Evidence for pore-forming ability by Legionella pneumophila

Molecular Microbiology

Volumn 27, Issue 2, 1998, Pages 323-336

  Kirby, James E ^a,b   Vogel, Joseph P ^a   Andrews, Helene L ^a,d   Isberg, Ralph R ^a,c  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL DERIVATIVE;

ARTICLE; CELL DEATH; CHANNEL GATING; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEGIONELLA PNEUMOPHILA; MACROPHAGE; MUTANT; NORMAL HUMAN; PRIORITY JOURNAL;

ANIMALS; BACTERIAL TOXINS; CELLS, CULTURED; FEMALE; HEMOLYSIS; LEGIONELLA PNEUMOPHILA; MACROPHAGES; MICE; MICE, INBRED A;

EUKARYOTA; LEGIONELLA PNEUMOPHILA; NEGIBACTERIA;

EID: 0031973809     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1998.00680.x     Document Type: Article

References (54)

1. Berger, K.H., and Isberg, R.R. (1993) Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol 7: 7-19.
2. Berger, K.H., Merriam, J.J., and Isberg, R.R. (1994) Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene. Mol Microbiol 14: 809-822.
3. Bhakdi, S., Roth, M., Sziegoleit, A., and Tranum-Jenson, J. (1984) Isolation and identification of two hemolytic forms of streptolysin-O. Infect Immun 46: 394-400.
4. Bhakdi, S., Mackman, N., Nicaud, J., and Holland, I.B. (1986) Escherichia coli hemolysin may damage target cell membranes by generating transmembrane pores. Infect Immun 52: 63-69.
5. Brand, B.C., Sadosky, A.B., and Shuman, H.A. (1994) The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages. Mol Microbiol 14: 797-808.
6. Buckingham, L., and Duncan, J.L. (1983) Approximate dimensions of membrane lesions produced by Streptolysin S and Streptolysin O. Biochim Biophys Acta 729: 115-122.
7. Caparon, M., and Johnson, W. (1988) Macrophage toxicity and complement sensitivity of virulent and avirulent strains of Legionella pneumophila. Rev Infect Dis 10 (suppl. 2): S377-S381.
8. Chen, L.M., Kaniga, K., and Galan, J.E. (1996) Salmonella spp. are cytotoxic for cultured macrophages. Mol Microbiol 21: 1101-15.
9. Clemens, D.L., and Horwitz, M.A. (1992) Membrane sorting during phagocytosis: selective exclusion of major histocompatibility complex molecules but not complement receptor CR3 during conventional and coiling phagocytosis. J Exp Med 175: 1317-1326.
10. Clemens, D.L., and Horwitz, M.A. (1995) Characterization of the Mycobaterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J Exp Med 181: 257-270.
11. Clinkenbeard, K.D., Mosier, D.A., and Confer, A.W. (1989) Transmembrane pore size and role of cell swelling in cytotoxicity caused by Pasteurella haemolytica leukotoxin. Infect Immun 57: 420-425.
12. Dykstra, M.J. (1993) A Manual of Applied Techniques for Biological Electron Microscopy. New York: Plenum Press.
13. Elfgang, C., Eckert, R., Lichtenberg-Frate, H., Butterwork, A., Traub, O., Klei, R.A., et al. (1995) Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J Cell Biol 129: 805-17.
14. Elliott, J.A., and Winn, W.C. (1986) Treatment of alveolar macrophages with cytochalasin D inhibits uptake and subsequent growth of Legionella pneumophila. Infect Immun 51: 31-36.
15. Finck-Barbancon, V., Duportail, G., Meunier, O., and Colin, D.A. (1993) Pore formation by a two-component leukocidin from Staphylococcus aureus within the membrane of human polymorphonuclear leukocytes. Biochim Biophys Acta 1182: 275-282.
16. Fischer, L.J., Quinn, F.D., White, E.H., and King, C.H. (1996) Intracellular growth and cytotoxicity of Mycobacterium haemophilum in a human epithelial cell line (Hec-1-B). Infect Immun 64: 269-276.
17. Fraser, D.W., Tsai, T.R., Orenstein, W., Parkin, W.E., Beecham, H.J., Sharrar, R.G., et al. (1977) Legionnaires' disease: description of an epidemic of pneumonia. N Engl J Med 297: 1189-97.
18. Guyton, A.C. (1986) Textbook of Medical Physiology, 7th edn. Philadelphia, PA: W.B. Saunders.
19. Hakansson, S., Schesser, K., Persson, C., Galyov, E.E., Rosqvist, R., Homble, F., and Wolf-Watz, H. (1996) The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. EMBO J 15: 5812-5823.
20. High, N., Mounier, J., Prevost, M.C., and Sansonetti, P.J. (1992) IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole. EMBO J 11: 1991-99.
21. Horwitz, M.A. (1983a) Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med 158: 1319-31.
22. Horwitz, M.A. (1983b) The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J Exp Med 158: 2108-26.
23. Horwitz, M.A. (1987) Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. J Exp Med 166: 1310-28.
24. Husmann, L.K., and Johnson, W. (1994) Cytotoxicity of extracellular Legionella pneumophila. Infect Immun 62: 2111-2114.
25. Isberg, R.R. (1994) Intracellular trafficking of Legionella pneumophila within phagocytic cells. In Molecular Genetics of Bacterial Pathogenesis. Miller, V.L., Kaper, J.B., Portnoy, D.A., and Isberg, R.R. (eds). Washington, DC: American Society of Microbiology, pp. 263-278.
26. Isberg, R.R., Voorhis, D.L., and Falkow, S. (1987) Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells. Cell 50: 769-778.
27. Iwase, M., Lally, E.T., Berthold, P., Korchak, H.M., and Taichman, N.S. (1990) Effects of cations and osmotic protectants on cytolytic activity of Actinobacillus actinomycetemcomitans. Infect Immun 58: 1782-1788.
28. Keen, M.G., and Hoffman, P.S. (1989) Characterization of a Legionella pneumophila extracellular protease exhibiting hemolytic and cytotoxic activities. Infect Immun 57: 732-738.
29. Kerr, J.F.R., Gobe, G.C., Winterford, C.M., and Harmon, B.V. (1995) Anatomical methods in cell death. Methods Cell Biol 46: 1-27.
30. King, C.H., Mundayoor, S., Crawford, J.T., and Shinnick, T.M. (1993) Expression of contact-dependent cytolytic activity by Mycobacterium tuberculosis and isolation of the genomic locus that encodes the activity. Infect Immun 61: 2708-2712.
31. Lalonde, G., McDonald, T.V., Gardner, P., and O'Hanley, P.D. (1989) Identification of a hemolysin from Actinobacillus pleuropneumoniae and characterization of its channel properties in planar phospholipid bilayers. J Biol Chem 264: 13559-13564.
32. Lobo, A.L., and Welch, R.A. (1994) Identification and assay of RTX family of cytolysins. Methods Enyzmol 235: 667-678.
33. McGahon, A.J., Martin, S.J., Bissonnette, R.P., Mahboubi, A., Shi, Y., Mogil, R.J., et al. (1995) The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol 46: 172-173.
34. Marra, A., Blander, S.J., Horwitz, M.A., and Shuman, H.A. (1992) Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc Natl Acad Sci USA 89: 9607-9611.
35. Menard, A., Altendorf, K., Breves, D., Mock, M., and Montecucco, C. (1996) The vacuolar ATPase proton pump is required for the cytotoxicity of Bacillus anthracis lethal toxin. FEBS Lett 386: 161-164.
36. Menestrina, G. (1986) Ionic channels formed by Staphylococcus aureus alpha toxin: voltage-dependent inhibition by divalent and trivalent cations. J Membr Biol 90: 177-190.
37. Moffat, J.F., Edelstein, P.H., Regula, Jr, D.P., Cirillo, J.D., and Tompkins, L.S. (1994) Effects of a Zn-metalloprotease-deficient mutant of Legionella pneumophila in a guinea-pig pneumonia model. Mol Microbiol 12: 693-705.
38. Muller, A., Hacker, J., and Brand, B.C. (1996) Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection. Infect Immun 64: 4900-4906.
39. Noronha, F.S.M., Ramalho-Pinto, F.J., and Horta, M.F. (1996) Cytolytic activity in the genus Leishmania: involvement of a putative pore-forming protein. Infect Immun 64: 3975-3982.
40. Papini, E., Rappuoli, R., Murgia, M., and Montecucco, C. (1993) Cell penetration of diphtheria toxin. J Biol Chem 268: 1467-1574.
41. Roy, C.R., and Isberg, R.R. (1997) Topology of Legionella pneumphila DotA: an inner membrane protein required for replication in macrophages. Infect Immun 65: 571-578.
42. Sadosky, A.B., Wiater, L.A., and Shuman, H.A. (1993) Identification of Legionella pneumophila genes required for growth within and killing of human macrophages. Infect Immun 61: 5361-5373.
43. Scherrer, R., and Gerhardt, P. (1971) Molecular sieving by the Bacillus megaterium cell wall and protoplast. J Bacteriol 107: 718-735.
44. Schwab, J., Beckers, C., and Joiner, K. (1994) The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve. Proc Natl Acad Sci USA 91: 509-13.
45. Song, L., Hobaugh, M.R., Shustak, C., Cheley, S., Bayley, H., and Gouaux, J.E. (1996) Structure of Staphylococcal α-hemolysin, a heptameric transmembrane pore. Science 274: 1859-1866.
46. Spack, Jr, E.G., Packard, B., Wier, M.L., Edidin, M. (1986) Hydrophobic adsorption chromatography to reduce non-specific staining by rhodamine-labeled antibodies. Anal Biochem 158: 233-237.
47. Swanson, M.S., and Isberg, R.R. (1995) Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun 63: 3609-3620.
48. Szeto, L., and Shuman, H.A. (1990) The Legionella pneumophila major secreted protein, a protease, is not required for intracellular growth or cell killing. Infect Immun 58: 2585-2592.
49. Thelestam, M., and Florin, I. (1994) Assay of cytopathogenic toxins in cultured cells. Methods Enzymol 235: 679-690.
50. Tosteson, D.C., and Hoffman, J.F. (1960) Regulation of cell volume by active cation transport in high and low potassium sheep red cells. J Gen Physiol 44: 169-194.
51. Vogel, J.P., Roy, C., and Isberg, R.R. (1996) Use of salt to isolate Legionella pneumophila mutants unable to replicate in macrophages. Ann NY Acad Sci 797: 271-272.
52. Winn, W.C., and Myerowitz, R.L. (1981) The pathology of the Legionella pneumonias. Hum Pathol 12: 401-422.
53. Wintermeyer, E., Rdest, U., Ludwig, B., Debes, A., and Hacker, J. (1991) Characterization of legiolysin (lly), responsible for haemolytic activity, colour production and fluorescence of Legionella pneumophila. Mol Microbiol 5: 1135-1143.
54. Wintermeyer, E., Flugel, M., Ott, M., Steinhert, M., Rdest, U., Mann, K.-H., and Hacker, J. (1994) Sequence determination and mutational analysis of the lly locus of Legionella pneumophila. Infect Immun 62: 1109-1117.