Pin1 down-regulates transforming growth factor-β (TGF-β) signaling by inducing degradation of Smad proteins

Journal of Biological Chemistry

Volumn 284, Issue 10, 2009, Pages 6109-6115

  Nakano, Ayako ^a,b   Koinuma, Daizo ^a   Miyazawa, Keiji ^c   Uchida, Takafumi ^d   Saitoh, Masao ^c   Kawabata, Masahiro ^a   Hanai, Jun Ichi ^a   Akiyama, Hirotada ^d   Abe, Masahiro ^a   Miyazono, Kohel ^c   Matsumoto, Toshio ^b   Imamura, Takeshi ^a  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL DEATH; PHOSPHORYLATION; SIGNALING; TRANSCRIPTION;

BONE MORPHOGENETIC PROTEINS; CELLULAR PROCESS; INDUCED TRANSCRIPTION; ISOMERASE ACTIVITY; PROTEASOMAL DEGRADATION; REGULATORY FACTORS; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN-PROTEASOME SYSTEM;

PROTEINS;

GENE PRODUCT; PEPTIDYLPROLYL ISOMERASE PIN1; PROTEIN SMURF2; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; BONE MORPHOGENETIC PROTEIN; NIMA INTERACTING PEPTIDYLPROLYL ISOMERASE; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; PEPTIDYLPROLYL ISOMERASE; PROTEASOME; SMAD2 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; SMURF2 PROTEIN, HUMAN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; GENE SILENCING; GENETICS; METABOLISM; METHODOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING;

AMINO ACID MOTIFS; ANIMALS; BONE MORPHOGENETIC PROTEINS; CERCOPITHECUS AETHIOPS; COS CELLS; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; PEPTIDYLPROLYL ISOMERASE; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 65249175171     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804659200     Document Type: Article

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