anemia and later mental retardation. Am J Clin Nutr 69: 4-5, 1999.
23. Trinder D, Oates PS, Thomas C, Sadleir J, and Morgan EH. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut 46: 270-276, 2000.
24. Zoller H, Koch RO, Theurl I, Obrist P, Pietrangelo A, Montosi G, Haile DJ, Vogel W, and Weiss G. Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Gastroenterology 120: 1412-1419, 2001.