Immunity to vacuolar pathogens: What can we learn from Legionella?

Cellular Microbiology

Volumn 6, Issue 11, 2004, Pages 1011-1018

  Neild, Annie L ^a   Roy, Craig R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIAL VACCINE; BACTERIUM LIPOPOLYSACCHARIDE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 60; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 4; LEGIONELLA VACCINE; LIPOPEPTIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN S; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TRANSFERRIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL IMMUNITY; BACTERIAL INFECTION; BACTERIAL SURVIVAL; BACTERIUM DETECTION; CELL ORGANELLE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENDOPLASMIC RETICULUM; ENDOSOME; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; HUMORAL IMMUNITY; INFECTION RESISTANCE; INTRACELLULAR SPACE; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; LYMPHOCYTE; MACROPHAGE; NONHUMAN; PATHOGENESIS; PHAGOCYTE; PRIORITY JOURNAL; PROTOZOON; SHORT SURVEY;

HUMANS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MACROPHAGES; VACUOLES;

BACTERIA (MICROORGANISMS); LEGIONELLA; LEGIONELLA PNEUMOPHILA; MAMMALIA; PROTOZOA;

EID: 6344233797     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2004.00450.x     Document Type: Short Survey

References (66)

1. Bhardwaj, N., Nash, T.W., and Horwitz, M.A. (1986) Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila. J Immunol 137: 2662-2669.
2. Blanchard, D.K., Friedman, H., Stewart, W.E., 2nd, Klein, T.W., and Djeu, J.Y. (1988) Role of gamma interferon in induction of natural killer activity by Legionella pneumophila in vitro and in an experimental murine infection model. Infect Immun 56: 1187-1193.
3. Blander, S.J., and Horwitz, M.A. (1989) Vaccination with the major secretory protein of Legionella pneumophila induces cell-mediated and protective immunity in a guinea pig model of Legionnaires' disease. J Exp Med 169: 691-705.
4. Blander, S.J., and Horwitz, M.A. (1991) Vaccination with the major secretory protein of Legionella induces humoral and cell-mediated immune responses and protective immunity across different serogroups of Legionella pneumophila and different species of Legionella. J Immunol 147: 285-291.
5. Blander, S.J., Breiman, R.F., and Horwitz, M.A. (1989) A live avirulent mutant Legionella pneumophila vaccine induces protective immunity against lethal aerosol challenge. J Clin Invest 83: 810-815.
6. Breiman, R.F., and Butler, J.C. (1998) Legionnaires' disease: clinical, epidemiological, and public health perspectives. Semin Respir Infect 13: 84-89.
7. Breiman, R.F., and Horwitz, M.A. (1987) Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses and are protected against lethal aerosol challenge. A model for studying host defense against lung infections caused by intracellular pathogens. J Exp Med 165: 799-811.
8. Brieland, J., Freeman, P., Kunkel, R., Chrisp, C., Hurley, M., Fantone, J., and Engleberg, C. (1994) Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires' disease. Am J Pathol 145: 1537-1546.
9. Brieland, J.K., Remick, D.G., Freeman, P.T., Hurley, M.C., Fantone, J.C., and Engleberg, N.C. (1995) In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide. Infect Immun 63 3253-3258.
10. Brieland, J.K., Remick, D.G., LeGendre, M.L., Engleberg, N.C., and Fantone, J.C. (1998) In vivo regulation of replicative Legionella pneumophila lung infection by endogenous interleukin-12. Infect Immun 66: 65-69.
11. Brieland, J.K., Jackson, C., Hurst, S., Loebenberg, D., Muchamuel, T., Debets, R et al. (2000) Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection. Infect Immun 68: 6567-6573.
12. Byrd, T.F., and Horwitz, M.A. (1989) Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. J Clin Invest 83: 1457-1465.
13. Byrd, T.F., and Horwitz, M.A. (1991) Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila. J Clin Invest 88: 1103-1112.
14. Chen, J., de Felipe, K.S., Clarke, M., Lu, H., Anderson, O.R., Segai, G., and Shuman, H.A. (2004) Legionella effectors that promote nonlytic release from protozoa. Science 303: 1358-1361.
15. Deng, J.C., Tateda, K., Zeng, X., and Standiford, T.J. (2001) Transient transgenic expression of gamma interferon promotes Legionella pneumophila clearance in immunocompetent hosts. Infect Immun 69: 6382-6390.
16. Diez, E., Lee, S.H., Gauthier, S., Yaraghi, Z., Tremblay, M., Vidal, S., and Gros, P. (2003) Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nat Genet 33: 55-60.
17. Fantuzzi, L., Puddu, P., Varano, B., Dei Corno, M., Belardelli, F., and Gessani, S. (2000) IFN-alpha and IL-18 exert opposite regulatory effects on the IL-12 receptor expression and IL-12-induced IFN-gamma production in mouse macrophages: novel pathways in the regulation of the inflammatory response of macrophages. J Leukoc Biol 68: 707-714.
18. Fields, B.S. (1996) The molecular ecology of legionellae. Trends Microbiol 4: 286-290.
19. Fraser, D.W., Tsai, T.R., Orenstein, W., Parkin, W.E., Beecham, H.J., Sharrar, R.G et al. (1977) Legionnaires' disease: description of an epidemic of pneumonia. N Engl J Med 297: 1189-1197.
20. Gebran, S.J., Yamamoto, Y., Newton, C., Klein, T.W., and Friedman, H. (1994) Inhibition of Legionella pneumophila growth by gamma interferon in permissive A/J mouse macrophages: role of reactive oxygen species, nitric oxide, tryptophan, and iron (III). Infect Immun 62: 3197-3205.
21. Girard, R., Pedron, T., Uematsu, S., Balloy, V., Chignard, M., Akira, S., and Chaby, R. (2003) Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci 116: 293-302.
22. Hawn, T.R., Verbon, A., Lettinga, K.D., Zhao, L.P., Li, S.S., Laws, R.J et al. (2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 198: 1563-1572.
23. Heath, L., Chrisp, C., Huffnagle, G., LeGendre, M., Osawa, Y., Hurley, M et al. (1996) Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts. Infect Immun 64: 5151-5160.
24. Heufler, C., Koch, F., Stanzl, U., Topar, G., Wysocka, M., Trinchieri, G et al. (1996) Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol 26: 659-668.
25. Horwitz, M.A. (1983) Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) In Human Monocytes J Exp Med 158: 1319-1331.
26. Horwitz, M.A. (1987) Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. J Exp Med 166: 1310-1328.
27. Horwitz, M.A., and Silverstein, S.C. (1980) Legionnaires' disease bacterium (Legionella pneumophila) Multiples Intracellularly Human Monocytes J Clin Invest 66: 441-450.
28. Horwitz, M.A., and Silverstein, S.C. (1981a) Activated human monocytes inhibit the intracellular multiplication of Legionnaires' disease bacteria. J Exp Med 154: 1618-1635.
29. Horwitz, M.A., and Silverstein, S.C. (1981b) Interaction of the legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. Pneumophila Monocytes But Does Not Inhibit Intracellular Multiplication J Exp Med 153: 398-406.
30. Inohara, N., and Nunez, G. (2003) NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 3: 371-382.
31. Kagan, J.C., and Roy, C.R. (2002) Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nat Cell Biol 4: 945-954.
32. Kirby, J.E., Vogel, J.P., Andrews, H.L., and Isberg, R.R. (1998) Evidence for pore-forming ability by Legionella pneumophila. Mol Microbiol 27: 323-336.
33. Klein, T.W., Yamamoto, Y., Brown, H.K., and Friedman, H. (1991) Interferon-gamma induced resistance to Legionella pneumophila in susceptible A/J mouse macrophages. J Leukoc Biol 49: 98-103.
34. Kopp, E., and Medzhitov, R. (2003) Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 15: 396-401.
35. Luo, Z.Q., and Isberg, R.R. (2004) Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc Natl Acad Sci U S A 101: 841-846.
36. Macatonia, S.E., Hosken, N.A., Litton, M., Vieira, P., Hsieh, C.S., Culpepper, J.A et al. (1995) Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 154: 5071-5079.
37. McDade, J.E., Shepard, C.C., Fraser, D.W., Tsai, T.R., Redus, M.A., and Dowdle, W.R. (1977) Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med 297: 1197-1203.
38. Marra, A., Blander, S.J., Horwitz, M.A., and Shuman, H.A. (1992) Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc Natl Acad Sci U S A 89: 9607-9611.
39. Matsunaga, K., Klein, T.W., Newton, C., Friedman, H., and Yamamoto, Y. (2001) Legionella pneumophila suppresses interleukin-12 production by macrophages. Infect Immun 69: 1929-1933.
40. Medzhitov, R., and Janeway, C., Jr (2000) The Toll receptor family and microbial recognition. Trends Microbiol 8: 452-456.
41. Muhlethaler-Mottet, A., Otten, L.A., Steimle, V., and Mach, B. (1997) Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J 16: 2851-2860.
42. Nagai, H., Kagan, J.C., Zhu, X., Kahn, R.A., and Roy, C.R. (2002) A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science 295: 679-682.
43. Nakanishi, K., Yoshimoto, T., Tsutsui, H., and Okamura, H. (2001) Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 19: 423-474.
44. Nash, T.W., Libby, D.M., and Horwitz, M.A. (1988) IFN-gamma-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila. J Immunol 140 3978-3981.
45. Neild, A.L., and Roy, C.R. (2003) Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentation. Immunity 18: 813-823.
46. Okamura, H., Kashiwamura, S., Tsutsui, H., Yoshimoto, T., and Nakanishi, K. (1998) Regulation of interferon-gamma production by IL-12 and IL-18. Curr Opin Immunol 10: 259-264.
47. Park, D.R., and Skerrett, S.J. (1996) IL-10 enhances the growth of Legionella pneumophila in human mononuclear phagocytes and reverses the protective effect of IFN-gamma: differential responses of blood monocytes and alveolar macrophages. J Immunol 157: 2528-2538.
48. Roy, C.R. (2003) Immunology: professional secrets. Nature 425: 351-352.
49. Roy, C.R., and Tilney, L.G. (2002) The road less traveled: transport of Legionella to the endoplasmic reticulum. J Cell Biol 158: 415-419.
50. Segal, G., Purcell, M., and Shuman, H.A. (1998) Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome. Proc Natl Acad Sci USA 95: 1669-1674.
51. Skerrett, S.J., and Martin, T.R. (1996) Roles for tumor necrosis factor alpha and nitric oxide in resistance of rat alveolar macrophages to Legionella pneumophila. Infect Immun 64: 3236-3243.
52. Skerrett, S.J., Bagby, G.J., Schmidt, R.A., and Nelson, S. (1997) Antibody-mediated depletion of tumor necrosis factor-alpha impairs pulmonary host defenses to Legionella pneumophila. J Infect Dis 176: 1019-1028.
53. Smith, K.D., Andersen-Nissen, E., Hayashi, F., Strobe, K., Bergman, M.A., Barrett, S.L et al. (2003) Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nat Immunol 4: 1247-1253.
54. Susa, M., Ticac, B., Rukavina, T., Doric, M., and Marre, R. (1998) Legionella pneumophila infection in intratracheally inoculated T cell-depleted or -nondepleted A/J mice. J Immunol 160: 316-321.
55. Tateda, K., Matsumoto, T., Ishii, Y., Furuya, N., Ohno, A., Miyazaki, S., and Yamaguchi, K. (1998) Serum cytokines in patients with Legionella pneumonia: relative predominance of Th1-type cytokines. Clin Diagn Laboratory Immunol 5: 401-403.
56. Tateda, K., Moore, T.A., Deng, J.C., Newstead, M.W., Zeng, X., Matsukawa, A et al. (2001) Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia. J Immunol 166: 3355-3361.
57. Tilney, L.G., Harb, O.S., Connelly, P.S., Robinson, C.G., and Roy, C.R. (2001) How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. J Cell Sci 114 4637-4650.
58. Trinchieri, G. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3: 133-146.
59. Trinchieri, G., and Gerosa, F. (1996) Immunoregulation by interleukin-12. J Leukoc Biol 59: 505-511.
60. Vogel, J.P., Andrews, H.L., Wong, S.K., and Isberg, R.R. (1998) Conjugative transfer by the virulence system of Legionella pneumophila. Science 279: 873-876.
61. Weeratna, R., Stamler, D.A., Edelstein, P.H., Ripley, M., Marrie, T., Hoskin, D., and Hoffman, P.S. (1994) Human and guinea pig immune responses to Legionella pneumophila protein antigens OmpS and Hsp60. Infect Immun 62: 3454-3462.
62. Wright, E.K., Goodart, S.A., Growney, J.D., Hadinoto, V., Endrizzi, M.G., Long, E.M et al. (2003) Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr Biol 13: 27-36.
63. Yamamoto, Y., Kleini T.W., and Friedman, H. (1996) Immunoregulatory role of nitric oxide in Legionella pneumophila infected macrophages. Cell Immunol 171: 231-239.
64. Yamamoto, Y., Klein, T.W., Newton, C.A., Widen, R., and Friedman, H. (1988) Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice. Infect Immun 56: 370-375.
65. Yamamoto, M., Takeda, K., and Akira, S. (2004) TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol 40: 861-868.
66. Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K,, Kashiwamura, S., Okamura, H et al. (1998) IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol 161: 3400-3407.