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Volumn 182, Issue 7, 2009, Pages 4192-4199

Signal transduction inhibition of APCs diminishes Th17 and Th1 responses in experimental autoimmune encephalomyelitis

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 23; INTERLEUKIN 6; LESTAURTINIB; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; CARBAZOLE DERIVATIVE; CD135 ANTIGEN; CYTOKINE; ENZYME INHIBITOR; FLT3 PROTEIN, MOUSE; INTERLEUKIN 17;

EID: 64249103526     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803631     Document Type: Article
Times cited : (48)

References (58)
  • 2
    • 0035871635 scopus 로고    scopus 로고
    • Resident and infiltrating central nervous system APCs regulate the emergence and resolution of experimental autoimmune encephalomyelitis
    • Juedes, A. E., and N. H. Ruddle. 2001. Resident and infiltrating central nervous system APCs regulate the emergence and resolution of experimental autoimmune encephalomyelitis. J. Immunol. 166: 5168-5175.
    • (2001) J. Immunol. , vol.166 , pp. 5168-5175
    • Juedes, A.E.1    Ruddle, N.H.2
  • 3
    • 34249049841 scopus 로고    scopus 로고
    • Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis
    • Miller, S. D., E. J. McMahon, B. Schreiner, and S. L. Bailey. 2007. Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann. NY Acad. Sci. 1103: 179-191.
    • (2007) Ann. NY Acad. Sci. , vol.1103 , pp. 179-191
    • Miller, S.D.1    McMahon, E.J.2    Schreiner, B.3    Bailey, S.L.4
  • 4
    • 0029000750 scopus 로고
    • Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
    • McRae, B. L., C. L. Vanderlugt, M. C. Dal Canto, and S. D. Miller. 1995. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 182: 75-85.
    • (1995) J. Exp. Med. , vol.182 , pp. 75-85
    • McRae, B.L.1    Vanderlugt, C.L.2    Dal Canto, M.C.3    Miller, S.D.4
  • 6
    • 16244417773 scopus 로고    scopus 로고
    • Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
    • McMahon, E. J., S. L. Bailey, C. V. Castenada, H. Waldner, and S. D. Miller. 2005. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 11: 335-339.
    • (2005) Nat. Med. , vol.11 , pp. 335-339
    • McMahon, E.J.1    Bailey, S.L.2    Castenada, C.V.3    Waldner, H.4    Miller, S.D.5
  • 7
    • 0030899404 scopus 로고    scopus 로고
    • Diversity and plasticity of self recognition during the development of multiple sclerosis
    • Tuohy, V. K., M. Yu, B. Weinstock-Guttman, and R. P. Kinkel. 1997. Diversity and plasticity of self recognition during the development of multiple sclerosis. J. Clin. Invest. 99: 1682-1690.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1682-1690
    • Tuohy, V.K.1    Yu, M.2    Weinstock-Guttman, B.3    Kinkel, R.P.4
  • 8
    • 35548931165 scopus 로고    scopus 로고
    • Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis
    • DOI 10.1016/j.neures.2007.08.014, PII S0168010207017634
    • Guo, X., K. Nakamura, K. Kohyama, C. Harada, H. A. Behanna, D. M. Watterson, Y. Matsumoto, and T. Harada. 2007. Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Neurosci. Res. 59: 457-466. (Pubitemid 350007814)
    • (2007) Neuroscience Research , vol.59 , Issue.4 , pp. 457-466
    • Guo, X.1    Nakamura, K.2    Kohyama, K.3    Harada, C.4    Behanna, H.A.5    Watterson, D.M.6    Matsumoto, Y.7    Harada, T.8
  • 9
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6    Vega, F.7    Yu, N.8    Wang, J.9    Singh, K.10
  • 10
    • 30944455075 scopus 로고    scopus 로고
    • IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin
    • Mensah-Brown, E. P., A. Shahin, M. Al-Shamisi, X. Wei, and M. L. Lukic. 2006. IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin. Eur. J. Immunol. 36: 216-223.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 216-223
    • Mensah-Brown, E.P.1    Shahin, A.2    Al-Shamisi, M.3    Wei, X.4    Lukic, M.L.5
  • 11
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice
    • Nakae, S., A. Nambu, K. Sudo, and Y. Iwakura. 2003. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171: 6173-6177. (Pubitemid 37467240)
    • (2003) Journal of Immunology , vol.171 , Issue.11 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 12
  • 13
    • 39749173780 scopus 로고    scopus 로고
    • The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells
    • DOI 10.1093/brain/awm295
    • Ifergan, I., H. Kebir, M. Bernard, K. Wosik, A. Dodelet-Devillers, R. Cayrol, N. Arbour, and A. Prat. 2008. The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain 131: 785-799. (Pubitemid 351294709)
    • (2008) Brain , vol.131 , Issue.3 , pp. 785-799
    • Ifergan, I.1    Kebir, H.2    Bernard, M.3    Wosik, K.4    Dodelet-Devillers, A.5    Cayrol, R.6    Arbour, N.7    Prat, A.8
  • 14
    • 0347357773 scopus 로고    scopus 로고
    • IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
    • DOI 10.1172/JCI200319079
    • Becher, B., B. G. Durell, and R. J. Noelle. 2003. IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. J. Clin. Invest. 112: 1186-1191. (Pubitemid 38056295)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.8 , pp. 1186-1191
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 15
    • 39449101603 scopus 로고    scopus 로고
    • Transcriptional regulation of Th17 cell differentiation
    • DOI 10.1016/j.smim.2007.10.011, PII S1044532307000887
    • Ivanov, I. I., L. Zhou, and D. R. Littman. 2007. Transcriptional regulation of Th17 cell differentiation. Semin. Immunol. 19: 409-417. (Pubitemid 351274050)
    • (2007) Seminars in Immunology , vol.19 , Issue.6 , pp. 409-417
    • Ivanov, I.I.1    Zhou, L.2    Littman, D.R.3
  • 20
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • DOI 10.1016/j.immuni.2006.01.001, PII S1074761306000045
    • Veldhoen, M., R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger. 2006. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189. (Pubitemid 43214587)
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 23
    • 0033179610 scopus 로고    scopus 로고
    • Synergistic action of fms-like tyrosine kinase 3 ligand and CD40 ligand in the induction of dendritic cells and generation of antitumor immunity in vivo
    • Borges, L., R. E. Miller, J. Jones, K. Ariail, J. Whitmore, W. Fanslow, and D. H. Lynch. 1999. Synergistic action of fms-like tyrosine kinase 3 ligand and CD40 ligand in the induction of dendritic cells and generation of antitumor immunity in vivo. J. Immunol. 163: 1289-1297. (Pubitemid 29352746)
    • (1999) Journal of Immunology , vol.163 , Issue.3 , pp. 1289-1297
    • Borges, L.1    Miller, R.E.2    Jones, J.3    Ariail, K.4    Whitmore, J.5    Fanslow, W.6    Lynch, D.H.7
  • 24
    • 0030952766 scopus 로고    scopus 로고
    • Flt3 ligand induces tumor regression and antitumor immune responses in vivo
    • DOI 10.1038/nm0697-625
    • Lynch, D. H., A. Andreasen, E. Maraskovsky, J. Whitmore, R. E. Miller, and J. C. Schuh. 1997. Flt3 ligand induces tumor regression and antitumor immune responses in vivo. Nat. Med. 3: 625-631. (Pubitemid 27264971)
    • (1997) Nature Medicine , vol.3 , Issue.6 , pp. 625-631
    • Lynch, D.H.1    Andreasen, A.2    Maraskovsky, E.3    Whitmore, J.4    Miller, R.E.5    Schuh, J.C.L.6
  • 26
    • 44049097818 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    • DOI 10.1038/ni.1615, PII NI.1615
    • Waskow, C., K. Liu, G. Darrasse-Jeze, P. Guermonprez, F. Ginhoux, M. Merad, T. Shengelia, K. Yao, and M. Nussenzweig. 2008. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat. Immunol. 9: 676-683. (Pubitemid 351712638)
    • (2008) Nature Immunology , vol.9 , Issue.6 , pp. 676-683
    • Waskow, C.1    Liu, K.2    Darrasse-Jeze, G.3    Guermonprez, P.4    Ginhoux, F.5    Merad, M.6    Shengelia, T.7    Yao, K.8    Nussenzweig, M.9
  • 28
  • 29
    • 47049098437 scopus 로고    scopus 로고
    • Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders
    • Hexner, E. O., C. Serdikoff, M. Jan, C. R. Swider, C. Robinson, S. Yang, T. Angeles, S. G. Emerson, M. Carroll, B. Ruggeri, and P. Dobrzanski. 2008. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders. Blood 111: 5663-5671.
    • (2008) Blood , vol.111 , pp. 5663-5671
    • Hexner, E.O.1    Serdikoff, C.2    Jan, M.3    Swider, C.R.4    Robinson, C.5    Yang, S.6    Angeles, T.7    Emerson, S.G.8    Carroll, M.9    Ruggeri, B.10    Dobrzanski, P.11
  • 30
    • 33845947424 scopus 로고    scopus 로고
    • Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells
    • Carmody, R. J., Q. Ruan, H. C. Liou, and Y. H. Chen. 2007. Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells. J. Immunol. 178: 186-191.
    • (2007) J. Immunol. , vol.178 , pp. 186-191
    • Carmody, R.J.1    Ruan, Q.2    Liou, H.C.3    Chen, Y.H.4
  • 33
    • 8644268027 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells that capture dead tumor cells secrete IL-12 and TNF-α through IL-12/TNF-α/NF-κB autocrine loop
    • DOI 10.1007/s00262-004-0568-y
    • Onishi, H., H. Kuroki, K. Matsumoto, E. Baba, N. Sasaki, H. Kuga, M. Tanaka, M. Katano, and T. Morisaki. 2004. Monocyte-derived dendritic cells that capture dead tumor cells secrete IL-12 and TNF-α through IL-12/TNF-α/NF-κB autocrine loop. Cancer Immunol. Immunother. 53: 1093-1100. (Pubitemid 39506398)
    • (2004) Cancer Immunology, Immunotherapy , vol.53 , Issue.12 , pp. 1093-1100
    • Onishi, H.1    Kuroki, H.2    Matsumoto, K.3    Baba, E.4    Sasaki, N.5    Kuga, H.6    Tanaka, M.7    Katano, M.8    Morisaki, T.9
  • 35
    • 0037053350 scopus 로고    scopus 로고
    • CD40 induces interleukin-6 gene transcription in dendritic cells. Regulation by TRAF2, AP-1, NF-κB, and CBF1
    • DOI 10.1074/jbc.M109250200
    • Mann, J., F. Oakley, P. W. Johnson, and D. A. Mann. 2002. CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-κB, and CBF1. J. Biol. Chem. 277: 17125-17138. (Pubitemid 34967745)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.19 , pp. 17125-17138
    • Mann, J.1    Oakley, F.2    Johnson, P.W.M.3    Mann, D.A.4
  • 36
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M. B., N. Kukutsch, A. L. Ogilvie, S. Rossner, F. Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223: 77-92.
    • (1999) J. Immunol. Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.3    Rossner, S.4    Koch, F.5    Romani, N.6    Schuler, G.7
  • 38
    • 0038523790 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    • DOI 10.1084/jem.20021603
    • Bettelli, E., M. Pagany, H. L. Weiner, C. Linington, R. A. Sobel, and V. K. Kuchroo. 2003. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 197: 1073-1081. (Pubitemid 36570063)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.9 , pp. 1073-1081
    • Bettelli, E.1    Pagany, M.2    Weiner, H.L.3    Linington, C.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 40
    • 33846906914 scopus 로고    scopus 로고
    • IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis
    • Thakker, P., M. W. Leach, W. Kuang, S. E. Benoit, J. P. Leonard, and S. Marusic. 2007. IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 178: 2589-2598. (Pubitemid 46233462)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2589-2598
    • Thakker, P.1    Leach, M.W.2    Kuang, W.3    Benoit, S.E.4    Leonard, J.P.5    Marusic, S.6
  • 41
    • 34249805698 scopus 로고    scopus 로고
    • Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis
    • Kroenke, M. A., and B. M. Segal. 2007. Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis. J. Neurosci. Res. 85: 1685-1693.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 1685-1693
    • Kroenke, M.A.1    Segal, B.M.2
  • 43
    • 46949104323 scopus 로고    scopus 로고
    • IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • Kroenke, M. A., T. J. Carlson, A. V. Andjelkovic, and B. M. Segal. 2008. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 205: 1535-1541.
    • (2008) J. Exp. Med. , vol.205 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 44
    • 0033636254 scopus 로고    scopus 로고
    • Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis
    • Serafini, B., S. Columba-Cabezas, F. Di Rosa, and F. Aloisi. 2000. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am. J. Pathol. 157: 1991-2002.
    • (2000) Am. J. Pathol. , vol.157 , pp. 1991-2002
    • Serafini, B.1    Columba-Cabezas, S.2    Di Rosa, F.3    Aloisi, F.4
  • 45
    • 25444484079 scopus 로고    scopus 로고
    • Microglial cell activation and proliferation precedes the onset of CNS autoimmunity
    • Ponomarev, E. D., L. P. Shriver, K. Maresz, and B. N. Dittel. 2005. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J. Neurosci. Res. 81: 374-389.
    • (2005) J. Neurosci. Res. , vol.81 , pp. 374-389
    • Ponomarev, E.D.1    Shriver, L.P.2    Maresz, K.3    Dittel, B.N.4
  • 47
    • 39749173780 scopus 로고    scopus 로고
    • The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells
    • DOI 10.1093/brain/awm295
    • Ifergan, I., H. Kebir, M. Bernard, K. Wosik, A. Dodelet-Devillers, R. Cayrol, N. Arbour, and A. Prat. 2008. The blood brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain 131: 785-799. (Pubitemid 351294709)
    • (2008) Brain , vol.131 , Issue.3 , pp. 785-799
    • Ifergan, I.1    Kebir, H.2    Bernard, M.3    Wosik, K.4    Dodelet-Devillers, A.5    Cayrol, R.6    Arbour, N.7    Prat, A.8
  • 50
    • 33749135066 scopus 로고    scopus 로고
    • Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-κB p65 trans activation plays a novel role
    • Utsugi, M., K. Dobashi, T. Ishizuka, T. Kawata, T. Hisada, Y. Shimizu, A. Ono, and M. Mori. 2006. Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-κB p65 trans activation plays a novel role. J. Immunol. 177: 4550-4557. (Pubitemid 44469786)
    • (2006) Journal of Immunology , vol.177 , Issue.7 , pp. 4550-4557
    • Utsugi, M.1    Dobashi, K.2    Ishizuka, T.3    Kawata, T.4    Hisada, T.5    Shimizu, Y.6    Ono, A.7    Mori, M.8
  • 51
    • 0038485645 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor α-mediated NFκB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) ligands
    • Ashton, A. W., G. M. Ware, D. K. Kaul, and J. A. Ware. 2003. Inhibition of tumor necrosis factor α-mediated NFκB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) ligands. J. Biol. Chem. 278: 11858-11866.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11858-11866
    • Ashton, A.W.1    Ware, G.M.2    Kaul, D.K.3    Ware, J.A.4
  • 52
    • 0029662224 scopus 로고    scopus 로고
    • Inhibition of NFκB activity through maintenance of IκBα levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
    • Keller, E. T., C. Chang, and W. B. Ershler. 1996. Inhibition of NFκB activity through maintenance of IκBα levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. J. Biol. Chem. 271: 26267-26275.
    • (1996) J. Biol. Chem. , vol.271 , pp. 26267-26275
    • Keller, E.T.1    Chang, C.2    Ershler, W.B.3
  • 53
    • 0030666761 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor induces a unique set of STAT factors in murine dendritic cells
    • DOI 10.1002/eji.1830271038
    • Welte, T., F. Koch, G. Schuler, J. Lechner, W. Doppler, and C. Heufler. 1997. Granulocyte-macrophage colony-stimulating factor induces a unique set of STAT factors in murine dendritic cells. Eur. J. Immunol. 27: 2737-2740. (Pubitemid 27453868)
    • (1997) European Journal of Immunology , vol.27 , Issue.10 , pp. 2737-2740
    • Welte, T.1    Koch, F.2    Schuler, G.3    Lechner, J.4    Doppler, W.5    Heufler, C.6
  • 54
    • 0030930196 scopus 로고    scopus 로고
    • STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression
    • Feldman, G. M., L. A. Rosenthal, X. Liu, M. P. Hayes, A. Wynshaw-Boris, W. J. Leonard, L. Hennighausen, and D. S. Finbloom. 1997. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90: 1768-1776.
    • (1997) Blood , vol.90 , pp. 1768-1776
    • Feldman, G.M.1    Rosenthal, L.A.2    Liu, X.3    Hayes, M.P.4    Wynshaw-Boris, A.5    Leonard, W.J.6    Hennighausen, L.7    Finbloom, D.S.8
  • 56
    • 0347480225 scopus 로고    scopus 로고
    • STAT3 Is Required for Flt3L-Dependent Dendritic Cell Differentiation
    • DOI 10.1016/S1074-7613(03)00332-7
    • Laouar, Y., T. Welte, X. Y. Fu, and R. A. Flavell. 2003. STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 19: 903-912. (Pubitemid 37542309)
    • (2003) Immunity , vol.19 , Issue.6 , pp. 903-912
    • Laouar, Y.1    Welte, T.2    Fu, X.-Y.3    Flavell, R.A.4
  • 57
    • 31344441376 scopus 로고    scopus 로고
    • Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development
    • DOI 10.1084/jem.20051645
    • Onai, N., A. Obata-Onai, R. Tussiwand, A. Lanzavecchia, and M. G. Manz. 2006. Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J. Exp. Med. 203: 227-238. (Pubitemid 43139660)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.1 , pp. 227-238
    • Onai, N.1    Obata-Onai, A.2    Tussiwand, R.3    Lanzavecchia, A.4    Manz, M.G.5
  • 58
    • 0033820091 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation
    • Tse, K. F., G. Mukherjee, and D. Small. 2000. Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia 14: 1766-1776.
    • (2000) Leukemia , vol.14 , pp. 1766-1776
    • Tse, K.F.1    Mukherjee, G.2    Small, D.3


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