메뉴 건너뛰기




Volumn 115, Issue 10, 2005, Pages 2731-2741

IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; JANUS KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; STAT PROTEIN;

EID: 26444619864     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI25141     Document Type: Article
Times cited : (128)

References (45)
  • 2
    • 0030964023 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials
    • Gadient, R.A., and Otten, U.H. 1997. Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials. Prog. Neurobiol. 52:379-390.
    • (1997) Prog. Neurobiol. , vol.52 , pp. 379-390
    • Gadient, R.A.1    Otten, U.H.2
  • 3
    • 0036838576 scopus 로고    scopus 로고
    • Growth factor treatment of demyelinating disease: At last, a leap into the light
    • Ransohoff, R.M., Howe, C.L., and Rodriguez, M. 2002. Growth factor treatment of demyelinating disease: at last, a leap into the light. Trends Immunol. 23:512-516.
    • (2002) Trends Immunol. , vol.23 , pp. 512-516
    • Ransohoff, R.M.1    Howe, C.L.2    Rodriguez, M.3
  • 4
    • 0031301027 scopus 로고    scopus 로고
    • Physiological and pathological roles of interleukin-6 in the central nervous system
    • Gruol, D.L., and Nelson, T.E. 1997. Physiological and pathological roles of interleukin-6 in the central nervous system. Mol. Neurobiol 15:307-339.
    • (1997) Mol. Neurobiol. , vol.15 , pp. 307-339
    • Gruol, D.L.1    Nelson, T.E.2
  • 5
    • 0036901234 scopus 로고    scopus 로고
    • Cytokines and cognition - The case for a head-to-toe inflammatory paradigm
    • Wilson, C.J., Finch, C.E., and Cohen, H.J. 2002. Cytokines and cognition-the case for a head-to-toe inflammatory paradigm. J. Am. Geriatr. Soc. 50:2041-2056.
    • (2002) J. Am. Geriatr. Soc. , vol.50 , pp. 2041-2056
    • Wilson, C.J.1    Finch, C.E.2    Cohen, H.J.3
  • 6
    • 0027433102 scopus 로고
    • Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6
    • Campbell, I.L., et al. 1993. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. U. S. A. 90:10061-10065.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 10061-10065
    • Campbell, I.L.1
  • 7
    • 0031920882 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein
    • Okuda, Y., et al. 1998. IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein. Int. Immunol. 10:703-708.
    • (1998) Int. Immunol. , vol.10 , pp. 703-708
    • Okuda, Y.1
  • 8
    • 0029411144 scopus 로고
    • Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation
    • Gijbels, K., Brocke, S., Abrams, J.S., and Steinman, L. 1995. Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation. Mol Med. 1:795-805.
    • (1995) Mol Med. , vol.1 , pp. 795-805
    • Gijbels, K.1    Brocke, S.2    Abrams, J.S.3    Steinman, L.4
  • 9
    • 0034859134 scopus 로고    scopus 로고
    • Effect of anti-rat interleukin-6 antibody after spinal cord injury in the rat: Inducible nitric oxide synthase expression, sodium- and potassium-activated, magnesium-dependent adenosine-5′-triphosphatase and superoxide dismutase activation, and ultrastructural changes
    • Tuna, M., et al. 2001. Effect of anti-rat interleukin-6 antibody after spinal cord injury in the rat: inducible nitric oxide synthase expression, sodium- and potassium-activated, magnesium-dependent adenosine-5′- triphosphatase and superoxide dismutase activation, and ultrastructural changes. J. Neurosurg. 95:64-73.
    • (2001) J. Neurosurg. , vol.95 , pp. 64-73
    • Tuna, M.1
  • 10
    • 0037844877 scopus 로고    scopus 로고
    • JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes
    • Yu, X., Kennedy, R.H., and Liu, S.J. 2003. JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes. J. Biol Chem. 278:16304-16309.
    • (2003) J. Biol Chem. , vol.278 , pp. 16304-16309
    • Yu, X.1    Kennedy, R.H.2    Liu, S.J.3
  • 11
    • 0033402420 scopus 로고    scopus 로고
    • Interleukin-6 expression and regulation in astrocytes
    • Van Wagoner, N.J., and Benveniste, E.N. 1999. Interleukin-6 expression and regulation in astrocytes. J. Neuroimmunol. 100:124-139.
    • (1999) J. Neuroimmunol. , vol.100 , pp. 124-139
    • Van Wagoner, N.J.1    Benveniste, E.N.2
  • 12
    • 0032710609 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
    • Liberatore, G.T., et al. 1999. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 5:1403-1409.
    • (1999) Nat. Med. , vol.5 , pp. 1403-1409
    • Liberatore, G.T.1
  • 14
    • 0028089896 scopus 로고
    • Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures
    • Dawson, V.L., Brahmbhatt, H.P., Mong, J.A., and Dawson, T.M. 1994. Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology. 33:1425-1430.
    • (1994) Neuropharmacology , vol.33 , pp. 1425-1430
    • Dawson, V.L.1    Brahmbhatt, H.P.2    Mong, J.A.3    Dawson, T.M.4
  • 15
    • 0037209850 scopus 로고    scopus 로고
    • Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells
    • Lieb, K., Engels, S., and Fiebich, B.L. 2003. Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells. Neurochem. Int. 42:131-137.
    • (2003) Neurochem. Int. , vol.42 , pp. 131-137
    • Lieb, K.1    Engels, S.2    Fiebich, B.L.3
  • 16
    • 0037110706 scopus 로고    scopus 로고
    • Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels
    • Calabrese, V., et al. 2002. Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. J. Neurosci. Res. 70:580-587.
    • (2002) J. Neurosci. Res. , vol.70 , pp. 580-587
    • Calabrese, V.1
  • 17
    • 0033852850 scopus 로고    scopus 로고
    • Aminoguanidine-induced amelioration of autoimmune encephalomyelitis is mediated by reduced expression of inducible nitric oxide synthase in the spinal cord
    • Shin, T., Kim, S., Moon, C., Wie, M., and Kim, H. 2000. Aminoguanidine-induced amelioration of autoimmune encephalomyelitis is mediated by reduced expression of inducible nitric oxide synthase in the spinal cord. Immunol. Invest. 29:233-241.
    • (2000) Immunol. Invest. , vol.29 , pp. 233-241
    • Shin, T.1    Kim, S.2    Moon, C.3    Wie, M.4    Kim, H.5
  • 18
    • 15944399431 scopus 로고    scopus 로고
    • Improved functional outcome after spinal cord injury in iNOS-deficient mice
    • Isaksson, J., Farooque, M., and Olsson, Y. 2005. Improved functional outcome after spinal cord injury in iNOS-deficient mice. Spinal Cord. 43:167-170.
    • (2005) Spinal Cord. , vol.43 , pp. 167-170
    • Isaksson, J.1    Farooque, M.2    Olsson, Y.3
  • 19
    • 0036229078 scopus 로고    scopus 로고
    • Role of nitric oxide in inflammatory conditions
    • Blantz, R.C., and Munger, K. 2002. Role of nitric oxide in inflammatory conditions. Nephron. 90:373-378.
    • (2002) Nephron , vol.90 , pp. 373-378
    • Blantz, R.C.1    Munger, K.2
  • 20
    • 4644312193 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro
    • Scott, G.S., Szabo, C., and Hooper, D.C. 2004. Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro. J. Neurotrauma. 21:1255-1263.
    • (2004) J. Neurotrauma. , vol.21 , pp. 1255-1263
    • Scott, G.S.1    Szabo, C.2    Hooper, D.C.3
  • 21
    • 0034814670 scopus 로고    scopus 로고
    • Physiology and pathophysiology of poly(ADP-ribosyl)ation
    • Burkle, A. 2001. Physiology and pathophysiology of poly(ADP-ribosyl) ation. Bioessays. 23:795-806.
    • (2001) Bioessays , vol.23 , pp. 795-806
    • Burkle, A.1
  • 22
    • 0033830186 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 in the nervous system
    • Ha, H.C., and Snyder, S.H. 2000. Poly(ADP-ribose) polymerase-1 in the nervous system. Neurobiol. Dis. 7:225-239.
    • (2000) Neurobiol. Dis. , vol.7 , pp. 225-239
    • Ha, H.C.1    Snyder, S.H.2
  • 23
    • 13244252358 scopus 로고    scopus 로고
    • Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma
    • Genovese, T., et al. 2005. Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. J. Pharmacol. Exp. Ther. 312:449-457.
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 449-457
    • Genovese, T.1
  • 24
    • 0034635824 scopus 로고    scopus 로고
    • 14-3-3 Protein in the cerebrospinal fluid of patients with acute transverse myelitis
    • Irani, D.N., and Kerr, D.A. 2000. 14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis [letter]. Lancet. 355:901.
    • (2000) Lancet , vol.355 , pp. 901
    • Irani, D.N.1    Kerr, D.A.2
  • 25
    • 1642570319 scopus 로고    scopus 로고
    • Nitric oxide, oxidants, and protein tyrosine nitration
    • Radi, R. 2004. Nitric oxide, oxidants, and protein tyrosine nitration. Proc. Natl. Acad. Sci. U. S. A. 101:4003-4008.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 4003-4008
    • Radi, R.1
  • 26
    • 2442497293 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: Distribution, cellular expression and association with myelin damage
    • Hill, K.E., Zollinger, L.V., Watt, H.E., Carlson, N.G., and Rose, J.W. 2004. Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage. J. Neuroimmunol. 151:171-179.
    • (2004) J. Neuroimmunol. , vol.151 , pp. 171-179
    • Hill, K.E.1    Zollinger, L.V.2    Watt, H.E.3    Carlson, N.G.4    Rose, J.W.5
  • 27
    • 3242730311 scopus 로고    scopus 로고
    • Soluble interleukin-6 receptor (sIL-6R) in cerebrospinal fluid of patients with inflammatory and non inflammatory neurological diseases
    • Michalopoulou, M., et al. 2004. Soluble interleukin-6 receptor (sIL-6R) in cerebrospinal fluid of patients with inflammatory and non inflammatory neurological diseases. Immunol. Lett. 94:183-189.
    • (2004) Immunol. Lett. , vol.94 , pp. 183-189
    • Michalopoulou, M.1
  • 28
    • 0037183489 scopus 로고    scopus 로고
    • Proposed diagnostic criteria and nosology of acute transverse myelitis
    • Transverse Myelitis Consortium Working Group. 2002. Proposed diagnostic criteria and nosology of acute transverse myelitis [review]. Neurology. 59:499-505.
    • (2002) Neurology , vol.59 , pp. 499-505
  • 29
    • 0037206543 scopus 로고    scopus 로고
    • Case records of the Massachusetts Genera Hospital. Weekly clinicopathological exercises. Case 34-2002. A 55-year-old man with cognitive and sensorimotor findings and intracranial lesions
    • Ravin, P., and Hedley-Whyte, E.T. 2002. Case records of the Massachusetts Genera Hospital. Weekly clinicopathological exercises. Case 34-2002. A 55-year-old man with cognitive and sensorimotor findings and intracranial lesions. N. Engl. J. Med. 347:1433-1440.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1433-1440
    • Ravin, P.1    Hedley-Whyte, E.T.2
  • 30
    • 0036042663 scopus 로고    scopus 로고
    • Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients
    • Miljkovic, D.J., et al. 2002. Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients. Eur. J. Neurol. 9:413-418.
    • (2002) Eur. J. Neurol. , vol.9 , pp. 413-418
    • Miljkovic, D.J.1
  • 31
    • 0242432319 scopus 로고    scopus 로고
    • cDNA microarray analysis in multiple sclerosis lesions: Detection of genes associated with disease activity
    • Mycko, M.P., Papoian, R., Boschert, U., Raine, C.S., and Selmaj, K-W. 2003. cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity. Brain. 126:1048-1057.
    • (2003) Brain , vol.126 , pp. 1048-1057
    • Mycko, M.P.1    Papoian, R.2    Boschert, U.3    Raine, C.S.4    Selmaj, K.-W.5
  • 32
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelins
    • Lock, C., et al. 2002. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelins. Nat. Med. 8:500-508.
    • (2002) Nat. Med. , vol.8 , pp. 500-508
    • Lock, C.1
  • 33
    • 0037064539 scopus 로고    scopus 로고
    • Molecular basis of the cell specificity of cytokine action
    • Ishihara, K., and Hirano, T. 2002. Molecular basis of the cell specificity of cytokine action. Biochim. Biophys. Acta. 1592:281-296.
    • (2002) Biochim. Biophys. Acta , vol.1592 , pp. 281-296
    • Ishihara, K.1    Hirano, T.2
  • 34
    • 0027939355 scopus 로고
    • Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis
    • Rodriguez, M., Pavelko, K.D., McKinney, C.W., and Leibowitz, J.L. 1994. Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis. J. Immunol. 153:3811-3821.
    • (1994) J. Immunol. , vol.153 , pp. 3811-3821
    • Rodriguez, M.1    Pavelko, K.D.2    McKinney, C.W.3    Leibowitz, J.L.4
  • 35
    • 2942566683 scopus 로고    scopus 로고
    • Enhancement of oligodendrocyte differentiation from marine embryonic stem cells by an activator of gp130 signaling
    • Zhang, P., Chebath, J., Lonai, P., and Revel, M. 2004. Enhancement of oligodendrocyte differentiation from marine embryonic stem cells by an activator of gp130 signaling. Stem Cells. 22:344-354.
    • (2004) Stem Cells , vol.22 , pp. 344-354
    • Zhang, P.1    Chebath, J.2    Lonai, P.3    Revel, M.4
  • 37
    • 1542467336 scopus 로고    scopus 로고
    • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
    • Lynch, J.R., et al. 2003. APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. J. Biol. Chem. 278:48529-48533.
    • (2003) J. Biol. Chem. , vol.278 , pp. 48529-48533
    • Lynch, J.R.1
  • 38
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda, K., et al. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 10:39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1
  • 39
    • 12144264780 scopus 로고    scopus 로고
    • Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide
    • Stagi, M., et al. 2005. Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide. J. Neurosci. 25:352-362.
    • (2005) J. Neurosci. , vol.25 , pp. 352-362
    • Stagi, M.1
  • 40
    • 3242737290 scopus 로고    scopus 로고
    • Role of PARP on iNOS pathway during endotoxin-induced acute lung injury
    • Kiefmann, R., et al. 2004. Role of PARP on iNOS pathway during endotoxin-induced acute lung injury. Intensive Care Med. 30:1421-1431.
    • (2004) Intensive Care Med. , vol.30 , pp. 1421-1431
    • Kiefmann, R.1
  • 41
    • 1842687173 scopus 로고    scopus 로고
    • Defective transcription factor activation for proinflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia
    • Ha, H.C. 2004. Defective transcription factor activation for proinflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia. Proc. Natl. Acad. Sci. U. S. A. 101:5087-5092.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 5087-5092
    • Ha, H.C.1
  • 42
    • 0030602849 scopus 로고    scopus 로고
    • The vulnerability of spinal cord neurons to excitotoxic injury: Comparison with cortical neurons
    • Regan, R.F. 1996. The vulnerability of spinal cord neurons to excitotoxic injury: comparison with cortical neurons. Neurosci. Lett. 213:9-12.
    • (1996) Neurosci. Lett. , vol.213 , pp. 9-12
    • Regan, R.F.1
  • 43
    • 0035854473 scopus 로고    scopus 로고
    • Interferon-gamma-mediated site-specific clearance of alpha-virus from CNS neurons
    • Binder, G.K., and Griffin, D.E. 2001. Interferon-gamma-mediated site-specific clearance of alpha-virus from CNS neurons. Science. 293:303-306.
    • (2001) Science , vol.293 , pp. 303-306
    • Binder, G.K.1    Griffin, D.E.2
  • 44
    • 0037213629 scopus 로고    scopus 로고
    • Role of microglial cells in selective replication of simian immunodeficiency virus genotypes in the brain
    • Babas, T., et al. 2003. Role of microglial cells in selective replication of simian immunodeficiency virus genotypes in the brain. J. Virol. 77:208-216.
    • (2003) J. Virol. , vol.77 , pp. 208-216
    • Babas, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.