메뉴 건너뛰기




Volumn 13, Issue 2, 2009, Pages 195-207

Pharmacotherapy of obesity: Emerging drugs and targets

Author keywords

Appetite regulation; Central targets of obesity; Metabolic syndrome; Peripheral targets of obesity

Indexed keywords

A 71378; ACETYL COENZYME A CARBOXYLASE; AMFEBUTAMONE; ANTIOBESITY AGENT; ARL 15849; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; C 75; CERULENIN; CETILISTAT; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; CP 640186; CP 945598; DIACYLGLYCEROL ACYLTRANSFERASE; DRF 2655; FATTY ACID SYNTHASE INHIBITOR; GI 181771; GW 0072; LG 100641; LIRAGLUTIDE; LORCASERIN; MELANIN CONCENTRATING HORMONE ANTAGONIST; MELANOCORTIN 4 RECEPTOR AGONIST; MELANOCORTIN RECEPTOR AGONIST; MIFOBATE; MK 0557; MLN 4760; NALTREXONE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NGD 4715; PEPTIDE YY [3-36]; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PHENTERMINE; PLACEBO; RIMONABANT; SEROTONIN 2C AGONIST; SIBUTRAMINE; TARANABANT; TOPIRAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZONISAMIDE;

EID: 64349117818     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728220802637063     Document Type: Review
Times cited : (35)

References (119)
  • 1
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2000
    • Flegal KM, Carrol MD, Ogden CL, et al. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002 ; 288 (14): 1723-1727
    • (2002) JAMA , vol.288 , Issue.14 , pp. 1723-1727
    • Flegal, K.M.1    Carrol, M.D.2    Ogden, C.L.3
  • 2
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    • Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 2003 ; 289 (1): 76-79
    • (2003) JAMA , vol.289 , Issue.1 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3
  • 3
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature 2000 ; 404 (6778): 635-643
    • (2000) Nature , vol.404 , Issue.6778 , pp. 635-643
    • Kopelman, P.G.1
  • 4
    • 33750510903 scopus 로고    scopus 로고
    • The obesity pipeline: Current strategies in the development of anti-obesity drugs
    • Cooke D, Bloom S. The obesity pipeline: current strategies in the development of anti-obesity drugs. Nat Rev Drug Discov 2006 ; 5 (11): 919-931
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.11 , pp. 919-931
    • Cooke, D.1    Bloom, S.2
  • 5
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995 ; 332 (10): 621-628
    • (1995) N Engl J Med , vol.332 , Issue.10 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 6
    • 2942716780 scopus 로고    scopus 로고
    • Modern science versus the stigma of obesity
    • A comprehensive review on the scientific basis of obesity
    • Friedman JM. Modern science versus the stigma of obesity. Nat Med 2004 ; 10 (6): 563 -9 • A comprehensive review on the scientific basis of obesity.
    • (2004) Nat Med , vol.10 , Issue.6 , pp. 563-569
    • Friedman, J.M.1
  • 7
    • 0036325531 scopus 로고    scopus 로고
    • Genetic approaches to studying energy balance: Perception and integration
    • Barsh GS, Schwartz MW. Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet 2002 ; 3 (8): 589-600
    • (2002) Nat Rev Genet , vol.3 , Issue.8 , pp. 589-600
    • Barsh, G.S.1    Schwartz, M.W.2
  • 8
    • 0037057755 scopus 로고    scopus 로고
    • Getting formal with dopamine and reward
    • Schultz W. Getting formal with dopamine and reward. Neuron 2002 ; 36 : 241-263
    • (2002) Neuron , vol.36 , pp. 241-263
    • Schultz, W.1
  • 9
    • 2442701355 scopus 로고    scopus 로고
    • Motivation concepts in behavioral neuroscience
    • Berridge KC. Motivation concepts in behavioral neuroscience. Physiol Behav 2004 ; 81 (2): 179-209
    • (2004) Physiol Behav , vol.81 , Issue.2 , pp. 179-209
    • Berridge, K.C.1
  • 10
    • 0029839328 scopus 로고    scopus 로고
    • Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction
    • Alvaro JD, Tatro JB, Quillan JM, et al. Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Mol Pharmacol 1996 ; 50 (3): 583-591
    • (1996) Mol Pharmacol , vol.50 , Issue.3 , pp. 583-591
    • Alvaro, J.D.1    Tatro, J.B.2    Quillan, J.M.3
  • 11
    • 0028228615 scopus 로고
    • Neuropeptide Y and energy balance: One way ahead for the treatment of obesity?
    • Dryden S, Frankish H, Wang Q, et al. Neuropeptide Y and energy balance: one way ahead for the treatment of obesity? Eur J Clin Invest 1994 ; 24 (5): 293-308
    • (1994) Eur J Clin Invest , vol.24 , Issue.5 , pp. 293-308
    • Dryden, S.1    Frankish, H.2    Wang, Q.3
  • 12
    • 0037178730 scopus 로고    scopus 로고
    • Activation of central melanocortin pathways by fenfl uramine
    • Heisler LK, Cowley MA, Tecott LH, et al. Activation of central melanocortin pathways by fenfl uramine. Science 2002 ; 297 (5581): 609-611
    • (2002) Science , vol.297 , Issue.5581 , pp. 609-611
    • Heisler, L.K.1    Cowley, M.A.2    Tecott, L.H.3
  • 13
    • 0032537810 scopus 로고    scopus 로고
    • Adaptive thermogenesis: Turning on the heat
    • Lowell BB. Adaptive thermogenesis: turning on the heat. Curr Biol 1998 ; 8 (15): R517 -20
    • (1998) Curr Biol , vol.8 , Issue.15
    • Lowell, B.B.1
  • 14
    • 0034189683 scopus 로고    scopus 로고
    • Orlistat in the treatment of obesity
    • Ballinger A. Orlistat in the treatment of obesity. Exp Opin Pharmacother 2000 ; 1 (4): 841-847
    • (2000) Exp Opin Pharmacother , vol.1 , Issue.4 , pp. 841-847
    • Ballinger, A.1
  • 16
    • 0031837935 scopus 로고    scopus 로고
    • Effect of the antiobesity agent sibutramine in obese-diabetic ob/ob mice
    • Day C, Baily CJ. Effect of the antiobesity agent sibutramine in obese-diabetic ob/ob mice. Int J Obes Relat Metab Disord 1998 ; 22 : 619-623
    • (1998) Int J Obes Relat Metab Disord , vol.22 , pp. 619-623
    • Day, C.1    Baily, C.J.2
  • 17
    • 1542666566 scopus 로고    scopus 로고
    • The role of silbutramin in the clinical management of obesity
    • Medeiros-Neto G, Halpern A, Bouchard C, editors. John Libby Eurotext, Montrouge, France
    • Ryan DH. The role of silbutramin in the clinical management of obesity. In: Medeiros-Neto G, Halpern A, Bouchard C, editors. Progress in obesity research: 9. John Libby Eurotext, Montrouge, France; 2003 . p. 1051 -1057
    • (2003) Progress in Obesity Research: 9 , pp. 1051-1057
    • Ryan, D.H.1
  • 18
    • 4544275181 scopus 로고    scopus 로고
    • The endocanabinoid system and its therapeutic exploitation
    • The endocanabinoid system and its therapeutic exploitation. Nat Rev 2004 ; 3 : 771-784
    • (2004) Nat Rev , vol.3 , pp. 771-784
  • 19
    • 0033921628 scopus 로고    scopus 로고
    • Cannabinoid receptor ligands: Clinical and neuropharmacological considerations, relevant to future drug discovery and development
    • A comprehensive review of the endocanabinoid system
    • Pertwee RG. Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development. Exp Opin Invest Drugs 2000 ; 9 (7): 1553 -71 •• A comprehensive review of the endocanabinoid system.
    • (2000) Exp Opin Invest Drugs , vol.9 , Issue.7 , pp. 1553-1571
    • Pertwee, R.G.1
  • 20
    • 32444440208 scopus 로고    scopus 로고
    • The emerging role of endocanabinoid system in endocrine regulation and energy balance
    • Pagotto U, Marsicano G, Cota D, et al. The emerging role of endocanabinoid system in endocrine regulation and energy balance. Endocrine Rev 2006 ; 27 : 73-100
    • (2006) Endocrine Rev , vol.27 , pp. 73-100
    • Pagotto, U.1    Marsicano, G.2    Cota, D.3
  • 21
    • 0037304290 scopus 로고    scopus 로고
    • Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice
    • Ravinet T, C Arnone, M Delgorge, et al. Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am J Physiol Regul Integr Comp Physiol 2003 ; 284 (2): R345 -53
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284 , Issue.2
    • Ravinet, T.1    Arnone, C.2    Delgorge, M.3
  • 22
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the CB1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients. RIO-Europe study
    • Van Gaal LF, Rissanen AM, Scheen AJ, et al. Effects of the CB1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients. RIO-Europe study. Lancet 2005 ; 365 : 1389-1397
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3
  • 23
    • 32644441249 scopus 로고    scopus 로고
    • Effect of rimonabant, a CB1 receptor blocker, on weight and cardiometabolic risk factors in overweight and obese patients. RIO-North America
    • Pi-sunyer RK, Aronne LJ, Heshmati HM, et al. Effect of rimonabant, a CB1 receptor blocker, on weight and cardiometabolic risk factors in overweight and obese patients. RIO-North America. JAMA 2006 ; 295 : 761-775
    • (2006) JAMA , vol.295 , pp. 761-775
    • Pi-sunyer, R.K.1    Aronne, L.J.2    Heshmati, H.M.3
  • 24
    • 0034610435 scopus 로고    scopus 로고
    • Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
    • Rothman RB, Baumann MH, Savage JE, et al. Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfl uramine and other serotonergic medications. Circulation 2000 ; 102 (23): 2836-2841
    • (2000) Circulation , vol.102 , Issue.23 , pp. 2836-2841
    • Rothman, R.B.1    Baumann, M.H.2    Savage, J.E.3
  • 25
    • 0033989494 scopus 로고    scopus 로고
    • Possible role of valvular serotonin 5-HT2B receptors in the cardiopathy associated with fenfl uramine
    • Fitzgerald LW, Burn TC, Brown BS, et al. Possible role of valvular serotonin 5-HT2B receptors in the cardiopathy associated with fenfl uramine. Mol Pharmacol 2000 ; 57 (1): 75-81
    • (2000) Mol Pharmacol , vol.57 , Issue.1 , pp. 75-81
    • Fitzgerald, L.W.1    Burn, T.C.2    Brown, B.S.3
  • 26
    • 0028909857 scopus 로고
    • Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    • Tecott LH, Sun LM, Akana SF, et al. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 1995 ; 374 (6522): 542-546
    • (1995) Nature , vol.374 , Issue.6522 , pp. 542-546
    • Tecott, L.H.1    Sun, L.M.2    Akana, S.F.3
  • 27
    • 0031721271 scopus 로고    scopus 로고
    • Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    • Nonogaki K, Strack AM, Dallman MF, et al. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med 1998 ; 4 (10): 1152-1156
    • (1998) Nat Med , vol.4 , Issue.10 , pp. 1152-1156
    • Nonogaki, K.1    Strack, A.M.2    Dallman, M.F.3
  • 28
    • 33644772628 scopus 로고    scopus 로고
    • The potential use of selective 5-HT2c agonists treating obesity
    • Smith BM, Thompson WJ, Grottick AJ, The potential use of selective 5-HT2c agonists treating obesity. Expert Opin Invest Drugs 2006 ; 15 (3): 257-266
    • (2006) Expert Opin Invest Drugs , vol.15 , Issue.3 , pp. 257-266
    • Smith, B.M.1    Thompson, W.J.2    Grottick, A.J.3
  • 29
    • 3042567101 scopus 로고    scopus 로고
    • Tonic regulation of satiety by 5-HT1B receptors in mice: Converging evidence from behavioural and c-fos immunoreactivity studies?
    • Lee MD, Somerville EM, Kennett GA, et al. Tonic regulation of satiety by 5-HT1B receptors in mice: converging evidence from behavioural and c-fos immunoreactivity studies? Eur J Neuroscience 2004 ; 19 (11): 3017-3025
    • (2004) Eur J Neuroscience , vol.19 , Issue.11 , pp. 3017-3025
    • Lee, M.D.1    Somerville, E.M.2    Kennett, G.A.3
  • 30
    • 38549144692 scopus 로고    scopus 로고
    • Selective 5-HT6 receptor ligands: Progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders
    • Heal DJ, Smith SL, Fisas A, et al. Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacol Ther 2008 ; 117 (2): 207-231
    • (2008) Pharmacol Ther , vol.117 , Issue.2 , pp. 207-231
    • Heal, D.J.1    Smith, S.L.2    Fisas, A.3
  • 31
    • 0037372451 scopus 로고    scopus 로고
    • The melanocortin system
    • A comprehensive review on the melanocortin system
    • Gantz I, Fong TM. The melanocortin system. Am J Physiol Endocrinol Metab 2003 ; 284 (3): E468 -74 • A comprehensive review on the melanocortin system.
    • (2003) Am J Physiol Endocrinol Metab , vol.284 , Issue.3
    • Gantz, I.1    Fong, T.M.2
  • 33
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar D, Lynch CA, Fairchild H, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997 ; 88 (1): 131-141
    • (1997) Cell , vol.88 , Issue.1 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild, H.3
  • 34
    • 13344279395 scopus 로고    scopus 로고
    • A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    • Qu D, Ludwig DS, Gammeltoft S, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996 ; 380 (6571): 243-247
    • (1996) Nature , vol.380 , Issue.6571 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3
  • 35
    • 13344279395 scopus 로고    scopus 로고
    • A role of MCH in the central regulation of feeding behavior
    • Qu D, Ludwig DS, Gammeltoft S, et al. A role of MCH in the central regulation of feeding behavior. Nature 1996 ; 380 : 243-247
    • (1996) Nature , vol.380 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3
  • 36
    • 18444375866 scopus 로고    scopus 로고
    • Targeted disruption of the melanin-c?ncentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity
    • Chen Y, Hu C, Hsu CK, et al. Targeted disruption of the melanin-c?ncentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology 2002 ; 143 (7): 2469-2477
    • (2002) Endocrinology , vol.143 , Issue.7 , pp. 2469-2477
    • Chen, Y.1    Hu, C.2    Hsu, C.K.3
  • 38
    • 0034117088 scopus 로고    scopus 로고
    • The role of NPY in metabolic homeostasis: Implications for obesity therapy
    • Wieland HA, Bradford SH, Krist B, et al. The role of NPY in metabolic homeostasis: implications for obesity therapy. Exp Opin Invest Drugs 2000 ; 9 (6): 1327-1346
    • (2000) Exp Opin Invest Drugs , vol.9 , Issue.6 , pp. 1327-1346
    • Wieland, H.A.1    Bradford, S.H.2    Krist, B.3
  • 39
    • 33748920715 scopus 로고    scopus 로고
    • Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults
    • Erondu N, Gantz I, Musser B, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab 2006 ; 4 : 274-282
    • (2006) Cell Metab , vol.4 , pp. 274-282
    • Erondu, N.1    Gantz, I.2    Musser, B.3
  • 40
    • 34249862701 scopus 로고    scopus 로고
    • Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults
    • Gantz I, Erundo N, Mallick M, et al. Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults. J Clin Endocrinol Metab 2007 ; 92 (5): 1754-1757
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.5 , pp. 1754-1757
    • Gantz, I.1    Erundo, N.2    Mallick, M.3
  • 41
    • 0029665961 scopus 로고    scopus 로고
    • Functional β3-adrenoceptor in the human heart
    • Gauthier C, Tavernier G, Charpentier F, et al. Functional β3-adrenoceptor in the human heart. J Clin Invest 1996 ; 98 (2): 556-562
    • (1996) J Clin Invest , vol.98 , Issue.2 , pp. 556-562
    • Gauthier, C.1    Tavernier, G.2    Charpentier, F.3
  • 42
    • 0038124917 scopus 로고    scopus 로고
    • The tissue distribution of the human β3-adrenoceptor studied using a monoclonal antibody: Direct evidence of the β3-adrenoceptor in human adipose tissue, atrium and skeletal muscle
    • Chamberlain PD, Jennings KH, Paul F, et al. The tissue distribution of the human β3-adrenoceptor studied using a monoclonal antibody: direct evidence of the β3-adrenoceptor in human adipose tissue, atrium and skeletal muscle. Int J Obes Relat Metab Diord 1999 ; 23 (10): 1057-1065
    • (1999) Int J Obes Relat Metab Diord , vol.23 , Issue.10 , pp. 1057-1065
    • Chamberlain, P.D.1    Jennings, K.H.2    Paul, F.3
  • 43
    • 0024831575 scopus 로고
    • Brown adipose tissue thermogenesis and obesity
    • Himms-hagen J. Brown adipose tissue thermogenesis and obesity. Prog Lipid Res 1989 ; 28 : 67-115
    • (1989) Prog Lipid Res , vol.28 , pp. 67-115
    • Himms-hagen, J.1
  • 44
    • 0032923340 scopus 로고    scopus 로고
    • Development of beta3-adrenoceptor agonists for the treatment of obesity and diabetes-an update
    • Weyer C, Gautier JF, Danforth E Jr, et al. Development of beta3-adrenoceptor agonists for the treatment of obesity and diabetes-an update. Diabetes Metab 1999 ; 25 (1): 11-21
    • (1999) Diabetes Metab , vol.25 , Issue.1 , pp. 11-21
    • Weyer, C.1    Gautier, J.F.2    Danforth Jr., E.3
  • 46
    • 13144281703 scopus 로고    scopus 로고
    • Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
    • Cases S, Smith SJ, Zheng YW, et al. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci USA 1998 ; 95 (22): 13018-13023
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.22 , pp. 13018-13023
    • Cases, S.1    Smith, S.J.2    Zheng, Y.W.3
  • 47
    • 0035914356 scopus 로고    scopus 로고
    • Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members
    • Cases S, Stone SJ, Zhou P, et al. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem 2001 ; 276 (42): 38870-38876
    • (2001) J Biol Chem , vol.276 , Issue.42 , pp. 38870-38876
    • Cases, S.1    Stone, S.J.2    Zhou, P.3
  • 48
    • 0036823446 scopus 로고    scopus 로고
    • Microbial metabolites with inhibitory activity against lipid metabolism
    • Tomoda H, Namatame I, Omura S. Microbial metabolites with inhibitory activity against lipid metabolism. Proc Jpn Acad Ser B:Phys Biol Sci 2002 ; 78 (8): 217-240
    • (2002) Proc Jpn Acad Ser B:Phys Biol Sci , vol.78 , Issue.8 , pp. 217-240
    • Tomoda, H.1    Namatame, I.2    Omura, S.3
  • 49
    • 0037411269 scopus 로고    scopus 로고
    • Structural and functional organization of the animal fatty acid synthase
    • Smith S, Witkowski A, Joshi AK. Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res 2003 ; 42 (4): 289-317
    • (2003) Prog Lipid Res , vol.42 , Issue.4 , pp. 289-317
    • Smith, S.1    Witkowski, A.2    Joshi, A.K.3
  • 50
    • 0029051666 scopus 로고
    • Human fatty acid synthase: Properties and molecular cloning
    • Jayakumar A, Tai MH, Huang WY, et al. Human fatty acid synthase: properties and molecular cloning. Proc Natl Acad Sci 1995 ; 92 (19): 8695-8699
    • (1995) Proc Natl Acad Sci , vol.92 , Issue.19 , pp. 8695-8699
    • Jayakumar, A.1    Tai, M.H.2    Huang, W.Y.3
  • 51
    • 4344598315 scopus 로고    scopus 로고
    • Lipid metabolic enzymes: Emerging drug targets for the treatment of obesity
    • A comprehensive review on lipid metabolizing enzymes
    • Shi Y, Burn P. Lipid metabolic enzymes: emerging drug targets for the treatment of obesity. Nat Rev Drug Discov 2004 ; 3 (8): 695 -710 • A comprehensive review on lipid metabolizing enzymes.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.8 , pp. 695-710
    • Shi, Y.1    Burn, P.2
  • 52
    • 0034733730 scopus 로고    scopus 로고
    • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
    • Loftus TM, Jaworsky DE, Frehywot GL, et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000;288(5475):2379-2381
    • (2000) Science , vol.288 , Issue.5475 , pp. 2379-2381
    • Loftus, T.M.1    Jaworsky, D.E.2    Frehywot, G.L.3
  • 53
    • 0037133185 scopus 로고    scopus 로고
    • Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice
    • Shimokawa T, Kumar MV, Lane MD. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc Natl Acad Sci 2002 ; 99 (4): 1921-1925
    • (2002) Proc Natl Acad Sci , vol.99 , Issue.4 , pp. 1921-1925
    • Shimokawa, T.1    Kumar, M.V.2    Lane, M.D.3
  • 54
    • 0030939116 scopus 로고    scopus 로고
    • Human acetyl-CoA carboxyl?se 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms
    • Abu-elheiga L, Almarza-ortega DB, Baldini A, et al. Human acetyl-CoA carboxyl?se 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms. J Biol Chem 1997 ; 272 (16): 10669-10677
    • (1997) J Biol Chem , vol.272 , Issue.16 , pp. 10669-10677
    • Abu-elheiga, L.1    Almarza-ortega, D.B.2    Baldini, A.3
  • 55
    • 0034652297 scopus 로고    scopus 로고
    • The subcellular localization of acetyl-CoA carboxylase 2
    • Abu-elheiga L, Brinkley WR, Zhong L, et al. The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci 2000 ; 97 (4): 1444-1449
    • (2000) Proc Natl Acad Sci , vol.97 , Issue.4 , pp. 1444-1449
    • Abu-elheiga, L.1    Brinkley, W.R.2    Zhong, L.3
  • 56
    • 0042337449 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
    • Abu-elheiga L, Oh W, Kordari P, et al. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high- carbohydrate diets. Proc Natl Acad Sci 2003 ; 100 (18): 10207-10212
    • (2003) Proc Natl Acad Sci , vol.100 , Issue.18 , pp. 10207-10212
    • Abu-elheiga, L.1    Oh, W.2    Kordari, P.3
  • 57
    • 67649604433 scopus 로고    scopus 로고
    • ACC Inhibitors
    • Pfizer Products, Inc. WO2003072197
    • Pfizer Products, Inc. ACC Inhibitors. WO2003072197; 2003.
    • (2003)
  • 58
    • 67649622558 scopus 로고    scopus 로고
    • Chem Abstr 2003 ; 139 : 230625
    • (2003) Chem Abstr , vol.139 , pp. 230625
  • 59
    • 0026753102 scopus 로고
    • Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster
    • Arbeeny CM, Meyers DS, Bergquist KE, et al. Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster. J Lipid Res 1992 ; 33 (6): 843-851
    • (1992) J Lipid Res , vol.33 , Issue.6 , pp. 843-851
    • Arbeeny, C.M.1    Meyers, D.S.2    Bergquist, K.E.3
  • 60
    • 0141510051 scopus 로고    scopus 로고
    • Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals
    • Harwood HJ Jr, Petras SF, Shelly LD, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem 2003 ; 278 (39): 37099-37111
    • (2003) J Biol Chem , vol.278 , Issue.39 , pp. 37099-37111
    • Harwood Jr., H.J.1    Petras, S.F.2    Shelly, L.D.3
  • 61
    • 18144396604 scopus 로고    scopus 로고
    • Treating the metabolic syndrome: Acetyl-CoA carboxylase inhibition
    • Harwood HJ. Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition. Exp Opin Ther Targets 2005 ; 9 (2): 267-281
    • (2005) Exp Opin Ther Targets , vol.9 , Issue.2 , pp. 267-281
    • Harwood, H.J.1
  • 62
    • 0037470947 scopus 로고    scopus 로고
    • Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase
    • Zhang H, Yang Z, Shen Y, et al. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science 2003 ; 299 (5615): 2064-2067
    • (2003) Science , vol.299 , Issue.5615 , pp. 2064-2067
    • Zhang, H.1    Yang, Z.2    Shen, Y.3
  • 63
    • 0037832581 scopus 로고    scopus 로고
    • Recent insights into stearoyl-CoA desaturase-1
    • Ntambi JM, Miyazaki M. Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol 2003 ; 14 (3): 255-261
    • (2003) Curr Opin Lipidol , vol.14 , Issue.3 , pp. 255-261
    • Ntambi, J.M.1    Miyazaki, M.2
  • 64
    • 2342652187 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    • Dobrzyn P, Dobrzyn A, Miyazaki M, et al. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver Proc Natl Acad Sci 2004 ; 101 (17): 6409-6414
    • (2004) Proc Natl Acad Sci , vol.101 , Issue.17 , pp. 6409-6414
    • Dobrzyn, P.1    Dobrzyn, A.2    Miyazaki, M.3
  • 65
    • 0034847971 scopus 로고    scopus 로고
    • Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    • Miyazaki M, Man WC, Ntambi JM. Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J Nutr 2001 ; 131 (9): 2260-2268
    • (2001) J Nutr , vol.131 , Issue.9 , pp. 2260-2268
    • Miyazaki, M.1    Man, W.C.2    Ntambi, J.M.3
  • 66
    • 0037067570 scopus 로고    scopus 로고
    • Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
    • Cohen P, Miyazaki M, Socci ND, et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 2002 ; 297 (5579): 240-243
    • (2002) Science , vol.297 , Issue.5579 , pp. 240-243
    • Cohen, P.1    Miyazaki, M.2    Socci, N.D.3
  • 67
    • 24644458630 scopus 로고    scopus 로고
    • Steroyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development
    • Miyazaki M, Dobrzyn A, Elias PM, et al. Steroyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc Natl Acad Sc 2005 ; 102 (85): 12501-12506
    • (2005) Proc Natl Acad Sc , vol.102 , Issue.85 , pp. 12501-12506
    • Miyazaki, M.1    Dobrzyn, A.2    Elias, P.M.3
  • 68
    • 0026725823 scopus 로고
    • Purification and characterization of an extracellular lipase from fungus Rhizopus delkemar
    • Haas MJ, Cichowicz DJ, Bailey DG. Purification and characterization of an extracellular lipase from fungus Rhizopus delkemar. Lipids 1992 ; 27 : 571-576
    • (1992) Lipids , vol.27 , pp. 571-576
    • Haas, M.J.1    Cichowicz, D.J.2    Bailey, D.G.3
  • 69
    • 17144409447 scopus 로고    scopus 로고
    • Advances in anti-obesity therapeutics
    • Fong TM. Advances in anti-obesity therapeutics. Exp Opin Invest Drugs 2005 ; 14 (3): 243-250
    • (2005) Exp Opin Invest Drugs , vol.14 , Issue.3 , pp. 243-250
    • Fong, T.M.1
  • 70
    • 18144379221 scopus 로고    scopus 로고
    • Diabetes: The latest developments in inhibitors, insulin sensitisers, new drug targets and novel approaches
    • October 18-19, 2004, The Hatton, London, UK. An excellent review on antidiabetic and metabolic syndrome therapy
    • Rondinone CM. Diabetes: the latest developments in inhibitors, insulin sensitisers, new drug targets and novel approaches. October 18-19, 2004, The Hatton, London, UK. Exp Opin Ther Targets 2005 ; 9 (2): 415 -8 •• An excellent review on antidiabetic and metabolic syndrome therapy.
    • (2005) Exp Opin Ther Targets , vol.9 , Issue.2 , pp. 415-418
    • Rondinone, C.M.1
  • 71
    • 26944468314 scopus 로고    scopus 로고
    • Non-insulin dependent diabetes mellitus: Present therapies and new drug targets
    • Das SK, Chakrabarti R. Non-insulin dependent diabetes mellitus: present therapies and new drug targets. Mini Rev Med Chem 2005 ; 5 (11): 1019-1034
    • (2005) Mini Rev Med Chem , vol.5 , Issue.11 , pp. 1019-1034
    • Das, S.K.1    Chakrabarti, R.2
  • 72
    • 0029063165 scopus 로고
    • Neurobiology of?holecystokinin
    • Moran TH, Schwartz GJ, et al. Neurobiology of ?holecystokinin. Crit Rev Neurobiol 1994 ; 9 (1): 1-28
    • (1994) Crit Rev Neurobiol , vol.9 , Issue.1 , pp. 1-28
    • Moran, T.H.1    Schwartz, G.J.2
  • 73
    • 0032189179 scopus 로고    scopus 로고
    • CCK receptor antagonists
    • Dunlop J. CCK receptor antagonists. Gen Pharmacol 1998 ; 31 (4): 519-524
    • (1998) Gen Pharmacol , vol.31 , Issue.4 , pp. 519-524
    • Dunlop, J.1
  • 74
    • 0038660488 scopus 로고    scopus 로고
    • CCK1R agonists: A promising target for the pharmacological treatment of obesity
    • Szewczyk JR, Laudeman C. CCK1R agonists: a promising target for the pharmacological treatment of obesity. Curr Top Med Chem 2003 ; 3 (8): 837-854
    • (2003) Curr Top Med Chem , vol.3 , Issue.8 , pp. 837-854
    • Szewczyk, J.R.1    Laudeman, C.2
  • 75
    • 0026699197 scopus 로고
    • Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo
    • Holladay MW, Bennett MJ, Tufano MD, et al. Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo. J Med Chem 1992 ; 35 (16): 2919-2928
    • (1992) J Med Chem , vol.35 , Issue.16 , pp. 2919-2928
    • Holladay, M.W.1    Bennett, M.J.2    Tufano, M.D.3
  • 76
    • 0025306479 scopus 로고
    • A71378: A CCK agonist with high potency and selectivity for CCK-A receptors
    • Lin CW, Holladay MW, Witte DG, et al. A71378: a CCK agonist with high potency and selectivity for CCK-A receptors. Am J Physiol 1990 ; 258 (4 Pt 1): G648 -51
    • (1990) Am J Physiol , vol.258 , Issue.4 PART 1
    • Lin, C.W.1    Holladay, M.W.2    Witte, D.G.3
  • 77
    • 0031463595 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of potent, selective, hexapeptide CCK-A agonist anorectic agents
    • Pierson ME, Comstock JM, Simmons RD, et al. Synthesis and biological evaluation of potent, selective, hexapeptide CCK-A agonist anorectic agents. J Med Chem 1997 ; 40 (26): 4302-4307
    • (1997) J Med Chem , vol.40 , Issue.26 , pp. 4302-4307
    • Pierson, M.E.1    Comstock, J.M.2    Simmons, R.D.3
  • 78
    • 0028198272 scopus 로고
    • FPL 14294: A novel CCK-8 agonist with potent intranasal anorectic activity in the rat
    • Simmons RD, Blosser JC, Rosamond JD. FPL 14294: a novel CCK-8 agonist with potent intranasal anorectic activity in the rat. Pharmacol Biochem Behav 1994 ; 47 (3): 701-708
    • (1994) Pharmacol Biochem Behav , vol.47 , Issue.3 , pp. 701-708
    • Simmons, R.D.1    Blosser, J.C.2    Rosamond, J.D.3
  • 79
    • 38349104637 scopus 로고    scopus 로고
    • Stimulation of cholecystokinin a receptors with GI181771X does not cause weight loss in overweight or obese patients
    • Jordan J, Greenway FL, Leiter LA, et al. Stimulation of cholecystokinin A receptors with GI181771X does not cause weight loss in overweight or obese patients. Clin Pharmacol Ther 2007 ; 83 : 281-287
    • (2007) Clin Pharmacol Ther , vol.83 , pp. 281-287
    • Jordan, J.1    Greenway, F.L.2    Leiter, L.A.3
  • 81
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999 ; 402 (6762): 656-660
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3
  • 82
    • 0035216623 scopus 로고    scopus 로고
    • Ghrelin enhances apetite and increases food intake in humans
    • Wren AM, Seal LJ, Cohen MA. Ghrelin enhances apetite and increases food intake in humans. J Clin Endocrinol Metab 2001 ; 86 : 5592-5595
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5592-5595
    • Wren, A.M.1    Seal, L.J.2    Cohen, M.A.3
  • 83
    • 7644219561 scopus 로고    scopus 로고
    • Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats
    • Beck B, Richy S, Sticker-krangard S. Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. Life Sci 2004 ; 76 (4): 473-478
    • (2004) Life Sci , vol.76 , Issue.4 , pp. 473-478
    • Beck, B.1    Richy, S.2    Sticker-krangard, S.3
  • 84
  • 85
    • 0037409319 scopus 로고    scopus 로고
    • Obesity-associated activation of angiotensin and endothelin in the cardiovascular system
    • Barton M, Carmona R, Ortmann J, et al. Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. Int J Biochem Cell Biol 2003 ; 35 (6): 826-837
    • (2003) Int J Biochem Cell Biol , vol.35 , Issue.6 , pp. 826-837
    • Barton, M.1    Carmona, R.2    Ortmann, J.3
  • 86
    • 3042739624 scopus 로고    scopus 로고
    • The role of PPARs in obesity and other insulin resistance associated disorders
    • A comprehensive review on role of PPAR on obesity and metabolism
    • Chakrabarti R, Rajagopalan R. The role of PPARs in obesity and other insulin resistance associated disorders. Curr Med Chem Immun Endoc Metab Agents 2004 ; 4 : 67 -72 •• A comprehensive review on role of PPAR on obesity and metabolism.
    • (2004) Curr Med Chem Immun Endoc Metab Agents , vol.4 , pp. 67-72
    • Chakrabarti, R.1    Rajagopalan, R.2
  • 87
    • 0037396860 scopus 로고    scopus 로고
    • Do peroxisome proliferation receptor- γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs?
    • Doggrell S. Do peroxisome proliferation receptor- γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs? Exp Opin Invest Drugs 2003 ; 12 (4): 713-716
    • (2003) Exp Opin Invest Drugs , vol.12 , Issue.4 , pp. 713-716
    • Doggrell, S.1
  • 88
    • 13044286786 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation
    • Oberfield JL, Collins JL, Holmes CP, et al. A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation. Proc Natl Acad Sci 1999 ; 96 (11): 6102-6106
    • (1999) Proc Natl Acad Sci , vol.96 , Issue.11 , pp. 6102-6106
    • Oberfield, J.L.1    Collins, J.L.2    Holmes, C.P.3
  • 89
    • 0033766035 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor- γ (PPAR γ ) modulator blocks adipocyte differentiation but stimulates glucose?uptake in 3T3-L1 adipocytes
    • Mukherjee R, Hoener PA, Jow L, et al. A selective peroxisome proliferator-activated receptor- γ (PPAR γ ) modulator blocks adipocyte differentiation but stimulates glucose?uptake in 3T3-L1 adipocytes. Mol Endocrinol 2000 ; 14 (9): 1425-1433
    • (2000) Mol Endocrinol , vol.14 , Issue.9 , pp. 1425-1433
    • Mukherjee, R.1    Hoener, P.A.2    Jow, L.3
  • 90
    • 0034630720 scopus 로고    scopus 로고
    • Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight
    • Chaput E, Saladin R, Silvertre M, et al. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem Biophys Res Commun 2000 ; 271 (2): 445-450
    • (2000) Biochem Biophys Res Commun , vol.271 , Issue.2 , pp. 445-450
    • Chaput, E.1    Saladin, R.2    Silvertre, M.3
  • 91
    • 0035936883 scopus 로고    scopus 로고
    • Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats
    • Mancini FP, Lanni A, Sabatino L, et al. Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. FEBS Lett 2001 ; 491 (1-2): 154-158
    • (2001) FEBS Lett , vol.491 , Issue.1-2 , pp. 154-158
    • Mancini, F.P.1    Lanni, A.2    Sabatino, L.3
  • 92
    • 0042229358 scopus 로고    scopus 로고
    • DRF 2655: A unique molecule that reduces body weight and ameliorates metabolic abnormalities
    • Vikramadithyan RK, Hiriyan J, Suresh J, et al. DRF 2655: a unique molecule that reduces body weight and ameliorates metabolic abnormalities. Obes Res 2003 ; 11 (2): 292-303
    • (2003) Obes Res , vol.11 , Issue.2 , pp. 292-303
    • Vikramadithyan, R.K.1    Hiriyan, J.2    Suresh, J.3
  • 93
    • 0041321275 scopus 로고    scopus 로고
    • Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR- α
    • Fu J, Gaetani S, Oveisi F, et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR- α . Nature 2003 ; 425 (6953): 90-93
    • (2003) Nature , vol.425 , Issue.6953 , pp. 90-93
    • Fu, J.1    Gaetani, S.2    Oveisi, F.3
  • 94
    • 0033625677 scopus 로고    scopus 로고
    • Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β (δ)
    • Peters JM, Lee SS, Li W, et al. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β (δ). Mol Cell Biol 2000 ; 20 (14): 5119-5128
    • (2000) Mol Cell Biol , vol.20 , Issue.14 , pp. 5119-5128
    • Peters, J.M.1    Lee, S.S.2    Li, W.3
  • 95
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S, et al. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 2003 ; 113 (2): 159-170
    • (2003) Cell , vol.113 , Issue.2 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3
  • 96
    • 67649631421 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase-1b (Ptp-1b) deficient mice and uses thereof
    • Merck Frosst, Canada & Co McGill, et al. WO200006712;
    • Merck Frosst, Canada & Co McGill, et al. Protein tyrosine phosphatase-1b (Ptp-1b) deficient mice and uses thereof WO200006712; 2000.
    • (2000)
  • 97
    • 67649580432 scopus 로고    scopus 로고
    • Chem Abstr 2000 ; 132 : 150278
    • (2000) Chem Abstr , vol.132 , pp. 150278
  • 98
    • 0036736491 scopus 로고    scopus 로고
    • Anti-obesity drug development
    • Bays H, Dujovne C. Anti-obesity drug development. Exp Opin Invest Drugs 2002 ; 11 (9): 1189-1204
    • (2002) Exp Opin Invest Drugs , vol.11 , Issue.9 , pp. 1189-1204
    • Bays, H.1    Dujovne, C.2
  • 99
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Ann Rev Biochem 1998 ; 67 : 821-855
    • (1998) Ann Rev Biochem , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 100
    • 0032973130 scopus 로고    scopus 로고
    • Dealing with energy demand: The AMP-activated protein kinase
    • A comprehensive review on the pathophysiological role of AMP kinase
    • Kemp BE, Mitchelhill KI, Stapleton D, et al. Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci 1999 ; 24 (1): 22 -5 • A comprehensive review on the pathophysiological role of AMP kinase.
    • (1999) Trends Biochem Sci , vol.24 , Issue.1 , pp. 22-25
    • Kemp, B.E.1    Mitchelhill, K.I.2    Stapleton, D.3
  • 101
    • 0037058977 scopus 로고    scopus 로고
    • AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    • Zong H, Ren JM, Young LH, et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci 2002 ; 99 (25): 15983-15987
    • (2002) Proc Natl Acad Sci , vol.99 , Issue.25 , pp. 15983-15987
    • Zong, H.1    Ren, J.M.2    Young, L.H.3
  • 102
    • 0032792665 scopus 로고    scopus 로고
    • AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes
    • Winder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999 ; 277 (1 Pt 1): E1 -10
    • (1999) Am J Physiol , vol.277 , Issue.1 PART 1
    • Winder, W.W.1    Hardie, D.G.2
  • 103
    • 0035947235 scopus 로고    scopus 로고
    • A role for AMP-activated protein kinase in contraction- And hypoxia-regulated glucose transport in skeletal muscle
    • Mu J, Brozinick JT Jr, Valladares O, et al. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 2002 ; 7 (5): 1085-1094
    • (2002) Mol Cell , vol.7 , Issue.5 , pp. 1085-1094
    • Mu, J.1    Brozinick Jr., J.T.2    Valladares, O.3
  • 104
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002 ; 415 (6869): 339-343
    • (2002) Nature , vol.415 , Issue.6869 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3
  • 105
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
    • Tomas E, Tsao TS, Saha AK, et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci 2002 ; 99 (25): 16309-16313
    • (2002) Proc Natl Acad Sci , vol.99 , Issue.25 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3
  • 106
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002 ; 8 (11): 1288-1295
    • (2002) Nat Med , vol.8 , Issue.11 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3
  • 107
    • 0032966874 scopus 로고    scopus 로고
    • Effect of AMPK activation on muscle glucose metabolism in conscious rats
    • Bergeron R, Russell RR 3rd,?Young LH, et al. Effect of AMPK activation on muscle glucose metabolism in conscious rats. Am J Physiol 1999;276(5 Pt 1):E938-44
    • (1999) Am J Physiol , vol.276 , Issue.5 PART 1
    • Bergeron, R.1    Russell III, R.R.2    Young, L.H.3
  • 108
    • 0031417390 scopus 로고    scopus 로고
    • Exercise regulation of glucose transport in skeletal muscle
    • Hayashi T, Wojtaszewski JF, Goodyear LJ. Exercise regulation of glucose transport in skeletal muscle. Am J Physiol 1997 ; 273 (6 Pt 1): E1039 -51
    • (1997) Am J Physiol , vol.273 , Issue.6 PART 1
    • Hayashi, T.1    Wojtaszewski, J.F.2    Goodyear, L.J.3
  • 109
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • Merrill GF, Kurth EJ, Hardie DG, et al. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 1997 ; 273 (6 Pt 1): E1107 -12
    • (1997) Am J Physiol , vol.273 , Issue.6 PART 1
    • Merrill, G.F.1    Kurth, E.J.2    Hardie, D.G.3
  • 110
    • 0033820422 scopus 로고    scopus 로고
    • 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes
    • Salt IP, Connell JM, Gould GW. 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes 2000 ; 49 (10): 1649-1656
    • (2000) Diabetes , vol.49 , Issue.10 , pp. 1649-1656
    • Salt, I.P.1    Connell, J.M.2    Gould, G.W.3
  • 111
    • 79959465813 scopus 로고    scopus 로고
    • Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same
    • Les Laboratories. WO2004043957
    • Les Laboratories. Rault S, Lancelot JC, et al. Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same. WO2004043957; 2004.
    • (2004)
    • Rault, S.1    Lancelot, J.C.2
  • 112
    • 67649625435 scopus 로고    scopus 로고
    • Chem Abst 2004 ; 140 : 375173
    • (2004) Chem Abst , vol.140 , pp. 375173
  • 113
    • 3142677140 scopus 로고    scopus 로고
    • Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
    • Kim MS, Park JY, Namkoong C, et al. Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 2004 ; 10 (7): 727-733
    • (2004) Nat Med , vol.10 , Issue.7 , pp. 727-733
    • Kim, M.S.1    Park, J.Y.2    Namkoong, C.3
  • 114
    • 34250614199 scopus 로고    scopus 로고
    • Low dose pramlintide reduced food intake and meal duration in healthy, normal weight subjects
    • Chapman I, Parker B, Doran S, et al. Low dose pramlintide reduced food intake and meal duration in healthy, normal weight subjects. Obesity 2007 ; 15 (5): 1179-1186
    • (2007) Obesity , vol.15 , Issue.5 , pp. 1179-1186
    • Chapman, I.1    Parker, B.2    Doran, S.3
  • 118
    • 45849123051 scopus 로고    scopus 로고
    • The 24 week experience with a combination sustained release product of zonisamide and bupropion: Evidence of an encouraging benefit:risk profile
    • Fujioka K, Greenway F, Cowley MG, et al. The 24 week experience with a combination sustained release product of zonisamide and bupropion: evidence of an encouraging benefit:risk profile. Obesity 2007 ; 15 (9): A85
    • (2007) Obesity , vol.15 , Issue.9
    • Fujioka, K.1    Greenway, F.2    Cowley, M.G.3
  • 119
    • 34249775328 scopus 로고    scopus 로고
    • A 24 wk randomized controlled trial of VI-0521, a combination weight loss therapy in obese adults
    • Gadde KM, Yonish GM, Foust MS, et al. A 24 wk randomized controlled trial of VI-0521, a combination weight loss therapy in obese adults. Obesity 2006 ; 14 (Suppl): A17
    • (2006) Obesity , vol.14 , Issue.SUPPL.
    • Gadde, K.M.1    Yonish, G.M.2    Foust, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.