NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-β (transforming growth factor-β) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-β type I receptor

Biochemical Journal

Volumn 386, Issue 3, 2005, Pages 461-470

  Kuratomi, Go ^a,b   Komuro, Akiyoshi ^c   Goto, Kouichiro ^a,c   Shinozaki, Masahiko ^c   Miyazawa, Keiji ^c   Miyazono, Kohei ^a,c   Imamura, Takeshi ^a,b  

^a CANCER INSTITUTE   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bone morphogenetic protein (BMP); Developmentally down regulated 4 2 (NEDD4 2); Homologous to the E6 accessory protein C terminus (HECT); Neural precursor cell expressed; Smad; Transforming growth factor (TGF )

Indexed keywords

BINDING ENERGY; DEGRADATION; GENES; NEUROLOGY; PROTEINS; RNA; YEAST;

INDUCED DEGRADATION; NEURAL PRECUSSOR CELLS; NOVEL PROTEINS;

CELLS;

CYTOKINE; PROTEIN E6; PROTEIN SMURF; SMAD PROTEIN; SMAD2 PROTEIN; SMAD7 PROTEIN; SMALL INTERFERING RNA; SMALL NUCLEOLAR RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRYPTOPHAN; UBIQUITIN PROTEIN LIGASE NEDD4; UBIQUITIN PROTEIN LIGASE NEDD4 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOREGULATION; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM; UBIQUITINATION;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; DNA-BINDING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MICE; PROTEIN BINDING; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 15944370597     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040738     Document Type: Article

References (42)

1. Roberts, A. B. and Sporn, M. B. (1990) The transforming growth factor-βs. In Peptide Growth Factors and Their Receptors, Part I (Sporn, M. B. and Roberts, A. B., eds.), pp. 419-472, Springer-Verlag, Heidelberg
2. Heldin, C.-H., Miyazono, K. and ten Dijke, P. (1997) TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature (London) 390, 465-471
3. Massagué, J. (1998) TGF-β signal transduction. Annu. Rev. Biochem. 67, 753-791
4. Derynck, R., Zhang, Y. and Feng, X.-H. (1998) Smads: transcriptional activators of TGF-β responses. Cell 95, 737-740
5. Attisano, L. and Wrana, J. L. (2000) Smads as transcriptional co-modulators. Curr. Opin. Cell Biol. 12, 235-243
6. Imamura, T. Takase, M., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M. and Miyazono, K. (1997) Smad6 inhibits signalling by the TGF-β superfamily. Nature (London) 389, 622-626
7. Hanyu, A., Ishidou, Y., Ebisawa, T. Shimanuki, T., Imamura, T. and Miyazono, K. (2001) The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling. J. Cell Biol. 155, 1017-1028
8. Hershko, A. and Ciechanover, A. (1998) The ubiquitin system. Annu. Rev. Biochem. 67, 425-479
9. Jesenberger, V. and Jentsch, S. (2002) Deadly encounter: ubiquitin meets apoptosis. Nat. Rev. Mol. Cell Biol. 3, 112-121
10. Laney, J. D. and Hochstrasser, M. (1999) Substrate targeting in the ubiquitin system. Cell 97, 427-430
11. Fukuchi, M., Imamura, T., Chiba, T., Ebisawa, T., Kawabata, M., Tanaka, K. and Miyazono, K. (2001) Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Mol. Biol. Cell 12, 1431-1443
12. Wan, M., Tang, Y., Tytler, E. M., Lu, C., Jin, B., Vickers, S. M., Yang, L., Shi, X. and Cao, X. (2004) Smad4 protein stability is regulated by ubiquitin ligase SCF β-TrCP1. J. Biol. Chem. 279, 14484-14484
13. Zhu, H., Kavsak, P., Abodollah, S., Wrana, J. L. and Thomsen, G. H. (1999) A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature (London) 400, 687-693
14. Lin, X., Liang, M. and Feng, X.-H. (2000) Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-β signaling. J. Biol. Chem. 275, 36818-36822
15. Zhang, Y., Chang, C., Gehling, D. J., Hemmati-Brivanlou, A. and Derynck, R. (2001) Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A. 98, 974-979
16. Kavsak, P., Rasmussen, R. K., Causing, C. G., Bonni, S., Zhu, H., Thomsen, G. H. and Wrana, J. L. (2000) Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation. Mol. Cell 6, 1365-1375
17. Ebisawa, T., Fukuchi, M., Murakami, G., Chiba, T., Tanaka, K., Imamura, T. and Miyazono, K. (2001) Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation, J. Biol. Chem. 276, 12477-12480
18. Tajima, Y., Goto, K., Yoshida, M., Shinomiya, K., Sekimoto, T., Yoneda, Y., Miyazono, K. and Imamura, T. (2003) Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7. J. Biol. Chem. 278, 10716-10721
19. Suzuki, C., Murakami, G., Fukuchi, M., Shimanuki, T., Shikauchi, Y., Imamura, T. and Miyazono, K. (2002) Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J. Biol. Chem. 277, 39919-39925
20. Kim, B. C., Lee, H. J., Park, S. H., Lee, S. R., Karpova, T. S., McNally, J. G., Felici, A., Lee, D. K. and Kim, S. J. (2004) Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor β signaling by binding to Smad7 and promoting its degradation. Mol. Cell. Biol. 24, 2251-2262
21. Bonni, S., Wang, H. R., Causing, C. G., Kavsak, P., Stroschein, S. L., Luo, K. and Wrana, J. L. (2001) TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol. 3, 587-595
22. Koinuma, D., Shinozaki, M., Komuro, A., Goto, K., Saitoh, M., Hanyu, A., Ebina, M., Nukiwa, T., Miyazawa, K., Imamura, T. and Miyazono, K. (2003) Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7. EMBO J. 22, 6458-6470
23. +. Proc. Natl. Acad. Sci. U.S.A. 95, 7169-7173
24. + channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome. J. Biol. Chem. 273, 30012-30017
25. + channel (H1) by the ubiquitin-protein ligase Nedd4. FEBS Lett. 466, 377-380
26. +. J. Biol. Chem. 274, 12525-12530
27. Harvey, K. F., Dinudom, A., Cook, D. I. and Kumar, S. (2001) The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. J. Biol. Chem. 276, 8597-8601
28. +-channel subunits. Biochem. J. 345, 503-509
29. + channel. FASEB J. 15, 204-214
30. + channel regulation. Am. J. Physiol. Renal Physiol. 281, F469-F477
31. + channel by human Nedd4. J. Biol. Chem. 276, 28321-28326
32. Kawabata, M., Inoue, H., Hanyu, A., Imamura, T. and Miyazono, K. (1998) Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J. 17, 4056-4065
33. Ebisawa, T., Tada, K., Kitajima, I., Tojo, K., Sampath, T. K., Kawabata, M., Miyazono, K. and Imamura, T. (1999) Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. J. Cell Sci. 112, 3519-3527
34. Frolik, C. A., Wakefield, L. M., Smith, D. M. and Sporn, M. B. (1984) Characterization of a membrane receptor for transforming growth factor-β in normal rat kidney fibroblasts. J. Biol. Chem. 259, 10995-11000
35. Dan, S., Tsunoda, T., Kitahara, O., Yanagawa, R., Zembutsu, H., Katagiri, T., Yamazaki, K., Nakamura, Y. and Yamori, T. (2002) An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines. Cancer Res. 62, 1139-1147
36. Li, C. Y., Suardet, L. and Little, J. B. (1995) Potential role of WAF1/Cip1/p21 as a mediator of TGF-β cytoinhibitory effect. J. Biol. Chem. 270, 4971-4974
37. Ito, M., Yasui, W., Nakayama, H., Yokozaki, H., Ito, H. and Tahara, E. (1992) Reduced levels of transforming growth factor-β type I receptor in human gastric carcinomas. Jpn. J. Cancer Res. 83, 86-92
38. Ito, M., Yasui, W., Kyo, E., Yokozaki, H., Nakayama, H., Ito, H. and Tahara, E. (1992) Growth inhibition of transforming growth factor β on human gastric carcinoma cells: receptor and postreceptor signaling. Cancer Res. 52, 295-300
39. Murakami, G., Watabe, T., Takaoka, K., Miyazono, K. and Imamura, T. (2003) Inhibition of BMP signaling by Smurf1 and inhibitory Smads. Mol. Biol. Cell 14, 2809-2817
40. Nomura, T., Khan, M. M., Kaul, S. C., Dong, H.-D., Wadhwa, R., Colmenares, C., Kohno, I. and Ishii, S. (1999) Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 13, 412-423
41. Akiyoshi, S., Inoue, H., Hanai, J., Kusanagi, K., Nemoto, N., Miyazono, K. and Kawabata, M. (1999) c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with Smads. J. Biol. Chem. 274, 35269-35277
42. Stroschein, S. L., Wang, W., Zhou, S., Zhou, Q. and Luo, K. (1999) Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science 286, 771-774