Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain

Neurobiology of Aging

Volumn 26, Issue 5, 2005, Pages 739-748

  Ke, Ya ^a,b,c   Chang, Yan Zhong ^a,c   Duan, Xiang Lin ^a,c   Du, Jin Rong ^a   Zhu, Li ^a   Wang, Kui ^b,c   Yang, Xiao Da ^b   Ho, Kwok Ping ^a   Qian, Zhong Ming ^a,b,c,d  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c HEBEI NORMAL UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Age and iron status; Brain iron metabolism; Brain regions; DMT1(Nramp2 DCT1) expression

Indexed keywords

IRON; ISOPROTEIN; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN LEVEL; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DIET THERAPY; EVALUATION; GENE EXPRESSION; HIPPOCAMPUS; IRON INTAKE; IRON TRANSPORT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SUBSTANTIA NIGRA;

EID: 13644278965     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2004.06.002     Document Type: Article

References (48)

1. P. Aisen, M. Wessling-Resnick, and E.A. Leibold Iron metabolism Curr Opin Chem Biol 3 1999 200 206
2. N.C. Andrews, M.D. Fleming, and H. Gunshin Iron transport across biological membranes Nutr Rev 57 1999 114 123
3. J.R. Burdo, J. Martin, S.L. Menzies, K.G. Dolan, M.A. Romano, and R.J. Fletcher Cellular distribution of iron in the brain of the Belgrade rat Neuroscience 93 1999 1189 1196
4. J.R. Burdo, S.L. Menzies, I.A. Simpson, L.M. Garrick, M.D. Garrick, and K.G. Dolan Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat J Neurosci Res 66 2001 1198 1207
5. J.R. Burdo, I.A. Simpson, S. Menzies, J. Beard, and J.R. Connor Regulation of the profile of iron-management proteins in brain microvasculature J Cereb Blood Flow Metab 24 1 2004 67 74
6. J.L. Casey, M.W. Hentze, D.M. Koeller, S.W. Caughman, T.A. Rouault, and R.D. Klausner Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation Science 240 4854 1988 924 928
7. F. Canonne-Hergaux, S. Gruenheid, P. Ponka, and P. Gros Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron Blood 93 12 1999 4406 4417
8. F. Canonne-Hergaux, and P. Gros Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice Kidney Int 6 1 2002 147 156
9. F. Dupic, S. Fruchon, M. Bensaid, O. Loreal, P. Brissot, and N. Borot Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice Gut 51 5 2002 648 653
10. M.D. Fleming, C.C. Trenor 3rd, M.A. Su, D. Foernzler, D.R. Beier, and W.F. Dietrich Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene Nat Genet 16 1997 383 386
11. R.E. Fleming, M.C. Migas, X. Zhou, J. Jiang, R.S. Britton, and E.M. Brunt Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1 Proc Natl Acad Sci USA 96 6 1999 3143 3148
12. S.J. Focht, B.S. Snyder, J.L. Beard, W. Van Gelder, L.R. Williams, and J.R. Connor Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains Neuroscience 79 1 1997 255 261
13. M.D. Garrick, K.G. Dolan, C. Horbinski, A.J. Ghio, D. Higgins, and M. Porubcin DMT1: a mammalian transporter for multiple metals Biometals 16 1 2003 41 54
14. S. Grunheid, M. Cellier, S. Vidal, and P. Gros Identification and characterization of a second mouse Nramp gene Genomics 25 1995 514 525
15. S. Gruenheid, F. Canonne-Hergaux, S. Gauthier, D.J. Hackam, S. Grinstein, and P. Gros The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes J Exp Med 189 5 1999 831 841
16. H. Gunshin, B. Mackenzie, U.V. Berger, Y. Gunshin, M.F. Romero, and W.F. Boron Cloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 388 1997 482 488
17. H. Gunshin, C.R. Allerson, M. Polycarpou-Schwarz, A. Rofts, J.T. Rogers, and F. Kishi Iron-dependent regulation of the divalent metal ion transporter FEBS Lett 509 2 2001 309 316
18. M.W. Hentze, and L.C. Kuhn Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress Proc Natl Acad Sci USA 93 16 1996 8175 8182
19. N. Hubert, and M.W. Hentze Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function Proc Natl Acad Sci USA 99 19 2002 12345 12350
20. W.A. Jefferies, M.R. Food, R. Gabathuler, S. Rothenberger, T. Yamada, and O. Yasuhara Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin Brain Res 712 1996 122 126
21. K.A. Jellinger The role of iron in neurodegeneration Drugs Aging 14 1999 115 140
22. Y. Ke, and Z.M. Qian Iron misregulation in the brain: a primary cause of neurodegenerative disorders Lancet Neurol 2 2003 246 253
23. Knutson M, Menzies S, Connor J, Wessling-Resnick M. Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain. J Neurosci Res 2004 1;76(5):633-641.
24. P.L. Lee, T. Gelbart, C. West, C. Halloran, and E. Beutler The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms Blood Cell Mol Dis 24 1998 199 215
25. S. Mandel, E. Grunblatt, P. Riederer, and M.B. Youdim Genes and oxidative stress in parkinsonism: cDNA microarray studies Adv Neurol 91 2003 123 132
26. T. Moos, and E.H. Morgan The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain J Neurochem 88 1 2004 233 245
27. E.W. Mullner, and L.C. Kuhn A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm Cell 53 5 1988 815 825
28. E.W. Mullner, B. Neupert, and L.C. Kuhn A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA Cell 58 2 1989 373 382
29. P.S. Oates, C. Thomas, E. Freitas, M.J. Callow, and E.H. Morgan Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats Am J Physiol 278 6 2000 G930 G936
30. D.J. Pinero, N.Q. Li, J.R. Connor, and J.L. Beard Variations in dietary iron alter brain iron metabolism in developing rats J Nutr 130 2 2000 254 263
31. Z.M. Qian, and Q. Wang Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders Brain Res Rev 27 3 1998 257 267
32. Z.M. Qian, D.S. Xiao, P.L. Tang, F.Y.D. Yao, and Q.K. Liao The increased expression of transferrin receptor on the membrane of erythroblast in strenuous exercised rats J Appl Physiol 87 1999 523 529
33. Z.M. Qian, D.S. Xiao, Y. Ke, and Q.K. Liao Increased nitric oxide is one of the causes of changes of iron metabolism in strenuously exercised rats Am J Physiol 280 2001 R739 R743
34. Z.M. Qian, and X. Shen Brain iron transport and neurodegeneration Trends Mol Med 7 3 2001 103 108
35. M.A. Su, C.C. Trenor, J.C. Fleming, and D.M. Templeton The G185R mutation disrupts function of the iron transporter Nramp2 Blood 92 1998 2157 2163
36. L.M. Sayre, G. Perry, and M.A. Smith Redox metals and neurodegeneratiove disease Curr Opin Chem Biol 3 1999 220 225
37. A.J. Siddappa, R.B. Rao, J.D. Wobken, E.A. Leibold, J.R. Connor, and M.K. Georgieff Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain J Neurosci Res 68 6 2002 761 775
38. A.J. Siddappa, R.B. Rao, J.D. Wobken, K. Casperson, E.A. Leibold, and J.R. Connor Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain Pediatr Res 53 5 2003 800 807
39. K.F. Swaiman Hallervorden-Spatz and brain iron metabolism Arch Neurol 48 1991 1285 1293
40. M. Tabuchi, T. Yoshimori, K. Yamaguchi, T. Yoshida, and F. Kishi Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells J Biol Chem 275 2000 22220 22228
41. S. Tandy, M. Williams, A. Leggett, M. Lopez-Jimenez, M. Dedes, and B. Ramesh Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells J Biol Chem 275 2000 1023 1029
42. D. Trinder, P.S. Oates, C. Thomas, J. Sadleir, and E.H. Morgan Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload Gut 46 2000 270 276
43. X.S. Wang, W.Y. Ong, and J.R. Connor A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus J Neurocytol 30 4 2001 353 360
44. X.S. Wang, W.Y. Ong, and J.R. Connor A light and electron microscopic study of divalent metal transporter-1 distribution in the rat hippocampus, after kainate-induced neuronal injury Exp Neurol 177 1 2002 193 201
45. S.L. Wardrop, and D.R. Richardson The effect of intracellular iron concentration and nitrogen monoxide on NRAMP2 expression and non-transferrin-bound iron uptake Eur J Biochem 263 1999 41 49
46. S.L. Wardrop, and D.R. Richardson Interferon-gamma and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages Eur J Biochem 267 22 2000 6586 6593
47. K. Williams, M.A. Wilson, and J. Bressler Regulation and developmental expression of the divalent metal-ion transporter in the rat brain Cell Mol Biol (Noisy-le-grand) 46 3 2000 563 571
48. K.Y. Yeh, M. Yeh, J.A. Watkins, J. Rodriguez-Paris, and J. Glass Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression Am J Physiol 279 2000 G1070 G1079