Antibody-mediated depletion of tumor necrosis factor-α impairs pulmonary host defenses to Legionella pneumophila

Journal of Infectious Diseases

Volumn 176, Issue 4, 1997, Pages 1019-1028

  Skerrett, Shawn J ^a   Bagby, Gregory J ^b   Schmidt, Rodney A ^b   Nelson, Steve ^b  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIUM CULTURE; CELLULAR IMMUNITY; CYTOPATHOLOGY; GENE EXPRESSION; HISTOPATHOLOGY; HOST RESISTANCE; IMMUNE RESPONSE; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; LUNG LAVAGE; MALE; MYCOBACTERIUM TUBERCULOSIS; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; RAT; TUBERCULOSIS;

EID: 0030820062     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/516530     Document Type: Article

References (17)

1. Horwitz MA, Silverstein SC. Legionnaires' disease bacterium (Legionella pneumophila) multiplies intracellularly in human monocytes. J Clin Invest 1980;66:441-50.
2. Horwitz MA. Cell mediated immunity in Legionnaires' disease. J Clin Invest 1983;71:1686-97.
3. Finegold SM. Legionnaire's disease - still with us. N Engl J Med 1988;318:571-3.
4. Skerrett SJ, Martin TR. Alveolar macrophage activation in experimental legionellosis. J Immunol 1991;147:337-45.
5. Bhardwaj N, Nash TW, Horwitz MA. Interferon-gamma-activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila. J Immunol 1986;137:2662-9.
6. Jenson WA, Rose RM, Wasserman AS, Kalb TH, Anton K, Remold HG. In vitro activation of the antibacterial activity of human pulmonary macrophages by recombinant gamma interferon. J Infect Dis 1987;155:574-7.
7. Nash TW, Libby DM, Horwitz MA. IFN-γ-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila. J Immunol 1988;140:3978-81.
8. Skerrett SJ, Martin TR. Recombinant murine interferon-γ reversibly activates rat alveolar macrophages to kill Legionella pneumophila. J Infect Dis 1992;166:1354-61.
9. Park DR, Skerrett SJ. IL-10 enhances the growth of Legionella pneumophila in human mononuclear phagocytes and reverses the protective effect of IFN-γ. Differential responses of blood monocytes and alveolar macrophages. J Immunol 1996;157:2528-38.
10. Blanchard DK, Friedman H, Stewart WE, Klein TW, Djeu JY. Role of gamma interferon in induction of natural killer activity by Legionella pneumophila in vitro and in vivo in an experimental murine infection model. Infect Immun 1988;56:1187-93.
11. Brieland J, Freeman P, Kunkel R, et al. Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. Am J Pathol 1994;145:1537-46.
12. Heath L, Chrisp C, Huffnagle G, et al. Effector mechanisms responsible for gamma interferon-mediated host resistance to Legionella pneumophila lung infection: the role of endogenous nitric oxide differs in susceptible and resistant murine hosts. Infect Immun 1996;64:5151-60.
13. Skerrett SJ, Martin TR. Intratracheal interferon-γ augments pulmonary defenses in experimental legionellosis. Am J Respir Crit Care Med 1994;149:50-8.
14. Havell EA. Production of tumor necrosis factor during murine listeriosis. J Immunol 1987;139:4225-31.
15. Nakane A, Minagawa T, Kalo K. Endogenous tumor necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection. Infect Immun 1988;56:2563-9.
16. Havell EA. Evidence that tumor necrosis factor has an important role in antibacterial resistance. J Immunol 1989;143:2894-9.
17. Kindler V, Sappino AP, Grau GE, Piguet PF, Vassali P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 1989;56:731-40.