Pin1 promotes production of Alzheimer's amyloid β from β-cleaved amyloid precursor protein

Biochemical and Biophysical Research Communications

Volumn 336, Issue 2, 2005, Pages 521-529

  Akiyama, Hirotada ^a   Shin, Ryong Woon ^b   Uchida, Chiyoko ^a,c   Kitamoto, Tetsuyuki ^b   Uchida, Takafumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c IBARAKI UNIVERSITY   (Japan)

Author keywords

Secretase cleavage; Alzheimer's disease; Amyloid ; Amyloid precursor protein; GSK 3 ; Lithium; Pin1

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; ISOPROTEIN; LITHIUM; PROTEIN SUBUNIT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL LINE; CELL STRAIN COS7; ENZYME ACTIVITY; GENETIC TRANSFECTION; IMMUNOASSAY; IMMUNOPRECIPITATION; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; WILD TYPE;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELLS, CULTURED; FIBROBLASTS; MICE; PEPTIDYLPROLYL ISOMERASE;

EID: 24644444767     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.08.130     Document Type: Article

References (36)

1. S. Matsuda, Y. Miwa, Y. Hirata, A. Minowa, J. Tanaka, E. Nishida, and S. Koyasu Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT EMBO J. 23 2004 2577 2585
2. Y.X. Xu, and J.L. Manley Pinning down transcription: regulation of RNA polymerase II activity during the cell cycle Cell Cycle 3 2004 432 435
3. F. Tsuruta, J. Sunayama, Y. Mori, S. Hattori, S. Shimizu, Y. Tsujimoto, K. Yoshioka, N. Masuyama, and Y. Gotoh JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins EMBO J. 23 2004 1889 1899
4. K.P. Lu, D.D. Hanes, and T. Hunter A human peptidyl-prolyl isomerase essential for regulation of mitosis Nature 380 1996 544 547
5. M.B. Yaffe, M. Schutkowski, M. Shen, X.Z. Zhou, P.T. Stukenberg, J.U. Rahfeld, J. Xu, J. Kuang, M.W. Kirschner, G. Fischer, L.C. Cantley, and K.P. Lu Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism Science 278 1997 1957 1960
6. P.J. Lu, X.Z. Zhou, M. Shen, and K.P. Lu Function of WW domains as phosphoserine- or phosphothreonine-binding modules Science 283 1999 1325 1328
7. J.W. Husseman, D. Nochlin, and I. Vincent Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases Neurobiol. Aging 21 2000 815 828
8. P.J. Lu, G. Wulf, X.Z. Zhou, P. Davies, and K.P. Lu The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein Nature 399 1999 784 788
9. F. Fujimori, K. Takahashi, C. Uchida, and T. Uchida Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest Biochem. Biophys. Res. Commun. 265 1999 658 663
10. Y.C. Liou, A. Ryo, H.K. Huang, P.J. Lu, R. Bronson, F. Fujimori, T. Uchida, T. Hunter, and T.K.P. Lu Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes Proc. Natl. Acad. Sci. USA 99 2002 1335 1340
11. Y.C. Liou, A. Sun, A. Ryo, X.Z. Zhou, Z.X. Yu, H.K. Huang, T. Uchida, R. Bronson, G. Bing, X. Li, T. Hunter, and K.P. Lu Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration Nature 424 2003 556 561
12. D.J. Selkoe Alzheimer's disease: genes, proteins, and therapy Physiol. Rev. 81 2001 741 766
13. M. Oishi, A.C. Nairn, A.J. Czernik, G.S. Lim, T. Isohara, S.E. Gandy, P. Greengard, and T. Suzuki The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells Mol. Med. 3 1997 111 123
14. A.E. Aplin, G.M. Gibb, J.S. Jacobsen, J.M. Gallo, and B.H. Anderton In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta J. Neurochem. 67 1996 699 707
15. C.L. Standen, J. Brownlees, A.J. Grierson, S. Kesavapany, K.F. Lau, D.M. McLoughlin, and C.C. Miller Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3) J. Neurochem. 76 2001 316 320
16. K. Iijima, K. Ando, S. Takeda, Y. Satoh, T. Seki, S. Itohara, P. Greengard, Y. Kirino, A.C. Nairn, and T. Suzuki Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5 J. Neurochem. 75 2000 1085 1091
17. T. Suzuki, M. Oishi, D.R. Marshak, A.J. Czernik, A.C. Nairn, and P. Greengard Cell cycle-dependent regulation of the phosphorylation and metabolism of the alzheimer amyloid precursor protein EMBO J. 13 1994 1114 1122
18. K. Ando, K.I. Iijima, J.I. Elliott, Y. Kirino, and T. Suzuki Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid J. Biol. Chem. 276 2001 40353 40361
19. M.S. Lee, S.C. Kao, C.A. Lemere, W. Xia, H.C. Tseng, Y. Zhou, R. Neve, M.K. Ahlijanian, and L.H. Tsai APP processing is regulated by cytoplasmic phosphorylation J. Cell Biol. 163 2003 83 95
20. N. Suzuki, T.T. Cheung, X.D. Cai, A. Odaka, L. Otvos Jr., C. Eckman, T.E. Golde, and S.G. Younkin An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants Science 264 1994 1336 1340
21. T. Uchida, M. Takamiya, M. Takahashi, H. Miyashita, H. Ikeda, T. Terada, Y. Matsuo, M. Shirouzu, S. Yokoyama, F. Fujimori, and T. Hunter Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation Chem. Biol. 10 2003 15 24
22. H. Zheng, H. You, X.Z. Zhou, S.A. Murray, T. Uchida, G. Wulf, L. Gu, X. Tang, K.P. Lu, and Z.X. Xiao The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response Nature 419 2002 849 853
23. P. Zacchi, M. Gostissa, T. Uchida, C. Salvagno, F. Avolio, S. Volinia, Z. Ronai, G. Blandino, C. Schneider, and G. Del Sal The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults Nature 419 2002 853 857
24. R.W. Shin, T.C. Saido, M. Maeda, and T. Kitamoto Novel α-secretase cleavage of Alzheimer's amyloid β precursor protein in the endoplasmic reticulum of COS7 cells Neurosci. Lett. 376 2005 14 19
25. A. Yamamoto, R.W. Shin, K. Hasegawa, H. Naiki, H. Sato, Y. Yoshimasu, and T. Kitamoto Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease J. Neurochem. 82 2002 1137 1147
26. K. Ishiguro, A. Shiratsuchi, S. Sato, A. Omori, M. Arioka, S. Kobayashi, T. Uchida, and K. Imahori Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments FEBS Lett. 325 1993 167 172
27. S. Tomita, T. Ozaki, H. Taru, S. Oguchi, S. Takeda, Y. Yagi, S. Sakiyama, Y. Kirino, and T. Suzuki Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein J. Biol. Chem. 274 1999 2243 2254
28. E. Yeh, M. Cunningham, H. Arnold, D. Chasse, T. Monteith, G. Ivaldi, W.C. Hahn, P.T. Stukenberg, S. Shenolikar, T. Uchida, C.M. Counter, J.R. Nevins, A.R. Means, and R. Sears A signaling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells Nature Cell Biol. 6 2004 308 318
29. R. Vassar, B.D. Bennett, S. Babu-Khan, S. Kahn, E.A. Mendiaz, P. Denis, D.B. Teplow, S. Ross, P. Amarante, R. Loeloff, Y. Luo, S. Fisher, J. Fuller, S. Edenson, J. Lile, M.A. Jarosinski, A.L. Biere, E. Curran, T. Burgess, J.C Louis, F. Collins, J. Treanor, G. Rogers, and M. Citron Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 1999 735 741
30. C. Nordstedt, S.E. Gandy, I. Alafuzoff, G.L. Caporaso, K. Iverfeldt, J.A. Grebb, B. Winblad, and P. Greengard Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment Proc. Natl. Acad. Sci. USA 88 1991 8910 8914
31. V. Stambolic, L. Ruel, and J.R. Woodgett Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells Curr. Biol. 6 1996 1664 1668
32. X. Sun, S. Sato, O. Murayama, M. Murayama, J.M. Park, H. Yamaguchi, and A. Takashima Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100 Neurosci. Lett. 321 2002 61 64
33. C.J. Phiel, C.A. Wilson, V.M. Lee, and P.S. Klein GSK-3alpha regulates production of alzheimer's disease amyloid-beta peptides Nature 423 2003 435 439
34. J. Ryder, Y. Su, F. Liu, B. Li, Y. Zhou, and B. Ni Divergent roles of GSK3 and CDK5 in APP processing Biochem. Biophys. Res. Commun. 312 2003 922 929
35. Y. Su, J. Ryder, B. Li, X. Wu, N. Fox, P. Solenberg, K. Brune, S. Paul, Y. Zhou, F. Liu, and B. Ni Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing Biochemistry 43 2004 6899 6908
36. T.A. Ramelot, and L.K. Nicholson Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR J. Mol. Biol. 307 2001 871 884