Inflammation and bronchopulmonary dysplasia

Seminars in Neonatology

Volumn 8, Issue 1, 2003, Pages 29-38

  Speer, Christian P ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Bronchopulmonary dysplasia; Cytokines; Inflammation; Preterm infants; Proteases

Indexed keywords

CYTOKINE; ELASTASE; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTIFICIAL VENTILATION; CHEMOTAXIS; CHORIOAMNIONITIS; CLINICAL FEATURE; CYTOKINE PRODUCTION; HUMAN; HUMORAL IMMUNITY; INFLAMMATION; INFLAMMATORY CELL; INTRAUTERINE INFECTION; LUNG ALVEOLUS; LUNG BLOOD VESSEL; LUNG DYSPLASIA; LUNG INJURY; LUNG STRUCTURE; NEONATAL RESPIRATORY DISTRESS SYNDROME; NEWBORN; PATHOGENESIS; PNEUMONIA; PREMATURITY; PRENATAL EXPOSURE; PROTEIN DEGRADATION; REVIEW; RISK FACTOR; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 0037299164     PISSN: 10842756     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1084-2756(02)00190-2     Document Type: Review

References (99)

1. Pierce MR, Bancalari E. The role of inflammation in the pathogenesis of bronchopulmonary dysplasia. Pediatr Pulmonol 1995;19:371-8.
2. Zimmermann JJ. Bronchoalveolar inflammatory pathophysiology of bronchopulmonary dysplasia. Clin Perinatol 1995;22:429-56.
3. Kotecha S. Cytokines in chronic lung disease of prematurity. Eur J Pediatr 1996;155(Suppl 2):S14.
4. Speer CP, Groneck P. Oxygen radicals, cytokines, adhesion molecules and lung injury in neonates. Semin Neonatol 1998;3:219-28.
5. Speer CP. New insights into the pathogenesis of pulmonary inflammation in preterm infants. Biol Neonate 2001;79:205-9.
6. Speer CP, Groneck P. Inflammatory mediators in neonatal lung disease. In: Bland R, Coalson J, editors. Chronic lung disease in early infancy. New York: Marcel Dekker 2000;147-57.
7. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723-9.
8. Carlton DP, Albertine KH, Cho SC, Lont M, Bland RD. Role of neutrophils in lung vascular injury and edema after premature birth in lambs. J Appl Physiol 1997;83:1307-17.
9. Ferreira PJ, Bunch TJ, Albertine KH, Carlton DP. Circulating neutrophil concentration and respiratory distress in premature infants. J Pediatr 2000;136:466-72.
10. 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. J Clin Invest 1983;72:656-66.
11. Arnon S, Grigg J, Silverman M. Pulmonary inflammatory cells in ventilated preterm infants: effect of surfactant treatment. Arch Dis Child 1993;69:44-8.
12. Groneck P, Goetze-Speer B, Oppermann M, Eiffert H, Speer CP. Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high risk preterm infants. Pediatrics 1994;93:712-8.
13. Kotecha S, Chan B, Azam N, Silverman M, Shaw RJ. Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage of premature infants with chronic lung disease. Arch Dis Child 1995;72:F90.
14. Ogden BE, Murphy SA, Saunders GC, Pathak D, Johnson JD. Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance. Am Rev Respir Dis 1984;130:817-21.
15. Jackson JC, MacKenzie AP, Chi EY, Standaert TA, Truog WE, Hodson WA. Mechanisms for reduced total lung capacity at birth and during hyaline membrane disease in premature newborn monkeys. Am Rev Respir Dis 1990;142:413-9.
16. Clement A, Chadelat K, Sardet A, Grimfeld A, Tournier G. Alveolar macrophage status in bronchopulmonary dysplasia. Pediatr Res 1988;23:470-3.
17. Rindfleisch MS, Hasday JD, Taciak V, Broderick K, Viscardi RM. Potential role of interleukin-1 in the development of bronchopulmonary dysplasia. J Interferon Cytokine Res 1996;16:365-73.
18. Murch SH, Costeloe K, Klein NJ, Rees H, McIntosh N, Keeling JW et al. Mucosal tumor necrosis factor-α production and extensive disruption of sulfated glycosaminglycans begin within hours of birth in neonatal respiratory distress syndrome. Pediatr Res 1996;40:484-9.
19. Groneck P, Oppermann M, Speer CP. Levels of complement anaphylatoxin C5a in pulmonary effluent fluid of infants at risk for chronic lung disease and effects of dexamethasone treatment. Pediatr Res 1993;34:586-90.
20. Kunkel SL, Standiford T, Kasahara K, Strieter RM. Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung. Exp Lung Res 1991;17:17-23.
21. Stenmark KR, Eyzaguirre M, Westcott JY, Henson PM, Murphy RC. Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. Am Rev Respir Dis 1987;136:770-2.
22. Jones CA, Cayabyab RG, Kwong KY, Stotts C, Wong B, Hamdan H et al. Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. Pediatr Res 1996;39:966-75.
23. Jónsson B, Tullus K, Brauner A, Lu Y, Noack G. Early increase of TNFα and IL-6 in tracheobronchial aspirate fluid indicator of subsequent chronic lung disease in preterm infants. Arch Dis Child 1997;77:F198.
24. Speer CP. Inflammatory mechanisms in neonatal chronic lung disease. Eur J Pediatr 1999;158(Suppl 1):S18.
25. Little S, Dean T, Bevin S, Hall M, Ashton M, Church M et al. Role of elevated plasma soluble ICAM-1 and bronchial lavage fluid IL-8 levels as markers of chronic lung disease in premature infants. Thorax 1995;50:1073-9.
26. Munshi UK, Niu JO, Siddiq MM, Parton LA. Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. Pediatr Pulmonol 1997;24:331-6.
27. Takasaki J, Ogawa Y. Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease. Acta Paediatr Jpn 1997;39:437-41.
28. Wang H, Oei J, Lui K, Henry R. Interleukin-16 in tracheal aspirate fluids of newborn infants. Early Hum Dev 2002;67:79-86.
29. Inwald DP, Costeloe K, Murch SH. High concentrations of GRO-α and MCP-1 in bronchoalveolar fluid of infants with respiratory distress syndrome after surfactant. Arch Dis Child 1998;78:F234.
30. Kotecha S, Silverman M, Shaw RJ, Klein M. Soluble L-selectin concentrations in bronchoalveolar fluid obtained from infants who develop chronic lung disease. Arch Dis Child 1998;78:F143.
31. Ramsay PL, O'Brian Smith E, Hegemier S, Welty SE. Early clinical markers for the development of bronchopulmonary dysplasia: soluble E-Selectin and ICAM-1. Pediatrics 1998;102:927-32.
32. Brus F, van Oeveren W, Okken A, Bambang Oetomo S. Activation of the plasma clotting, fibrinolytic, and kininkallikrein system in preterm infants with severe idiopathic respiratory distress syndrome. Pediatr Res 1994;36:647-53.
33. Brus F, van Oeveren W, Okken A, Bambang Oetomo S. Activation of circulating polymorphonuclear leukocytes in preterm infants with severe idiopathic respiratory distress syndrome. Pediatr Res 1996;39:456-63.
34. Saugstad OD, Buo L, Johansen HT, Røise O, Aasen AO. Activation of the plasma kallikrein-kinin system in respiratory distress syndrome. Pediatr Res 1992;32:431-5.
35. Jaarsma AS, Braaksma MA, Geven WB, van Oeveren W, Oetomo SB. Early activation of inflammation and clotting in the preterm lamb with neonatal RDS: comparison of conventional ventilation and high frequency oscillatory ventilation. Pediatr Res 2001;50:650-7.
36. Nupponen I, Pesonen E, Andersson S, Mäkelä A, Turunen R, Kautiainen H et al. Neutrophil activation in preterm infants who have respiratory distress syndrome. Pediatrics 2002;110:36-41.
37. Lassus P, Turanlahti M, Heikkilä P, Anderssen LC, Nupponen I, Sarnesto A et al. Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 2001;164:1981-7.
38. Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM. Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1 and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;164:1971-80.
39. Kotecha S. Pathophysiology of chronic lung disease or prematurity. Biol Neonate 2000;78:233-68.
40. Jobe AH, Ikegami M. Mechanisms initiating lung injury in the preterm. Early Hum Dev 1998;53(1):81-94.
41. Groneck P, Schmale J, Soditt V, Stützer J, Goetze-Speer B, Speer CP. Bronchoalveolar inflammation following airway infection in preterm infants with chronic lung disease. Pediatr Pulmonol 2001;31:331-8.
42. Kotecha S, Wilson L, Wangoo A, Silverman M, Shaw RJ. Increase in interleukin (IL)-1α and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity. Pediatr Res 1996;40:250-6.
43. LoMonaco MB, Barber CM, Sinkin PA. Differential cytokine mRNA expression by neonatal pulmonary cells. Pediatr Res 1996;39:248-51.
44. Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J. Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 2001;107:1529-36.
45. Narimanbekov IO, Rozyiki HL. Effect of IL-1 blockade on inflammatory manifestations of acute ventilator-induced lung injury in a rabbit model. Exp Lung Res 1995;21:239-54.
46. Schmidt B, Cao L, Mackensen-Haen S, Kendziorra H, Klingel K, Speer CP. Chorioamnionitis and inflammation of the fetal lung. Am J Obstet Gynecol 2001;194:173-7.
47. Kwong KYC, Jones CA, Cayabyab R, Lecart C, Khuu N, Rhandhawa I et al. The effects of IL-10 on proinflammatory cytokine expression (IL-1β and IL-8) in hyaline membrane disease (HMD). Clin Immunol Immunopathol 1998;88:105-13.
48. Keane MP, Strieter RM. The importance of balanced proinflammatory and anti-inflammatory mechanisms in diffuse lung disease. Respir Res 2002;3:5.
49. Naik A, Kallapur S, Bachurski CJ, Michna J, Jobe AH, Ikegami M. Effects of different styles of ventilation on cytokine expression in preterm lamb lung. Pediatr Res 2000;47:370A.
50. Muscedere JG, Mullen JBM, Gan K, Slutsky AS. Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 1994;149:1327-34.
51. Dreyfuss D, Saumon G. Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 1998;157:294-323.
52. Albertine KH, Jones GP, Starcher BC, Bohnsack JF, Davis PL, Cho SC et al. Chronic lung injury in preterm lambs. Disordered respiratory tract development. Am J Respir Crit Care Med 1999;159:945-58.
53. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 1997;99:944-52.
54. Vlahakis NE, Schroeder MA, Limper AH, Hubmayr RD. Stretch induces cytokine release by alveolar epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol 1999;277(1):L167.
55. Yoder BA, Siler-Khodr T, Winter VT, Coalson JJ. High frequency oscillatory ventilation-effects on lung function, mechanics, and airway cytokines in the immature baboon model for neonatal chronic lung disease. Am J Respir Crit Care Med 2000;162:1867-76.
56. Thome U, Goetze-Speer B, Speer CP, Pohlandt F. Comparison of pulmonary inflammatory mediators in preterm infants treated with intermittent positive pressure ventilation or high frequency oscillatory ventilation. Pediatr Res 1998;44:330-7.
57. Van Marter LJ, Allred EN, Pagano M, Sanocka U, Parad R, Moore M et al. Do clinical markers of barotraumas and oxygen toxicity explain interhospital variation in rates of chronic lung disease? Pediatrics 2000;105:1194-201.
58. Yoon BH, Romero R, Jun JK, Park KH, Park JD, Ghezzi F et al. Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1997;177(4):825-30.
59. Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194-202.
60. Craven CM, Ward K. Fetal endothelial cells express vascular cell adhesion molecule in the setting of chorioamnionitis. Am J Reprod Immunol 2000;43:259-63.
61. Kramer BW, Kramer S, Ikegami M, Jobe AH. Injury inflammation and remodelling in fetal sheep lung after intraamniotic endotoxin. Am J Physiol 2002;283:L452.
62. Groneck P, Götze-Speer B, Speer CP. Inflammatory bronchopulmonary response of preterm infants with microbial colonisation of the airways at birth. Arch Dis Child 1996;74:F51.
63. Cordero L, Ayers LW, Davis K. Neonatal airway colonization with Gram-negative bacilli: association with severity of bronchopulmonary dysplasia. Pediatr Infect Dis J 1997;16:18-23.
64. Rojas MA, Gonzalez A, Bancalari E, Claure N, Poole C, Silva-Neto G. Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease. J Pediatr 1995;126:605-10.
65. Gonzales A, Sosenko IRS, Chandar J, Hummler H, Claure N, Bancalari E. Influence of infection on patent ductus arteriosus and chronic lung disease in premature infants weighing 1000 grams or less. J Pediatr 1996;128:470-8.
66. Wang EEL, Matlow AG, Ohlsson A, Nelson SC. Ureaplasma urealyticum infections in the perinatal period. Clin Perinatol 1997;24:91-105.
67. Li YH, Chen M, Brauner A, Zheng C, Jensen JS, Tullus K. Ureaplasma urealyticum induces apoptosis in human lung epithelial cells and macrophages. Biol Neonate 2002;82:166-73.
68. Van Marter LJ, Dammann O, Allred EN, Leviton A, Pagano M, Moore M et al. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr 2002;140:171-6.
69. Grigg J, Barber A, Silverman M. Increased levels of bronchoalveolar fluid interteukin-6 in preterm ventilated infants after prolonged rupture of membranes. Am Rev Respir Dis 1992;145:782-6.
70. Willmot RW, Kassab JT, Kilian PL, Benjamin WR, Douglas SD, Wood RE. Increased levels of interleukin-1 in bronchoalveolar washings from children with bacterial pulmonary infections. Am Rev Respir Dis 1990;142:365-8.
71. Speer CP, Ninjo O, Gahr M. Elastase-alpha-1-proteinase inhibitor in early diagnosis of neonatal septicemia. J Pediatr 1986;108:987-90.
72. 1-proteinase inhibitor, and fibronectin in bronchoalveolar lavage fluid from neonates. J Pediatr 1988;113:732-7.
73. Sveger KT, Svenningsen N. Protease inhibitors in bronchoalveolar lavage fluid from neonates with special references to secretory leukocyte protease inhibitor. Acta Paediatr 1992;81:757-9.
74. Yoder MC, Chua R, Tepper R. Effect of dexamethasone on pulmonary inflammation and pulmonary function of ventilator-dependent infants with bronchopulmonary dysplasia. Am Rev Respir Dis 1991;143:1044-8.
75. Merritt TA, Stuard ID, Puccia J, Edwards DK, Finkelstein J, Shapiro DL. Newborn tracheal aspirate cytology: classification during respiratory distress syndrome and bronchopulmonary dysplasia. J Pediatr 1986;98:949-56.
76. Speer CP, Ruess D, Harms K, Herting E, Gefeller O. Neutrophil elastase and acute pulmonary damage in neonates with severe respiratory distress syndrome. Pediatrics 1993;91:794-9.
77. Gerber CE, Bruchelt G, Stegmann H, Schweinsberg F, Speer CP. Presence of bleomycin-detectable free iron in the alveolar system of preterm infants. Biochem Biophys Res Commun 1999;257:218-22.
78. Speer CP, Pabst M, Hedegaard HB, Rest RF, Johnston RB. Enhanced release of oxygen metabolites by monocyte-derived macrophages exposed to proteolytic enzymes: activity of neutrophil elastase and cathepsin G. J Immunol 1984;133:2151-6.
79. Schock BC, Sweet DG, Ennis M, Warner JA, Young IS, Halliday HL. Oxidative stress and increased type-IV collagenase levels in bronchoalveolar lavage fluid from newborn babies. Pediatr Res 2002;50:29-33.
80. Sweet DG, McMahon KJ, Curley AE, O'Connor CM, Halliday HL. Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease. Arch Dis Child Fetal Neonatal Ed 2001;84:F168-71.
81. Cederquist K, Sorsa T, Tervahartiala T, Maisi P, Reunanen K, Lassus P et al. Matrix metalloproteinases-2, -8, and -9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress. Pediatrics 2001;108:686-92.
82. Margraf LR, Tomashefiski JF Jr., Bruse MC, Dahms B. Morphometric analysis of the lung in BPD. Am Rev Respir Dis 1991;143:391-400.
83. Pierce PA, Albertine KH, Starcher BC, Bohnsack JF, Carlton DP, Bland RD. Chronic lung injury in preterm lambs: disordered pulmonary elastin deposition. Am J Physiol 1997;272:L452.
84. Alnahhas MH, Karathanasis P, Martich Kriss V, Pauly TH, Bruce MC. Elevated laminin concentrations in lung secretions of preterm infants supported by mechanical ventilation are correlated with radiographic abnormalities. J Pediatr 1997;131:555-60.
85. Juul SE, Kinsella MG, Jackson JC, Truog WE, Standaert TA, Hodson WA. Changes in hyaluronan deposition during early respiratory distress syndrome in premature monkeys. Pediatr Res 1994;35:238-43.
86. Murch SH, MacDonald TT, Walker-Smith JA, Levin M, Lionetti P, Klein NJ. Disruption of sulphated glycosaminoglycans in intestinal inflammation. Lancet 1993;341:711-4.
87. Jefferies AL, Coates G, O'Brodovich H. Pulmonary epithelial permeability in hyaline-membrane disease. N Engl J Med 1984;311:1075-80.
88. Davidson D, Drafta D, Wilkens BA. Elevated urinary leukotriene E4 in chronic lung disease of extreme prematurity. Am J Respir Crit Care Med 1995;151:841-5.
89. Gaylord MS, Smith ZL, Lorch V, Blank ML, Snyder H. Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. Am J Med Sci 1996;312:149-54.
90. Kojima T, Hattori K, Hirata Y, Aoki T, Sasai-Takedatsu M, Kino M et al. Endothelin-1 has a priming effect on production of superoxide anion by alveolar macrophages: its possible correlation with bronchopulmonary dysplasia. Pediatr Res 1996;39:112-6.
91. Mirro R, Armstead W, Leffler C. Increased airway leukotriene levels in infants with severe bronchopulmonary dysplasia. Am J Dis Child 1990;144:160-1.
92. Niu JO, Munshi UK, Siddiq MM, Parton LA. Early increase in endothelin-1 in tracheal aspirates of preterm infants: correlation with bronchopulmonary dysplasia. J Pediatr 1998;132:965-70.
93. Saugstad OD. Bronchopulmonary dysplasia and oxidative stress: are we closer to an understanding of the pathogenesis of BPD? Acta Paediatr 1997;86:1277-82.
94. Coalson J, Winter V, Siler-Khodr T, Yoder B. Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med 1999;160:1333-46.
95. Grande JP. Role of transforming growth factor-β in tissue injury and repair. Proc Soc Exp Biol Med 1997;214:27-40.
96. Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL et al. Transfer of tumor necrosis factor-α to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-β1 and myofibroblasts. Am J Pathol 1998;153:825-32.
97. Kotecha S, Wangoo A, Silverman M, Shaw RJ. Increase in the concentration of transforming growth factor-β1 in bronchoalveolar lavage fluid before the development of chronic lung disease of prematurity. J Pediatr 1996;128:464-9.
98. Lecart C, Cayabyab R, Bockley S, Morrison J, Kwong KY, Warburton D et al. Bioactive transforming growth factor-β in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation. Biol Neonate 2000;77:217-23.
99. Jónsson B, Li Y-H, Noack G, Brauner A, Tullus K. Downregulatory cytokines in tracheobronchial aspirate fluid from infants with chronic lung disease of prematurity. Acta Paediatr 2000;89:1375-80.