6 Cytochrome P450 Metabolism and Inhibition: Analysis for Drug Discovery

Progress in Medicinal Chemistry

Volumn 47, Issue , 2009, Pages 239-263

  Jones, Barry C ^a   Middleton, Donald S ^a   Youdim, Kuresh ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CYCLOPHOSPHAMIDE; CYTOCHROME P450; DEXTROMETHORPHAN; DIAZEPAM; DICLOFENAC; EFAVIRENZ; ERYTHROMYCIN; ESTRADIOL; FLURBIPROFEN; GEMFIBROZIL; IMIPRAMINE; KETOCONAZOLE; MARAVIROC; MEPHENYTOIN; METHYLPHENOBARBITAL; METYRAPONE; MIDAZOLAM; MOCLOBEMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PROGESTERONE; PROGUANIL; PROPOFOL; SEROTONIN UPTAKE INHIBITOR; TACRINE; TOLBUTAMIDE; WARFARIN; DRUG; ENZYME INHIBITOR;

AREA UNDER THE CURVE; CELL FRACTIONATION; DRUG CLEARANCE; DRUG DESIGN; DRUG ELIMINATION; DRUG METABOLISM; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME STRUCTURE; GENETIC POLYMORPHISM; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CYTOSOL; LIVER MICROSOME; NONHUMAN; PHENOTYPE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; DRUG ANTAGONISM; DRUG DEVELOPMENT; ENZYME SPECIFICITY; ENZYMOLOGY; LIVER; METABOLISM; METHODOLOGY; STRUCTURE ACTIVITY RELATION;

CYTOCHROME P-450 ENZYME SYSTEM; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; LIVER; PHARMACEUTICAL PREPARATIONS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 62849113044     PISSN: 00796468     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6468(08)00206-3     Document Type: Review

References (79)

1. Gomez-Lechon M.J., Donato T., Ponsoda X., and Castell J.V. Altern. Lab. Anim. 31 (2003) 257-265
2. Lamb D.C., Waterman M.R., Kelly S.L., and Guengerich F.P. Curr. Opin. Biotechnol. 18 (2007) 504-512
3. Krueger S.K., and Williams D.E. Pharmacol. Ther. 106 (2005) 357-387
4. Olinga P., Elferink M.G., Draaisma A.L., Merema M.T., Castell J.V., Perez G., and Groothuis G.M. Eur. J. Pharm. Sci. 33 (2008) 380-389
5. Persson K.P., Ekehed S., Otter C., Lutz E.S., McPheat J., Masimirembwa C.M., and Andersson T.B. Pharm. Res. 23 (2006) 56-69
6. Lloyd T.D., Orr S., Skett P., Berry D.P., and Dennison A.R. Cell Tissue Bank 4 (2003) 3-15
7. Nussler A.K., Wang A., Neuhaus P., Fischer J., Yuan J., Liu L., Zeilinger K., Gerlach J., Arnold P.J., and Albrecht W. Altex 18 (2001) 91-101
8. Bjornsson T.D., Callaghan J.T., Einolf H.J., Fischer V., Gan L., Grimm S., et al. J. Clin. Pharmacol. 43 (2003) 443-469
9. McGinnity D.F., and Riley R.J. Biochem. Soc. Trans. 29 (2001) 135-139
10. Grime K., and Riley R.J. Curr. Drug Metab. 7 (2006) 251-264
11. Masimirembwa C.M., Bredberg U., and Andersson T.B. Clin. Pharmacokinet. 42 (2003) 515-528
12. Kumar V., Rock D.A., Warren C.J., Tracy T.S., and Wahlstrom J.L. Drug Metab. Dispos. 34 (2006) 1903-1908
13. Dickins M., Galetin A., and Proctor N. In: Taylor J.B., and Triggle D.J. (Eds). Comprehensive Medicinal Chemistry II (2007), Elsevier, Oxford 827-846
14. Proctor N.J., Tucker G.T., and Rostami-Hodjegan A. Xenobiotica 34 (2004) 151-178
15. Shou M., Lin Y., Lu P., Tang C., Mei Q., Cui D., et al. Curr. Drug Metab. 2 (2001) 17-36
16. Zlokarnik G., Grootenhuis P.D., and Watson J.B. Drug Discov. Today 10 (2005) 1443-1450
17. Crespi C.L., and Stresser D.M. J. Pharmacol. Toxicol. Methods 44 (2000) 325-331
18. Walsky R.L., and Obach R.S. Drug Metab. Dispos. 32 (2004) 647-660
19. Gao Z.W., Shi X.J., Yu C., Li S.J., and Zhong M.K. Yao Xue Xue Bao 42 (2007) 589-594
20. Tolonen A., Petsalo A., Turpeinen M., Uusitalo J., and Pelkonen O. J. Mass Spectrom. 42 (2007) 960-966
21. Di L., Kerns E.H., Li S.Q., and Carter G.T. Int. J. Pharm. 335 (2007) 1-11
22. Testino Jr. S.A., and Patonay G. J. Pharm. Biomed. Anal. 30 (2003) 1459-1467
23. Adedoyin A., Frye R.F., Mauro K., and Branch R.A. Br. J. Clin. Pharmacol. 46 (1998) 215-219
24. Dixit V., Hariparsad N., Desai P., and Unadkat J.D. Biopharm. Drug Dispos. 28 (2007) 257-262
25. Dierks E.A., Stams K.R., Lim H.K., Cornelius G., Zhang H., and Ball S.E. Drug Metab. Dispos. 29 (2001) 23-29
26. Bu H.Z., Magis L., Knuth K., and Teitelbaum P. Rapid Commun. Mass Spectrom. 15 (2001) 741-748
27. Smith D., Sadagopan N., Zientek M., Reddy A., and Cohen L. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 850 (2007) 455-463
28. Gao F., Johnson D.L., Ekins S., Janiszewski J., Kelly K.G., Meyer R.D., and West M. J. Biomol. Screen 7 (2002) 373-382
29. Fontana E., Dansette P.M., and Poli S.M. Curr. Drug Metab. 6 (2005) 413-454
30. Hollenberg P.F., Kent U.M., and Bumpus N.N. Chem. Res. Toxicol. 21 (2008) 189-205
31. Kalgutkar A.S., Obach R.S., and Maurer T.S. Curr. Drug Metab. 8 (2007) 407-447
32. Venkatakrishnan K., Obach R.S., and Rostami-Hodjegan A. Xenobiotica 37 (2007) 1225-1256
33. Polasek T.M., and Miners J.O. Expert Opin. Drug Metab. Toxicol. 3 (2007) 321-329
34. Ghanbari F., Rowland-Yeo K., Bloomer J.C., Clarke S.E., Lennard M.S., Tucker G.T., and Rostami-Hodjegan A. Curr. Drug Metab. 7 (2006) 315-334
35. Van L.M., Heydari A., Yang J., Hargreaves J., Rowland-Yeo K., Lennard M.S., Tucker G.T., and Rostami-Hodjegan A. J. Psychopharmacol. 20 (2006) 834-841
36. Riley R.J., Grime K., and Weaver R. Expert Opin. Drug Metab. Toxicol. 3 (2007) 51-66
37. Rane A., Wilkinson G.R., and Shand D.G. J. Pharmacol. Exp. Ther. 200 (1977) 420-424
38. Lave T., Coassolo P., and Reigner B. Clin. Pharmacokinet. 36 (1999) 211-231
39. Rowland M., and Matin S.B. J. Pharmacokinet. Biopharm. 1 (1973) 553-567
40. Barter Z.E., Bayliss M.K., Beaune P.H., Boobis A.R., Carlile D.J., Edwards R.J., et al. Curr. Drug Metab. 8 (2007) 33-45
41. Johnson T.N., Rostami-Hodjegan A., and Tucker G.T. Clin. Pharmacokinet. 45 (2006) 931-956
42. Obach R.S. Drugs Today (Barc.) 39 (2003) 301-338
43. Venkatakrishnan K., von Moltke L.L., Obach R.S., and Greenblatt D.J. Curr. Drug Metab. 4 (2003) 423-459
44. Obach R.S., and Reed-Hagen A.E. Drug Metab. Dispos. 30 (2002) 831-837
45. Smith D.A., and Jones B.C. Biochem. Pharmacol. 44 (1992) 2089-2098
46. Smith D.A., Ackland M.J., and Jones B.C. Drug Disc. Today 2 (1997) 479-486
47. Lewis D.F.V., and Lake B.G. Xenobiotica 26 (1996) 723-753
48. Jones B.C., Hawksworth G., Horne V.A., Newlands A., Morsman J., Tute M.S., and Smith D.A. Drug Metab. Dispos. 24 (1996) 1-7
49. de Groot M.J., Alex A.A., and Jones B.C. J. Med. Chem. 45 (2002) 1983-1993
50. Williams P.A., Cosme J., Ward A., Angrove H.C., Vinkovic D.M., and Jhoti H. Nature (London) 424 (2003) 464-468
51. Wester M.R., Yano J.K., Schoch G.A., Yang C., Griffin K.J., Stout C.D., and Johnson E.F. J. Biol. Chem. 279 (2004) 35630-35637
52. Wang J.-F., Wei D.-Q., Zheng S.-Y., Li Y.-X., and Chou K.-C. Biochem. Biophys. Res. Commun. 355 (2007) 513-519
53. de Groot M.J., Ackland M.J., Horne V.A., Alex A.A., and Jones B.C. J. Med. Chem. 42 (1999) 1515-1524
54. Halliday R.C., Jones B.C., Park B.K., and Smith D.A. Eur. J. Drug Metab. Pharmacokinet. 22 (1997) 291-294
55. Rowland P., Blany F.E., Smyth M.G., Jones J.J., Leydon V.R., Oxbrow A.K., et al. J. Biol. Chem. 281 (2006) 7614-7622
56. Niwa T., Murayama N., and Yamazaki H. Curr. Drug Metab. 9 (2008) 453-462
57. Koley A.P., Robinson R.C., and Friedman F.K. Biochimie 78 (1996) 706-713
58. Koley A.P., Buters J.T.M., Robinson R.C., Markowitz A., and Friedman F.K. J. Biol. Chem. 272 (1997) 3149-3152
59. Yano J.K., Wester M.R., Schoch G.A., Griffin K.J., Stout C.D., and Johnson E.F. J. Biol. Chem. 279 (2004) 38091-38094
60. Ekroos M., and Sjoegren T. Proc. Natl. Acad. Sci. USA 103 (2006) 13682-13687
61. Williams P.A., Cosme J., Vinkovic D.M., Ward A., Angove H.C., Day P.J., Vonrhein C., Tickle I.J., and Jhoti H. Science (Washington, DC) 305 (2004) 683-686
62. Hesse L.M., Venkatakrishnan K., Court M.H., von Moltke L.L., Duan S.X., Shader R.I., and Greenblatt D.J. Drug Metab. Dispos. 28 (2000) 1176-1183
63. Ward B.A., Gorski J.C., Jones D.R., Hall S.D., Flockhart D.A., and Desta Z. J. Pharmacol. Exp. Ther. 306 (2003) 287-300
64. Huang Z., Roy P., and Waxman D.J. Biochem. Pharmacol. 59 (2000) 961-972
65. Oda Y., Hamaoka N., Hiroi T., Imaoka S., Hase I., Tanaka K., Funae Y., Ishizaki T., and Asada A. Br. J. Clin. Pharmacol. 51 (2001) 281-285
66. Ekins S., Iyer M., Krasowski M.D., and Kharasch E.D. Curr. Drug Metab. 9 (2008) 363-373
67. Korhonen L.E., Turpeinen M., Rahnasto M., Wittekindt C., Poso A., Pelkonen O., Rauniol H., and Juvonen R.O. Br. J. Pharmacol. 150 (2007) 932-942
68. Ogilvie B.W., Zhang D., Li W., Rodrigues A.D., Gipson A.E., Holsapple J., Toren P., and Parkinson A. Drug Metab. Dispos. 34 (2006) 191-197
69. Delaforge M., Pruvost A., Perrin L., and Andre F. Drug Metab. Dispos. 33 (2005) 466-473
70. Melet A., Marques-Soares C., Schoch G.A., Macherey A.-C., Jaouen M., Dansette P.M., Sari M.-A., Johnson E.F., and Mansuy D. Biochemistry 43 (2004) 15379-15392
71. Schoch G.A., Yano J.K., Wester M.R., Griffin K.J., Stout C.D., and Johnson E.F. J. Biol. Chem. 279 (2004) 9497-9503
72. Schoch G.A., Yano J.K., Sansen S., Dansette P.M., Stout C.D., and Johnson E.F. J. Biol. Chem. 2889 (2008) 17227-17237
73. Armou D., de Groot M.J., Edwards M., Perros M., Pric D.A., Stammen B.L., and Wood A. Chem. Med. Chem. 1 (2006) 706-709
74. Skerratt S. 19th Symposium on Medicinal Chemistry in Eastern England (2008), University of Hertfordshire, Hatfield, UK
75. Middleton D.S., MacKenzie A.R., Newman S.D., Corless C., Warren A., Marchington A.P., and Jones B. Bioorg. Med. Chem. Lett. (2005) 3957-3961
76. Middleton, D.S. (2002) 223rd American Chemical Society Meeting, Orlando, FL, USA.
77. Middleton D.S., Andrews M., Glossop P., Gymer G., Hepworth D., Jessiman A., et al. Bioorg. Med. Chem. Lett. 18 (2008) 4018-4021
78. Middleton, D.S. (2005) 230th American Chemical Society Meeting. Washington, DC, USA.
79. Middleton D.S. 17th Symposium on Medicinal Chemistry in Eastern England (2006), University of Hertfordshire, Hatfield, UK