How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: Implications for conversion of plasma membrane to the ER membrane

Journal of Cell Science

Volumn 114, Issue 24, 2001, Pages 4637-4650

  Tilney, Lewis G ^a   Harb, Omar S ^a   Connelly, Patricia S ^a   Robinson, Camenzind G ^a   Roy, Craig R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Endoplasmic reticulum; Intracellular survival; L. pneumophila; Macrophage; Membrane; Ribosomes

Indexed keywords

CHOLESTEROL; GLYCOLIPID; SPHINGOLIPID;

ARTICLE; BACTERIAL INFECTION; BACTERIAL SURVIVAL; BACTERIUM TRANSFORMATION; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEGIONELLA PNEUMOPHILA; LIPID COMPOSITION; MACROPHAGE; MEMBRANE COMPONENT; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; RIBOSOME; ROUGH ENDOPLASMIC RETICULUM;

BACTERIAL PROTEINS; CARRIER PROTEINS; CELL FRACTIONATION; CELL MEMBRANE; GRAM-POSITIVE BACTERIA; HUMANS; INTRACELLULAR MEMBRANES; LEGIONELLA PNEUMOPHILA; LIPID METABOLISM; LYSOSOMES; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON; MITOCHONDRIA; MOLECULAR CHAPERONES; MUTATION; ORGANELLES; PHAGOSOMES; RIBOSOMES; TIME FACTORS; U937 CELLS;

BACTERIA (MICROORGANISMS); LEGIONELLA; LEGIONELLA PNEUMOPHILA; NEGIBACTERIA;

EID: 0035691622     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway
2. Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene
3. Cholesterol and the Golgi apparatus
4. Micro- and nanomechanics of the cochlear outer hair cell
5. Expression of Legionella pneumophila virulence traits in response to growth conditions
6. Specificity for the exchange of phospholipids through polymyxin B mediated intermembrane molecular contacts
7. Intermembrane molecular contacts by polymyxin B mediate exchange of phospholipids
8. Bacterial type IV secretion: Conjugation systems adapted to deliver effector molecules to host cells
9. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited
10. Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth
11. High pressure freezing of intact plant tissues. Evaluation and characterization of novel features of the endoplasmic reticulum and associated membrane systems
12. Substructure of freeze substituted plasmadesmata
13. Transformation of leukocytes by Theileria parva and T. annulata
14. A coat protein on phagosomes involved in the intracellular survival of Mycobacteria
15. Common themes in microbial pathogenicity revisited
16. Structural features of the lateral walls in mammalian cochlear outer hair cells
17. Heterogeneity in intracellular replication and cytopathogenicity of Legionella pneumophila and Legionella micdadei in mammalian and protozoan cells
18. Essential role for cholesterol in entry of Mycobacteria into macrophages
19. Localization of Legionella bacteria within ribosome-studded phagosomes is not restricted to Legionella pneumophila
20. Endoplasmic reticulum forms a dynamic continuum for lipid diffusion between contiguous soybean root cells
21. Trypanosoma cruzi: Mechanisms for entry into host cells
22. Identification of the aspartate-beta-semialdehyde dehydrogenase gene of Legionella pneumophila and characterization of a null mutant
23. Essential role for the Legionella pneumophila rep helicase homologue in intracellular infection of mammalian cells
24. From protozoa to mammalian cells: A new paradigm in the life cycle of intracellular bacterial pathogens
25. Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetti and Chlamydia trachomatis
26. Similarity of junctions between plasma membranes and endoplasmic reticulum in muscle and neurons
27. IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole
28. Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes
29. Endocytosis of simian virus 40 into the endoplasmic reticulum
30. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells
31. Characterization of mechanisms for transfer of cholesterol between human erythrocytes and plasma
32. Identification and subcellular localization of the Legionella pneumophila IcmX protein: A factor essential for establishment of a replicative organelle in eukaryotic host cells
33. Combined influence of cholesterol and synthetic amphiphillic peptides upon bilayer thickness in model membranes
34. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
35. Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
36. Characterization of the outer hair cell's lateral wall membranes
37. The cell biology of Listeria monocytogenes infection (escape from a vacuole)
38. Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake
39. Identification of Legionella pneumophila genes required for growth within and killing of human macrophages
40. Establishment and characterization of a human histocytic lymphoma cell line (U937)
41. Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome
42. Characterization of a new region required for macrophage killing by Legionella pneumophila
43. Interactions between Toxoplasma gondii and its mammalian host cells
44. Functional rafts in cell membranes
45. How cells handle cholesterol
46. Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: A high affinity interaction
47. Movement of plasma-membrane sterols to the endoplasmic reticulum in cultured cells
48. The plant ER: A dynamic organelle composed of a large number of discrete functional domains
49. Legionella pneumophila pathogenesis: A fateful journey from amoebae to macrophages
50. Association of Legionella pneumophila with the macrophage endoplasmic reticulum
51. The structure of plasmodesmata as revealed by plasmolysis, detergent extraction, and protease digestion
52. Conjugative transfer by the virulence system of Legionella pneumophila
53. Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila